UniProtKB - Q96Q05 (TPPC9_HUMAN)

BLAST

>sp|Q96Q05|TPPC9_HUMAN Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2
MSVPDYMQCAEDHQTLLVVVQPVGIVSEENFFRIYKRICSVSQISVRDSQRVLYIRYRHH
YPPENNEWGDFQTHRKVVGLITITDCFSAKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGL
QGEIVEQPRTDVAFYPNYEDCQTVEKRIEDFIESLFIVLESKRLDRATDKSGDKIPLLCV
PFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDSLVHYHMSVELLRSVNDFL
WLGAALEGLCSASVIYHYPGGTGGKSGARRFQGSTLPAEAANRHRPGAQEVLIDPGALTT
NGINPDTSTEIGRAKNCLSPEDIIDKYKEAISYYSKYKNAGVIELEACIKAVRVLAIQKR
SMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSI
AEPGWRACYKLLLETLPGYSLSLDPKDFSRGTHRGWAAVQMRLLHELVYASRRMGNPALS
VRHLSFLLQTMLDFLSDQEKKDVAQSLENYTSKCPGTMEPIALPGGLTLPPVPFTKLPIV
RHVKLLNLPASLRPHKMKSLLGQNVSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVCE
VQLMVYNPMPFELRVENMGLLTSGVEFESLPAALSLPAESGLYPVTLVGVPQTTGTITVN
GYHTTVFGVFSDCLLDNLPGIKTSGSTVEVIPALPRLQISTSLPRSAHSLQPSSGDEIST
NVSVQLYNGESQQLIIKLENIGMEPLEKLEVTSKVLTTKEKLYGDFLSWKLEETLAQFPL
QPGKVATFTINIKVKLDFSCQENLLQDLSDDGISVSGFPLSSPFRQVVRPRVEGKPVNPP
ESNKAGDYSHVKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATS
TRQCHLLLDVFNSTEHELTVSTRSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQF
ANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQLAPLQWDV
LVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDT
VSFVGSSTFYLDAVQPSGQSACLGALLFLYTGDFFLHIRFHEDSTSKELPPSWFCLPSVH
VCALEAQA

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History
Entry version 120 (07 Nov 2018)
Sequence version 2 (10 Jun 2008)
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Protein

Trafficking protein particle complex subunit 9

Gene

TRAPPC9

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cerebral cortex development
Source: GO_Central
Inferred from mutant phenotypeⁱ
- 20004763
COPII vesicle coating Source: Reactome
neuron differentiation Source: Ensembl
positive regulation of NF-kappaB transcription factor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation

Biological process

Differentiation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Trafficking protein particle complex subunit 9 Alternative name(s): NIK- and IKBKB-binding protein Tularik gene 1 protein
Gene namesⁱ	Name:TRAPPC9 Synonyms:KIAA1882, NIBP ORF Names:T1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167632.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30832 TRAPPC9
MIMⁱ	611966 gene
neXtProtⁱ	NX_Q96Q05

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mental retardation, autosomal recessive 13 (MRT13)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals.

Keywords - Diseaseⁱ

Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	83696
MalaCards human disease database More...MalaCardsⁱ	TRAPPC9
MIMⁱ	613192 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000167632
Orphanetⁱ	88616 Autosomal recessive non-syndromic intellectual disability 352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
PharmGKBⁱ	PA162406921

Polymorphism and mutation databases

BioMutaⁱ	TRAPPC9
DMDMⁱ	190359999

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000341586	1 – 1148	Trafficking protein particle complex subunit 9Add BLAST		1148

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	566	PhosphoserineCombined sources		1
Modified residueⁱ	953	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96Q05
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96Q05
PaxDbⁱ	Q96Q05
PeptideAtlas More...PeptideAtlasⁱ	Q96Q05
PRIDEⁱ	Q96Q05
ProteomicsDBⁱ	77800 77801 [Q96Q05-2] 77802 [Q96Q05-3]

PTM databases

iPTMnetⁱ	Q96Q05
PhosphoSitePlusⁱ	Q96Q05

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg
ExpressionAtlasⁱ	Q96Q05 baseline and differential
Genevisibleⁱ	Q96Q05 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026579

HPAⁱ

HPA026579

Interactionⁱ

Subunit structureⁱ

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Directly interacts with IKBKB and MAP3K14.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Trappc2	Q9CQP2	2	EBI-6160596,EBI-1172267	From Mus musculus.

