Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho GTPase-activating protein 7

Gene

DLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.3 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • lipid binding Source: InterPro
  • SH2 domain binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SIGNORiQ96QB1

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 7
Alternative name(s):
Deleted in liver cancer 1 protein
Short name:
DLC-1
HP protein
Rho-type GTPase-activating protein 7
START domain-containing protein 12
Short name:
StARD12
StAR-related lipid transfer protein 12
Gene namesi
Name:DLC1
Synonyms:ARHGAP7, KIAA1723, STARD12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164741.14
HGNCiHGNC:2897 DLC1
MIMi604258 gene
neXtProtiNX_Q96QB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi475F → G: Abolishes interaction with EF1A1. 1 Publication1
Mutagenesisi476L → G: Abolishes interaction with EF1A1. 1 Publication1
Mutagenesisi879Y → F: Unable to displace endogenous DLC1 from focal adhesions. 1 Publication1
Mutagenesisi1114R → E: No catalytic activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi10395
MalaCardsiDLC1
OpenTargetsiENSG00000164741
PharmGKBiPA27351

Polymorphism and mutation databases

BioMutaiDLC1
DMDMi313104315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567071 – 1528Rho GTPase-activating protein 7Add BLAST1528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei523PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei566PhosphoserineBy similarity1
Modified residuei757PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96QB1
PaxDbiQ96QB1
PeptideAtlasiQ96QB1
PRIDEiQ96QB1
ProteomicsDBi77848
77849 [Q96QB1-1]
77850 [Q96QB1-3]

PTM databases

iPTMnetiQ96QB1
PhosphoSitePlusiQ96QB1

Expressioni

Tissue specificityi

Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

Gene expression databases

BgeeiENSG00000164741 Expressed in 241 organ(s), highest expression level in upper lobe of lung
CleanExiHS_DLC1
ExpressionAtlasiQ96QB1 baseline and differential
GenevisibleiQ96QB1 HS

Organism-specific databases

HPAiHPA017753

Interactioni

Subunit structurei

Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115667, 20 interactors
DIPiDIP-56928N
IntActiQ96QB1, 34 interactors
MINTiQ96QB1
STRINGi9606.ENSP00000276297

Structurei

Secondary structure

11528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96QB1
SMRiQ96QB1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96QB1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 515SAMAdd BLAST68
Domaini1078 – 1284Rho-GAPPROSITE-ProRule annotationAdd BLAST207
Domaini1314 – 1521STARTPROSITE-ProRule annotationAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni710 – 884Focal adhesion-targeting (FAT)Add BLAST175
Regioni1051 – 1073Polybasic cluster (PBR)Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi741 – 747Poly-Ser7
Compositional biasi868 – 874Poly-Ser7

Domaini

The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity.1 Publication
The polybasic cluster is required for activation and mediates binding to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) containing membranes.1 Publication

Phylogenomic databases

eggNOGiKOG2200 Eukaryota
ENOG410XQ10 LUCA
GeneTreeiENSGT00760000119123
HOGENOMiHOG000039960
HOVERGENiHBG055955
InParanoidiQ96QB1
KOiK20632
OMAiCGPGKSK
OrthoDBiEOG091G00OE
PhylomeDBiQ96QB1
TreeFamiTF314044

