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UniProtKB - Q96Q15 (SMG1_HUMAN)

Entry version 178 (23 Feb 2022)
Sequence version 3 (08 Feb 2011)
Previous versions | rss
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Protein

Serine/threonine-protein kinase SMG1

Gene

SMG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.

4 Publications

Miscellaneous

This gene is located in a region of chromosome 16 that contains 2 segmental duplications. Other genes that are highly related to this exist, but they probably represent pseudogenes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by caffeine, LY294002 and wortmannin.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage, DNA repair, Nonsense-mediated mRNA decay
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96Q15

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96Q15

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96Q15

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase SMG1 (EC:2.7.11.1)
Short name:
SMG-1
Short name:
hSMG-1
Alternative name(s):
Lambda/iota protein kinase C-interacting protein1 Publication
Short name:
Lambda-interacting protein1 Publication
Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMG1Imported
Synonyms:ATXImported, KIAA0421Imported, LIPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30045, SMG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607032, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96Q15

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157106

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2335D → A: Loss of function. 3 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		23049

Open Targets

More...OpenTargetsi		ENSG00000157106

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164725852

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96Q15, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1795195

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2201

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SMG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		322510104

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002297911 – 3661Serine/threonine-protein kinase SMG1Add BLAST3661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei173N6-acetyllysineCombined sources1
Modified residuei3550PhosphothreonineCombined sources1
Modified residuei3556PhosphoserineCombined sources1
Modified residuei3570PhosphoserineCombined sources1
Modified residuei3573PhosphothreonineCombined sources1
Modified residuei3577PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96Q15

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96Q15

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96Q15

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96Q15

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96Q15

PeptideAtlas

More...PeptideAtlasi		Q96Q15

PRoteomics IDEntifications database

More...PRIDEi		Q96Q15

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77810 [Q96Q15-1]
77811 [Q96Q15-2]
77812 [Q96Q15-3]
77813 [Q96Q15-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96Q15

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q96Q15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96Q15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157106, Expressed in kidney and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96Q15, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96Q15, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157106, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain (PubMed:33205750).

Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

Part of a complex composed of SMG1, DHX34 and UPF1; within the complex DHX34 acts as a scaffolding protein to facilitate SMG1 phosphorylation of UPF1 (PubMed:26841701).

Interacts with PRKCI.

Interacts with TELO2 and TTI1.

Interacts with RUVBL1 and RUVBL2 (PubMed:33205750).

Interacts with UPF2.

Interacts with DHX34 (via C-terminus); the interaction is RNA-independent (PubMed:25220460, PubMed:33205750).

13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116687, 72 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96Q15

Protein interaction database and analysis system

More...IntActi		Q96Q15, 38 interactors

Molecular INTeraction database

More...MINTi		Q96Q15

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000402515

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q96Q15

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96Q15, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13661
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96Q15

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1283 – 1866FATPROSITE-ProRule annotationAdd BLAST584
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1817 – 1852HEATAdd BLAST36
Domaini2124 – 2463PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST340
Domaini3629 – 3661FATCPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1977Interaction with SMG8 and SMG91 PublicationAdd BLAST1977
Regioni1 – 101DisorderedSequence analysisAdd BLAST101
Regioni116 – 144DisorderedSequence analysisAdd BLAST29
Regioni1154 – 1175DisorderedSequence analysisAdd BLAST22
Regioni1898 – 1919DisorderedSequence analysisAdd BLAST22
Regioni2130 – 2136G-loopPROSITE-ProRule annotation7
Regioni2332 – 2340Catalytic loopPROSITE-ProRule annotation9
Regioni2352 – 2376Activation loopPROSITE-ProRule annotationAdd BLAST25
Regioni3568 – 3591DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 67Polar residuesSequence analysisAdd BLAST43
Compositional biasi68 – 82Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi87 – 101Polar residuesSequence analysisAdd BLAST15
Compositional biasi128 – 142Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3568 – 3583Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0891, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154776

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96Q15

Identification of Orthologs from Complete Genome Data

More...OMAi		ENRKEWP

Database of Orthologous Groups

More...OrthoDBi		26975at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96Q15

TreeFam database of animal gene trees

More...TreeFami		TF352560

Family and domain databases

Conserved Domains Database

More...CDDi		cd05170, PIKKc_SMG1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR014009, PIK_FAT
IPR031559, SMG1
IPR035175, SMG1_N
IPR039414, SMG1_PIKKc