With

Entry

#Exp.

IntAct

Notes

Trappc2

Q9CQP2

EBI-6160596,EBI-1172267

From Mus musculus.

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123730, 48 interactors
CORUMⁱ	Q96Q05
IntActⁱ	Q96Q05, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q96Q05
STRINGⁱ	9606.ENSP00000373979

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96Q05
SMRⁱ	Q96Q05
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NIBP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1953 Eukaryota ENOG410YEPC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006486
HOVERGENⁱ	HBG108595
InParanoidⁱ	Q96Q05
KEGG Orthology (KO) More...KOⁱ	K20306
OMAⁱ	FLFTPIH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00SS
PhylomeDBⁱ	Q96Q05
TreeFamⁱ	TF314341

Family and domain databases

InterProⁱ	View protein in InterPro IPR013935 TRAPP_II_complex_Trs120
PANTHERⁱ	PTHR21512 PTHR21512, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08626 TRAPPC9-Trs120, 3 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96Q05-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ 
        60         70         80         90        100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH 
       110        120        130        140        150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED 
       160        170        180        190        200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR 
       210        220        230        240        250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC 
       260        270        280        290        300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGAQE VLIDPGALTT 
       310        320        330        340        350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACIK 
       360        370        380        390        400
AVRVLAIQKR SMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF 
       410        420        430        440        450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSR 
       460        470        480        490        500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK 
       510        520        530        540        550
KDVAQSLENY TSKCPGTMEP IALPGGLTLP PVPFTKLPIV RHVKLLNLPA 
       560        570        580        590        600
SLRPHKMKSL LGQNVSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE 
       610        620        630        640        650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV 
       660        670        680        690        700
PQTTGTITVN GYHTTVFGVF SDCLLDNLPG IKTSGSTVEV IPALPRLQIS 
       710        720        730        740        750
TSLPRSAHSL QPSSGDEIST NVSVQLYNGE SQQLIIKLEN IGMEPLEKLE 
       760        770        780        790        800
VTSKVLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKVKLDFSC 
       810        820        830        840        850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVEGKPVNPP ESNKAGDYSH 
       860        870        880        890        900
VKTLEAVLNF KYSGGPGHTE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS 
       910        920        930        940        950
TRQCHLLLDV FNSTEHELTV STRSSEALIL HAGECQRMAI QVDKFNFESF 
       960        970        980        990       1000
PESPGEKGQF ANPKQLEEER REARGLEIHS KLGICWRIPS LKRSGEASVE 
      1010       1020       1030       1040       1050
GLLNQLVLEH LQLAPLQWDV LVDGQPCDRE AVAACQVGDP VRLEVRLTNR 
      1060       1070       1080       1090       1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDT VSFVGSSTFY LDAVQPSGQS 
      1110       1120       1130       1140 
ACLGALLFLY TGDFFLHIRF HEDSTSKELP PSWFCLPSVH VCALEAQA

Length:1,148

Mass (Da):128,530

Last modified:June 10, 2008 - v2

Checksum:ⁱ532932462A6853CC

Isoform 2 (identifier: Q96Q05-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MVPAGDQDRA...RALKDWDFKM