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR028854 DLC1
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PANTHERiPTHR12659:SF2 PTHR12659:SF2, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q96QB1-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVAIRKRSW EEHVTHWMGQ PFNSDDRNTA CHHGLVADSL QASMEKDATL
60 70 80 90 100
NVDRKEKCVS LPDCCHGSEL RDFPGRPMGH LSKDVDENDS HEGEDQFLSL
110 120 130 140 150
EASTETLVHV SDEDNNADLC LTDDKQVLNT QGQKTSGQHM IQGAGSLEKA
160 170 180 190 200
LPIIQSNQVS SNSWGIAGET ELALVKESGE RKVTDSISKS LELCNEISLS
210 220 230 240 250
EIKDAPKVNA VDTLNVKDIA PEKQLLNSAV IAQQRRKPDP PKDENERSTC
260 270 280 290 300
NVVQNEFLDT PCTNRGLPLL KTDFGSCLLQ PPSCPNGMSA ENGLEKSGFS
310 320 330 340 350
QHQNKSPPKV KAEDGMQCLQ LKETLATQEP TDNQVRLRKR KEIREDRDRA
360 370 380 390 400
RLDSMVLLIM KLDQLDQDIE NALSTSSSPS GTPTNLRRHV PDLESGSESG
410 420 430 440 450
ADTISVNQTR VNLSSDTEST DLPSSTPVAN SGTKPKTTAI QGISEKEKAE
460 470 480 490 500
IEAKEACDWL RATGFPQYAQ LYEDFLFPID ISLVKREHDF LDRDAIEALC
510 520 530 540 550
RRLNTLNKCA VMKLEISPHR KRSDDSDEDE PCAISGKWTF QRDSKRWSRL
560 570 580 590 600
EEFDVFSPKQ DLVPGSPDDS HPKDGPSPGG TLMDLSERQE VSSVRSLSST
610 620 630 640 650
GSLPSHAPPS EDAATPRTNS VISVCSSSNL AGNDDSFGSL PSPKELSSFS
660 670 680 690 700
FSMKGHEKTA KSKTRSLLKR MESLKLKSSH HSKHKAPSKL GLIISGPILQ
710 720 730 740 750
EGMDEEKLKQ LNCVEISALN GNRINVPMVR KRSVSNSTQT SSSSSQSETS
760 770 780 790 800
SAVSTPSPVT RTRSLSACNK RVGMYLEGFD PFNQSTFNNV VEQNFKNRES
810 820 830 840 850
YPEDTVFYIP EDHKPGTFPK ALTNGSFSPS GNNGSVNWRT GSFHGPGHIS
860 870 880 890 900
LRRENSSDSP KELKRRNSSS SMSSRLSIYD NVPGSILYSS SGDLADLENE
910 920 930 940 950
DIFPELDDIL YHVKGMQRIV NQWSEKFSDE GDSDSALDSV SPCPSSPKQI
960 970 980 990 1000
HLDVDNDRTT PSDLDSTGNS LNEPEEPSEI PERRDSGVGA SLTRSNRHRL
1010 1020 1030 1040 1050
RWHSFQSSHR PSLNSVSLQI NCQSVAQMNL LQKYSLLKLT ALLEKYTPSN
1060 1070 1080 1090 1100
KHGFSWAVPK FMKRIKVPDY KDRSVFGVPL TVNVQRTGQP LPQSIQQAMR
1110 1120 1130 1140 1150
YLRNHCLDQV GLFRKSGVKS RIQALRQMNE GAIDCVNYEG QSAYDVADML
1160 1170 1180 1190 1200
KQYFRDLPEP LMTNKLSETF LQIYQYVPKD QRLQAIKAAI MLLPDENREV
1210 1220 1230 1240 1250
LQTLLYFLSD VTAAVKENQM TPTNLAVCLA PSLFHLNTLK RENSSPRVMQ
1260 1270 1280 1290 1300
RKQSLGKPDQ KDLNENLAAT QGLAHMIAEC KKLFQVPEEM SRCRNSYTEQ
1310 1320 1330 1340 1350
ELKPLTLEAL GHLGNDDSAD YQHFLQDCVD GLFKEVKEKF KGWVSYSTSE
1360 1370 1380 1390 1400
QAELSYKKVS EGPPLRLWRS VIEVPAVPEE ILKRLLKEQH LWDVDLLDSK
1410 1420 1430 1440 1450
VIEILDSQTE IYQYVQNSMA PHPARDYVVL RTWRTNLPKG ACALLLTSVD
1460 1470 1480 1490 1500
HDRAPVVGVR VNVLLSRYLI EPCGPGKSKL TYMCRVDLRG HMPEWYTKSF
1510 1520
GHLCAAEVVK IRDSFSNQNT ETKDTKSR
Length:1,528
Mass (Da):170,591
Last modified:November 30, 2010 - v4
Checksum:i5D20F29CC606302E
GO
Isoform 1 (identifier: Q96QB1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-437: Missing.
     438-450: TAIQGISEKEKAE → MCRKKPDTMILTQ

Show »
Length:1,091
Mass (Da):122,827
Checksum:i422B9D58B528E26C
GO
Isoform 3 (identifier: Q96QB1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-498: EIEAKEACDW...DFLDRDAIEA → AVKSVKLEVD...FHVAGEENIT
     499-1528: Missing.

