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Entry version 149 (18 Sep 2019)
Sequence version 3 (28 Mar 2018)
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Protein

CUB and sushi domain-containing protein 1

Gene

CSMD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential suppressor of squamous cell carcinomas.

Miscellaneous

CSMD1 may be a candidate for oral and oropharyngeal squamous cell carcinomas (OSCCs). PubMed:12696061 and PubMed:14506705 are however in disagreement: while PubMed:14506705 considers CSMD1 as a strong candidate for OSCCs, PubMed:12696061 thinks it is not.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUB and sushi domain-containing protein 1
Alternative name(s):
CUB and sushi multiple domains protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSMD1
Synonyms:KIAA1890
ORF Names:UNQ5952/PRO19863
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14026 CSMD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608397 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 3487ExtracellularSequence analysisAdd BLAST3461
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3488 – 3508HelicalSequence analysisAdd BLAST21
Topological domaini3509 – 3564CytoplasmicSequence analysisAdd BLAST56

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64478

Open Targets

More...
OpenTargetsi
ENSG00000183117

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26947

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSMD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38604975

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002102527 – 3564CUB and sushi domain-containing protein 1Add BLAST3538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 58PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 185PROSITE-ProRule annotation
Disulfide bondi171 ↔ 202PROSITE-ProRule annotation
Disulfide bondi208 ↔ 234PROSITE-ProRule annotation
Disulfide bondi349 ↔ 389PROSITE-ProRule annotation
Disulfide bondi375 ↔ 406PROSITE-ProRule annotation
Disulfide bondi411 ↔ 437PROSITE-ProRule annotation
Disulfide bondi527 ↔ 567PROSITE-ProRule annotation
Disulfide bondi553 ↔ 580PROSITE-ProRule annotation
Disulfide bondi584 ↔ 610PROSITE-ProRule annotation
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi697 ↔ 738PROSITE-ProRule annotation
Disulfide bondi723 ↔ 754PROSITE-ProRule annotation
Disulfide bondi758 ↔ 784PROSITE-ProRule annotation
Disulfide bondi873 ↔ 913PROSITE-ProRule annotation
Disulfide bondi899 ↔ 926PROSITE-ProRule annotation
Disulfide bondi930 ↔ 956PROSITE-ProRule annotation
Glycosylationi955N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1015N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1034N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1045 ↔ 1085PROSITE-ProRule annotation
Disulfide bondi1071 ↔ 1100PROSITE-ProRule annotation
Disulfide bondi1104 ↔ 1130PROSITE-ProRule annotation
Glycosylationi1184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1217 ↔ 1258PROSITE-ProRule annotation
Disulfide bondi1244 ↔ 1273PROSITE-ProRule annotation
Disulfide bondi1277 ↔ 1304PROSITE-ProRule annotation
Disulfide bondi1391 ↔ 1431PROSITE-ProRule annotation
Glycosylationi1399N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1417 ↔ 1447PROSITE-ProRule annotation
Disulfide bondi1451 ↔ 1477PROSITE-ProRule annotation
Glycosylationi1454N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1564 ↔ 1604PROSITE-ProRule annotation
Glycosylationi1572N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1590 ↔ 1621PROSITE-ProRule annotation
Disulfide bondi1625 ↔ 1651PROSITE-ProRule annotation
Glycosylationi1644N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1741 ↔ 1781PROSITE-ProRule annotation
