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UniProtKB - Q96Q05 (TPPC9_HUMAN)

Entry version 127 (16 Oct 2019)
Sequence version 2 (10 Jun 2008)
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Protein

Trafficking protein particle complex subunit 9

Gene

TRAPPC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 9
Alternative name(s):
NIK- and IKBKB-binding protein
Tularik gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC9
Synonyms:KIAA1882, NIBP
ORF Names:T1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30832 TRAPPC9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611966 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96Q05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 13 (MRT13)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		83696

MalaCards human disease database

More...MalaCardsi		TRAPPC9
MIMi613192 phenotype

Open Targets

More...OpenTargetsi		ENSG00000167632

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		88616 Autosomal recessive non-syndromic intellectual disability
352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162406921

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96Q05

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRAPPC9

Domain mapping of disease mutations (DMDM)

More...DMDMi		190359999

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003415861 – 1148Trafficking protein particle complex subunit 9Add BLAST1148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei566PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96Q05

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96Q05

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96Q05

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96Q05

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96Q05

PeptideAtlas

More...PeptideAtlasi		Q96Q05

PRoteomics IDEntifications database

More...PRIDEi		Q96Q05

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77800 [Q96Q05-1]
77801 [Q96Q05-2]
77802 [Q96Q05-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96Q05

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96Q05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96Q05 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96Q05 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA026579

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Directly interacts with IKBKB and MAP3K14.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9CQP22EBI-6160596,EBI-1172267From Mus musculus.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		123730, 63 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96Q05

Protein interaction database and analysis system

More...IntActi		Q96Q05, 33 interactors

Molecular INTeraction database

More...MINTi		Q96Q05

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000373979

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96Q05

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NIBP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1953 Eukaryota
ENOG410YEPC LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006486

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96Q05

KEGG Orthology (KO)

More...KOi		K20306

Identification of Orthologs from Complete Genome Data

More...OMAi		FLFTPIH

Database of Orthologous Groups

More...OrthoDBi		71855at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96Q05

TreeFam database of animal gene trees

More...TreeFami		TF314341

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013935 TRAPP_II_complex_Trs120

The PANTHER Classification System

More...PANTHERi		PTHR21512 PTHR21512, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08626 TRAPPC9-Trs120, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96Q05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRICS VSQISVRDSQ 
        60         70         80         90        100
RVLYIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSAK DWPQTFEKFH 
       110        120        130        140        150
VQKEIYGSTL YDSRLFVFGL QGEIVEQPRT DVAFYPNYED CQTVEKRIED 
       160        170        180        190        200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR 
       210        220        230        240        250
CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL WLGAALEGLC 
       260        270        280        290        300
SASVIYHYPG GTGGKSGARR FQGSTLPAEA ANRHRPGAQE VLIDPGALTT 
       310        320        330        340        350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACIK 
       360        370        380        390        400
AVRVLAIQKR SMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF 
       410        420        430        440        450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSR 
       460        470        480        490        500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK 
       510        520        530        540        550
KDVAQSLENY TSKCPGTMEP IALPGGLTLP PVPFTKLPIV RHVKLLNLPA 
       560        570        580        590        600
SLRPHKMKSL LGQNVSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE 
       610        620        630        640        650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV 
       660        670        680        690        700
PQTTGTITVN GYHTTVFGVF SDCLLDNLPG IKTSGSTVEV IPALPRLQIS 
       710        720        730        740        750
TSLPRSAHSL QPSSGDEIST NVSVQLYNGE SQQLIIKLEN IGMEPLEKLE 
       760        770        780        790        800
VTSKVLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKVKLDFSC 
       810        820        830        840        850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVEGKPVNPP ESNKAGDYSH 
       860        870        880        890        900
VKTLEAVLNF KYSGGPGHTE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS 
       910        920        930        940        950
TRQCHLLLDV FNSTEHELTV STRSSEALIL HAGECQRMAI QVDKFNFESF 
       960        970        980        990       1000
PESPGEKGQF ANPKQLEEER REARGLEIHS KLGICWRIPS LKRSGEASVE 
      1010       1020       1030       1040       1050
GLLNQLVLEH LQLAPLQWDV LVDGQPCDRE AVAACQVGDP VRLEVRLTNR 
      1060       1070       1080       1090       1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDT VSFVGSSTFY LDAVQPSGQS 
      1110       1120       1130       1140 
ACLGALLFLY TGDFFLHIRF HEDSTSKELP PSWFCLPSVH VCALEAQA
Length:1,148
Mass (Da):128,530
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i532932462A6853CC
GO
Isoform 2 (identifier: Q96Q05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAGDQDRA...RALKDWDFKM

Note: No experimental confirmation available.
Show »
Length:1,246
Mass (Da):139,437
Checksum:i657FEFF8EB0E8008
GO
Isoform 3 (identifier: Q96Q05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-294: Missing.