Show »
Length:498
Mass (Da):54,552
Checksum:iAA2A500A52492F1F
GO
Isoform 4 (identifier: Q96QB1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-437: Missing.
     438-511: Missing.

Note: No experimental confirmation available.
Show »
Length:1,017
Mass (Da):114,152
Checksum:iA001B182EDE65398
GO
Isoform 5 (identifier: Q96QB1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-463: EIEAKEACDWLRAT → GKLTFWFCFLANLF
     464-1528: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):50,890
Checksum:i299AF4E12B29EEB1
GO
Isoform 6 (identifier: Q96QB1-6) [UniParc]FASTAAdd to basket
Also known as: i-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MSVAIRKRSW...VADSLQASME → MGDPKAHVMA...IWKNTRDRRL
     46-448: Missing.

Note: Produced by alternative promoter usage. ubiquitously expressed, significantly down-regulated in multiple carcinoma cell lines. PubMed:21217778 (ABX83661/ABX83662) sequences are in conflict in positions: 49-50:EA->KP.
Show »
Length:1,125
Mass (Da):126,746
Checksum:iA93D84FF40E9B92A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMP5R4GMP5_HUMAN
Rho GTPase-activating protein 7
DLC1
75Annotation score:
E5RI70E5RI70_HUMAN
Rho GTPase-activating protein 7
DLC1
48Annotation score:
A0A0J9YWS8A0A0J9YWS8_HUMAN
Rho GTPase-activating protein 7
DLC1
122Annotation score:

Sequence cautioni

The sequence AAB81637 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB21814 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43S → C in BAB14996 (PubMed:14702039).Curated1
Sequence conflicti130T → I in BAB14996 (PubMed:14702039).Curated1
Sequence conflicti571H → L in BAB21814 (PubMed:11214970).Curated1
Sequence conflicti1114R → K in AAB87700 (PubMed:9605766).Curated1
Sequence conflicti1364P → R in AAB87700 (PubMed:9605766).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05929327R → C. Corresponds to variant dbSNP:rs34575560Ensembl.1
Natural variantiVAR_05929481L → V. Corresponds to variant dbSNP:rs3816748Ensembl.1
Natural variantiVAR_059295254Q → H2 PublicationsCorresponds to variant dbSNP:rs11203495Ensembl.1
Natural variantiVAR_059296255N → D3 PublicationsCorresponds to variant dbSNP:rs11203494Ensembl.1
Natural variantiVAR_059297260T → I2 PublicationsCorresponds to variant dbSNP:rs3816747Ensembl.1
Natural variantiVAR_059298320Q → H. Corresponds to variant dbSNP:rs34591797Ensembl.1
Natural variantiVAR_014229712N → S2 PublicationsCorresponds to variant dbSNP:rs1044092Ensembl.1
Natural variantiVAR_014230791V → M5 PublicationsCorresponds to variant dbSNP:rs532841Ensembl.1
Natural variantiVAR_014231959T → A1 PublicationCorresponds to variant dbSNP:rs121908500EnsemblClinVar.1
Natural variantiVAR_014232998H → Q1 PublicationCorresponds to variant dbSNP:rs149295187Ensembl.1
Natural variantiVAR_0142331025V → A1 Publication1
Natural variantiVAR_0142341199E → V2 PublicationsCorresponds to variant dbSNP:rs1044093Ensembl.1
Natural variantiVAR_0142351209S → C2 PublicationsCorresponds to variant dbSNP:rs1044094Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0378711 – 437Missing in isoform 1 and isoform 4. 3 PublicationsAdd BLAST437
Alternative sequenceiVSP_0538361 – 45MSVAI…QASME → MGDPKAHVMARPLRAPLRRS FSDHIRDSTARALDVIWKNT RDRRL in isoform 6. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_05383746 – 448Missing in isoform 6. 1 PublicationAdd BLAST403
Alternative sequenceiVSP_044651438 – 511Missing in isoform 4. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_037872438 – 450TAIQG…KEKAE → MCRKKPDTMILTQ in isoform 1. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_037873450 – 498EIEAK…DAIEA → AVKSVKLEVDEDKSTKGSNF SNSEVAIGLSPYTFPQKRLF HVAGEENIT in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_046331450 – 463EIEAK…WLRAT → GKLTFWFCFLANLF in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_046332464 – 1528Missing in isoform 5. 1 PublicationAdd BLAST1065
Alternative sequenceiVSP_037874499 – 1528Missing in isoform 3. 1 PublicationAdd BLAST1030

