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Entry version 147 (08 May 2019)
Sequence version 3 (05 Oct 2010)
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Protein

Kinesin-like protein KIF20B

Gene

KIF20B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi152 – 159ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF20BCurated
Alternative name(s):
Cancer/testis antigen 90
Short name:
CT90
Kinesin family member 20BImported
Kinesin-related motor interacting with PIN11 Publication
M-phase phosphoprotein 11 Publication
Short name:
MPP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF20BImported
Synonyms:KRMP11 Publication, MPHOSPH11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7212 KIF20B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605498 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96Q89

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
9585

Open Targets

More...
OpenTargetsi
ENSG00000138182

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393285

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2021752

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIF20B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153587

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002740531 – 1820Kinesin-like protein KIF20BAdd BLAST1820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei488PhosphoserineCombined sources1
Modified residuei560PhosphothreonineCombined sources1
Modified residuei997PhosphoserineBy similarity1
Modified residuei1588PhosphoserineCombined sources1
Modified residuei1644Phosphothreonine; by CDK11 Publication1
Modified residuei1658PhosphoserineCombined sources1
Modified residuei1715PhosphoserineCombined sources1
Modified residuei1740PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis by CDK1 (PubMed:11470801, PubMed:12740395).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96Q89

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96Q89

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96Q89

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96Q89

PeptideAtlas

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PeptideAtlasi
Q96Q89

PRoteomics IDEntifications database

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PRIDEi
Q96Q89

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77838
77839 [Q96Q89-2]
77840 [Q96Q89-3]
77841 [Q96Q89-4]
77842 [Q96Q89-5]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q96Q89

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96Q89

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96Q89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, ovary, kidney and testis (at protein level) (PubMed:12740395). Overexpressed in bladder cancer cells (at protein level) (PubMed:17409436). Expressed in testis. Overexpressed in bladder cancer cells (PubMed:17409436).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138182 Expressed in 157 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96Q89 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96Q89 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031263

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomerizes (via kinesin motor domain) (PubMed:11470801). Associates with microtubules (PubMed:12740395). Interacts (via C-terminal globular tail region) with PIN1 (via WW domain) (PubMed:11470801). Interacts with PRC1 (PubMed:17409436). Interacts with SHTN1 (via N-terminus); the interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114953, 29 interactors

Database of interacting proteins

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DIPi
DIP-103N

Protein interaction database and analysis system

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IntActi
Q96Q89, 25 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360793

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 479Kinesin motorPROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1050 – 1107Necessary and sufficient for interaction with SHTN1By similarityAdd BLAST58
Regioni1560 – 1820Interaction with PIN11 PublicationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili523 – 603Sequence analysisAdd BLAST81
Coiled coili674 – 793Sequence analysisAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1247 – 1251Poly-Glu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0247 Eukaryota
COG5059 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155989

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96Q89

KEGG Orthology (KO)

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KOi
K10402

Identification of Orthologs from Complete Genome Data

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OMAi
KNTGAQG

Database of Orthologous Groups

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OrthoDBi
314538at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96Q89

