UniProtKB - Q96Q15 (SMG1_HUMAN)
Serine/threonine-protein kinase SMG1
SMG1
Functioni
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.
4 PublicationsMiscellaneous
Catalytic activityi
Cofactori
Activity regulationi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein kinase activity Source: UniProtKB
- protein kinase C activity Source: Reactome
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- RNA binding Source: UniProtKB
- telomeric DNA binding Source: BHF-UCL
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- mRNA export from nucleus Source: UniProtKB
- negative regulation of macroautophagy Source: GO_Central
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
- peptidyl-serine phosphorylation Source: UniProtKB
- phosphatidylinositol phosphate biosynthetic process Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- regulation of response to DNA damage stimulus Source: UniProtKB
- regulation of telomere maintenance Source: BHF-UCL
- TORC1 signaling Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | DNA damage, DNA repair, Nonsense-mediated mRNA decay |
Ligand | ATP-binding, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q96Q15 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | Q96Q15 |
SIGNORi | Q96Q15 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase SMG1 (EC:2.7.11.1)Short name: SMG-1 Short name: hSMG-1 Alternative name(s): Lambda/iota protein kinase C-interacting protein1 Publication Short name: Lambda-interacting protein1 Publication Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30045, SMG1 |
MIMi | 607032, gene |
neXtProti | NX_Q96Q15 |
VEuPathDBi | HostDB:ENSG00000157106 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- TORC1 complex Source: GO_Central
- TORC2 complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2335 | D → A: Loss of function. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 23049 |
OpenTargetsi | ENSG00000157106 |
PharmGKBi | PA164725852 |
Miscellaneous databases
Pharosi | Q96Q15, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1795195 |
GuidetoPHARMACOLOGYi | 2201 |
Genetic variation databases
BioMutai | SMG1 |
DMDMi | 322510104 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000229791 | 1 – 3661 | Serine/threonine-protein kinase SMG1Add BLAST | 3661 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 173 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 3550 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 3556 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3570 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3573 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 3577 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96Q15 |
jPOSTi | Q96Q15 |
MassIVEi | Q96Q15 |
MaxQBi | Q96Q15 |
PaxDbi | Q96Q15 |
PeptideAtlasi | Q96Q15 |
PRIDEi | Q96Q15 |
ProteomicsDBi | 77810 [Q96Q15-1] 77811 [Q96Q15-2] 77812 [Q96Q15-3] 77813 [Q96Q15-4] |
PTM databases
iPTMneti | Q96Q15 |
MetOSitei | Q96Q15 |
PhosphoSitePlusi | Q96Q15 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000157106, Expressed in kidney and 229 other tissues |
ExpressionAtlasi | Q96Q15, baseline and differential |
Genevisiblei | Q96Q15, HS |
Organism-specific databases
HPAi | ENSG00000157106, Low tissue specificity |
Interactioni
Subunit structurei
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain (PubMed:33205750).
Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.
Part of a complex composed of SMG1, DHX34 and UPF1; within the complex DHX34 acts as a scaffolding protein to facilitate SMG1 phosphorylation of UPF1 (PubMed:26841701).
Interacts with PRKCI.
Interacts with TELO2 and TTI1.
Interacts with RUVBL1 and RUVBL2 (PubMed:33205750).
Interacts with UPF2.
Interacts with DHX34 (via C-terminus); the interaction is RNA-independent (PubMed:25220460, PubMed:33205750).