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035119 mRNA Translation: AAB87700.1
AF026219 mRNA Translation: AAB81637.1 Different initiation.
AF408781
, AF408768, AF408769, AF408770, AF408771, AF408772, AF408773, AF408774, AF408775, AF408776, AF408777, AF408778, AF408779, AF408780 Genomic DNA Translation: AAK97501.1
AB051510 mRNA Translation: BAB21814.1 Different initiation.
AK024774 mRNA Translation: BAB14996.1
AK299049 mRNA Translation: BAG61122.1
AC015641 Genomic DNA No translation available.
AC019270 Genomic DNA No translation available.
AC022844 Genomic DNA No translation available.
AC106845 Genomic DNA No translation available.
BC049842 mRNA Translation: AAH49842.1
BC054511 mRNA Translation: AAH54511.1
EU159199 mRNA Translation: ABX83661.1
EU159200 mRNA Translation: ABX83662.1
CCDSiCCDS55201.1 [Q96QB1-4]
CCDS5989.1 [Q96QB1-2]
CCDS5990.1 [Q96QB1-1]
CCDS5991.2 [Q96QB1-5]
CCDS83253.1 [Q96QB1-6]
RefSeqiNP_001157743.1, NM_001164271.1 [Q96QB1-4]
NP_001303597.1, NM_001316668.1 [Q96QB1-6]
NP_001335010.1, NM_001348081.1 [Q96QB1-2]
NP_001335011.1, NM_001348082.1 [Q96QB1-4]
NP_001335012.1, NM_001348083.1 [Q96QB1-4]
NP_001335013.1, NM_001348084.1 [Q96QB1-4]
NP_006085.2, NM_006094.4 [Q96QB1-1]
NP_079043.3, NM_024767.3 [Q96QB1-5]
NP_872584.2, NM_182643.2 [Q96QB1-2]
XP_005273431.1, XM_005273374.1 [Q96QB1-2]
UniGeneiHs.134296
Hs.738560

Genome annotation databases

EnsembliENST00000276297; ENSP00000276297; ENSG00000164741 [Q96QB1-2]
ENST00000316609; ENSP00000321034; ENSG00000164741 [Q96QB1-3]
ENST00000358919; ENSP00000351797; ENSG00000164741 [Q96QB1-1]
ENST00000511869; ENSP00000425878; ENSG00000164741 [Q96QB1-5]
ENST00000512044; ENSP00000422595; ENSG00000164741 [Q96QB1-6]
ENST00000520226; ENSP00000428028; ENSG00000164741 [Q96QB1-4]
ENST00000644385; ENSP00000495134; ENSG00000285265 [Q96QB1-5]
ENST00000645814; ENSP00000496212; ENSG00000285265 [Q96QB1-3]
GeneIDi10395
KEGGihsa:10395
UCSCiuc003wwk.2 human [Q96QB1-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035119 mRNA Translation: AAB87700.1
AF026219 mRNA Translation: AAB81637.1 Different initiation.
AF408781
, AF408768, AF408769, AF408770, AF408771, AF408772, AF408773, AF408774, AF408775, AF408776, AF408777, AF408778, AF408779, AF408780 Genomic DNA Translation: AAK97501.1
AB051510 mRNA Translation: BAB21814.1 Different initiation.
AK024774 mRNA Translation: BAB14996.1
AK299049 mRNA Translation: BAG61122.1
AC015641 Genomic DNA No translation available.
AC019270 Genomic DNA No translation available.
AC022844 Genomic DNA No translation available.
AC106845 Genomic DNA No translation available.
BC049842 mRNA Translation: AAH49842.1
BC054511 mRNA Translation: AAH54511.1
EU159199 mRNA Translation: ABX83661.1
EU159200 mRNA Translation: ABX83662.1
CCDSiCCDS55201.1 [Q96QB1-4]
CCDS5989.1 [Q96QB1-2]
CCDS5990.1 [Q96QB1-1]
CCDS5991.2 [Q96QB1-5]
CCDS83253.1 [Q96QB1-6]
RefSeqiNP_001157743.1, NM_001164271.1 [Q96QB1-4]
NP_001303597.1, NM_001316668.1 [Q96QB1-6]
NP_001335010.1, NM_001348081.1 [Q96QB1-2]
NP_001335011.1, NM_001348082.1 [Q96QB1-4]
NP_001335012.1, NM_001348083.1 [Q96QB1-4]
NP_001335013.1, NM_001348084.1 [Q96QB1-4]
NP_006085.2, NM_006094.4 [Q96QB1-1]
NP_079043.3, NM_024767.3 [Q96QB1-5]
NP_872584.2, NM_182643.2 [Q96QB1-2]
XP_005273431.1, XM_005273374.1 [Q96QB1-2]
UniGeneiHs.134296
Hs.738560

