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Entry version 128 (02 Jun 2021)
Sequence version 2 (21 Aug 2007)
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Protein

Perilipin-4

Gene

PLIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).

By similarity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96Q06

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Perilipin-4
Alternative name(s):
Adipocyte protein S3-12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLIN4
Synonyms:KIAA1881
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29393, PLIN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613247, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96Q06

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000167676.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000167676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165394042

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96Q06, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLIN4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156630940

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002975591 – 1357Perilipin-4Add BLAST1357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96Q06

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96Q06

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96Q06

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96Q06

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96Q06

PeptideAtlas

More...
PeptideAtlasi
Q96Q06

PRoteomics IDEntifications database

More...
PRIDEi
Q96Q06

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77803 [Q96Q06-1]
77804 [Q96Q06-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2883, 1 O-Linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96Q06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96Q06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167676, Expressed in adipose tissue of abdominal region and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96Q06, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96Q06, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167676, Group enriched (adipose tissue, breast, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
609760, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96Q06, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301286

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96Q06, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96Q06

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati95 – 1271Add BLAST33
Repeati128 – 1602Add BLAST33
Repeati161 – 1933Add BLAST33
Repeati194 – 2264Add BLAST33
Repeati227 – 2595Add BLAST33
Repeati260 – 2926Add BLAST33
Repeati293 – 3257Add BLAST33
Repeati326 – 3588Add BLAST33
Repeati359 – 3919Add BLAST33
Repeati392 – 42410Add BLAST33
Repeati425 – 45711Add BLAST33
Repeati458 – 49012Add BLAST33
Repeati491 – 52313Add BLAST33
Repeati524 – 55614Add BLAST33
Repeati557 – 58915Add BLAST33
Repeati590 – 62216Add BLAST33
Repeati623 – 65517Add BLAST33
Repeati656 – 68818Add BLAST33
Repeati689 – 72119Add BLAST33
Repeati722 – 75420Add BLAST33
Repeati755 – 78721Add BLAST33
Repeati788 – 82022Add BLAST33
Repeati821 – 85323Add BLAST33
Repeati854 – 88624Add BLAST33
Repeati887 – 91925Add BLAST33
Repeati920 – 95226Add BLAST33
Repeati953 – 98527Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 74DisorderedSequence analysisAdd BLAST48
Regioni95 – 98527 X 33 AA approximate tandem repeatAdd BLAST891
Regioni1046 – 1079DisorderedSequence analysisAdd BLAST34
Regioni1226 – 1246DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1046 – 1076Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4744, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182920

