Trafficking protein particle complex subunit 9

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• Rab guanyl-nucleotide exchange factor activity Source: Reactome

GO - Biological processⁱ

• cerebral cortex development Source: GO_Central <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20004763
• COPII vesicle coating Source: Reactome
• neuron differentiation Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• Rab guanyl-nucleotide exchange factor activity Source: Reactome

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 2 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ 
        60         70         80         90        100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH 
       110        120        130        140        150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED 
       160        170        180        190        200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR 
       210        220        230        240        250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC 
       260        270        280        290        300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGAQE VLIDPGALTT 
       310        320        330        340        350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACIK 
       360        370        380        390        400
AVRVLAIQKR SMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF 
       410        420        430        440        450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSR 
       460        470        480        490        500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK 
       510        520        530        540        550
KDVAQSLENY TSKCPGTMEP IALPGGLTLP PVPFTKLPIV RHVKLLNLPA 
       560        570        580        590        600
SLRPHKMKSL LGQNVSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE 
       610        620        630        640        650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV 
       660        670        680        690        700
PQTTGTITVN GYHTTVFGVF SDCLLDNLPG IKTSGSTVEV IPALPRLQIS 
       710        720        730        740        750
TSLPRSAHSL QPSSGDEIST NVSVQLYNGE SQQLIIKLEN IGMEPLEKLE 
       760        770        780        790        800
VTSKVLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKVKLDFSC 
       810        820        830        840        850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVEGKPVNPP ESNKAGDYSH 
       860        870        880        890        900
VKTLEAVLNF KYSGGPGHTE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS 
       910        920        930        940        950
TRQCHLLLDV FNSTEHELTV STRSSEALIL HAGECQRMAI QVDKFNFESF 
       960        970        980        990       1000
PESPGEKGQF ANPKQLEEER REARGLEIHS KLGICWRIPS LKRSGEASVE 
      1010       1020       1030       1040       1050
GLLNQLVLEH LQLAPLQWDV LVDGQPCDRE AVAACQVGDP VRLEVRLTNR 
      1060       1070       1080       1090       1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDT VSFVGSSTFY LDAVQPSGQS 
      1110       1120       1130       1140 
ACLGALLFLY TGDFFLHIRF HEDSTSKELP PSWFCLPSVH VCALEAQA   

        10         20         30         40         50
MVPAGDQDRA PHRGKPAQAG ARTSRASRAL RSWRRSQAAR ATVTHPRGGH 
        60         70         80         90        100
DRGSHGGYRE GHRGCRRDPQ WASAGPPPLS FTEEVKFELR ALKDWDFKMS 
       110        120        130        140        150
VPDYMQCAED HQTLLVVVQP VGIVSEENFF RIYKRICSVS QISVRDSQRV 
       160        170        180        190        200
LYIRYRHHYP PENNEWGDFQ THRKVVGLIT ITDCFSAKDW PQTFEKFHVQ 
       210        220        230        240        250
KEIYGSTLYD SRLFVFGLQG EIVEQPRTDV AFYPNYEDCQ TVEKRIEDFI 
       260        270        280        290        300
ESLFIVLESK RLDRATDKSG DKIPLLCVPF EKKDFVGLDT DSRHYKKRCQ 
       310        320        330        340        350
GRMRKHVGDL CLQAGMLQDS LVHYHMSVEL LRSVNDFLWL GAALEGLCSA 
       360        370        380        390        400
SVIYHYPGGT GGKSGARRFQ GSTLPAEAAN RHRPGAQEVL IDPGALTTNG 
       410        420        430        440        450
INPDTSTEIG RAKNCLSPED IIDKYKEAIS YYSKYKNAGV IELEACIKAV 
       460        470        480        490        500
RVLAIQKRSM EASEFLQNAV YINLRQLSEE EKIQRYSILS ELYELIGFHR 
       510        520        530        540        550
KSAFFKRVAA MQCVAPSIAE PGWRACYKLL LETLPGYSLS LDPKDFSRGT 
       560        570        580        590        600
HRGWAAVQMR LLHELVYASR RMGNPALSVR HLSFLLQTML DFLSDQEKKD 
       610        620        630        640        650
VAQSLENYTS KCPGTMEPIA LPGGLTLPPV PFTKLPIVRH VKLLNLPASL 
       660        670        680        690        700
RPHKMKSLLG QNVSTKSPFI YSPIIAHNRG EERNKKIDFQ WVQGDVCEVQ 
       710        720        730        740        750
LMVYNPMPFE LRVENMGLLT SGVEFESLPA ALSLPAESGL YPVTLVGVPQ 
       760        770        780        790        800
TTGTITVNGY HTTVFGVFSD CLLDNLPGIK TSGSTVEVIP ALPRLQISTS 
       810        820        830        840        850
LPRSAHSLQP SSGDEISTNV SVQLYNGESQ QLIIKLENIG MEPLEKLEVT 
       860        870        880        890        900
SKVLTTKEKL YGDFLSWKLE ETLAQFPLQP GKVATFTINI KVKLDFSCQE 
       910        920        930        940        950
NLLQDLSDDG ISVSGFPLSS PFRQVVRPRV EGKPVNPPES NKAGDYSHVK 
       960        970        980        990       1000
TLEAVLNFKY SGGPGHTEGY YRNLSLGLHV EVEPSVFFTR VSTLPATSTR 
      1010       1020       1030       1040       1050
QCHLLLDVFN STEHELTVST RSSEALILHA GECQRMAIQV DKFNFESFPE 
      1060       1070       1080       1090       1100
SPGEKGQFAN PKQLEEERRE ARGLEIHSKL GICWRIPSLK RSGEASVEGL 
      1110       1120       1130       1140       1150
LNQLVLEHLQ LAPLQWDVLV DGQPCDREAV AACQVGDPVR LEVRLTNRSP 
      1160       1170       1180       1190       1200
RSVGPFALTV VPFQDHQNGV HNYDLHDTVS FVGSSTFYLD AVQPSGQSAC 
      1210       1220       1230       1240 
LGALLFLYTG DFFLHIRFHE DSTSKELPPS WFCLPSVHVC ALEAQA     