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF15785, SMG1, 1 hit
PF17229, SMG1_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRAPGSRL SSGGGGGGTK YPRSWNDWQP RTDSASADPD NLKYSSSRDR 
        60         70         80         90        100
GGSSSYGLQP SNSAVVSRQR HDDTRVHADI QNDEKGGYSV NGGSGENTYG 
       110        120        130        140        150
RKSLGQELRV NNVTSPEFTS VQHGSRALAT KDMRKSQERS MSYSDESRLS 
       160        170        180        190        200
NLLRRITRED DRDRRLATVK QLKEFIQQPE NKLVLVKQLD NILAAVHDVL 
       210        220        230        240        250
NESSKLLQEL RQEGACCLGL LCASLSYEAE KIFKWIFSKF SSSAKDEVKL 
       260        270        280        290        300
LYLCATYKAL ETVGEKKAFS SVMQLVMTSL QSILENVDTP ELLCKCVKCI 
       310        320        330        340        350
LLVARCYPHI FSTNFRDTVD ILVGWHIDHT QKPSLTQQVS GWLQSLEPFW 
       360        370        380        390        400
VADLAFSTTL LGQFLEDMEA YAEDLSHVAS GESVDEDVPP PSVSLPKLAA 
       410        420        430        440        450
LLRVFSTVVR SIGERFSPIR GPPITEAYVT DVLYRVMRCV TAANQVFFSE 
       460        470        480        490        500
AVLTAANECV GVLLGSLDPS MTIHCDMVIT YGLDQLENCQ TCGTDYIISV 
       510        520        530        540        550
LNLLTLIVEQ INTKLPSSFV EKLFIPSSKL LFLRYHKEKE VVAVAHAVYQ 
       560        570        580        590        600
AVLSLKNIPV LETAYKLILG EMTCALNNLL HSLQLPEACS EIKHEAFKNH 
       610        620        630        640        650
VFNVDNAKFV VIFDLSALTT IGNAKNSLIG MWALSPTVFA LLSKNLMIVH 
       660        670        680        690        700
SDLAVHFPAI QYAVLYTLYS HCTRHDHFIS SSLSSSSPSL FDGAVISTVT 
       710        720        730        740        750
TATKKHFSII LNLLGILLKK DNLNQDTRKL LMTWALEAAV LMKKSETYAP 
       760        770        780        790        800
LFSLPSFHKF CKGLLANTLV EDVNICLQAC SSLHALSSSL PDDLLQRCVD 
       810        820        830        840        850
VCRVQLVHSG TRIRQAFGKL LKSIPLDVVL SNNNHTEIQE ISLALRSHMS 
       860        870        880        890        900
KAPSNTFHPQ DFSDVISFIL YGNSHRTGKD NWLERLFYSC QRLDKRDQST 
       910        920        930        940        950
IPRNLLKTDA VLWQWAIWEA AQFTVLSKLR TPLGRAQDTF QTIEGIIRSL 
       960        970        980        990       1000
AAHTLNPDQD VSQWTTADND EGHGNNQLRL VLLLQYLENL EKLMYNAYEG 
      1010       1020       1030       1040       1050
CANALTSPPK VIRTFFYTNR QTCQDWLTRI RLSIMRVGLL AGQPAVTVRH 
      1060       1070       1080       1090       1100
GFDLLTEMKT TSLSQGNELE VTIMMVVEAL CELHCPEAIQ GIAVWSSSIV 
      1110       1120       1130       1140       1150
GKNLLWINSV AQQAEGRFEK ASVEYQEHLC AMTGVDCCIS SFDKSVLTLA 
      1160       1170       1180       1190       1200
NAGRNSASPK HSLNGESRKT VLSKPTDSSP EVINYLGNKA CECYISIADW 
      1210       1220       1230       1240       1250