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96Q06

Database of Orthologous Groups

More...
OrthoDBi
71918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96Q06

TreeFam database of animal gene trees

More...
TreeFami
TF328397

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004279, Perilipin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03036, Perilipin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQTLGSFFGS LPGFSSARNL VANAHSSARA RPAADPTGAP AAEAAQPQAQ
60 70 80 90 100
VAAHPEQTAP WTEKELQPSE KQMVSGAKDL VCSKMSRAKD AVSSGVASVV
110 120 130 140 150
DVAKGVVQGG LDTTRSALTG TKEVVSSGVT GAMDMAKGAV QGGLDTSKAV
160 170 180 190 200
LTGTKDTVST GLTGAVNVAK GTVQAGVDTT KTVLTGTKDT VTTGVMGAVN
210 220 230 240 250
LAKGTVQTGV ETSKAVLTGT KDAVSTGLTG AVNVARGSIQ TGVDTSKTVL
260 270 280 290 300
TGTKDTVCSG VTGAMNVAKG TIQTGVDTSK TVLTGTKDTV CSGVTGAMNV
310 320 330 340 350
AKGTIQTGVD TSKTVLTGTK DTVCSGVTGA MNVAKGTIQT GVDTTKTVLT
360 370 380 390 400
GTKNTVCSGV TGAVNLAKEA IQGGLDTTKS MVMGTKDTMS TGLTGAANVA
410 420 430 440 450
KGAMQTGLNT TQNIATGTKD TVCSGVTGAM NLARGTIQTG VDTTKIVLTG
460 470 480 490 500
TKDTVCSGVT GAANVAKGAV QGGLDTTKSV LTGTKDAVST GLTGAVNVAK
510 520 530 540 550
GTVQTGVDTT KTVLTGTKDT VCSGVTSAVN VAKGAVQGGL DTTKSVVIGT
560 570 580 590 600
KDTMSTGLTG AANVAKGAVQ TGVDTAKTVL TGTKDTVTTG LVGAVNVAKG
610 620 630 640 650
TVQTGMDTTK TVLTGTKDTI YSGVTSAVNV AKGAVQTGLK TTQNIATGTK
660 670 680 690 700
NTFGSGVTSA VNVAKGAAQT GVDTAKTVLT GTKDTVTTGL MGAVNVAKGT
710 720 730 740 750
VQTSVDTTKT VLTGTKDTVC SGVTGAANVA KGAIQGGLDT TKSVLTGTKD
760 770 780 790 800
AVSTGLTGAV KLAKGTVQTG MDTTKTVLTG TKDAVCSGVT GAANVAKGAV
810 820 830 840 850
QMGVDTAKTV LTGTKDTVCS GVTGAANVAK GAVQTGLKTT QNIATGTKNT
860 870 880 890 900
LGSGVTGAAK VAKGAVQGGL DTTKSVLTGT KDAVSTGLTG AVNLAKGTVQ
910 920 930 940 950
TGVDTSKTVL TGTKDTVCSG VTGAVNVAKG TVQTGVDTAK TVLSGAKDAV
960 970 980 990 1000
TTGVTGAVNV AKGTVQTGVD ASKAVLMGTK DTVFSGVTGA MSMAKGAVQG
1010 1020 1030 1040 1050
GLDTTKTVLT GTKDAVSAGL MGSGNVATGA THTGLSTFQN WLPSTPATSW
1060 1070 1080 1090 1100
GGLTSSRTTD NGGEQTALSP QEAPFSGIST PPDVLSVGPE PAWEAAATTK
1110 1120 1130 1140 1150
GLATDVATFT QGAAPGREDT GLLATTHGPE EAPRLAMLQN ELEGLGDIFH
1160 1170 1180 1190 1200
PMNAEEQAQL AASQPGPKVL SAEQGSYFVR LGDLGPSFRQ RAFEHAVSHL
1210 1220 1230 1240 1250
QHGQFQARDT LAQLQDCFRL IEKAQQAPEG QPRLDQGSGA SAEDAAVQEE
1260 1270 1280 1290 1300
RDAGVLSRVC GLLRQLHTAY SGLVSSLQGL PAELQQPVGR ARHSLCELYG
1310 1320 1330 1340 1350
IVASAGSVEE LPAERLVQSR EGVHQAWQGL EQLLEGLQHN PPLSWLVGPF

ALPAGGQ
Length:1,357
Mass (Da):134,431
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24CCB9D3DD6B480D
GO
Isoform 2 (identifier: Q96Q06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     720-720: C → CSGVTGAANVAKGAVQTGVDTAKTVLTGTKDTVCSGVTGAVNVAKGAVQTGLKTTQNIATGTKNTLG