13 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 116687, 72 interactors |
CORUMi | Q96Q15 |
IntActi | Q96Q15, 38 interactors |
MINTi | Q96Q15 |
STRINGi | 9606.ENSP00000402515 |
Chemistry databases
BindingDBi | Q96Q15 |
Miscellaneous databases
RNActi | Q96Q15, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96Q15 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1283 – 1866 | FATPROSITE-ProRule annotationAdd BLAST | 584 | |
Repeati | 1817 – 1852 | HEATAdd BLAST | 36 | |
Domaini | 2124 – 2463 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 340 | |
Domaini | 3629 – 3661 | FATCPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 1977 | Interaction with SMG8 and SMG91 PublicationAdd BLAST | 1977 | |
Regioni | 1 – 101 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 116 – 144 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1154 – 1175 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1898 – 1919 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2130 – 2136 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 2332 – 2340 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 2352 – 2376 | Activation loopPROSITE-ProRule annotationAdd BLAST | 25 | |
Regioni | 3568 – 3591 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 67 | Polar residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 68 – 82 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 87 – 101 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 128 – 142 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 3568 – 3583 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0891, Eukaryota |
GeneTreei | ENSGT00940000154776 |
InParanoidi | Q96Q15 |
OMAi | ENRKEWP |
OrthoDBi | 26975at2759 |
PhylomeDBi | Q96Q15 |
TreeFami | TF352560 |
Family and domain databases
CDDi | cd05170, PIKKc_SMG1, 1 hit |
Gene3Di | 1.10.1070.11, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR014009, PIK_FAT IPR031559, SMG1 IPR035175, SMG1_N IPR039414, SMG1_PIKKc |
Pfami | View protein in Pfam PF02260, FATC, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF15785, SMG1, 1 hit PF17229, SMG1_N, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRRAPGSRL SSGGGGGGTK YPRSWNDWQP RTDSASADPD NLKYSSSRDR
60 70 80 90 100
GGSSSYGLQP SNSAVVSRQR HDDTRVHADI QNDEKGGYSV NGGSGENTYG
110 120 130 140 150
RKSLGQELRV NNVTSPEFTS VQHGSRALAT KDMRKSQERS MSYSDESRLS
160 170 180 190 200
NLLRRITRED DRDRRLATVK QLKEFIQQPE NKLVLVKQLD NILAAVHDVL
210 220 230 240 250
NESSKLLQEL RQEGACCLGL LCASLSYEAE KIFKWIFSKF SSSAKDEVKL
260 270 280 290 300
LYLCATYKAL ETVGEKKAFS SVMQLVMTSL QSILENVDTP ELLCKCVKCI
310 320 330 340 350
LLVARCYPHI FSTNFRDTVD ILVGWHIDHT QKPSLTQQVS GWLQSLEPFW
360 370 380 390 400
VADLAFSTTL LGQFLEDMEA YAEDLSHVAS GESVDEDVPP PSVSLPKLAA
410 420 430 440 450
LLRVFSTVVR SIGERFSPIR GPPITEAYVT DVLYRVMRCV TAANQVFFSE
460 470 480 490 500
AVLTAANECV GVLLGSLDPS MTIHCDMVIT YGLDQLENCQ TCGTDYIISV
510 520 530 540 550