AAVQEWQNAI HDLKKSTSST SLNLKADFNY IKSLSSFESG KFVECTEQLE 
      1260       1270       1280       1290       1300
LLPGENINLL AGGSKEKIDM KKLLPNMLSP DPRELQKSIE VQLLRSSVCL 
      1310       1320       1330       1340       1350
ATALNPIEQD QKWQSITENV VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS 
      1360       1370       1380       1390       1400
TLQLYCSSAL ENTVSNRLST EDCLIPLFSE ALRSCKQHDV RPWMQALRYT 
      1410       1420       1430       1440       1450
MYQNQLLEKI KEQTVPIRSH LMELGLTAAK FARKRGNVSL ATRLLAQCSE 
      1460       1470       1480       1490       1500
VQLGKTTTAQ DLVQHFKKLS TQGQVDEKWG PELDIEKTKL LYTAGQSTHA 
      1510       1520       1530       1540       1550
MEMLSSCAIS FCKSVKAEYA VAKSILTLAK WIQAEWKEIS GQLKQVYRAQ 
      1560       1570       1580       1590       1600
HQQNFTGLST LSKNILTLIE LPSVNTMEEE YPRIESESTV HIGVGEPDFI 
      1610       1620       1630       1640       1650
LGQLYHLSSV QAPEVAKSWA ALASWAYRWG RKVVDNASQG EGVRLLPREK 
      1660       1670       1680       1690       1700
SEVQNLLPDT ITEEEKERIY GILGQAVCRP AGIQDEDITL QITESEDNEE 
      1710       1720       1730       1740       1750
DDMVDVIWRQ LISSCPWLSE LDESATEGVI KVWRKVVDRI FSLYKLSCSA 
      1760       1770       1780       1790       1800
YFTFLKLNAG QIPLDEDDPR LHLSHRVEQS TDDMIVMATL RLLRLLVKHA 
      1810       1820       1830       1840       1850
GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ 
      1860       1870       1880       1890       1900
DSPHLILYPA IVGTISLSSE SQASGNKFST AIPTLLGNIQ GEELLVSECE 
      1910       1920       1930       1940       1950
GGSPPASQDS NKDEPKSGLN EDQAMMQDCY SKIVDKLSSA NPTMVLQVQM 
      1960       1970       1980       1990       2000
LVAELRRVTV LWDELWLGVL LQQHMYVLRR IQQLEDEVKR VQNNNTLRKE 
      2010       2020       2030       2040       2050
EKIAIMREKH TALMKPIVFA LEHVRSITAA PAETPHEKWF QDNYGDAIEN 
      2060       2070       2080       2090       2100
ALEKLKTPLN PAKPGSSWIP FKEIMLSLQQ RAQKRASYIL RLEEISPWLA 
      2110       2120       2130       2140       2150
AMTNTEIALP GEVSARDTVT IHSVGGTITI LPTKTKPKKL LFLGSDGKSY 
      2160       2170       2180       2190       2200
PYLFKGLEDL HLDERIMQFL SIVNTMFATI NRQETPRFHA RHYSVTPLGT 
      2210       2220       2230       2240       2250
RSGLIQWVDG ATPLFGLYKR WQQREAALQA QKAQDSYQTP QNPGIVPRPS 
      2260       2270       2280       2290       2300
ELYYSKIGPA LKTVGLSLDV SRRDWPLHVM KAVLEELMEA TPPNLLAKEL 
      2310       2320       2330       2340       2350
WSSCTTPDEW WRVTQSYARS TAVMSMVGYI IGLGDRHLDN VLIDMTTGEV 
      2360       2370       2380       2390       2400
VHIDYNVCFE KGKSLRVPEK VPFRMTQNIE TALGVTGVEG VFRLSCEQVL 
      2410       2420       2430       2440       2450
HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAESKQS 
      2460       2470       2480       2490       2500
KREMEREITR SLFSSRVAEI KVNWFKNRDE MLVVLPKLDG SLDEYLSLQE 