Disulfide bondi1767 ↔ 1798PROSITE-ProRule annotation
Glycosylationi1792N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1802 ↔ 1828PROSITE-ProRule annotation
Glycosylationi1805N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1882N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1915 ↔ 1955PROSITE-ProRule annotation
Disulfide bondi1941 ↔ 1970PROSITE-ProRule annotation
Disulfide bondi1974 ↔ 2000PROSITE-ProRule annotation
Glycosylationi2018N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2087 ↔ 2127PROSITE-ProRule annotation
Disulfide bondi2113 ↔ 2142PROSITE-ProRule annotation
Disulfide bondi2146 ↔ 2172PROSITE-ProRule annotation
Glycosylationi2149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2187N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2258 ↔ 2300PROSITE-ProRule annotation
Disulfide bondi2286 ↔ 2315PROSITE-ProRule annotation
Disulfide bondi2319 ↔ 2347PROSITE-ProRule annotation
Glycosylationi2358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2432 ↔ 2473PROSITE-ProRule annotation
Glycosylationi2445N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2459 ↔ 2490PROSITE-ProRule annotation
Glycosylationi2470N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2495 ↔ 2537PROSITE-ProRule annotation
Glycosylationi2503N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2521 ↔ 2552PROSITE-ProRule annotation
Disulfide bondi2557 ↔ 2602PROSITE-ProRule annotation
Disulfide bondi2588 ↔ 2617PROSITE-ProRule annotation
Glycosylationi2605N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2622 ↔ 2662PROSITE-ProRule annotation
Disulfide bondi2648 ↔ 2675PROSITE-ProRule annotation
Disulfide bondi2680 ↔ 2720PROSITE-ProRule annotation
Disulfide bondi2706 ↔ 2733PROSITE-ProRule annotation
Disulfide bondi2738 ↔ 2778PROSITE-ProRule annotation
Glycosylationi2750N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2761N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2764 ↔ 2791PROSITE-ProRule annotation
Glycosylationi2795N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2796 ↔ 2841PROSITE-ProRule annotation
Disulfide bondi2827 ↔ 2854PROSITE-ProRule annotation
Disulfide bondi2859 ↔ 2899PROSITE-ProRule annotation
Disulfide bondi2885 ↔ 2912PROSITE-ProRule annotation
Glycosylationi2894N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2920 ↔ 2960PROSITE-ProRule annotation
Disulfide bondi2946 ↔ 2973PROSITE-ProRule annotation
Glycosylationi2963N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2978 ↔ 3019PROSITE-ProRule annotation
Disulfide bondi3005 ↔ 3032PROSITE-ProRule annotation
Glycosylationi3022N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3037 ↔ 3079PROSITE-ProRule annotation
Glycosylationi3056N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3063 ↔ 3092PROSITE-ProRule annotation
Disulfide bondi3097 ↔ 3137PROSITE-ProRule annotation
Glycosylationi3105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3123 ↔ 3150PROSITE-ProRule annotation
Disulfide bondi3155 ↔ 3195PROSITE-ProRule annotation
Disulfide bondi3181 ↔ 3208PROSITE-ProRule annotation
Disulfide bondi3216 ↔ 3257PROSITE-ProRule annotation
Glycosylationi3228N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3243 ↔ 3270PROSITE-ProRule annotation
Glycosylationi3260N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3275 ↔ 3317PROSITE-ProRule annotation
Disulfide bondi3302 ↔ 3330PROSITE-ProRule annotation
Glycosylationi3339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3386N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96PZ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96PZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PZ7

