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Entry version 167 (08 May 2019)
Sequence version 2 (18 May 2010)
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Protein

CCA tRNA nucleotidyltransferase 1, mitochondrial

Gene

TRNT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.1 Publication
Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei77By similarity1
Active sitei79By similarity1
Active sitei121By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
Biological processtRNA processing
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.72 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-6785470 tRNA processing in the mitochondrion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CCA tRNA nucleotidyltransferase 1, mitochondrial (EC:2.7.7.721 Publication)
Alternative name(s):
Mitochondrial tRNA nucleotidyl transferase, CCA-adding
mt CCA-adding enzyme
mt tRNA CCA-diphosphorylase
mt tRNA CCA-pyrophosphorylase
mt tRNA adenylyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRNT1
ORF Names:CGI-47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17341 TRNT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612907 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96Q11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by severe sideroblastic anemia with onset in the neonatal period or infancy, recurrent periodic fevers without an infectious etiology, B-cell lymphopenia and hypogammaglobulinemia. Affected individuals show delayed psychomotor development with variable neurodegeneration. Additional variable features include sensorineural hearing loss, retinitis pigmentosa, nephrocalcinosis, and cardiomyopathy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072421154T → I in SIFD; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs606231290EnsemblClinVar.1
Natural variantiVAR_072422158M → V in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs771781629Ensembl.1
Natural variantiVAR_072423166L → S in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs606231289EnsemblClinVar.1
Natural variantiVAR_072424190R → I in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs606231287EnsemblClinVar.1
Natural variantiVAR_072425223I → T in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs370011798EnsemblClinVar.1
Natural variantiVAR_072426326I → T in SIFD; loss of activity. 1 Publication1
Natural variantiVAR_072427416K → E in SIFD. 1 PublicationCorresponds to variant dbSNP:rs199931785Ensembl.1
Retinitis pigmentosa and erythrocytic microcytosis (RPEM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by retinitis pigmentosa, red blood cell microcytosis and anisocytosis with mild anemia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07692443Missing in RPEM. 1 Publication1

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
51095

MalaCards human disease database

More...
MalaCardsi
TRNT1
MIMi616084 phenotype
616959 phenotype

Open Targets

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OpenTargetsi
ENSG00000072756

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
369861 Congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38446

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRNT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452848

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000478242 – 434CCA tRNA nucleotidyltransferase 1, mitochondrialAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi373Interchain
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei400PhosphoserineCombined sources1
Modified residuei402N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96Q11

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96Q11

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96Q11

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96Q11

PeptideAtlas

More...
PeptideAtlasi
Q96Q11

PRoteomics IDEntifications database

More...
PRIDEi
Q96Q11

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77807
77808 [Q96Q11-2]
77809 [Q96Q11-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96Q11

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96Q11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000072756 Expressed in 200 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96Q11 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96Q11 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA036938

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer, and homodimer; disulfide-linked.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119284, 25 interactors

Protein interaction database and analysis system

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IntActi
Q96Q11, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000251607

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1434
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96Q11

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q96Q11

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2159 Eukaryota
COG0617 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009678

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000253345

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96Q11

KEGG Orthology (KO)

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KOi
K00974

Identification of Orthologs from Complete Genome Data

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OMAi
ATTRVCE

Database of Orthologous Groups

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OrthoDBi
730946at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96Q11

