UniProtKB - Q96Q05 (TPPC9_HUMAN)
Trafficking protein particle complex subunit 9
TRAPPC9
Functioni
GO - Biological processi
- cerebral cortex development Source: GO_Central
- COPII vesicle coating Source: Reactome
- neuron differentiation Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Keywordsi
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q96Q05 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking protein particle complex subunit 9Alternative name(s): NIK- and IKBKB-binding protein Tularik gene 1 protein |
Gene namesi | Name:TRAPPC9 Synonyms:KIAA1882, NIBP ORF Names:T1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30832, TRAPPC9 |
MIMi | 611966, gene |
neXtProti | NX_Q96Q05 |
VEuPathDBi | HostDB:ENSG00000167632.14 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Golgi apparatus
- cis-Golgi network By similarity
Other locations
- Cytoplasm By similarity
Note: Processes and cell bodies of neurons.By similarity
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: GOC
- trans-Golgi network Source: GO_Central
Other locations
- TRAPP complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Golgi apparatusPathology & Biotechi
Involvement in diseasei
Mental retardation, autosomal recessive 13 (MRT13)2 Publications
Keywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 83696 |
MalaCardsi | TRAPPC9 |
MIMi | 613192, phenotype |
OpenTargetsi | ENSG00000167632 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability 352530, Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome |
PharmGKBi | PA162406921 |
Miscellaneous databases
Pharosi | Q96Q05, Tbio |
Genetic variation databases
BioMutai | TRAPPC9 |
DMDMi | 190359999 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341586 | 1 – 1148 | Trafficking protein particle complex subunit 9Add BLAST | 1148 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 566 | PhosphoserineCombined sources | 1 | |
Modified residuei | 953 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96Q05 |
jPOSTi | Q96Q05 |
MassIVEi | Q96Q05 |
MaxQBi | Q96Q05 |
PaxDbi | Q96Q05 |
PeptideAtlasi | Q96Q05 |
PRIDEi | Q96Q05 |
ProteomicsDBi | 77800 [Q96Q05-1] 77801 [Q96Q05-2] 77802 [Q96Q05-3] |
PTM databases
iPTMneti | Q96Q05 |
MetOSitei | Q96Q05 |
PhosphoSitePlusi | Q96Q05 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000167632, Expressed in muscle of leg and 221 other tissues |
ExpressionAtlasi | Q96Q05, baseline and differential |
Genevisiblei | Q96Q05, HS |
Organism-specific databases
HPAi | ENSG00000167632, Low tissue specificity |
Interactioni
Subunit structurei
Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Directly interacts with IKBKB and MAP3K14.
2 PublicationsBinary interactionsi
Q96Q05
With | #Exp. | IntAct |
---|---|---|
Trappc2 [Q9CQP2] from Mus musculus. | 2 | EBI-6160596,EBI-1172267 |
Protein-protein interaction databases
BioGRIDi | 123730, 64 interactors |
ComplexPortali | CPX-4749, TRAPP II complex |
CORUMi | Q96Q05 |
IntActi | Q96Q05, 36 interactors |
MINTi | Q96Q05 |
STRINGi | 9606.ENSP00000373979 |
Miscellaneous databases
RNActi | Q96Q05, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1953, Eukaryota |
GeneTreei | ENSGT00390000006486 |
InParanoidi | Q96Q05 |
OMAi | LGVKSNC |
OrthoDBi | 71855at2759 |
PhylomeDBi | Q96Q05 |
TreeFami | TF314341 |
Family and domain databases
InterProi | View protein in InterPro IPR013935, TRAPP_II_complex_Trs120 |
PANTHERi | PTHR21512, PTHR21512, 1 hit |
Pfami | View protein in Pfam PF08626, TRAPPC9-Trs120, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ
60 70 80 90 100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH
110 120 130 140 150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED
160 170 180 190 200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR
210 220 230 240 250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC
260 270 280 290 300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGAQE VLIDPGALTT
310 320 330 340 350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACIK
360 370 380 390 400
AVRVLAIQKR SMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF
410 420 430 440 450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSR
460 470 480 490 500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK
510 520 530 540 550
KDVAQSLENY TSKCPGTMEP IALPGGLTLP PVPFTKLPIV RHVKLLNLPA
560 570 580 590 600
SLRPHKMKSL LGQNVSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE
610 620 630 640 650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV
660 670 680 690 700
PQTTGTITVN GYHTTVFGVF SDCLLDNLPG IKTSGSTVEV IPALPRLQIS
710 720 730 740 750
TSLPRSAHSL QPSSGDEIST NVSVQLYNGE SQQLIIKLEN IGMEPLEKLE
760 770 780 790 800
VTSKVLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKVKLDFSC
810 820 830 840 850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVEGKPVNPP ESNKAGDYSH
860 870 880 890 900
VKTLEAVLNF KYSGGPGHTE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS
910 920 930 940 950
TRQCHLLLDV FNSTEHELTV STRSSEALIL HAGECQRMAI QVDKFNFESF
960 970 980 990 1000
PESPGEKGQF ANPKQLEEER REARGLEIHS KLGICWRIPS LKRSGEASVE
1010 1020 1030 1040 1050