LNLLTLIVEQ INTKLPSSFV EKLFIPSSKL LFLRYHKEKE VVAVAHAVYQ
560 570 580 590 600
AVLSLKNIPV LETAYKLILG EMTCALNNLL HSLQLPEACS EIKHEAFKNH
610 620 630 640 650
VFNVDNAKFV VIFDLSALTT IGNAKNSLIG MWALSPTVFA LLSKNLMIVH
660 670 680 690 700
SDLAVHFPAI QYAVLYTLYS HCTRHDHFIS SSLSSSSPSL FDGAVISTVT
710 720 730 740 750
TATKKHFSII LNLLGILLKK DNLNQDTRKL LMTWALEAAV LMKKSETYAP
760 770 780 790 800
LFSLPSFHKF CKGLLANTLV EDVNICLQAC SSLHALSSSL PDDLLQRCVD
810 820 830 840 850
VCRVQLVHSG TRIRQAFGKL LKSIPLDVVL SNNNHTEIQE ISLALRSHMS
860 870 880 890 900
KAPSNTFHPQ DFSDVISFIL YGNSHRTGKD NWLERLFYSC QRLDKRDQST
910 920 930 940 950
IPRNLLKTDA VLWQWAIWEA AQFTVLSKLR TPLGRAQDTF QTIEGIIRSL
960 970 980 990 1000
AAHTLNPDQD VSQWTTADND EGHGNNQLRL VLLLQYLENL EKLMYNAYEG
1010 1020 1030 1040 1050
CANALTSPPK VIRTFFYTNR QTCQDWLTRI RLSIMRVGLL AGQPAVTVRH
1060 1070 1080 1090 1100
GFDLLTEMKT TSLSQGNELE VTIMMVVEAL CELHCPEAIQ GIAVWSSSIV
1110 1120 1130 1140 1150
GKNLLWINSV AQQAEGRFEK ASVEYQEHLC AMTGVDCCIS SFDKSVLTLA
1160 1170 1180 1190 1200
NAGRNSASPK HSLNGESRKT VLSKPTDSSP EVINYLGNKA CECYISIADW
1210 1220 1230 1240 1250
AAVQEWQNAI HDLKKSTSST SLNLKADFNY IKSLSSFESG KFVECTEQLE
1260 1270 1280 1290 1300
LLPGENINLL AGGSKEKIDM KKLLPNMLSP DPRELQKSIE VQLLRSSVCL
1310 1320 1330 1340 1350
ATALNPIEQD QKWQSITENV VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS
1360 1370 1380 1390 1400
TLQLYCSSAL ENTVSNRLST EDCLIPLFSE ALRSCKQHDV RPWMQALRYT
1410 1420 1430 1440 1450
MYQNQLLEKI KEQTVPIRSH LMELGLTAAK FARKRGNVSL ATRLLAQCSE
1460 1470 1480 1490 1500
VQLGKTTTAQ DLVQHFKKLS TQGQVDEKWG PELDIEKTKL LYTAGQSTHA
1510 1520 1530 1540 1550
MEMLSSCAIS FCKSVKAEYA VAKSILTLAK WIQAEWKEIS GQLKQVYRAQ
1560 1570 1580 1590 1600
HQQNFTGLST LSKNILTLIE LPSVNTMEEE YPRIESESTV HIGVGEPDFI
1610 1620 1630 1640 1650
LGQLYHLSSV QAPEVAKSWA ALASWAYRWG RKVVDNASQG EGVRLLPREK
1660 1670 1680 1690 1700
SEVQNLLPDT ITEEEKERIY GILGQAVCRP AGIQDEDITL QITESEDNEE
1710 1720 1730 1740 1750
DDMVDVIWRQ LISSCPWLSE LDESATEGVI KVWRKVVDRI FSLYKLSCSA
1760 1770 1780 1790 1800
YFTFLKLNAG QIPLDEDDPR LHLSHRVEQS TDDMIVMATL RLLRLLVKHA
1810 1820 1830 1840 1850
GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ
1860 1870 1880 1890 1900
DSPHLILYPA IVGTISLSSE SQASGNKFST AIPTLLGNIQ GEELLVSECE
1910 1920 1930 1940 1950
GGSPPASQDS NKDEPKSGLN EDQAMMQDCY SKIVDKLSSA NPTMVLQVQM
1960 1970 1980 1990 2000
LVAELRRVTV LWDELWLGVL LQQHMYVLRR IQQLEDEVKR VQNNNTLRKE
2010 2020 2030 2040 2050
EKIAIMREKH TALMKPIVFA LEHVRSITAA PAETPHEKWF QDNYGDAIEN
2060 2070 2080 2090 2100
ALEKLKTPLN PAKPGSSWIP FKEIMLSLQQ RAQKRASYIL RLEEISPWLA
2110 2120 2130 2140 2150
AMTNTEIALP GEVSARDTVT IHSVGGTITI LPTKTKPKKL LFLGSDGKSY
2160 2170 2180 2190 2200
PYLFKGLEDL HLDERIMQFL SIVNTMFATI NRQETPRFHA RHYSVTPLGT
2210 2220 2230 2240 2250
RSGLIQWVDG ATPLFGLYKR WQQREAALQA QKAQDSYQTP QNPGIVPRPS
2260 2270 2280 2290 2300
ELYYSKIGPA LKTVGLSLDV SRRDWPLHVM KAVLEELMEA TPPNLLAKEL
2310 2320 2330 2340 2350
WSSCTTPDEW WRVTQSYARS TAVMSMVGYI IGLGDRHLDN VLIDMTTGEV
2360 2370 2380 2390 2400
