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Protein

Trafficking protein particle complex subunit 9

Gene

TRAPPC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 9
Alternative name(s):
NIK- and IKBKB-binding protein
Tularik gene 1 protein
Gene namesi
Name:TRAPPC9
Synonyms:KIAA1882, NIBP
ORF Names:T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000167632.14
HGNCiHGNC:30832 TRAPPC9
MIMi611966 gene
neXtProtiNX_Q96Q05

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal recessive 13 (MRT13)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals.
See also OMIM:613192

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi83696
MalaCardsiTRAPPC9
MIMi613192 phenotype
OpenTargetsiENSG00000167632
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
PharmGKBiPA162406921

Polymorphism and mutation databases

BioMutaiTRAPPC9
DMDMi190359999

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415861 – 1148Trafficking protein particle complex subunit 9Add BLAST1148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei566PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96Q05
MaxQBiQ96Q05
PaxDbiQ96Q05
PeptideAtlasiQ96Q05
PRIDEiQ96Q05
ProteomicsDBi77800
77801 [Q96Q05-2]
77802 [Q96Q05-3]

PTM databases

iPTMnetiQ96Q05
PhosphoSitePlusiQ96Q05

Expressioni

Tissue specificityi

Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.1 Publication

Gene expression databases

BgeeiENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ96Q05 baseline and differential
GenevisibleiQ96Q05 HS

Organism-specific databases

HPAiHPA026579

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Directly interacts with IKBKB and MAP3K14.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Trappc2Q9CQP22EBI-6160596,EBI-1172267From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123730, 48 interactors
CORUMiQ96Q05
IntActiQ96Q05, 12 interactors
MINTiQ96Q05
STRINGi9606.ENSP00000373979

Structurei

3D structure databases

ProteinModelPortaliQ96Q05
SMRiQ96Q05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NIBP family.Curated

Phylogenomic databases

eggNOGiKOG1953 Eukaryota
ENOG410YEPC LUCA
GeneTreeiENSGT00390000006486
HOVERGENiHBG108595
InParanoidiQ96Q05
KOiK20306
OMAiFLFTPIH
OrthoDBiEOG091G00SS
PhylomeDBiQ96Q05
TreeFamiTF314341

Family and domain databases

InterProiView protein in InterPro
IPR013935 TRAPP_II_complex_Trs120
PANTHERiPTHR21512 PTHR21512, 1 hit
PfamiView protein in Pfam
PF08626 TRAPPC9-Trs120, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ
60 70 80 90 100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH
110 120 130 140 150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED
160 170 180 190 200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR
210 220 230 240 250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC
260 270 280 290 300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGAQE VLIDPGALTT
310 320 330 340 350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACIK
360 370 380 390 400
AVRVLAIQKR SMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF
410 420 430 440 450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSR
460 470 480 490 500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK
510 520 530 540 550
KDVAQSLENY TSKCPGTMEP IALPGGLTLP PVPFTKLPIV RHVKLLNLPA
560 570 580 590 600
SLRPHKMKSL LGQNVSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE
610 620 630 640 650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV
660 670 680 690 700
PQTTGTITVN GYHTTVFGVF SDCLLDNLPG IKTSGSTVEV IPALPRLQIS
710 720 730 740 750
TSLPRSAHSL QPSSGDEIST NVSVQLYNGE SQQLIIKLEN IGMEPLEKLE
760 770 780 790 800
VTSKVLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKVKLDFSC
810 820 830 840 850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVEGKPVNPP ESNKAGDYSH
860 870 880 890 900
VKTLEAVLNF KYSGGPGHTE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS
910 920 930 940 950
TRQCHLLLDV FNSTEHELTV STRSSEALIL HAGECQRMAI QVDKFNFESF
960 970 980 990 1000
PESPGEKGQF ANPKQLEEER REARGLEIHS KLGICWRIPS LKRSGEASVE
1010 1020 1030 1040 1050
GLLNQLVLEH LQLAPLQWDV LVDGQPCDRE AVAACQVGDP VRLEVRLTNR
1060 1070 1080 1090 1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDT VSFVGSSTFY LDAVQPSGQS
1110 1120 1130 1140
ACLGALLFLY TGDFFLHIRF HEDSTSKELP PSWFCLPSVH VCALEAQA
Length:1,148
Mass (Da):128,530
Last modified:June 10, 2008 - v2
Checksum:i532932462A6853CC
GO
Isoform 2 (identifier: Q96Q05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAGDQDRA...RALKDWDFKM

Note: No experimental confirmation available.
Show »
Length:1,246
Mass (Da):139,437
Checksum:i657FEFF8EB0E8008
GO
Isoform 3 (identifier: Q96Q05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-294: Missing.