« Hide

        10         20         30         40         50
MVPAGDQDRA PHRGKPAQAG ARTSRASRAL RSWRRSQAAR ATVTHPRGGH 
        60         70         80         90        100
DRGSHGGYRE GHRGCRRDPQ WASAGPPPLS FTEEVKFELR ALKDWDFKMS 
       110        120        130        140        150
VPDYMQCAED HQTLLVVVQP VGIVSEENFF RIYKRICSVS QISVRDSQRV 
       160        170        180        190        200
LYIRYRHHYP PENNEWGDFQ THRKVVGLIT ITDCFSAKDW PQTFEKFHVQ 
       210        220        230        240        250
KEIYGSTLYD SRLFVFGLQG EIVEQPRTDV AFYPNYEDCQ TVEKRIEDFI 
       260        270        280        290        300
ESLFIVLESK RLDRATDKSG DKIPLLCVPF EKKDFVGLDT DSRHYKKRCQ 
       310        320        330        340        350
GRMRKHVGDL CLQAGMLQDS LVHYHMSVEL LRSVNDFLWL GAALEGLCSA 
       360        370        380        390        400
SVIYHYPGGT GGKSGARRFQ GSTLPAEAAN RHRPGAQEVL IDPGALTTNG 
       410        420        430        440        450
INPDTSTEIG RAKNCLSPED IIDKYKEAIS YYSKYKNAGV IELEACIKAV 
       460        470        480        490        500
RVLAIQKRSM EASEFLQNAV YINLRQLSEE EKIQRYSILS ELYELIGFHR 
       510        520        530        540        550
KSAFFKRVAA MQCVAPSIAE PGWRACYKLL LETLPGYSLS LDPKDFSRGT 
       560        570        580        590        600
HRGWAAVQMR LLHELVYASR RMGNPALSVR HLSFLLQTML DFLSDQEKKD 
       610        620        630        640        650
VAQSLENYTS KCPGTMEPIA LPGGLTLPPV PFTKLPIVRH VKLLNLPASL 
       660        670        680        690        700
RPHKMKSLLG QNVSTKSPFI YSPIIAHNRG EERNKKIDFQ WVQGDVCEVQ 
       710        720        730        740        750
LMVYNPMPFE LRVENMGLLT SGVEFESLPA ALSLPAESGL YPVTLVGVPQ 
       760        770        780        790        800
TTGTITVNGY HTTVFGVFSD CLLDNLPGIK TSGSTVEVIP ALPRLQISTS 
       810        820        830        840        850
LPRSAHSLQP SSGDEISTNV SVQLYNGESQ QLIIKLENIG MEPLEKLEVT 
       860        870        880        890        900
SKVLTTKEKL YGDFLSWKLE ETLAQFPLQP GKVATFTINI KVKLDFSCQE 
       910        920        930        940        950
NLLQDLSDDG ISVSGFPLSS PFRQVVRPRV EGKPVNPPES NKAGDYSHVK 
       960        970        980        990       1000
TLEAVLNFKY SGGPGHTEGY YRNLSLGLHV EVEPSVFFTR VSTLPATSTR 
      1010       1020       1030       1040       1050
QCHLLLDVFN STEHELTVST RSSEALILHA GECQRMAIQV DKFNFESFPE 
      1060       1070       1080       1090       1100
SPGEKGQFAN PKQLEEERRE ARGLEIHSKL GICWRIPSLK RSGEASVEGL 
      1110       1120       1130       1140       1150
LNQLVLEHLQ LAPLQWDVLV DGQPCDREAV AACQVGDPVR LEVRLTNRSP 
      1160       1170       1180       1190       1200
RSVGPFALTV VPFQDHQNGV HNYDLHDTVS FVGSSTFYLD AVQPSGQSAC 
      1210       1220       1230       1240 
LGALLFLYTG DFFLHIRFHE DSTSKELPPS WFCLPSVHVC ALEAQA

Note: No experimental confirmation available.

Show »

Length:1,246

Mass (Da):139,437

Checksum:ⁱ657FEFF8EB0E8008

Isoform 3 (identifier: Q96Q05-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
286-294: Missing.

« Hide

        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ 
        60         70         80         90        100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH 
       110        120        130        140        150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED 
       160        170        180        190        200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR 
       210        220        230        240        250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC 
       260        270        280        290        300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGALT TNGINPDTST 
       310        320        330        340        350
EIGRAKNCLS PEDIIDKYKE AISYYSKYKN AGVIELEACI KAVRVLAIQK 
       360        370        380        390        400
RSMEASEFLQ NAVYINLRQL SEEEKIQRYS ILSELYELIG FHRKSAFFKR 
       410        420        430        440        450
VAAMQCVAPS IAEPGWRACY KLLLETLPGY SLSLDPKDFS RGTHRGWAAV 
       460        470        480        490        500
QMRLLHELVY ASRRMGNPAL SVRHLSFLLQ TMLDFLSDQE KKDVAQSLEN 
       510        520        530        540        550
YTSKCPGTME PIALPGGLTL PPVPFTKLPI VRHVKLLNLP ASLRPHKMKS 
       560        570        580        590        600
LLGQNVSTKS PFIYSPIIAH NRGEERNKKI DFQWVQGDVC EVQLMVYNPM 
       610        620        630        640        650
PFELRVENMG LLTSGVEFES LPAALSLPAE SGLYPVTLVG VPQTTGTITV 
       660        670        680        690        700
NGYHTTVFGV FSDCLLDNLP GIKTSGSTVE VIPALPRLQI STSLPRSAHS 
       710        720        730        740        750
LQPSSGDEIS TNVSVQLYNG ESQQLIIKLE NIGMEPLEKL EVTSKVLTTK 
       760        770        780        790        800
EKLYGDFLSW KLEETLAQFP LQPGKVATFT INIKVKLDFS CQENLLQDLS 
       810        820        830        840        850
DDGISVSGFP LSSPFRQVVR PRVEGKPVNP PESNKAGDYS HVKTLEAVLN 
       860        870        880        890        900
FKYSGGPGHT EGYYRNLSLG LHVEVEPSVF FTRVSTLPAT STRQCHLLLD 
       910        920        930        940        950
VFNSTEHELT VSTRSSEALI LHAGECQRMA IQVDKFNFES FPESPGEKGQ 
       960        970        980        990       1000
FANPKQLEEE RREARGLEIH SKLGICWRIP SLKRSGEASV EGLLNQLVLE 
      1010       1020       1030       1040       1050
HLQLAPLQWD VLVDGQPCDR EAVAACQVGD PVRLEVRLTN RSPRSVGPFA 
      1060       1070       1080       1090       1100
LTVVPFQDHQ NGVHNYDLHD TVSFVGSSTF YLDAVQPSGQ SACLGALLFL 
      1110       1120       1130 
YTGDFFLHIR FHEDSTSKEL PPSWFCLPSV HVCALEAQA