VHIDYNVCFE KGKSLRVPEK VPFRMTQNIE TALGVTGVEG VFRLSCEQVL
2410 2420 2430 2440 2450
HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAESKQS
2460 2470 2480 2490 2500
KREMEREITR SLFSSRVAEI KVNWFKNRDE MLVVLPKLDG SLDEYLSLQE
2510 2520 2530 2540 2550
QLTDVEKLQG KLLEEIEFLE GAEGVDHPSH TLQHRYSEHT QLQTQQRAVQ
2560 2570 2580 2590 2600
EAIQVKLNEF EQWITHYQAA FNNLEATQLA SLLQEISTQM DLGPPSYVPA
2610 2620 2630 2640 2650
TAFLQNAGQA HLISQCEQLE GEVGALLQQR RSVLRGCLEQ LHHYATVALQ
2660 2670 2680 2690 2700
YPKAIFQKHR IEQWKTWMEE LICNTTVERC QELYRKYEMQ YAPQPPPTVC
2710 2720 2730 2740 2750
QFITATEMTL QRYAADINSR LIRQVERLKQ EAVTVPVCED QLKEIERCIK
2760 2770 2780 2790 2800
VFLHENGEEG SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD
2810 2820 2830 2840 2850
GAWFLEELCS MSGNVTCLVQ LLKQCHLVPQ DLDIPNPMEA SETVHLANGV
2860 2870 2880 2890 2900
YTSLQELNSN FRQIIFPEAL RCLMKGEYTL ESMLHELDGL IEQTTDGVPL
2910 2920 2930 2940 2950
QTLVESLQAY LRNAAMGLEE ETHAHYIDVA RLLHAQYGEL IQPRNGSVDE
2960 2970 2980 2990 3000
TPKMSAGQML LVAFDGMFAQ VETAFSLLVE KLNKMEIPIA WRKIDIIREA
3010 3020 3030 3040 3050
RSTQVNFFDD DNHRQVLEEI FFLKRLQTIK EFFRLCGTFS KTLSGSSSLE
3060 3070 3080 3090 3100
DQNTVNGPVQ IVNVKTLFRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ
3110 3120 3130 3140 3150
ALGLTLCSFI SALGVDIIAQ VEAKDFGAES KVSVDDLCKK AVEHNIQIGK
3160 3170 3180 3190 3200
FSQLVMNRAT VLASSYDTAW KKHDLVRRLE TSISSCKTSL QRVQLHIAMF
3210 3220 3230 3240 3250
QWQHEDLLIN RPQAMSVTPP PRSAILTSMK KKLHTLSQIE TSIATVQEKL
3260 3270 3280 3290 3300
AALESSIEQR LKWAGGANPA LAPVLQDFEA TIAERRNLVL KESQRASQVT
3310 3320 3330 3340 3350
FLCSNIIHFE SLRTRTAEAL NLDAALFELI KRCQQMCSFA SQFNSSVSEL
3360 3370 3380 3390 3400
ELRLLQRVDT GLEHPIGSSE WLLSAHKQLT QDMSTQRAIQ TEKEQQIETV
3410 3420 3430 3440 3450
CETIQNLVDN IKTVLTGHNR QLGDVKHLLK AMAKDEEAAL ADGEDVPYEN
3460 3470 3480 3490 3500
SVRQFLGEYK SWQDNIQTVL FTLVQAMGQV RSQEHVEMLQ EITPTLKELK
3510 3520 3530 3540 3550
TQSQSIYNNL VSFASPLVTD ATNECSSPTS SATYQPSFAA AVRSNTGQKT
3560 3570 3580 3590 3600
QPDVMSQNAR KLIQKNLATS ADTPPSTVPG TGKSVACSPK KAVRDPKTGK
3610 3620 3630 3640 3650
AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDYV IKEATNLDNL
3660
AQLYEGWTAW V
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KRA9 | J3KRA9_HUMAN | Non-specific serine/threonine prote... | SMG1 | 3,551 | Annotation score: | ||
E9PNP6 | E9PNP6_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 335 | Annotation score: | ||
I3L0W2 | I3L0W2_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 607 | Annotation score: | ||
I3L400 | I3L400_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 551 | Annotation score: | ||
H3BR09 | H3BR09_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 56 | Annotation score: | ||
H3BQN7 | H3BQN7_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 853 | Annotation score: | ||
I3L144 | I3L144_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 321 | Annotation score: | ||