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKYNMR-A451-515[»]
2GYTNMR-A451-513[»]
2KAPNMR-A454-513[»]
2LOZNMR-B811-824[»]
3KUQX-ray2.30A1074-1283[»]
5FZTX-ray2.10B904-926[»]
ProteinModelPortaliQ96QB1
SMRiQ96QB1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115667, 20 interactors
DIPiDIP-56928N
IntActiQ96QB1, 34 interactors
MINTiQ96QB1
STRINGi9606.ENSP00000276297

PTM databases

iPTMnetiQ96QB1
PhosphoSitePlusiQ96QB1

Polymorphism and mutation databases

BioMutaiDLC1
DMDMi313104315

Proteomic databases

EPDiQ96QB1
PaxDbiQ96QB1
PeptideAtlasiQ96QB1
PRIDEiQ96QB1
ProteomicsDBi77848
77849 [Q96QB1-1]
77850 [Q96QB1-3]

Protocols and materials databases

DNASUi10395
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276297; ENSP00000276297; ENSG00000164741 [Q96QB1-2]
ENST00000316609; ENSP00000321034; ENSG00000164741 [Q96QB1-3]
ENST00000358919; ENSP00000351797; ENSG00000164741 [Q96QB1-1]
ENST00000511869; ENSP00000425878; ENSG00000164741 [Q96QB1-5]
ENST00000512044; ENSP00000422595; ENSG00000164741 [Q96QB1-6]
ENST00000520226; ENSP00000428028; ENSG00000164741 [Q96QB1-4]
ENST00000644385; ENSP00000495134; ENSG00000285265 [Q96QB1-5]
ENST00000645814; ENSP00000496212; ENSG00000285265 [Q96QB1-3]
GeneIDi10395
KEGGihsa:10395
UCSCiuc003wwk.2 human [Q96QB1-2]

Organism-specific databases

CTDi10395
DisGeNETi10395
EuPathDBiHostDB:ENSG00000164741.14
GeneCardsiDLC1
HGNCiHGNC:2897 DLC1
HPAiHPA017753
MalaCardsiDLC1
MIMi604258 gene
neXtProtiNX_Q96QB1
OpenTargetsiENSG00000164741
PharmGKBiPA27351
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2200 Eukaryota
ENOG410XQ10 LUCA
GeneTreeiENSGT00760000119123
HOGENOMiHOG000039960
HOVERGENiHBG055955
InParanoidiQ96QB1
KOiK20632
OMAiCGPGKSK
OrthoDBiEOG091G00OE
PhylomeDBiQ96QB1
TreeFamiTF314044

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SIGNORiQ96QB1

Miscellaneous databases

ChiTaRSiDLC1 human
EvolutionaryTraceiQ96QB1
GeneWikiiDLC1
GenomeRNAii10395
PROiPR:Q96QB1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164741 Expressed in 241 organ(s), highest expression level in upper lobe of lung
CleanExiHS_DLC1
ExpressionAtlasiQ96QB1 baseline and differential
GenevisibleiQ96QB1 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR028854 DLC1
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PANTHERiPTHR12659:SF2 PTHR12659:SF2, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHG07_HUMAN
AccessioniPrimary (citable) accession number: Q96QB1
Secondary accession number(s): B4DR10
, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q9C0E0, Q9H7A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 30, 2010
Last modified: October 10, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again