GSDMA

Functionⁱ

May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).Curated1 Publication

GO - Molecular functionⁱ

phosphatidylinositol-4,5-bisphosphate binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylinositol-4-phosphate binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylserine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17471240
pyroptosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Necrosis

Biological process

Necrosis

Protein family/group databases

TCDBⁱ	1.C.123.1.2 the pore-forming gasdermin (gasdermin) family

TCDBⁱ

1.C.123.1.2 the pore-forming gasdermin (gasdermin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gasdermin-A Alternative name(s): Gasdermin-1
Gene namesⁱ	Name:GSDMA Synonyms:GSDM, GSDM1 ORF Names:FKSG9
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167914.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13311 GSDMA
MIMⁱ	611218 gene
neXtProtⁱ	NX_Q96QA5

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	260	L → D: Spontaneous pyroptosis-inducing activity. 1 Publication	1
Mutagenesisⁱ	334	Y → D: Spontaneous pyroptosis-inducing activity. 1 Publication	1
Mutagenesisⁱ	338	A → D: Spontaneous pyroptosis-inducing activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	284110
Open Targets More...OpenTargetsⁱ	ENSG00000167914
PharmGKBⁱ	PA162390274

Polymorphism and mutation databases

BioMutaⁱ	GSDMA
DMDMⁱ	296439478

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000148173	1 – 445	Gasdermin-AAdd BLAST		445

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	Q96QA5
PaxDbⁱ	Q96QA5
PeptideAtlas More...PeptideAtlasⁱ	Q96QA5
PRIDEⁱ	Q96QA5
ProteomicsDBⁱ	77846

PTM databases

iPTMnetⁱ	Q96QA5
PhosphoSitePlusⁱ	Q96QA5

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium. Down-regulateded in gastric cancer cells.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000167914 Expressed in 65 organ(s), highest expression level in skin of leg
CleanExⁱ	HS_GSDMA
ExpressionAtlasⁱ	Q96QA5 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023313 HPA064826

HPAⁱ

HPA023313
HPA064826

Interactionⁱ

Subunit structureⁱ

The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.By similarity

Protein-protein interaction databases

BioGridⁱ	129762, 23 interactors
IntActⁱ	Q96QA5, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q96QA5
STRINGⁱ	9606.ENSP00000301659

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96QA5
SMRⁱ	Q96QA5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 251	Triggers pyroptosis1 PublicationAdd BLAST		251

Domainⁱ

Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.By similarity

Sequence similaritiesⁱ

Belongs to the gasdermin family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IH8H Eukaryota ENOG41116WI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063218
HOGENOMⁱ	HOG000082450
HOVERGENⁱ	HBG107968
InParanoidⁱ	Q96QA5
KEGG Orthology (KO) More...KOⁱ	K22141
OMAⁱ	RQLMVNG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09ST
PhylomeDBⁱ	Q96QA5
TreeFamⁱ	TF331886

Family and domain databases

InterProⁱ	View protein in InterPro IPR007677 Gasdermin
PANTHERⁱ	PTHR16399 PTHR16399, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04598 Gasdermin, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q96QA5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTMFENVTRA LARQLNPRGD LTPLDSLIDF KRFHPFCLVL RKRKSTLFWG 
        60         70         80         90        100
ARYVRTDYTL LDVLEPGSSP SDPTDTGNFG FKNMLDTRVE GDVDVPKTVK 
       110        120        130        140        150
VKGTAGLSQN STLEVQTLSV APKALETVQE RKLAADHPFL KEMQDQGENL 
       160        170        180        190        200
YVVMEVVETV QEVTLERAGK AEACFSLPFF APLGLQGSIN HKEAVTIPKG 
       210        220        230        240        250
CVLAFRVRQL MVKGKDEWDI PHICNDNMQT FPPGEKSGEE KVILIQASDV 
       260        270        280        290        300
GDVHEGFRTL KEEVQRETQQ VEKLSRVGQS SLLSSLSKLL GKKKELQDLE 
       310        320        330        340        350
LALEGALDKG HEVTLEALPK DVLLSKEAVG AILYFVGALT ELSEAQQKLL 
       360        370        380        390        400
VKSMEKKILP VQLKLVESTM EQNFLLDKEG VFPLQPELLS SLGDEELTLT 
       410        420        430        440 
EALVGLSGLE VQRSGPQYMW DPDTLPRLCA LYAGLSLLQQ LTKAS

Length:445

Mass (Da):49,365

Last modified:May 18, 2010 - v4

Checksum:ⁱFC745B63B9C40BCF

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	J3KRG2	J3KRG2_HUMAN		Gasdermin-A Gasdermin-A	GSDMA	158	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	131	R → RR in AAL14426 (Ref. 2) Curated	1
Sequence conflictⁱ	181 – 186	APLGLQ → LPIGAT in AAL14426 (Ref. 2) Curated	6
Sequence conflictⁱ	235 – 242	EKSGEEKV → GKPGEGKF in AAL14426 (Ref. 2) Curated	8
Sequence conflictⁱ	252 – 253	DV → EM in AAL14426 (Ref. 2) Curated	2
Sequence conflictⁱ	367 – 368	ES → RG in AAL14426 (Ref. 2) Curated	2
Sequence conflictⁱ	437	L → H in BAC04790 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_035010	18	R → Q. Corresponds to variant dbSNP:rs3894194Ensembl.	1
Natural variantⁱVAR_035011	128	V → L3 PublicationsCorresponds to variant dbSNP:rs7212938Ensembl.	1
Natural variantⁱVAR_035012	130	E → K1 PublicationCorresponds to variant dbSNP:rs7212944Ensembl.	1
Natural variantⁱVAR_062005	314	T → N1 PublicationCorresponds to variant dbSNP:rs56030650Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB093591 mRNA Translation: BAC75636.1 AF307953 mRNA Translation: AAL14426.1 AK096439 mRNA Translation: BAC04790.1 AC090844 Genomic DNA No translation available. BC109197 mRNA Translation: AAI09198.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45669.1
NCBI Reference Sequences More...RefSeqⁱ	NP_835465.2, NM_178171.4 XP_006721895.1, XM_006721832.2
UniGeneⁱ	Hs.448873