GLLNQLVLEH LQLAPLQWDV LVDGQPCDRE AVAACQVGDP VRLEVRLTNR
1060 1070 1080 1090 1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDT VSFVGSSTFY LDAVQPSGQS
1110 1120 1130 1140
ACLGALLFLY TGDFFLHIRF HEDSTSKELP PSWFCLPSVH VCALEAQA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBR0 | H0YBR0_HUMAN | Trafficking protein particle comple... | TRAPPC9 | 992 | Annotation score: | ||
A0A0J9YWK7 | A0A0J9YWK7_HUMAN | Trafficking protein particle comple... | TRAPPC9 | 91 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 505 | Missing in CAH56384 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 539 | I → V in BAC87600 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 669 | V → E in BAB55299 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034349 | 1 | M → MVPAGDQDRAPHRGKPAQAG ARTSRASRALRSWRRSQAAR ATVTHPRGGHDRGSHGGYRE GHRGCRRDPQWASAGPPPLS FTEEVKFELRALKDWDFKM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_034350 | 286 – 294 | Missing in isoform 3. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB067469 mRNA Translation: BAB67775.1 Different initiation. AK027689 mRNA Translation: BAB55299.1 Different initiation. AK128755 mRNA Translation: BAC87600.1 BC003650 mRNA Translation: AAH03650.3 BC006206 mRNA Translation: AAH06206.3 Different initiation. BC065288 mRNA Translation: AAH65288.1 AL833973 mRNA Translation: CAH56384.1 AY190606 mRNA Translation: AAO38740.1 AY630619 mRNA Translation: AAV31908.1 |
CCDSi | CCDS34946.1 [Q96Q05-1] CCDS55278.1 [Q96Q05-1] |
RefSeqi | NP_001153844.1, NM_001160372.3 [Q96Q05-1] NP_001308575.1, NM_001321646.1 [Q96Q05-3] NP_113654.4, NM_031466.7 [Q96Q05-1] |
Genome annotation databases
Ensembli | ENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2] ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1] ENST00000648948; ENSP00000498020; ENSG00000167632 [Q96Q05-1] |
GeneIDi | 83696 |
KEGGi | hsa:83696 |
UCSCi | uc003yvh.2, human [Q96Q05-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB067469 mRNA Translation: BAB67775.1 Different initiation. AK027689 mRNA Translation: BAB55299.1 Different initiation. AK128755 mRNA Translation: BAC87600.1 BC003650 mRNA Translation: AAH03650.3 BC006206 mRNA Translation: AAH06206.3 Different initiation. BC065288 mRNA Translation: AAH65288.1 AL833973 mRNA Translation: CAH56384.1 AY190606 mRNA Translation: AAO38740.1 AY630619 mRNA Translation: AAV31908.1 |
CCDSi | CCDS34946.1 [Q96Q05-1] CCDS55278.1 [Q96Q05-1] |
RefSeqi | NP_001153844.1, NM_001160372.3 [Q96Q05-1] NP_001308575.1, NM_001321646.1 [Q96Q05-3] NP_113654.4, NM_031466.7 [Q96Q05-1] |
3D structure databases
SMRi | Q96Q05 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123730, 64 interactors |
ComplexPortali | CPX-4749, TRAPP II complex |
CORUMi | Q96Q05 |
IntActi | Q96Q05, 36 interactors |
MINTi | Q96Q05 |
STRINGi | 9606.ENSP00000373979 |
PTM databases
iPTMneti | Q96Q05 |
MetOSitei | Q96Q05 |
PhosphoSitePlusi | Q96Q05 |
Genetic variation databases
BioMutai | TRAPPC9 |
DMDMi | 190359999 |
Proteomic databases
EPDi | Q96Q05 |
jPOSTi | Q96Q05 |
MassIVEi | Q96Q05 |
MaxQBi | Q96Q05 |
PaxDbi | Q96Q05 |
PeptideAtlasi | Q96Q05 |
PRIDEi | Q96Q05 |
ProteomicsDBi | 77800 [Q96Q05-1] 77801 [Q96Q05-2] 77802 [Q96Q05-3] |
Protocols and materials databases
Antibodypediai | 14382, 112 antibodies |
Genome annotation databases
Ensembli | ENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2] ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1] ENST00000648948; ENSP00000498020; ENSG00000167632 [Q96Q05-1] |
GeneIDi | 83696 |
KEGGi | hsa:83696 |
UCSCi | uc003yvh.2, human [Q96Q05-1] |
Organism-specific databases
CTDi | 83696 |
DisGeNETi | 83696 |
GeneCardsi | TRAPPC9 |
HGNCi | HGNC:30832, TRAPPC9 |
HPAi | ENSG00000167632, Low tissue specificity |
MalaCardsi | TRAPPC9 |
MIMi | 611966, gene 613192, phenotype |
neXtProti | NX_Q96Q05 |
OpenTargetsi | ENSG00000167632 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability 352530, Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome |
PharmGKBi | PA162406921 |
VEuPathDBi | HostDB:ENSG00000167632.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1953, Eukaryota |
GeneTreei | ENSGT00390000006486 |
InParanoidi | Q96Q05 |
OMAi | LGVKSNC |
OrthoDBi | 71855at2759 |
PhylomeDBi | Q96Q05 |
TreeFami | TF314341 |
Enzyme and pathway databases
PathwayCommonsi | Q96Q05 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 83696, 9 hits in 874 CRISPR screens |
ChiTaRSi | TRAPPC9, human |
GenomeRNAii | 83696 |
Pharosi | Q96Q05, Tbio |
PROi | PR:Q96Q05 |
RNActi | Q96Q05, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167632, Expressed in muscle of leg and 221 other tissues |
ExpressionAtlasi | Q96Q05, baseline and differential |
Genevisiblei | Q96Q05, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013935, TRAPP_II_complex_Trs120 |
PANTHERi | PTHR21512, PTHR21512, 1 hit |
Pfami | View protein in Pfam PF08626, TRAPPC9-Trs120, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPPC9_HUMAN | |
Accessioni | Q96Q05Primary (citable) accession number: Q96Q05 Secondary accession number(s): Q4VTT3 Q9BQA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families