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UniProtKB - Q96Q35 (FACC1_HUMAN)

Entry version 133 (08 May 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Flagellum-associated coiled-coil domain-containing protein 1

Gene

FLACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flagellum-associated coiled-coil domain-containing protein 1Curated
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLACC1Imported
Synonyms:ALS2CR12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14439 FLACC1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96Q35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		130540

Open Targets

More...OpenTargetsi		ENSG00000155749

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24735

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALS2CR12

Domain mapping of disease mutations (DMDM)

More...DMDMi		212278361

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645401 – 445Flagellum-associated coiled-coil domain-containing protein 1Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei376N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96Q35

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96Q35

PeptideAtlas

More...PeptideAtlasi		Q96Q35

PRoteomics IDEntifications database

More...PRIDEi		Q96Q35

ProteomicsDB human proteome resource

More...ProteomicsDBi		77818

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96Q35

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96Q35

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155749 Expressed in 112 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96Q35 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96Q35 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035793

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		126239, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q96Q35, 25 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385098

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96Q35

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili122 – 226Sequence analysisAdd BLAST105
Coiled coili283 – 315Sequence analysisAdd BLAST33
Coiled coili387 – 414Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IKTG Eukaryota
ENOG411218R LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00400000022323

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000033891

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96Q35

Identification of Orthologs from Complete Genome Data

More...OMAi		KNMFRTY

Database of Orthologous Groups

More...OrthoDBi		1374230at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96Q35

TreeFam database of animal gene trees

More...TreeFami		TF338239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026674 ALS2CR12

The PANTHER Classification System

More...PANTHERi		PTHR21707 PTHR21707, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPNPLIYCT CWDPWNLGPR KLIKTPQLPR KNSTGSSKLT PLVPAPKNHN 
        60         70         80         90        100
YLQPTKPVVS PKMKIHSARQ EETNKSFYEV INVSPGYQLV RNREQISVTL 
       110        120        130        140        150
GDEMFDRKKR WESEIPDKGR FSRTNIISDL EEQISELTAI IEQMNRDHQS 
       160        170        180        190        200
AQKLLSSEMD LRCAEMKQNF ENKNRELKEA HEAELSELEN NYKAALKAEK 
       210        220        230        240        250
LAAQEKLEEM GKEYKYLKNM FRTYQDSIYD EMEEKWSKQK AKWKKDEKFE 
       260        270        280        290        300
RENILLQQKK KMTKKFEMES GEEDKKINES CSAVFENFIQ EKEELLKQHQ 
       310        320        330        340        350
SDTLQLEELR KTKEVPWRRD QINRHWHDVL QQLLLMQVMQ EELHAQALIL 
       360        370        380        390        400
ESLNTNLYYT QLELQKEKAI VGNLEKMLQT KFAETEEKYK HTIQILTEEN 
       410        420        430        440 
IHLKQKIISK NEEICEGCSG RLASITVSKD DSDTVQDGSK KGQES
Length:445
Mass (Da):52,439
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8E65CEC49AFD522
GO
Isoform 2 (identifier: Q96Q35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-337: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):49,474
Checksum:i047EB5D22DA8DE4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTY0C9JTY0_HUMAN
Flagellum-associated coiled-coil do...
FLACC1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZS0C9JZS0_HUMAN
Amyotrophic lateral sclerosis 2 (Ju...
FLACC1 ALS2CR12, hCG_16990
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1T5H7C1T5_HUMAN
Flagellum-associated coiled-coil do...
FLACC1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04562543V → L2 PublicationsCorresponds to variant dbSNP:rs13014235Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046184315 – 337Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB053314 mRNA Translation: BAB69022.1
AC007256 Genomic DNA Translation: AAY24226.1
CH471063 Genomic DNA Translation: EAW70267.1
CH471063 Genomic DNA Translation: EAW70269.1
BC031603 mRNA Translation: AAH31603.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2346.1 [Q96Q35-1]
CCDS46488.1 [Q96Q35-2]

NCBI Reference Sequences

More...RefSeqi		NP_001120863.1, NM_001127391.2 [Q96Q35-2]
NP_001276922.1, NM_001289993.1 [Q96Q35-2]
NP_631902.2, NM_139163.3 [Q96Q35-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286190; ENSP00000286190; ENSG00000155749 [Q96Q35-1]
ENST00000392257; ENSP00000376086; ENSG00000155749 [Q96Q35-2]
ENST00000405148; ENSP00000385098; ENSG00000155749 [Q96Q35-1]
ENST00000439709; ENSP00000412073; ENSG00000155749 [Q96Q35-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		130540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:130540

UCSC genome browser

More...UCSCi		uc002uya.5 human [Q96Q35-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053314 mRNA Translation: BAB69022.1
AC007256 Genomic DNA Translation: AAY24226.1
CH471063 Genomic DNA Translation: EAW70267.1
CH471063 Genomic DNA Translation: EAW70269.1
BC031603 mRNA Translation: AAH31603.1
CCDSiCCDS2346.1 [Q96Q35-1]
CCDS46488.1 [Q96Q35-2]
RefSeqiNP_001120863.1, NM_001127391.2 [Q96Q35-2]
NP_001276922.1, NM_001289993.1 [Q96Q35-2]
NP_631902.2, NM_139163.3 [Q96Q35-1]

3D structure databases

SMRiQ96Q35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126239, 7 interactors
IntActiQ96Q35, 25 interactors
STRINGi9606.ENSP00000385098

PTM databases

iPTMnetiQ96Q35
PhosphoSitePlusiQ96Q35

Polymorphism and mutation databases

BioMutaiALS2CR12
DMDMi212278361

Proteomic databases

jPOSTiQ96Q35
PaxDbiQ96Q35
PeptideAtlasiQ96Q35
PRIDEiQ96Q35
ProteomicsDBi77818

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		130540
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286190; ENSP00000286190; ENSG00000155749 [Q96Q35-1]
ENST00000392257; ENSP00000376086; ENSG00000155749 [Q96Q35-2]
ENST00000405148; ENSP00000385098; ENSG00000155749 [Q96Q35-1]
ENST00000439709; ENSP00000412073; ENSG00000155749 [Q96Q35-2]
GeneIDi130540
KEGGihsa:130540
UCSCiuc002uya.5 human [Q96Q35-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		130540
DisGeNETi130540

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALS2CR12

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0002737
HGNCiHGNC:14439 FLACC1
HPAiHPA035793
neXtProtiNX_Q96Q35
OpenTargetsiENSG00000155749
PharmGKBiPA24735

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IKTG Eukaryota
ENOG411218R LUCA
GeneTreeiENSGT00400000022323
HOGENOMiHOG000033891
InParanoidiQ96Q35
OMAiKNMFRTY
OrthoDBi1374230at2759
PhylomeDBiQ96Q35
TreeFamiTF338239

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALS2CR12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		130540

Protein Ontology

More...PROi		PR:Q96Q35

Gene expression databases

BgeeiENSG00000155749 Expressed in 112 organ(s), highest expression level in testis
ExpressionAtlasiQ96Q35 baseline and differential
GenevisibleiQ96Q35 HS

Family and domain databases

InterProiView protein in InterPro
IPR026674 ALS2CR12
PANTHERiPTHR21707 PTHR21707, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFACC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96Q35
Secondary accession number(s): G5E9S3, Q53TT6, Q8N1B6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: July 22, 2008
Last modified: May 8, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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