      2510       2520       2530       2540       2550
QLTDVEKLQG KLLEEIEFLE GAEGVDHPSH TLQHRYSEHT QLQTQQRAVQ 
      2560       2570       2580       2590       2600
EAIQVKLNEF EQWITHYQAA FNNLEATQLA SLLQEISTQM DLGPPSYVPA 
      2610       2620       2630       2640       2650
TAFLQNAGQA HLISQCEQLE GEVGALLQQR RSVLRGCLEQ LHHYATVALQ 
      2660       2670       2680       2690       2700
YPKAIFQKHR IEQWKTWMEE LICNTTVERC QELYRKYEMQ YAPQPPPTVC 
      2710       2720       2730       2740       2750
QFITATEMTL QRYAADINSR LIRQVERLKQ EAVTVPVCED QLKEIERCIK 
      2760       2770       2780       2790       2800
VFLHENGEEG SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD 
      2810       2820       2830       2840       2850
GAWFLEELCS MSGNVTCLVQ LLKQCHLVPQ DLDIPNPMEA SETVHLANGV 
      2860       2870       2880       2890       2900
YTSLQELNSN FRQIIFPEAL RCLMKGEYTL ESMLHELDGL IEQTTDGVPL 
      2910       2920       2930       2940       2950
QTLVESLQAY LRNAAMGLEE ETHAHYIDVA RLLHAQYGEL IQPRNGSVDE 
      2960       2970       2980       2990       3000
TPKMSAGQML LVAFDGMFAQ VETAFSLLVE KLNKMEIPIA WRKIDIIREA 
      3010       3020       3030       3040       3050
RSTQVNFFDD DNHRQVLEEI FFLKRLQTIK EFFRLCGTFS KTLSGSSSLE 
      3060       3070       3080       3090       3100
DQNTVNGPVQ IVNVKTLFRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ 
      3110       3120       3130       3140       3150
ALGLTLCSFI SALGVDIIAQ VEAKDFGAES KVSVDDLCKK AVEHNIQIGK 
      3160       3170       3180       3190       3200
FSQLVMNRAT VLASSYDTAW KKHDLVRRLE TSISSCKTSL QRVQLHIAMF 
      3210       3220       3230       3240       3250
QWQHEDLLIN RPQAMSVTPP PRSAILTSMK KKLHTLSQIE TSIATVQEKL 
      3260       3270       3280       3290       3300
AALESSIEQR LKWAGGANPA LAPVLQDFEA TIAERRNLVL KESQRASQVT 
      3310       3320       3330       3340       3350
FLCSNIIHFE SLRTRTAEAL NLDAALFELI KRCQQMCSFA SQFNSSVSEL 
      3360       3370       3380       3390       3400
ELRLLQRVDT GLEHPIGSSE WLLSAHKQLT QDMSTQRAIQ TEKEQQIETV 
      3410       3420       3430       3440       3450
CETIQNLVDN IKTVLTGHNR QLGDVKHLLK AMAKDEEAAL ADGEDVPYEN 
      3460       3470       3480       3490       3500
SVRQFLGEYK SWQDNIQTVL FTLVQAMGQV RSQEHVEMLQ EITPTLKELK 
      3510       3520       3530       3540       3550
TQSQSIYNNL VSFASPLVTD ATNECSSPTS SATYQPSFAA AVRSNTGQKT 
      3560       3570       3580       3590       3600
QPDVMSQNAR KLIQKNLATS ADTPPSTVPG TGKSVACSPK KAVRDPKTGK 
      3610       3620       3630       3640       3650
AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDYV IKEATNLDNL 
      3660 
AQLYEGWTAW V
Length:3,661
Mass (Da):410,501
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i216A55F3121F5829
GO
Isoform 2 (identifier: Q96Q15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.