TreeFam database of animal gene trees

More...
TreeFami
TF313253

Family and domain databases

Conserved Domains Database

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CDDi
cd05398 NT_ClassII-CCAase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002646 PolA_pol_head_dom
IPR032828 PolyA_RNA-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01743 PolyA_pol, 1 hit
PF12627 PolyA_pol_RNAbd, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRCLYHWHR PVLNRRWSRL CLPKQYLFTM KLQSPEFQSL FTEGLKSLTE
60 70 80 90 100
LFVKENHELR IAGGAVRDLL NGVKPQDIDF ATTATPTQMK EMFQSAGIRM
110 120 130 140 150
INNRGEKHGT ITARLHEENF EITTLRIDVT TDGRHAEVEF TTDWQKDAER
160 170 180 190 200
RDLTINSMFL GFDGTLFDYF NGYEDLKNKK VRFVGHAKQR IQEDYLRILR
210 220 230 240 250
YFRFYGRIVD KPGDHDPETL EAIAENAKGL AGISGERIWV ELKKILVGNH
260 270 280 290 300
VNHLIHLIYD LDVAPYIGLP ANASLEEFDK VSKNVDGFSP KPVTLLASLF
310 320 330 340 350
KVQDDVTKLD LRLKIAKEEK NLGLFIVKNR KDLIKATDSS DPLKPYQDFI
360 370 380 390 400
IDSREPDATT RVCELLKYQG EHCLLKEMQQ WSIPPFPVSG HDIRKVGISS
410 420 430
GKEIGALLQQ LREQWKKSGY QMEKDELLSY IKKT
Length:434
Mass (Da):50,128
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60B7387E203A53D0
GO
Isoform 2 (identifier: Q96Q11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-267: Missing.

Show »
Length:414
Mass (Da):47,829
Checksum:i8E95DCE9B13C3743
GO
Isoform 3 (identifier: Q96Q11-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-57: ELFVKENH → GINAFHEN
     58-434: Missing.

Note: No experimental confirmation available.
Show »
Length:57
Mass (Da):6,937
Checksum:iB76351899690B303
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W8C3F8W8C3_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C181A0A494C181_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1D4A0A494C1D4_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0Y2A0A494C0Y2_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1L4A0A494C1L4_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0A0A0A494C0A0_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0N8A0A494C0N8_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRS7C9JRS7_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZV5A0A494BZV5_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1P4A0A494C1P4_HUMAN
CCA tRNA nucleotidyltransferase 1, ...
TRNT1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34042 differs from that shown. Reason: Frameshift at position 16.Curated
The sequence AAH12537 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04869823P → L6 PublicationsCorresponds to variant dbSNP:rs334773Ensembl.1
Natural variantiVAR_07692443Missing in RPEM. 1 Publication1
Natural variantiVAR_072421154T → I in SIFD; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs606231290EnsemblClinVar.1
Natural variantiVAR_072422158M → V in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs771781629Ensembl.1
Natural variantiVAR_072423166L → S in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs606231289EnsemblClinVar.1
Natural variantiVAR_072424190R → I in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs606231287EnsemblClinVar.1
Natural variantiVAR_072425223I → T in SIFD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs370011798EnsemblClinVar.1
Natural variantiVAR_072426326I → T in SIFD; loss of activity. 1 Publication1
Natural variantiVAR_072427416K → E in SIFD. 1 PublicationCorresponds to variant dbSNP:rs199931785Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00844050 – 57ELFVKENH → GINAFHEN in isoform 3. 1 Publication8
Alternative sequenceiVSP_00844158 – 434Missing in isoform 3. 1 PublicationAdd BLAST377
Alternative sequenceiVSP_008442248 – 267Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB063105 mRNA Translation: BAB70662.1
AF151805 mRNA Translation: AAD34042.1 Frameshift.
AK290411 mRNA Translation: BAF83100.1
AL834397 mRNA Translation: CAD39059.1
AC024060 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW63886.1
BC005184 mRNA Translation: AAH05184.1
BC012537 mRNA Translation: AAH12537.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2561.2 [Q96Q11-1]
CCDS77691.1 [Q96Q11-2]

NCBI Reference Sequences

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RefSeqi
NP_001289875.1, NM_001302946.1 [Q96Q11-2]
NP_886552.2, NM_182916.2 [Q96Q11-1]
XP_011532078.1, XM_011533776.2
XP_011532079.1, XM_011533777.2
XP_011532080.1, XM_011533778.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251607; ENSP00000251607; ENSG00000072756 [Q96Q11-1]
ENST00000280591; ENSP00000280591; ENSG00000072756 [Q96Q11-2]
ENST00000339437; ENSP00000342985; ENSG00000072756 [Q96Q11-3]
ENST00000402675; ENSP00000385745; ENSG00000072756 [Q96Q11-3]
ENST00000420393; ENSP00000400394; ENSG00000072756 [Q96Q11-3]
ENST00000434583; ENSP00000415100; ENSG00000072756 [Q96Q11-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51095

