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Entry version 127 (16 Oct 2019)
Sequence version 2 (10 Jun 2008)
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Protein

Trafficking protein particle complex subunit 9

Gene

TRAPPC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 9
Alternative name(s):
NIK- and IKBKB-binding protein
Tularik gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC9
Synonyms:KIAA1882, NIBP
ORF Names:T1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30832 TRAPPC9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611966 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96Q05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 13 (MRT13)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
83696

MalaCards human disease database

More...
MalaCardsi
TRAPPC9
MIMi613192 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167632

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88616 Autosomal recessive non-syndromic intellectual disability
352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406921

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96Q05

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAPPC9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190359999

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003415861 – 1148Trafficking protein particle complex subunit 9Add BLAST1148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei566PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96Q05

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96Q05

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96Q05

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96Q05

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96Q05

PeptideAtlas

More...
PeptideAtlasi
Q96Q05

PRoteomics IDEntifications database

More...
PRIDEi
Q96Q05

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77800 [Q96Q05-1]
77801 [Q96Q05-2]
77802 [Q96Q05-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96Q05

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96Q05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96Q05 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96Q05 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026579

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Directly interacts with IKBKB and MAP3K14.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9CQP22EBI-6160596,EBI-1172267From Mus musculus.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123730, 63 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96Q05

Protein interaction database and analysis system

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IntActi
Q96Q05, 33 interactors

Molecular INTeraction database

More...
MINTi
Q96Q05

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373979

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96Q05

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NIBP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1953 Eukaryota
ENOG410YEPC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006486

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96Q05

KEGG Orthology (KO)

More...
KOi
K20306

Identification of Orthologs from Complete Genome Data

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OMAi
FLFTPIH

Database of Orthologous Groups

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OrthoDBi
71855at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96Q05

TreeFam database of animal gene trees

More...
TreeFami
TF314341

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013935 TRAPP_II_complex_Trs120

The PANTHER Classification System

More...
PANTHERi
PTHR21512 PTHR21512, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08626 TRAPPC9-Trs120, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ
60 70 80 90 100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH
110 120 130 140 150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED
160 170 180 190 200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR
210 220 230 240 250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC
260 270 280 290 300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGAQE VLIDPGALTT
310 320 330 340 350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACIK
360 370 380 390 400
AVRVLAIQKR SMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF
410 420 430 440 450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSR
460 470 480 490 500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK
510 520 530 540 550
KDVAQSLENY TSKCPGTMEP IALPGGLTLP PVPFTKLPIV RHVKLLNLPA
560 570 580 590 600
SLRPHKMKSL LGQNVSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE
610 620 630 640 650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV
660 670 680 690 700
PQTTGTITVN GYHTTVFGVF SDCLLDNLPG IKTSGSTVEV IPALPRLQIS
710 720 730 740 750
TSLPRSAHSL QPSSGDEIST NVSVQLYNGE SQQLIIKLEN IGMEPLEKLE
760 770 780 790 800
VTSKVLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKVKLDFSC
810 820 830 840 850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVEGKPVNPP ESNKAGDYSH
860 870 880 890 900
VKTLEAVLNF KYSGGPGHTE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS
910 920 930 940 950
TRQCHLLLDV FNSTEHELTV STRSSEALIL HAGECQRMAI QVDKFNFESF
960 970 980 990 1000
PESPGEKGQF ANPKQLEEER REARGLEIHS KLGICWRIPS LKRSGEASVE
1010 1020 1030 1040 1050
GLLNQLVLEH LQLAPLQWDV LVDGQPCDRE AVAACQVGDP VRLEVRLTNR
1060 1070 1080 1090 1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDT VSFVGSSTFY LDAVQPSGQS
1110 1120 1130 1140
ACLGALLFLY TGDFFLHIRF HEDSTSKELP PSWFCLPSVH VCALEAQA
Length:1,148
Mass (Da):128,530
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i532932462A6853CC
GO
Isoform 2 (identifier: Q96Q05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAGDQDRA...RALKDWDFKM

Note: No experimental confirmation available.
Show »
Length:1,246
Mass (Da):139,437
Checksum:i657FEFF8EB0E8008
GO
Isoform 3 (identifier: Q96Q05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-294: Missing.