A0A087X1K8 | A0A087X1K8_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 85 | Annotation score: | ||
A0A087WXM7 | A0A087WXM7_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 197 | Annotation score: | ||
H3BPS6 | H3BPS6_HUMAN | Serine/threonine-protein kinase SMG... | SMG1 | 62 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | G → GGGGG in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 20 | K → N in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 22 | P → S in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 40 | D → G in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 686 | S → A in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 743 | K → R in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 1193 | C → F in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 2009 | K → R in BAB70696 (PubMed:11544179).Curated | 1 | |
Sequence conflicti | 2077 | S → N in AAK58892 (PubMed:9566925).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041623 | 35 | A → T1 PublicationCorresponds to variant dbSNP:rs12051350Ensembl. | 1 | |
Natural variantiVAR_041624 | 126 | R → C1 PublicationCorresponds to variant dbSNP:rs752796432Ensembl. | 1 | |
Natural variantiVAR_041625 | 144 | S → C2 PublicationsCorresponds to variant dbSNP:rs766737607Ensembl. | 1 | |
Natural variantiVAR_041626 | 151 | N → Y1 PublicationCorresponds to variant dbSNP:rs750788715Ensembl. | 1 | |
Natural variantiVAR_041627 | 160 | D → N1 Publication | 1 | |
Natural variantiVAR_041628 | 167 | A → V1 PublicationCorresponds to variant dbSNP:rs1382468496Ensembl. | 1 | |
Natural variantiVAR_041629 | 320 | D → G1 Publication | 1 | |
Natural variantiVAR_041630 | 465 | G → S1 PublicationCorresponds to variant dbSNP:rs200419100Ensembl. | 1 | |
Natural variantiVAR_041631 | 546 | H → R1 PublicationCorresponds to variant dbSNP:rs376234691Ensembl. | 1 | |
Natural variantiVAR_041632 | 588 | A → S1 PublicationCorresponds to variant dbSNP:rs750840136Ensembl. | 1 | |
Natural variantiVAR_041633 | 612 | I → K2 PublicationsCorresponds to variant dbSNP:rs17842615Ensembl. | 1 | |
Natural variantiVAR_041634 | 753 | S → C1 PublicationCorresponds to variant dbSNP:rs569679854Ensembl. | 1 | |
Natural variantiVAR_041635 | 809 | S → C1 PublicationCorresponds to variant dbSNP:rs919788709Ensembl. | 1 | |
Natural variantiVAR_041636 | 812 | R → C1 PublicationCorresponds to variant dbSNP:rs1233400465Ensembl. | 1 | |
Natural variantiVAR_041637 | 829 | V → I1 Publication | 1 | |
Natural variantiVAR_041638 | 832 | N → D1 PublicationCorresponds to variant dbSNP:rs80176913Ensembl. | 1 | |
Natural variantiVAR_041639 | 952 | A → G1 PublicationCorresponds to variant dbSNP:rs555078480Ensembl. | 1 | |
Natural variantiVAR_041640 | 969 | N → S1 PublicationCorresponds to variant dbSNP:rs1412788971Ensembl. | 1 | |
Natural variantiVAR_041641 | 1016 | F → L1 PublicationCorresponds to variant dbSNP:rs1394431566Ensembl. | 1 | |
Natural variantiVAR_041642 | 1029 | R → Q1 Publication | 1 | |