TreeFam database of animal gene trees

More...
TreeFami
TF105232

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028828 KIF20B
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24115 PTHR24115, 1 hit
PTHR24115:SF534 PTHR24115:SF534, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225 Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA
60 70 80 90 100
NSFESKDYLQ VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR
110 120 130 140 150
LSEKSSGQMA QKFSFSKVFG PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT
160 170 180 190 200
YGLTNSGKTY TFQGTEENIG ILPRTLNVLF DSLQERLYTK MNLKPHRSRE
210 220 230 240 250
YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL TNSLNISEFE
260 270 280 290 300
ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML
310 320 330 340 350
RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR
360 370 380 390 400
SHSIFTVKIL QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET
410 420 430 440 450
GNINTSLLTL GKCINVLKNS EKSKFQQHVP FRESKLTHYF QSFFNGKGKI
460 470 480 490 500
CMIVNISQCY LAYDETLNVL KFSAIAQKVC VPDTLNSSQE KLFGPVKSSQ
510 520 530 540 550
DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE NAEETQNVET
560 570 580 590 600
KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK
610 620 630 640 650
IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD
660 670 680 690 700
TREEAAKDIC ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI
710 720 730 740 750
ASLPDPQEAT ACLELKFNQI KAELAKTKGE LIKTKEELKK RENESDSLIQ
760 770 780 790 800
ELETSNKKII TQNQRIKELI NIIDQKEDTI NEFQNLKSHM ENTFKCNDKA
810 820 830 840 850
DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ QDEPPAKKGS
860 870 880 890 900
IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN
910 920 930 940 950
EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ
960 970 980 990 1000
KSKNQEQEEK IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ
1010 1020 1030 1040 1050
ISNIDLLNLR DLSNGSEEDN LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE
1060 1070 1080 1090 1100
NSFHSSIEAI WEECKEIVKA SSKKSHQIEE LEQQIEKLQA EVKGYKDENN
1110 1120 1130 1140 1150
RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ HVVEGKRALS
1160 1170 1180 1190 1200
ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN
1210 1220 1230 1240 1250
LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE
1260 1270 1280 1290 1300
ETNRQETEKL KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK
1310 1320 1330 1340 1350
QVQKEVSVMR DEDKLLRIKI NELEKKKNQC SQELDMKQRT IQQLKEQLNN
1360 1370 1380 1390 1400
QKVEEAIQQY ERACKDLNVK EKIIEDMRMT LEEQEQTQVE QDQVLEAKLE
1410 1420 1430 1440 1450
EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK LTNLQDELQE
1460 1470 1480 1490 1500
SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE
1510 1520 1530 1540 1550
MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL
1560 1570 1580 1590 1600
KRIISETSKI ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS
1610 1620 1630 1640 1650
VVLDSCEVST ENDQSTRFPK PELEIQFTPL QPNKMAVKHP GCTTPVTVKI
1660 1670 1680 1690 1700
PKARKRKSNE MEEDLVKCEN KKNATPRTNL KFPISDDRNS SVKKEQKVAI
1710 1720 1730 1740 1750
RPSSKKTYSL RSQASIIGVN LATKKKEGTL QKFGDFLQHS PSILQSKAKK
1760 1770 1780 1790 1800
IIETMSSSKL SNVEASKENV SQPKRAKRKL YTSEISSPID ISGQVILMDQ
1810 1820
KMKESDHQII KRRLRTKTAK
Length:1,820
Mass (Da):210,629
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A6FE95A6F3BA20C
GO
Isoform 2 (identifier: Q96Q89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: G → GTTSAASSRRLRKLISKPKKGVNRTRQTEGHSLV

Show »
Length:1,853
Mass (Da):214,276
Checksum:i07E7FFF9A7D116C5
GO
Isoform 3 (identifier: Q96Q89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-707: Missing.

Show »
Length:1,780
Mass (Da):206,136
Checksum:i084B8D31404946E4
GO
Isoform 4 (identifier: Q96Q89-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1722: DLVKCENKKN...QASIIGVNLA → SASPPPKECS...EVENFEKNLD
     1723-1820: Missing.

Show »
Length:1,722
Mass (Da):199,810
Checksum:i6B5B4801B38BFF40
GO
Isoform 5 (identifier: Q96Q89-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1308: Missing.