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51095

UCSC genome browser

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UCSCi
uc003bpn.2 human [Q96Q11-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063105 mRNA Translation: BAB70662.1
AF151805 mRNA Translation: AAD34042.1 Frameshift.
AK290411 mRNA Translation: BAF83100.1
AL834397 mRNA Translation: CAD39059.1
AC024060 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW63886.1
BC005184 mRNA Translation: AAH05184.1
BC012537 mRNA Translation: AAH12537.1 Different initiation.
CCDSiCCDS2561.2 [Q96Q11-1]
CCDS77691.1 [Q96Q11-2]
RefSeqiNP_001289875.1, NM_001302946.1 [Q96Q11-2]
NP_886552.2, NM_182916.2 [Q96Q11-1]
XP_011532078.1, XM_011533776.2
XP_011532079.1, XM_011533777.2
XP_011532080.1, XM_011533778.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OU5X-ray3.40A/B30-434[»]
4X4WX-ray1.90A/B28-434[»]
SMRiQ96Q11
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119284, 25 interactors
IntActiQ96Q11, 2 interactors
STRINGi9606.ENSP00000251607

PTM databases

iPTMnetiQ96Q11
PhosphoSitePlusiQ96Q11

Polymorphism and mutation databases

BioMutaiTRNT1
DMDMi296452848

Proteomic databases

EPDiQ96Q11
jPOSTiQ96Q11
MaxQBiQ96Q11
PaxDbiQ96Q11
PeptideAtlasiQ96Q11
PRIDEiQ96Q11
ProteomicsDBi77807
77808 [Q96Q11-2]
77809 [Q96Q11-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51095
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251607; ENSP00000251607; ENSG00000072756 [Q96Q11-1]
ENST00000280591; ENSP00000280591; ENSG00000072756 [Q96Q11-2]
ENST00000339437; ENSP00000342985; ENSG00000072756 [Q96Q11-3]
ENST00000402675; ENSP00000385745; ENSG00000072756 [Q96Q11-3]
ENST00000420393; ENSP00000400394; ENSG00000072756 [Q96Q11-3]
ENST00000434583; ENSP00000415100; ENSG00000072756 [Q96Q11-1]
GeneIDi51095
KEGGihsa:51095
UCSCiuc003bpn.2 human [Q96Q11-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51095
DisGeNETi51095

GeneCards: human genes, protein and diseases

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GeneCardsi
TRNT1
HGNCiHGNC:17341 TRNT1
HPAiHPA036938
MalaCardsiTRNT1
MIMi612907 gene
616084 phenotype
616959 phenotype
neXtProtiNX_Q96Q11
OpenTargetsiENSG00000072756
Orphaneti369861 Congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome
PharmGKBiPA38446

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2159 Eukaryota
COG0617 LUCA
GeneTreeiENSGT00390000009678
HOGENOMiHOG000253345
InParanoidiQ96Q11
KOiK00974
OMAiATTRVCE
OrthoDBi730946at2759
PhylomeDBiQ96Q11
TreeFamiTF313253

Enzyme and pathway databases

BRENDAi2.7.7.72 2681
ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6785470 tRNA processing in the mitochondrion

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRNT1 human
EvolutionaryTraceiQ96Q11

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRNT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51095

Protein Ontology

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PROi
PR:Q96Q11

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000072756 Expressed in 200 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ96Q11 baseline and differential
GenevisibleiQ96Q11 HS

Family and domain databases

CDDicd05398 NT_ClassII-CCAase, 1 hit
InterProiView protein in InterPro
IPR002646 PolA_pol_head_dom
IPR032828 PolyA_RNA-bd
PfamiView protein in Pfam
PF01743 PolyA_pol, 1 hit
PF12627 PolyA_pol_RNAbd, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRNT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96Q11
Secondary accession number(s): A8K2Z6
, B7WP13, C9JKA2, Q8ND57, Q9BS97, Q9Y362
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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