UniProtKB - Q96QA6 (YPEL2_HUMAN)
Protein
Protein yippee-like 2
Gene
YPEL2
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 23 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 26 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 79 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 82 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96QA6 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein yippee-like 2 |
Gene namesi | Name:YPEL2 ORF Names:FKSG4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18326, YPEL2 |
MIMi | 609723, gene |
neXtProti | NX_Q96QA6 |
VEuPathDBi | HostDB:ENSG00000175155.8 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 388403 |
OpenTargetsi | ENSG00000175155 |
PharmGKBi | PA134978522 |
Miscellaneous databases
Pharosi | Q96QA6, Tdark |
Genetic variation databases
BioMutai | YPEL2 |
DMDMi | 27805781 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212385 | 1 – 119 | Protein yippee-like 2Add BLAST | 119 |
Proteomic databases
MassIVEi | Q96QA6 |
PaxDbi | Q96QA6 |
PeptideAtlasi | Q96QA6 |
PRIDEi | Q96QA6 |
ProteomicsDBi | 77847 |
PTM databases
iPTMneti | Q96QA6 |
PhosphoSitePlusi | Q96QA6 |
Expressioni
Tissue specificityi
Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000175155, Expressed in brain and 224 other tissues |
Genevisiblei | Q96QA6, HS |
Organism-specific databases
HPAi | ENSG00000175155, Low tissue specificity |
Interactioni
Subunit structurei
May interact with FAM168B.
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 132675, 5 interactors |
IntActi | Q96QA6, 5 interactors |
MINTi | Q96QA6 |
STRINGi | 9606.ENSP00000312272 |
Miscellaneous databases
RNActi | Q96QA6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 116 | YippeePROSITE-ProRule annotationAdd BLAST | 98 |
Sequence similaritiesi
Belongs to the yippee family.Curated
Phylogenomic databases
eggNOGi | KOG3399, Eukaryota |
GeneTreei | ENSGT00940000159010 |
HOGENOMi | CLU_043857_5_2_1 |
InParanoidi | Q96QA6 |
OMAi | EGEPNDR |
OrthoDBi | 1431042at2759 |
PhylomeDBi | Q96QA6 |
TreeFami | TF313936 |
Family and domain databases
InterProi | View protein in InterPro IPR034751, Yippee IPR004910, Yippee/Mis18/Cereblon IPR039058, Yippee_fam |
PANTHERi | PTHR13848, PTHR13848, 1 hit |
Pfami | View protein in Pfam PF03226, Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51792, YIPPEE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96QA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKMTRSKTF QAYLPSCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY
110
KEGKYIIELA HMIKDNGWD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9ZH55 | A0A5F9ZH55_HUMAN | Protein yippee-like | YPEL2 YPEL | 152 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098736 Genomic DNA Translation: BAD51377.1 AF305195 mRNA Translation: AAL09354.1 BC127924 mRNA Translation: AAI27925.1 BC132884 mRNA Translation: AAI32885.1 BC132886 mRNA Translation: AAI32887.1 |
CCDSi | CCDS32695.1 |
RefSeqi | NP_001005404.1, NM_001005404.3 XP_016880110.1, XM_017024621.1 |
Genome annotation databases
Ensembli | ENST00000312655; ENSP00000312272; ENSG00000175155 ENST00000585166; ENSP00000464285; ENSG00000175155 |
GeneIDi | 388403 |
KEGGi | hsa:388403 |
UCSCi | uc002ixm.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098736 Genomic DNA Translation: BAD51377.1 AF305195 mRNA Translation: AAL09354.1 BC127924 mRNA Translation: AAI27925.1 BC132884 mRNA Translation: AAI32885.1 BC132886 mRNA Translation: AAI32887.1 |
CCDSi | CCDS32695.1 |
RefSeqi | NP_001005404.1, NM_001005404.3 XP_016880110.1, XM_017024621.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132675, 5 interactors |
IntActi | Q96QA6, 5 interactors |
MINTi | Q96QA6 |
STRINGi | 9606.ENSP00000312272 |
PTM databases
iPTMneti | Q96QA6 |
PhosphoSitePlusi | Q96QA6 |
Genetic variation databases
BioMutai | YPEL2 |
DMDMi | 27805781 |
Proteomic databases
MassIVEi | Q96QA6 |
PaxDbi | Q96QA6 |
PeptideAtlasi | Q96QA6 |
PRIDEi | Q96QA6 |
ProteomicsDBi | 77847 |
Protocols and materials databases
Antibodypediai | 56995, 25 antibodies |
DNASUi | 388403 |
Genome annotation databases
Ensembli | ENST00000312655; ENSP00000312272; ENSG00000175155 ENST00000585166; ENSP00000464285; ENSG00000175155 |
GeneIDi | 388403 |
KEGGi | hsa:388403 |
UCSCi | uc002ixm.2, human |
Organism-specific databases
CTDi | 388403 |
DisGeNETi | 388403 |
GeneCardsi | YPEL2 |
HGNCi | HGNC:18326, YPEL2 |
HPAi | ENSG00000175155, Low tissue specificity |
MIMi | 609723, gene |
neXtProti | NX_Q96QA6 |
OpenTargetsi | ENSG00000175155 |
PharmGKBi | PA134978522 |
VEuPathDBi | HostDB:ENSG00000175155.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3399, Eukaryota |
GeneTreei | ENSGT00940000159010 |
HOGENOMi | CLU_043857_5_2_1 |
InParanoidi | Q96QA6 |
OMAi | EGEPNDR |
OrthoDBi | 1431042at2759 |
PhylomeDBi | Q96QA6 |
TreeFami | TF313936 |
Enzyme and pathway databases
PathwayCommonsi | Q96QA6 |
Miscellaneous databases
BioGRID-ORCSi | 388403, 11 hits in 997 CRISPR screens |
ChiTaRSi | YPEL2, human |
GenomeRNAii | 388403 |
Pharosi | Q96QA6, Tdark |
PROi | PR:Q96QA6 |
RNActi | Q96QA6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175155, Expressed in brain and 224 other tissues |
Genevisiblei | Q96QA6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR034751, Yippee IPR004910, Yippee/Mis18/Cereblon IPR039058, Yippee_fam |
PANTHERi | PTHR13848, PTHR13848, 1 hit |
Pfami | View protein in Pfam PF03226, Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51792, YIPPEE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YPEL2_HUMAN | |
Accessioni | Q96QA6Primary (citable) accession number: Q96QA6 Secondary accession number(s): A0PK16 Q8N3W2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families