Show »
Length:512
Mass (Da):59,621
Checksum:i15D67C1B5D1FBD7B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSJ5A0A0A0MSJ5_HUMAN
Kinesin-like protein KIF20B
KIF20B
206Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH46134 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH58913 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH93089 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI08689 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15043 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti266S → T in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti296 – 297KR → NT in BAB69456 (PubMed:11470801).Curated2
Sequence conflicti357V → I in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti388M → V in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti593E → K in AAI08689 (PubMed:15489334).Curated1
Sequence conflicti705 – 707DPQ → ETE in AAP40331 (PubMed:12740395).Curated3
Sequence conflicti753E → K in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti797N → S in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti870N → S in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti915F → S in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti1105K → R in BAB15043 (PubMed:14702039).Curated1
Sequence conflicti1302V → E in AAC37542 (PubMed:8290587).Curated1
Sequence conflicti1459R → S in AAC37542 (PubMed:8290587).Curated1
Sequence conflicti1608V → A in BAB69456 (PubMed:11470801).Curated1
Sequence conflicti1649K → E in CAB55962 (PubMed:11230166).Curated1
Sequence conflicti1649K → E in BAB15194 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03018150A → G. Corresponds to variant dbSNP:rs1129777Ensembl.1
Natural variantiVAR_030182490E → D2 PublicationsCorresponds to variant dbSNP:rs17484219Ensembl.1
Natural variantiVAR_030183756N → I2 PublicationsCorresponds to variant dbSNP:rs12572012Ensembl.1
Natural variantiVAR_030184789H → L2 PublicationsCorresponds to variant dbSNP:rs3758388Ensembl.1
Natural variantiVAR_0301851011D → E. Corresponds to variant dbSNP:rs1062465Ensembl.1
Natural variantiVAR_0301861127E → Q. Corresponds to variant dbSNP:rs11185863Ensembl.1
Natural variantiVAR_0757041148A → V1 PublicationCorresponds to variant dbSNP:rs117564945Ensembl.1
Natural variantiVAR_0301871177C → R6 PublicationsCorresponds to variant dbSNP:rs1886996Ensembl.1
Natural variantiVAR_0301881219N → S. Corresponds to variant dbSNP:rs1886997Ensembl.1
Natural variantiVAR_0757051589F → Y1 PublicationCorresponds to variant dbSNP:rs117258675Ensembl.1
Natural variantiVAR_0301891789I → V. Corresponds to variant dbSNP:rs3758390Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0226181 – 1308Missing in isoform 5. 1 PublicationAdd BLAST1308
Alternative sequenceiVSP_022619668 – 707Missing in isoform 3. 4 PublicationsAdd BLAST40
Alternative sequenceiVSP_022620849G → GTTSAASSRRLRKLISKPKK GVNRTRQTEGHSLV in isoform 2. 1 Publication1
Alternative sequenceiVSP_0226211664 – 1722DLVKC…GVNLA → SASPPPKECSSSPAMEQSWK ENDFDKLREEGFRRSNYSEL QEEIQTKGKEVENFEKNLD in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_0226221723 – 1820Missing in isoform 4. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB033337 mRNA Translation: BAB69456.1
AB033338 mRNA Translation: BAB20417.1
AL117496 mRNA Translation: CAB55962.1
AK024959 mRNA Translation: BAB15043.1 Sequence problems.
AK025628 mRNA Translation: BAB15194.1
AL157389 Genomic DNA No translation available.
AL157400 Genomic DNA No translation available.
AY282406 mRNA Translation: AAP40330.1
AY282407 mRNA Translation: AAP40331.1
BC046134 mRNA Translation: AAH46134.1 Sequence problems.
BC058913 mRNA Translation: AAH58913.1 Sequence problems.
BC093089 mRNA Translation: AAH93089.1 Sequence problems.
BC108688 mRNA Translation: AAI08689.1 Sequence problems.
AL137392 mRNA Translation: CAB70720.1
U93121 mRNA Translation: AAB88727.1
AY739715 mRNA Translation: AAW65984.1
L16782 mRNA Translation: AAC37542.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS60590.1 [Q96Q89-1]
CCDS7407.1 [Q96Q89-3]