Natural variantiVAR_041643 | 1072 | T → S1 PublicationCorresponds to variant dbSNP:rs45516593Ensembl. | 1 | |
Natural variantiVAR_041644 | 1103 | N → H1 PublicationCorresponds to variant dbSNP:rs563883658Ensembl. | 1 | |
Natural variantiVAR_041645 | 1275 | P → R1 Publication | 1 | |
Natural variantiVAR_041646 | 1292 | Q → P1 PublicationCorresponds to variant dbSNP:rs375411122Ensembl. | 1 | |
Natural variantiVAR_041647 | 1332 | I → V1 PublicationCorresponds to variant dbSNP:rs949474935Ensembl. | 1 | |
Natural variantiVAR_041648 | 1358 | S → P1 Publication | 1 | |
Natural variantiVAR_041649 | 1418 | R → T1 PublicationCorresponds to variant dbSNP:rs17731779Ensembl. | 1 | |
Natural variantiVAR_041650 | 2171 | S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041651 | 2258 | G → S1 PublicationCorresponds to variant dbSNP:rs35572280Ensembl. | 1 | |
Natural variantiVAR_041652 | 2345 | M → K1 PublicationCorresponds to variant dbSNP:rs56276814Ensembl. | 1 | |
Natural variantiVAR_041653 | 2730 | Q → E1 PublicationCorresponds to variant dbSNP:rs34960798Ensembl. | 1 | |
Natural variantiVAR_041654 | 2889 | G → S1 PublicationCorresponds to variant dbSNP:rs35952340Ensembl. | 1 | |
Natural variantiVAR_041655 | 2899 | P → A1 PublicationCorresponds to variant dbSNP:rs55782217Ensembl. | 1 | |
Natural variantiVAR_041656 | 3239 | I → T in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041657 | 3583 | K → Q in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017746 | 1 – 1269 | Missing in isoform 4. 1 PublicationAdd BLAST | 1269 | |
Alternative sequenceiVSP_017747 | 1 – 630 | Missing in isoform 3. 1 PublicationAdd BLAST | 630 | |
Alternative sequenceiVSP_017748 | 1 – 140 | Missing in isoform 2. 1 PublicationAdd BLAST | 140 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF186377 mRNA Translation: AAK58892.1 AB061371 mRNA Translation: BAB70696.1 AY014957 mRNA Translation: AAK00511.1 AF395444 mRNA Translation: AAM73708.1 AC092287 Genomic DNA No translation available. AB007881 mRNA Translation: BAA24851.2 U32581 mRNA Translation: AAA86535.2 Different initiation. |
CCDSi | CCDS45430.1 [Q96Q15-1] |
PIRi | JC6084 |
RefSeqi | NP_055907.3, NM_015092.4 [Q96Q15-1] |
Genome annotation databases
Ensembli | ENST00000446231; ENSP00000402515; ENSG00000157106 |
GeneIDi | 23049 |
KEGGi | hsa:23049 |
MANE-Selecti | ENST00000446231.7; ENSP00000402515.3; NM_015092.5; NP_055907.3 |
UCSCi | uc002dfm.4, human [Q96Q15-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF186377 mRNA Translation: AAK58892.1 AB061371 mRNA Translation: BAB70696.1 AY014957 mRNA Translation: AAK00511.1 AF395444 mRNA Translation: AAM73708.1 AC092287 Genomic DNA No translation available. AB007881 mRNA Translation: BAA24851.2 U32581 mRNA Translation: AAA86535.2 Different initiation. |
CCDSi | CCDS45430.1 [Q96Q15-1] |
PIRi | JC6084 |
RefSeqi | NP_055907.3, NM_015092.4 [Q96Q15-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6L53 | electron microscopy | 3.63 | A | 1-3661 | [»] | |