Show »

Length:1,139

Mass (Da):127,607

Checksum:ⁱ9A75186A0673E4AD

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YBR0	H0YBR0_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit 9	TRAPPC9	992	Annotation score:
A0A0J9YWK7	A0A0J9YWK7_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit 9	TRAPPC9	91	Annotation score:

Sequence cautionⁱ

The sequence AAH06206 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB55299 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB67775 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	505	Missing in CAH56384 (PubMed:17974005).Curated	1
Sequence conflictⁱ	539	I → V in BAC87600 (PubMed:14702039).Curated	1
Sequence conflictⁱ	669	V → E in BAB55299 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034349	1	M → MVPAGDQDRAPHRGKPAQAG ARTSRASRALRSWRRSQAAR ATVTHPRGGHDRGSHGGYRE GHRGCRRDPQWASAGPPPLS FTEEVKFELRALKDWDFKM in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_034350	286 – 294	Missing in isoform 3. 1 Publication		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB067469 mRNA Translation: BAB67775.1 Different initiation. AK027689 mRNA Translation: BAB55299.1 Different initiation. AK128755 mRNA Translation: BAC87600.1 BC003650 mRNA Translation: AAH03650.3 BC006206 mRNA Translation: AAH06206.3 Different initiation. BC065288 mRNA Translation: AAH65288.1 AL833973 mRNA Translation: CAH56384.1 AY190606 mRNA Translation: AAO38740.1 AY630619 mRNA Translation: AAV31908.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34946.1 [Q96Q05-2] CCDS55278.1 [Q96Q05-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153844.1, NM_001160372.3 [Q96Q05-1] NP_001308575.1, NM_001321646.1 [Q96Q05-3] NP_113654.4, NM_031466.7 [Q96Q05-2]
UniGeneⁱ	Hs.654911 Hs.733622

Genome annotation databases

Ensemblⁱ	ENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2] ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
GeneIDⁱ	83696
KEGGⁱ	hsa:83696
UCSC genome browser More...UCSCⁱ	uc003yvh.2 human [Q96Q05-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96Q05	Isoform 2 of Trafficking protein particle complex subunit 9		HUMAN		1246	UniRef100_Q96Q05
UPI0005CFFC98		HUMAN		631
UPI0007DC595D		HUMAN		688

Protein	Similar proteins		Species	Score	Length	Source
Q96Q05	Isoform 2 of Trafficking protein particle complex subunit 9		HUMAN		1246	UniRef90_Q96Q05
TRAPPC9 isoform 1		PANTR		1246
TRAPPC9 isoform 1		PONAB		1246
Uncharacterized protein		Cebus capucinus imitator		1240
Trafficking protein particle complex 9		GORGO		1239
+43
Q96Q05-3	Trafficking protein particle complex subunit 9		MOUSE		1148	UniRef90_Q96Q05-3
trafficking protein particle complex subunit 9 isoform X1		BALAS		1170
Trafficking protein particle complex 9		MYOLU		1149
Uncharacterized protein		COLAP		1148
trafficking protein particle complex subunit 9		LIPVE		1148
+149