Show »
Length:1,139
Mass (Da):127,607
Checksum:i9A75186A0673E4AD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBR0H0YBR0_HUMAN
Trafficking protein particle comple...
TRAPPC9
992Annotation score:
A0A0J9YWK7A0A0J9YWK7_HUMAN
Trafficking protein particle comple...
TRAPPC9
91Annotation score:

Sequence cautioni

The sequence AAH06206 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55299 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB67775 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti505Missing in CAH56384 (PubMed:17974005).Curated1
Sequence conflicti539I → V in BAC87600 (PubMed:14702039).Curated1
Sequence conflicti669V → E in BAB55299 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0343491M → MVPAGDQDRAPHRGKPAQAG ARTSRASRALRSWRRSQAAR ATVTHPRGGHDRGSHGGYRE GHRGCRRDPQWASAGPPPLS FTEEVKFELRALKDWDFKM in isoform 2. 1 Publication1
Alternative sequenceiVSP_034350286 – 294Missing in isoform 3. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067469 mRNA Translation: BAB67775.1 Different initiation.
AK027689 mRNA Translation: BAB55299.1 Different initiation.
AK128755 mRNA Translation: BAC87600.1
BC003650 mRNA Translation: AAH03650.3
BC006206 mRNA Translation: AAH06206.3 Different initiation.
BC065288 mRNA Translation: AAH65288.1
AL833973 mRNA Translation: CAH56384.1
AY190606 mRNA Translation: AAO38740.1
AY630619 mRNA Translation: AAV31908.1
CCDSiCCDS34946.1 [Q96Q05-2]
CCDS55278.1 [Q96Q05-1]
RefSeqiNP_001153844.1, NM_001160372.3 [Q96Q05-1]
NP_001308575.1, NM_001321646.1 [Q96Q05-3]
NP_113654.4, NM_031466.7 [Q96Q05-2]
UniGeneiHs.654911
Hs.733622

Genome annotation databases

EnsembliENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
GeneIDi83696
KEGGihsa:83696
UCSCiuc003yvh.2 human [Q96Q05-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067469 mRNA Translation: BAB67775.1 Different initiation.
AK027689 mRNA Translation: BAB55299.1 Different initiation.
AK128755 mRNA Translation: BAC87600.1
BC003650 mRNA Translation: AAH03650.3
BC006206 mRNA Translation: AAH06206.3 Different initiation.
BC065288 mRNA Translation: AAH65288.1
AL833973 mRNA Translation: CAH56384.1
AY190606 mRNA Translation: AAO38740.1
AY630619 mRNA Translation: AAV31908.1
CCDSiCCDS34946.1 [Q96Q05-2]
CCDS55278.1 [Q96Q05-1]
RefSeqiNP_001153844.1, NM_001160372.3 [Q96Q05-1]
NP_001308575.1, NM_001321646.1 [Q96Q05-3]
NP_113654.4, NM_031466.7 [Q96Q05-2]
UniGeneiHs.654911
Hs.733622

3D structure databases

ProteinModelPortaliQ96Q05
SMRiQ96Q05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123730, 48 interactors
CORUMiQ96Q05
IntActiQ96Q05, 12 interactors
MINTiQ96Q05
STRINGi9606.ENSP00000373979

PTM databases

iPTMnetiQ96Q05
PhosphoSitePlusiQ96Q05

Polymorphism and mutation databases

BioMutaiTRAPPC9
DMDMi190359999

Proteomic databases

EPDiQ96Q05
MaxQBiQ96Q05
PaxDbiQ96Q05
PeptideAtlasiQ96Q05
PRIDEiQ96Q05
ProteomicsDBi77800
77801 [Q96Q05-2]
77802 [Q96Q05-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
GeneIDi83696
KEGGihsa:83696
UCSCiuc003yvh.2 human [Q96Q05-1]

Organism-specific databases

CTDi83696
DisGeNETi83696
EuPathDBiHostDB:ENSG00000167632.14
GeneCardsiTRAPPC9
H-InvDBiHIX0019731
HGNCiHGNC:30832 TRAPPC9
HPAiHPA026579
MalaCardsiTRAPPC9
MIMi611966 gene
613192 phenotype
neXtProtiNX_Q96Q05
OpenTargetsiENSG00000167632
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
PharmGKBiPA162406921
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1953 Eukaryota
ENOG410YEPC LUCA
GeneTreeiENSGT00390000006486
HOVERGENiHBG108595
InParanoidiQ96Q05
KOiK20306
OMAiFLFTPIH
OrthoDBiEOG091G00SS
PhylomeDBiQ96Q05
TreeFamiTF314341

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTRAPPC9 human
GenomeRNAii83696
PROiPR:Q96Q05
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ96Q05 baseline and differential
GenevisibleiQ96Q05 HS

Family and domain databases

InterProiView protein in InterPro
IPR013935 TRAPP_II_complex_Trs120
PANTHERiPTHR21512 PTHR21512, 1 hit
PfamiView protein in Pfam
PF08626 TRAPPC9-Trs120, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC9_HUMAN
AccessioniPrimary (citable) accession number: Q96Q05
Secondary accession number(s): Q4VTT3
, Q658K7, Q6P149, Q6ZQT3, Q7L5C4, Q86Y21, Q96SL2, Q9BQA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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