Show »
Length:1,139
Mass (Da):127,607
Checksum:i9A75186A0673E4AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBR0H0YBR0_HUMAN
Trafficking protein particle comple...
TRAPPC9
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWK7A0A0J9YWK7_HUMAN
Trafficking protein particle comple...
TRAPPC9
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH06206 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55299 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB67775 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti505Missing in CAH56384 (PubMed:17974005).Curated1
Sequence conflicti539I → V in BAC87600 (PubMed:14702039).Curated1
Sequence conflicti669V → E in BAB55299 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0343491M → MVPAGDQDRAPHRGKPAQAG ARTSRASRALRSWRRSQAAR ATVTHPRGGHDRGSHGGYRE GHRGCRRDPQWASAGPPPLS FTEEVKFELRALKDWDFKM in isoform 2. 1 Publication1
Alternative sequenceiVSP_034350286 – 294Missing in isoform 3. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB067469 mRNA Translation: BAB67775.1 Different initiation.
AK027689 mRNA Translation: BAB55299.1 Different initiation.
AK128755 mRNA Translation: BAC87600.1
BC003650 mRNA Translation: AAH03650.3
BC006206 mRNA Translation: AAH06206.3 Different initiation.
BC065288 mRNA Translation: AAH65288.1
AL833973 mRNA Translation: CAH56384.1
AY190606 mRNA Translation: AAO38740.1
AY630619 mRNA Translation: AAV31908.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34946.1 [Q96Q05-2]
CCDS55278.1 [Q96Q05-1]

NCBI Reference Sequences

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RefSeqi
NP_001153844.1, NM_001160372.3 [Q96Q05-1]
NP_001308575.1, NM_001321646.1 [Q96Q05-3]
NP_113654.4, NM_031466.7 [Q96Q05-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
ENST00000648948; ENSP00000498020; ENSG00000167632 [Q96Q05-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83696

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83696

UCSC genome browser

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UCSCi
uc003yvh.2 human [Q96Q05-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067469 mRNA Translation: BAB67775.1 Different initiation.
AK027689 mRNA Translation: BAB55299.1 Different initiation.
AK128755 mRNA Translation: BAC87600.1
BC003650 mRNA Translation: AAH03650.3
BC006206 mRNA Translation: AAH06206.3 Different initiation.
BC065288 mRNA Translation: AAH65288.1
AL833973 mRNA Translation: CAH56384.1
AY190606 mRNA Translation: AAO38740.1
AY630619 mRNA Translation: AAV31908.1
CCDSiCCDS34946.1 [Q96Q05-2]
CCDS55278.1 [Q96Q05-1]
RefSeqiNP_001153844.1, NM_001160372.3 [Q96Q05-1]
NP_001308575.1, NM_001321646.1 [Q96Q05-3]
NP_113654.4, NM_031466.7 [Q96Q05-2]

3D structure databases

SMRiQ96Q05
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123730, 63 interactors
CORUMiQ96Q05
IntActiQ96Q05, 33 interactors
MINTiQ96Q05
STRINGi9606.ENSP00000373979

PTM databases

iPTMnetiQ96Q05
PhosphoSitePlusiQ96Q05

Polymorphism and mutation databases

BioMutaiTRAPPC9
DMDMi190359999

Proteomic databases

EPDiQ96Q05
jPOSTiQ96Q05
MassIVEiQ96Q05
MaxQBiQ96Q05
PaxDbiQ96Q05
PeptideAtlasiQ96Q05
PRIDEiQ96Q05
ProteomicsDBi77800 [Q96Q05-1]
77801 [Q96Q05-2]
77802 [Q96Q05-3]

Genome annotation databases

EnsembliENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
ENST00000648948; ENSP00000498020; ENSG00000167632 [Q96Q05-1]
GeneIDi83696
KEGGihsa:83696
UCSCiuc003yvh.2 human [Q96Q05-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83696
DisGeNETi83696

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAPPC9
HGNCiHGNC:30832 TRAPPC9
HPAiHPA026579
MalaCardsiTRAPPC9
MIMi611966 gene
613192 phenotype
neXtProtiNX_Q96Q05
OpenTargetsiENSG00000167632
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
PharmGKBiPA162406921

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1953 Eukaryota
ENOG410YEPC LUCA
GeneTreeiENSGT00390000006486
InParanoidiQ96Q05
KOiK20306
OMAiFLFTPIH
OrthoDBi71855at2759
PhylomeDBiQ96Q05
TreeFamiTF314341

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRAPPC9 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83696
PharosiQ96Q05

Protein Ontology

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PROi
PR:Q96Q05

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ96Q05 baseline and differential
GenevisibleiQ96Q05 HS

Family and domain databases

InterProiView protein in InterPro
IPR013935 TRAPP_II_complex_Trs120
PANTHERiPTHR21512 PTHR21512, 1 hit
PfamiView protein in Pfam
PF08626 TRAPPC9-Trs120, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPPC9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96Q05
Secondary accession number(s): Q4VTT3
, Q658K7, Q6P149, Q6ZQT3, Q7L5C4, Q86Y21, Q96SL2, Q9BQA2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 16, 2019
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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