Show »
Length:1,423
Mass (Da):140,675
Checksum:i15CBE032145C63E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YXN7A0A0J9YXN7_HUMAN
Perilipin-4
PLIN4
1,372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti263G → S in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti668A → V in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti734I → V in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti819 – 826CSGVTGAA → TTGLMGAV in BAB67774 (PubMed:11572484).Curated8
Sequence conflicti832A → T in BAB67774 (PubMed:11572484).Curated1
Sequence conflicti836 – 844GLKTTQNIA → SVDTTKTVL in BAB67774 (PubMed:11572484).Curated9
Sequence conflicti849 – 852NTLG → DTVC in BAB67774 (PubMed:11572484).Curated4
Sequence conflicti883A → T in BAB67774 (PubMed:11572484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061507124V → A1 PublicationCorresponds to variant dbSNP:rs4807597Ensembl.1
Natural variantiVAR_061508421T → A. Corresponds to variant dbSNP:rs55901236Ensembl.1
Natural variantiVAR_050483659S → G1 PublicationCorresponds to variant dbSNP:rs7260518Ensembl.1
Natural variantiVAR_061509761K → N1 PublicationCorresponds to variant dbSNP:rs7256387Ensembl.1
Natural variantiVAR_061510802M → T. Corresponds to variant dbSNP:rs7256712Ensembl.1
Natural variantiVAR_061511826A → E. Corresponds to variant dbSNP:rs7255187Ensembl.1
Natural variantiVAR_061512826A → G. Corresponds to variant dbSNP:rs7255187Ensembl.1
Natural variantiVAR_061513826A → V. Corresponds to variant dbSNP:rs7255187Ensembl.1
Natural variantiVAR_061514860K → N1 PublicationCorresponds to variant dbSNP:rs7259721Ensembl.1
Natural variantiVAR_0346371124A → T1 PublicationCorresponds to variant dbSNP:rs7251858Ensembl.1
Natural variantiVAR_0504841134R → C. Corresponds to variant dbSNP:rs7250947Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027278720C → CSGVTGAANVAKGAVQTGVD TAKTVLTGTKDTVCSGVTGA VNVAKGAVQTGLKTTQNIAT GTKNTLG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011498 Genomic DNA No translation available.
AB067468 mRNA Translation: BAB67774.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073869.1, NM_001080400.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301286; ENSP00000301286; ENSG00000167676 [Q96Q06-1]

UCSC genome browser

More...
UCSCi
uc002mar.2, human [Q96Q06-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011498 Genomic DNA No translation available.
AB067468 mRNA Translation: BAB67774.1
RefSeqiNP_001073869.1, NM_001080400.1

3D structure databases

SMRiQ96Q06
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi609760, 4 interactors
IntActiQ96Q06, 3 interactors
STRINGi9606.ENSP00000301286

PTM databases

GlyConnecti2883, 1 O-Linked glycan (1 site)
iPTMnetiQ96Q06
PhosphoSitePlusiQ96Q06

Genetic variation databases

BioMutaiPLIN4
DMDMi156630940

Proteomic databases

EPDiQ96Q06
jPOSTiQ96Q06
MassIVEiQ96Q06
MaxQBiQ96Q06
PaxDbiQ96Q06
PeptideAtlasiQ96Q06
PRIDEiQ96Q06
ProteomicsDBi77803 [Q96Q06-1]
77804 [Q96Q06-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23665, 113 antibodies

The CPTC Antibody Portal

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CPTCi
Q96Q06, 2 antibodies

Genome annotation databases

EnsembliENST00000301286; ENSP00000301286; ENSG00000167676 [Q96Q06-1]
UCSCiuc002mar.2, human [Q96Q06-1]

Organism-specific databases

GeneCards: human genes, protein and diseases

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GeneCardsi
PLIN4
HGNCiHGNC:29393, PLIN4
HPAiENSG00000167676, Group enriched (adipose tissue, breast, skeletal muscle)
MIMi613247, gene
neXtProtiNX_Q96Q06
OpenTargetsiENSG00000167676
PharmGKBiPA165394042
VEuPathDBiHostDB:ENSG00000167676.4

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4744, Eukaryota
GeneTreeiENSGT00950000182920
InParanoidiQ96Q06
OrthoDBi71918at2759
PhylomeDBiQ96Q06
TreeFamiTF328397

Enzyme and pathway databases

PathwayCommonsiQ96Q06

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
729359, 4 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLIN4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
729359
PharosiQ96Q06, Tbio

Protein Ontology

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PROi
PR:Q96Q06
RNActiQ96Q06, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167676, Expressed in adipose tissue of abdominal region and 190 other tissues
ExpressionAtlasiQ96Q06, baseline and differential
GenevisibleiQ96Q06, HS

Family and domain databases

InterProiView protein in InterPro
IPR004279, Perilipin
PfamiView protein in Pfam
PF03036, Perilipin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLIN4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96Q06
Secondary accession number(s): A6NEI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 2, 2021
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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