6L54 | electron microscopy | 3.43 | A | 1-3661 | [»] | |
6SYT | electron microscopy | 3.45 | A | 311-3661 | [»] | |
6Z3R | electron microscopy | 2.97 | A | 259-3661 | [»] | |
SMRi | Q96Q15 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116687, 72 interactors |
CORUMi | Q96Q15 |
IntActi | Q96Q15, 38 interactors |
MINTi | Q96Q15 |
STRINGi | 9606.ENSP00000402515 |
Chemistry databases
BindingDBi | Q96Q15 |
ChEMBLi | CHEMBL1795195 |
GuidetoPHARMACOLOGYi | 2201 |
PTM databases
iPTMneti | Q96Q15 |
MetOSitei | Q96Q15 |
PhosphoSitePlusi | Q96Q15 |
Genetic variation databases
BioMutai | SMG1 |
DMDMi | 322510104 |
Proteomic databases
EPDi | Q96Q15 |
jPOSTi | Q96Q15 |
MassIVEi | Q96Q15 |
MaxQBi | Q96Q15 |
PaxDbi | Q96Q15 |
PeptideAtlasi | Q96Q15 |
PRIDEi | Q96Q15 |
ProteomicsDBi | 77810 [Q96Q15-1] 77811 [Q96Q15-2] 77812 [Q96Q15-3] 77813 [Q96Q15-4] |
Protocols and materials databases
Antibodypediai | 6280, 207 antibodies from 16 providers |
DNASUi | 23049 |
Genome annotation databases
Ensembli | ENST00000446231; ENSP00000402515; ENSG00000157106 |
GeneIDi | 23049 |
KEGGi | hsa:23049 |
MANE-Selecti | ENST00000446231.7; ENSP00000402515.3; NM_015092.5; NP_055907.3 |
UCSCi | uc002dfm.4, human [Q96Q15-1] |
Organism-specific databases
CTDi | 23049 |
DisGeNETi | 23049 |
GeneCardsi | SMG1 |
HGNCi | HGNC:30045, SMG1 |
HPAi | ENSG00000157106, Low tissue specificity |
MIMi | 607032, gene |
neXtProti | NX_Q96Q15 |
OpenTargetsi | ENSG00000157106 |
PharmGKBi | PA164725852 |
VEuPathDBi | HostDB:ENSG00000157106 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0891, Eukaryota |
GeneTreei | ENSGT00940000154776 |
InParanoidi | Q96Q15 |
OMAi | ENRKEWP |
OrthoDBi | 26975at2759 |
PhylomeDBi | Q96Q15 |
TreeFami | TF352560 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q96Q15 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | Q96Q15 |
SIGNORi | Q96Q15 |
Miscellaneous databases
BioGRID-ORCSi | 23049, 639 hits in 1089 CRISPR screens |
ChiTaRSi | SMG1, human |
GeneWikii | SMG1_(gene) |
GenomeRNAii | 23049 |
Pharosi | Q96Q15, Tchem |
PROi | PR:Q96Q15 |
RNActi | Q96Q15, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157106, Expressed in kidney and 229 other tissues |
ExpressionAtlasi | Q96Q15, baseline and differential |
Genevisiblei | Q96Q15, HS |
Family and domain databases
CDDi | cd05170, PIKKc_SMG1, 1 hit |
Gene3Di | 1.10.1070.11, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR014009, PIK_FAT IPR031559, SMG1 IPR035175, SMG1_N IPR039414, SMG1_PIKKc |
Pfami | View protein in Pfam PF02260, FATC, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF15785, SMG1, 1 hit PF17229, SMG1_N, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SMG1_HUMAN | |
Accessioni | Q96Q15Primary (citable) accession number: Q96Q15 Secondary accession number(s): O43305 Q96RW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families