        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ 
        60         70         80         90        100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH 
       110        120        130        140        150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED 
       160        170        180        190        200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR 
       210        220        230        240        250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC 
       260        270        280        290        300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGALT TNGINPDTST 
       310        320        330        340        350
EIGRAKNCLS PEDIIDKYKE AISYYSKYKN AGVIELEACI KAVRVLAIQK 
       360        370        380        390        400
RSMEASEFLQ NAVYINLRQL SEEEKIQRYS ILSELYELIG FHRKSAFFKR 
       410        420        430        440        450
VAAMQCVAPS IAEPGWRACY KLLLETLPGY SLSLDPKDFS RGTHRGWAAV 
       460        470        480        490        500
QMRLLHELVY ASRRMGNPAL SVRHLSFLLQ TMLDFLSDQE KKDVAQSLEN 
       510        520        530        540        550
YTSKCPGTME PIALPGGLTL PPVPFTKLPI VRHVKLLNLP ASLRPHKMKS 
       560        570        580        590        600
LLGQNVSTKS PFIYSPIIAH NRGEERNKKI DFQWVQGDVC EVQLMVYNPM 
       610        620        630        640        650
PFELRVENMG LLTSGVEFES LPAALSLPAE SGLYPVTLVG VPQTTGTITV 
       660        670        680        690        700
NGYHTTVFGV FSDCLLDNLP GIKTSGSTVE VIPALPRLQI STSLPRSAHS 
       710        720        730        740        750
LQPSSGDEIS TNVSVQLYNG ESQQLIIKLE NIGMEPLEKL EVTSKVLTTK 
       760        770        780        790        800
EKLYGDFLSW KLEETLAQFP LQPGKVATFT INIKVKLDFS CQENLLQDLS 
       810        820        830        840        850
DDGISVSGFP LSSPFRQVVR PRVEGKPVNP PESNKAGDYS HVKTLEAVLN 
       860        870        880        890        900
FKYSGGPGHT EGYYRNLSLG LHVEVEPSVF FTRVSTLPAT STRQCHLLLD 
       910        920        930        940        950
VFNSTEHELT VSTRSSEALI LHAGECQRMA IQVDKFNFES FPESPGEKGQ 
       960        970        980        990       1000
FANPKQLEEE RREARGLEIH SKLGICWRIP SLKRSGEASV EGLLNQLVLE 
      1010       1020       1030       1040       1050
HLQLAPLQWD VLVDGQPCDR EAVAACQVGD PVRLEVRLTN RSPRSVGPFA 
      1060       1070       1080       1090       1100
LTVVPFQDHQ NGVHNYDLHD TVSFVGSSTF YLDAVQPSGQ SACLGALLFL 
      1110       1120       1130 
YTGDFFLHIR FHEDSTSKEL PPSWFCLPSV HVCALEAQA             

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