Show »
Length:3,521
Mass (Da):395,382
Checksum:iC2DDDEEA77C6D976
GO
Isoform 3 (identifier: Q96Q15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-630: Missing.

Show »
Length:3,031
Mass (Da):340,674
Checksum:i1932F4BF6722348C
GO
Isoform 4 (identifier: Q96Q15-4) [UniParc]FASTAAdd to basket
Also known as: BLIP

The sequence of this isoform differs from the canonical sequence as follows:
     1-1269: Missing.

Show »
Length:2,392
Mass (Da):269,425
Checksum:iD63ECA30F812D7A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRA9J3KRA9_HUMAN
Non-specific serine/threonine prote...
SMG1
3,551Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNP6E9PNP6_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0W2I3L0W2_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
607Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L400I3L400_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
551Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR09H3BR09_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQN7H3BQN7_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
853Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L144I3L144_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1K8A0A087X1K8_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXM7A0A087WXM7_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPS6H3BPS6_HUMAN
Serine/threonine-protein kinase SMG...
SMG1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA86535 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14G → GGGGG in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti20K → N in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti22P → S in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti40D → G in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti686S → A in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti743K → R in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti1193C → F in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti2009K → R in BAB70696 (PubMed:11544179).Curated1
Sequence conflicti2077S → N in AAK58892 (PubMed:9566925).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04162335A → T1 PublicationCorresponds to variant dbSNP:rs12051350Ensembl.1
Natural variantiVAR_041624126R → C1 PublicationCorresponds to variant dbSNP:rs752796432Ensembl.1
Natural variantiVAR_041625144S → C2 PublicationsCorresponds to variant dbSNP:rs766737607Ensembl.1
Natural variantiVAR_041626151N → Y1 PublicationCorresponds to variant dbSNP:rs750788715Ensembl.1
Natural variantiVAR_041627160D → N1 Publication1
Natural variantiVAR_041628167A → V1 PublicationCorresponds to variant dbSNP:rs1382468496Ensembl.1
Natural variantiVAR_041629320D → G1 Publication1
Natural variantiVAR_041630465G → S1 PublicationCorresponds to variant dbSNP:rs200419100Ensembl.1
Natural variantiVAR_041631546H → R1 PublicationCorresponds to variant dbSNP:rs376234691Ensembl.1
Natural variantiVAR_041632588A → S1 PublicationCorresponds to variant dbSNP:rs750840136Ensembl.1
Natural variantiVAR_041633612I → K2 PublicationsCorresponds to variant dbSNP:rs17842615Ensembl.1
Natural variantiVAR_041634753S → C1 PublicationCorresponds to variant dbSNP:rs569679854Ensembl.1
Natural variantiVAR_041635809S → C1 PublicationCorresponds to variant dbSNP:rs919788709Ensembl.1
Natural variantiVAR_041636812R → C1 PublicationCorresponds to variant dbSNP:rs1233400465Ensembl.1
Natural variantiVAR_041637829V → I1 Publication1
Natural variantiVAR_041638832N → D1 PublicationCorresponds to variant dbSNP:rs80176913Ensembl.1
Natural variantiVAR_041639952A → G1 PublicationCorresponds to variant dbSNP:rs555078480Ensembl.1
Natural variantiVAR_041640969N → S1 PublicationCorresponds to variant dbSNP:rs1412788971Ensembl.1
Natural variantiVAR_0416411016F → L1 PublicationCorresponds to variant dbSNP:rs1394431566Ensembl.1
Natural variantiVAR_0416421029R → Q1 Publication1
Natural variantiVAR_0416431072T → S1 PublicationCorresponds to variant dbSNP:rs45516593Ensembl.1
Natural variantiVAR_0416441103N → H1 PublicationCorresponds to variant dbSNP:rs563883658Ensembl.1
Natural variantiVAR_0416451275P → R1 Publication1
Natural variantiVAR_0416461292Q → P1 PublicationCorresponds to variant dbSNP:rs375411122Ensembl.1
Natural variantiVAR_0416471332I → V1 PublicationCorresponds to variant dbSNP:rs949474935Ensembl.1
Natural variantiVAR_0416481358S → P1 Publication1
Natural variantiVAR_0416491418R → T1 PublicationCorresponds to variant dbSNP:rs17731779Ensembl.1
Natural variantiVAR_0416502171S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0416512258G → S1 PublicationCorresponds to variant dbSNP:rs35572280Ensembl.1
Natural variantiVAR_0416522345M → K1 PublicationCorresponds to variant dbSNP:rs56276814Ensembl.1
Natural variantiVAR_0416532730Q → E1 PublicationCorresponds to variant dbSNP:rs34960798Ensembl.1
Natural variantiVAR_0416542889G → S1 PublicationCorresponds to variant dbSNP:rs35952340Ensembl.1
Natural variantiVAR_0416552899P → A1 PublicationCorresponds to variant dbSNP:rs55782217Ensembl.1
Natural variantiVAR_0416563239I → T in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0416573583K → Q in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0177461 – 1269Missing in isoform 4. 1 PublicationAdd BLAST1269
Alternative sequenceiVSP_0177471 – 630Missing in isoform 3. 1 PublicationAdd BLAST630
Alternative sequenceiVSP_0177481 – 140Missing in isoform 2. 1 PublicationAdd BLAST140

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF186377 mRNA Translation: AAK58892.1
AB061371 mRNA Translation: BAB70696.1
AY014957 mRNA Translation: AAK00511.1
AF395444 mRNA Translation: AAM73708.1
AC092287 Genomic DNA No translation available.
AB007881 mRNA Translation: BAA24851.2
U32581 mRNA Translation: AAA86535.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45430.1 [Q96Q15-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC6084