Protein	Similar proteins		Species	Score	Length	Source
Q96Q05	Trafficking protein particle complex subunit 9		BOVIN		1138	UniRef50_Q96Q05
Trafficking protein particle complex subunit 9		XENLA		1151
Trafficking protein particle complex subunit 9		MOUSE		1148
Isoform 2 of Trafficking protein particle complex subunit 9		HUMAN		1246
TRAPPC9 isoform 1		PONAB		1246
+556

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB067469 mRNA Translation: BAB67775.1 Different initiation. AK027689 mRNA Translation: BAB55299.1 Different initiation. AK128755 mRNA Translation: BAC87600.1 BC003650 mRNA Translation: AAH03650.3 BC006206 mRNA Translation: AAH06206.3 Different initiation. BC065288 mRNA Translation: AAH65288.1 AL833973 mRNA Translation: CAH56384.1 AY190606 mRNA Translation: AAO38740.1 AY630619 mRNA Translation: AAV31908.1
CCDSⁱ	CCDS34946.1 [Q96Q05-2] CCDS55278.1 [Q96Q05-1]
RefSeqⁱ	NP_001153844.1, NM_001160372.3 [Q96Q05-1] NP_001308575.1, NM_001321646.1 [Q96Q05-3] NP_113654.4, NM_031466.7 [Q96Q05-2]
UniGeneⁱ	Hs.654911 Hs.733622

3D structure databases

ProteinModelPortalⁱ	Q96Q05
SMRⁱ	Q96Q05
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123730, 48 interactors
CORUMⁱ	Q96Q05
IntActⁱ	Q96Q05, 12 interactors
MINTⁱ	Q96Q05
STRINGⁱ	9606.ENSP00000373979

PTM databases

iPTMnetⁱ	Q96Q05
PhosphoSitePlusⁱ	Q96Q05

Polymorphism and mutation databases

BioMutaⁱ	TRAPPC9
DMDMⁱ	190359999

Proteomic databases

EPDⁱ	Q96Q05
MaxQBⁱ	Q96Q05
PaxDbⁱ	Q96Q05
PeptideAtlasⁱ	Q96Q05
PRIDEⁱ	Q96Q05
ProteomicsDBⁱ	77800 77801 [Q96Q05-2] 77802 [Q96Q05-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2] ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
GeneIDⁱ	83696
KEGGⁱ	hsa:83696
UCSCⁱ	uc003yvh.2 human [Q96Q05-1]

Organism-specific databases

CTDⁱ	83696
DisGeNETⁱ	83696
EuPathDBⁱ	HostDB:ENSG00000167632.14
GeneCardsⁱ	TRAPPC9
H-InvDBⁱ	HIX0019731
HGNCⁱ	HGNC:30832 TRAPPC9
HPAⁱ	HPA026579
MalaCardsⁱ	TRAPPC9
MIMⁱ	611966 gene 613192 phenotype
neXtProtⁱ	NX_Q96Q05
OpenTargetsⁱ	ENSG00000167632
Orphanetⁱ	88616 Autosomal recessive non-syndromic intellectual disability 352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
PharmGKBⁱ	PA162406921
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1953 Eukaryota ENOG410YEPC LUCA
GeneTreeⁱ	ENSGT00390000006486
HOVERGENⁱ	HBG108595
InParanoidⁱ	Q96Q05
KOⁱ	K20306
OMAⁱ	FLFTPIH
OrthoDBⁱ	EOG091G00SS
PhylomeDBⁱ	Q96Q05
TreeFamⁱ	TF314341

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	TRAPPC9 human
GenomeRNAiⁱ	83696
Protein Ontology More...PROⁱ	PR:Q96Q05
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg
ExpressionAtlasⁱ	Q96Q05 baseline and differential
Genevisibleⁱ	Q96Q05 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013935 TRAPP_II_complex_Trs120
PANTHERⁱ	PTHR21512 PTHR21512, 1 hit
Pfamⁱ	View protein in Pfam PF08626 TRAPPC9-Trs120, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPPC9_HUMAN
Accessionⁱ	Q96Q05Primary (citable) accession number: Q96Q05 Secondary accession number(s): Q4VTT3 Q9BQA2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - Q96Q05 (TPPC9_HUMAN)

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Trafficking protein particle complex subunit 9

TRAPPC9

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

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GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

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PTM databases

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Proteomic databases

Protocols and materials databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