Genome annotation databases

Ensemblⁱ	ENST00000301659; ENSP00000301659; ENSG00000167914 ENST00000635792; ENSP00000490739; ENSG00000167914
GeneIDⁱ	284110
KEGGⁱ	hsa:284110
UCSC genome browser More...UCSCⁱ	uc002htl.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96QA5	Gasdermin-A (Fragment)		HUMAN		158	UniRef100_Q96QA5
UPI0005D0339C		HUMAN		303

Protein	Similar proteins		Species	Score	Length	Source
Q96QA5	Gasdermin-A (Fragment)		HUMAN		158	UniRef90_Q96QA5
Uncharacterized protein		CALJA		446
Uncharacterized protein		Cebus capucinus imitator		446
Gasdermin A		RHIBE		445
Gasdermin A		MACFA		445
+27

Protein	Similar proteins		Species	Score	Length	Source
Q96QA5	Gasdermin-A		MOUSE		446	UniRef50_Q96QA5
Gasdermin-A (Fragment)		HUMAN		158
Uncharacterized protein		Cebus capucinus imitator		446
Uncharacterized protein		CALJA		446
GSDMA isoform 1		PONAB		445
+165

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB093591 mRNA Translation: BAC75636.1 AF307953 mRNA Translation: AAL14426.1 AK096439 mRNA Translation: BAC04790.1 AC090844 Genomic DNA No translation available. BC109197 mRNA Translation: AAI09198.1
CCDSⁱ	CCDS45669.1
RefSeqⁱ	NP_835465.2, NM_178171.4 XP_006721895.1, XM_006721832.2
UniGeneⁱ	Hs.448873

3D structure databases

ProteinModelPortalⁱ	Q96QA5
SMRⁱ	Q96QA5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129762, 23 interactors
IntActⁱ	Q96QA5, 1 interactor
MINTⁱ	Q96QA5
STRINGⁱ	9606.ENSP00000301659

Protein family/group databases

TCDBⁱ	1.C.123.1.2 the pore-forming gasdermin (gasdermin) family

TCDBⁱ

1.C.123.1.2 the pore-forming gasdermin (gasdermin) family

PTM databases

iPTMnetⁱ	Q96QA5
PhosphoSitePlusⁱ	Q96QA5

Polymorphism and mutation databases

BioMutaⁱ	GSDMA
DMDMⁱ	296439478

Proteomic databases

EPDⁱ	Q96QA5
PaxDbⁱ	Q96QA5
PeptideAtlasⁱ	Q96QA5
PRIDEⁱ	Q96QA5
ProteomicsDBⁱ	77846

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000301659; ENSP00000301659; ENSG00000167914 ENST00000635792; ENSP00000490739; ENSG00000167914
GeneIDⁱ	284110
KEGGⁱ	hsa:284110
UCSCⁱ	uc002htl.1 human

Organism-specific databases

CTDⁱ	284110
DisGeNETⁱ	284110
EuPathDBⁱ	HostDB:ENSG00000167914.10
GeneCardsⁱ	GSDMA
H-InvDBⁱ	HIX0202459
HGNCⁱ	HGNC:13311 GSDMA
HPAⁱ	HPA023313 HPA064826
MIMⁱ	611218 gene
neXtProtⁱ	NX_Q96QA5
OpenTargetsⁱ	ENSG00000167914
PharmGKBⁱ	PA162390274
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH8H Eukaryota ENOG41116WI LUCA
GeneTreeⁱ	ENSGT00530000063218
HOGENOMⁱ	HOG000082450
HOVERGENⁱ	HBG107968
InParanoidⁱ	Q96QA5
KOⁱ	K22141
OMAⁱ	RQLMVNG
OrthoDBⁱ	EOG091G09ST
PhylomeDBⁱ	Q96QA5
TreeFamⁱ	TF331886

Miscellaneous databases

GenomeRNAiⁱ	284110
Protein Ontology More...PROⁱ	PR:Q96QA5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167914 Expressed in 65 organ(s), highest expression level in skin of leg
CleanExⁱ	HS_GSDMA
ExpressionAtlasⁱ	Q96QA5 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR007677 Gasdermin
PANTHERⁱ	PTHR16399 PTHR16399, 1 hit
Pfamⁱ	View protein in Pfam PF04598 Gasdermin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GSDMA_HUMAN
Accessionⁱ	Q96QA5Primary (citable) accession number: Q96QA5 Secondary accession number(s): Q32MC5, Q86VE7, Q8N1M6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 106 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q96QA5 (GSDMA_HUMAN)

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Gasdermin-A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma membrane

Other locations

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