Protein sequence database of the Protein Information Resource

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PIRi
T17272

NCBI Reference Sequences

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RefSeqi
NP_001271188.1, NM_001284259.1 [Q96Q89-1]
NP_057279.2, NM_016195.3 [Q96Q89-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260753; ENSP00000260753; ENSG00000138182 [Q96Q89-3]
ENST00000371728; ENSP00000360793; ENSG00000138182 [Q96Q89-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9585

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9585

UCSC genome browser

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UCSCi
uc001kgr.3 human [Q96Q89-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033337 mRNA Translation: BAB69456.1
AB033338 mRNA Translation: BAB20417.1
AL117496 mRNA Translation: CAB55962.1
AK024959 mRNA Translation: BAB15043.1 Sequence problems.
AK025628 mRNA Translation: BAB15194.1
AL157389 Genomic DNA No translation available.
AL157400 Genomic DNA No translation available.
AY282406 mRNA Translation: AAP40330.1
AY282407 mRNA Translation: AAP40331.1
BC046134 mRNA Translation: AAH46134.1 Sequence problems.
BC058913 mRNA Translation: AAH58913.1 Sequence problems.
BC093089 mRNA Translation: AAH93089.1 Sequence problems.
BC108688 mRNA Translation: AAI08689.1 Sequence problems.
AL137392 mRNA Translation: CAB70720.1
U93121 mRNA Translation: AAB88727.1
AY739715 mRNA Translation: AAW65984.1
L16782 mRNA Translation: AAC37542.1
CCDSiCCDS60590.1 [Q96Q89-1]
CCDS7407.1 [Q96Q89-3]
PIRiT17272
RefSeqiNP_001271188.1, NM_001284259.1 [Q96Q89-1]
NP_057279.2, NM_016195.3 [Q96Q89-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi114953, 29 interactors
DIPiDIP-103N
IntActiQ96Q89, 25 interactors
STRINGi9606.ENSP00000360793

Chemistry databases

ChEMBLiCHEMBL2021752

PTM databases

CarbonylDBiQ96Q89
iPTMnetiQ96Q89
PhosphoSitePlusiQ96Q89

Polymorphism and mutation databases

BioMutaiKIF20B
DMDMi308153587

Proteomic databases

EPDiQ96Q89
jPOSTiQ96Q89
MaxQBiQ96Q89
PaxDbiQ96Q89
PeptideAtlasiQ96Q89
PRIDEiQ96Q89
ProteomicsDBi77838
77839 [Q96Q89-2]
77840 [Q96Q89-3]
77841 [Q96Q89-4]
77842 [Q96Q89-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9585
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260753; ENSP00000260753; ENSG00000138182 [Q96Q89-3]
ENST00000371728; ENSP00000360793; ENSG00000138182 [Q96Q89-1]
GeneIDi9585
KEGGihsa:9585
UCSCiuc001kgr.3 human [Q96Q89-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9585
DisGeNETi9585

GeneCards: human genes, protein and diseases

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GeneCardsi
KIF20B
HGNCiHGNC:7212 KIF20B
HPAiHPA031263
MIMi605498 gene
neXtProtiNX_Q96Q89
OpenTargetsiENSG00000138182
PharmGKBiPA162393285

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0247 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000155989
InParanoidiQ96Q89
KOiK10402
OMAiKNTGAQG
OrthoDBi314538at2759
PhylomeDBiQ96Q89
TreeFamiTF105232

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIF20B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MPHOSPH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9585

Protein Ontology

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PROi
PR:Q96Q89

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138182 Expressed in 157 organ(s), highest expression level in intestine
ExpressionAtlasiQ96Q89 baseline and differential
GenevisibleiQ96Q89 HS

Family and domain databases

Gene3Di3.40.850.10, 2 hits
InterProiView protein in InterPro
IPR028828 KIF20B
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF534 PTHR24115:SF534, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI20B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96Q89
Secondary accession number(s): A8MXM7
, O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 5, 2010
Last modified: May 8, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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