NCBI Reference Sequences

More...RefSeqi		NP_055907.3, NM_015092.4 [Q96Q15-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000446231; ENSP00000402515; ENSG00000157106

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23049

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23049

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000446231.7; ENSP00000402515.3; NM_015092.5; NP_055907.3

UCSC genome browser

More...UCSCi		uc002dfm.4, human [Q96Q15-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186377 mRNA Translation: AAK58892.1
AB061371 mRNA Translation: BAB70696.1
AY014957 mRNA Translation: AAK00511.1
AF395444 mRNA Translation: AAM73708.1
AC092287 Genomic DNA No translation available.
AB007881 mRNA Translation: BAA24851.2
U32581 mRNA Translation: AAA86535.2 Different initiation.
CCDSiCCDS45430.1 [Q96Q15-1]
PIRiJC6084
RefSeqiNP_055907.3, NM_015092.4 [Q96Q15-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6L53electron microscopy3.63A1-3661[»]
6L54electron microscopy3.43A1-3661[»]
6SYTelectron microscopy3.45A311-3661[»]
6Z3Relectron microscopy2.97A259-3661[»]
SMRiQ96Q15
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116687, 72 interactors
CORUMiQ96Q15
IntActiQ96Q15, 38 interactors
MINTiQ96Q15
STRINGi9606.ENSP00000402515

Chemistry databases

BindingDBiQ96Q15
ChEMBLiCHEMBL1795195
GuidetoPHARMACOLOGYi2201

PTM databases

iPTMnetiQ96Q15
MetOSiteiQ96Q15
PhosphoSitePlusiQ96Q15

Genetic variation databases

BioMutaiSMG1
DMDMi322510104

Proteomic databases

EPDiQ96Q15
jPOSTiQ96Q15
MassIVEiQ96Q15
MaxQBiQ96Q15
PaxDbiQ96Q15
PeptideAtlasiQ96Q15
PRIDEiQ96Q15
ProteomicsDBi77810 [Q96Q15-1]
77811 [Q96Q15-2]
77812 [Q96Q15-3]
77813 [Q96Q15-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6280, 207 antibodies from 16 providers

The DNASU plasmid repository

More...DNASUi		23049

Genome annotation databases

EnsembliENST00000446231; ENSP00000402515; ENSG00000157106
GeneIDi23049
KEGGihsa:23049
MANE-SelectiENST00000446231.7; ENSP00000402515.3; NM_015092.5; NP_055907.3
UCSCiuc002dfm.4, human [Q96Q15-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23049
DisGeNETi23049

GeneCards: human genes, protein and diseases

More...GeneCardsi		SMG1
HGNCiHGNC:30045, SMG1
HPAiENSG00000157106, Low tissue specificity
MIMi607032, gene
neXtProtiNX_Q96Q15
OpenTargetsiENSG00000157106
PharmGKBiPA164725852
VEuPathDBiHostDB:ENSG00000157106

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0891, Eukaryota
GeneTreeiENSGT00940000154776
InParanoidiQ96Q15
OMAiENRKEWP
OrthoDBi26975at2759
PhylomeDBiQ96Q15
TreeFamiTF352560

Enzyme and pathway databases

BRENDAi2.7.11.1, 2681
PathwayCommonsiQ96Q15
ReactomeiR-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiQ96Q15
SIGNORiQ96Q15

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23049, 639 hits in 1089 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SMG1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SMG1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23049
PharosiQ96Q15, Tchem

Protein Ontology

More...PROi		PR:Q96Q15
RNActiQ96Q15, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157106, Expressed in kidney and 229 other tissues
ExpressionAtlasiQ96Q15, baseline and differential
GenevisibleiQ96Q15, HS

Family and domain databases

CDDicd05170, PIKKc_SMG1, 1 hit
Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR014009, PIK_FAT
IPR031559, SMG1
IPR035175, SMG1_N
IPR039414, SMG1_PIKKc
PfamiView protein in Pfam
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF15785, SMG1, 1 hit
PF17229, SMG1_N, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96Q15
Secondary accession number(s): O43305
, Q13284, Q8NFX2, Q96QV0, Q96RW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 8, 2011
Last modified: February 23, 2022
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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