Show »
Length:1,139
Mass (Da):127,607
Checksum:i9A75186A0673E4AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBR0H0YBR0_HUMAN
Trafficking protein particle comple...
TRAPPC9
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWK7A0A0J9YWK7_HUMAN
Trafficking protein particle comple...
TRAPPC9
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH06206 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55299 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB67775 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti505Missing in CAH56384 (PubMed:17974005).Curated1
Sequence conflicti539I → V in BAC87600 (PubMed:14702039).Curated1
Sequence conflicti669V → E in BAB55299 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0343491M → MVPAGDQDRAPHRGKPAQAG ARTSRASRALRSWRRSQAAR ATVTHPRGGHDRGSHGGYRE GHRGCRRDPQWASAGPPPLS FTEEVKFELRALKDWDFKM in isoform 2. 1 Publication1
Alternative sequenceiVSP_034350286 – 294Missing in isoform 3. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB067469 mRNA Translation: BAB67775.1 Different initiation.
AK027689 mRNA Translation: BAB55299.1 Different initiation.
AK128755 mRNA Translation: BAC87600.1
BC003650 mRNA Translation: AAH03650.3
BC006206 mRNA Translation: AAH06206.3 Different initiation.
BC065288 mRNA Translation: AAH65288.1
AL833973 mRNA Translation: CAH56384.1
AY190606 mRNA Translation: AAO38740.1
AY630619 mRNA Translation: AAV31908.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34946.1 [Q96Q05-2]
CCDS55278.1 [Q96Q05-1]

NCBI Reference Sequences

More...RefSeqi		NP_001153844.1, NM_001160372.3 [Q96Q05-1]
NP_001308575.1, NM_001321646.1 [Q96Q05-3]
NP_113654.4, NM_031466.7 [Q96Q05-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
ENST00000648948; ENSP00000498020; ENSG00000167632 [Q96Q05-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83696

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83696

UCSC genome browser

More...UCSCi		uc003yvh.2 human [Q96Q05-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067469 mRNA Translation: BAB67775.1 Different initiation.
AK027689 mRNA Translation: BAB55299.1 Different initiation.
AK128755 mRNA Translation: BAC87600.1
BC003650 mRNA Translation: AAH03650.3
BC006206 mRNA Translation: AAH06206.3 Different initiation.
BC065288 mRNA Translation: AAH65288.1
AL833973 mRNA Translation: CAH56384.1
AY190606 mRNA Translation: AAO38740.1
AY630619 mRNA Translation: AAV31908.1
CCDSiCCDS34946.1 [Q96Q05-2]
CCDS55278.1 [Q96Q05-1]
RefSeqiNP_001153844.1, NM_001160372.3 [Q96Q05-1]
NP_001308575.1, NM_001321646.1 [Q96Q05-3]
NP_113654.4, NM_031466.7 [Q96Q05-2]

3D structure databases

SMRiQ96Q05
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123730, 63 interactors
CORUMiQ96Q05
IntActiQ96Q05, 33 interactors
MINTiQ96Q05
STRINGi9606.ENSP00000373979

PTM databases

iPTMnetiQ96Q05
PhosphoSitePlusiQ96Q05

Polymorphism and mutation databases

BioMutaiTRAPPC9
DMDMi190359999

Proteomic databases

EPDiQ96Q05
jPOSTiQ96Q05
MassIVEiQ96Q05
MaxQBiQ96Q05
PaxDbiQ96Q05
PeptideAtlasiQ96Q05
PRIDEiQ96Q05
ProteomicsDBi77800 [Q96Q05-1]
77801 [Q96Q05-2]
77802 [Q96Q05-3]

Genome annotation databases

EnsembliENST00000389328; ENSP00000373979; ENSG00000167632 [Q96Q05-2]
ENST00000438773; ENSP00000405060; ENSG00000167632 [Q96Q05-1]
ENST00000648948; ENSP00000498020; ENSG00000167632 [Q96Q05-1]
GeneIDi83696
KEGGihsa:83696
UCSCiuc003yvh.2 human [Q96Q05-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83696
DisGeNETi83696

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRAPPC9
HGNCiHGNC:30832 TRAPPC9
HPAiHPA026579
MalaCardsiTRAPPC9
MIMi611966 gene
613192 phenotype
neXtProtiNX_Q96Q05
OpenTargetsiENSG00000167632
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
352530 Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
PharmGKBiPA162406921

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1953 Eukaryota
ENOG410YEPC LUCA
GeneTreeiENSGT00390000006486
InParanoidiQ96Q05
KOiK20306
OMAiFLFTPIH
OrthoDBi71855at2759
PhylomeDBiQ96Q05
TreeFamiTF314341

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRAPPC9 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83696
PharosiQ96Q05

Protein Ontology

More...PROi		PR:Q96Q05

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167632 Expressed in 209 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ96Q05 baseline and differential
GenevisibleiQ96Q05 HS

Family and domain databases

InterProiView protein in InterPro
IPR013935 TRAPP_II_complex_Trs120
PANTHERiPTHR21512 PTHR21512, 1 hit
PfamiView protein in Pfam
PF08626 TRAPPC9-Trs120, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPPC9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96Q05
Secondary accession number(s): Q4VTT3
, Q658K7, Q6P149, Q6ZQT3, Q7L5C4, Q86Y21, Q96SL2, Q9BQA2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 16, 2019
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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