PeptideAtlas

More...
PeptideAtlasi
Q96PZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q96PZ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77795 [Q96PZ7-1]
77796 [Q96PZ7-2]
77797 [Q96PZ7-3]
77798 [Q96PZ7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96PZ7 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA074707

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122185, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96PZ7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000430733

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13564
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96PZ7

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96PZ7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 140CUB 1PROSITE-ProRule annotationAdd BLAST109
Domaini143 – 204Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini208 – 312CUB 2PROSITE-ProRule annotationAdd BLAST105
Domaini347 – 408Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini411 – 522CUB 3PROSITE-ProRule annotationAdd BLAST112
Domaini525 – 582Sushi 3PROSITE-ProRule annotationAdd BLAST58
Domaini584 – 692CUB 4PROSITE-ProRule annotationAdd BLAST109
Domaini695 – 756Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini758 – 866CUB 5PROSITE-ProRule annotationAdd BLAST109
Domaini871 – 928Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini930 – 1040CUB 6PROSITE-ProRule annotationAdd BLAST111
Domaini1043 – 1102Sushi 6PROSITE-ProRule annotationAdd BLAST60
Domaini1104 – 1212CUB 7PROSITE-ProRule annotationAdd BLAST109
Domaini1215 – 1275Sushi 7PROSITE-ProRule annotationAdd BLAST61
Domaini1277 – 1386CUB 8PROSITE-ProRule annotationAdd BLAST110
Domaini1389 – 1449Sushi 8PROSITE-ProRule annotationAdd BLAST61
Domaini1451 – 1559CUB 9PROSITE-ProRule annotationAdd BLAST109
Domaini1562 – 1623Sushi 9PROSITE-ProRule annotationAdd BLAST62
Domaini1625 – 1733CUB 10PROSITE-ProRule annotationAdd BLAST109
Domaini1739 – 1800Sushi 10PROSITE-ProRule annotationAdd BLAST62
Domaini1802 – 1910CUB 11PROSITE-ProRule annotationAdd BLAST109
Domaini1913 – 1972Sushi 11PROSITE-ProRule annotationAdd BLAST60
Domaini1974 – 2082CUB 12PROSITE-ProRule annotationAdd BLAST109
Domaini2085 – 2144Sushi 12PROSITE-ProRule annotationAdd BLAST60
Domaini2146 – 2257CUB 13PROSITE-ProRule annotationAdd BLAST112
Domaini2256 – 2317Sushi 13PROSITE-ProRule annotationAdd BLAST62
Domaini2319 – 2430CUB 14PROSITE-ProRule annotationAdd BLAST112
Domaini2430 – 2492Sushi 14PROSITE-ProRule annotationAdd BLAST63
Domaini2493 – 2554Sushi 15PROSITE-ProRule annotationAdd BLAST62
Domaini2555 – 2619Sushi 16PROSITE-ProRule annotationAdd BLAST65
Domaini2620 – 2677Sushi 17PROSITE-ProRule annotationAdd BLAST58
Domaini2678 – 2735Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2736 – 2793Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2794 – 2856Sushi 20PROSITE-ProRule annotationAdd BLAST63
Domaini2857 – 2914Sushi 21PROSITE-ProRule annotationAdd BLAST58
Domaini2918 – 2975Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2976 – 3034Sushi 23PROSITE-ProRule annotationAdd BLAST59
Domaini3035 – 3094Sushi 24PROSITE-ProRule annotationAdd BLAST60
Domaini3095 – 3152Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini3153 – 3210Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3214 – 3272Sushi 27PROSITE-ProRule annotationAdd BLAST59
Domaini3273 – 3332Sushi 28PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSMD family.Curated

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PZ7

KEGG Orthology (KO)

More...
KOi
K17495

Database of Orthologous Groups

More...
OrthoDBi
2377at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PZ7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 28 hits
cd00041 CUB, 14 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 14 hits
PF00084 Sushi, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 28 hits
SM00042 CUB, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 14 hits
SSF57535 SSF57535, 28 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 14 hits
PS50923 SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTAWRRFQSL LLLLGLLVLC ARLLTAAKGQ NCGGLVQGPN GTIESPGFPH
60 70 80 90 100
GYPNYANCTW IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV
110 120 130 140 150
RLSGFQLPSS IVSTGSILTL WFTTDFAVSA QGFKALYEVL PSHTCGNPGE
160 170 180 190 200
ILKGVLHGTR FNIGDKIRYS CLPGYILEGH AILTCIVSPG NGASWDFPAP
210 220 230 240 250
FCRAEGACGG TLRGTSSSIS SPHFPSEYEN NADCTWTILA EPGDTIALVF
260 270 280 290 300
TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH
310 320 330 340 350
RRKGFNAQFQ VKKAIELKSR GVKMLPSKDG SHKNSVLSQG GVALVSDMCP
360 370 380 390 400
DPGIPENGRR AGSDFRVGAN VQFSCEDNYV LQGSKSITCQ RVTETLAAWS
410 420 430 440 450
DHRPICRART CGSNLRGPSG VITSPNYPVQ YEDNAHCVWV ITTTDPDKVI
460 470 480 490 500
KLAFEEFELE RGYDTLTVGD AGKVGDTRSV LYVLTGSSVP DLIVSMSNQM
510 520 530 540 550
WLHLQSDDSI GSPGFKAVYQ EIEKGGCGDP GIPAYGKRTG SSFLHGDTLT
560 570 580 590 600
FECPAAFELV GERVITCQQN NQWSGNKPSC VFSCFFNFTA SSGIILSPNY
610 620 630 640 650
PEEYGNNMNC VWLIISEPGS RIHLIFNDFD VEPQFDFLAV KDDGISDITV
660 670 680 690 700
LGTFSGNEVP SQLASSGHIV RLEFQSDHST TGRGFNITYT TFGQNECHDP
710 720 730 740 750
GIPINGRRFG DRFLLGSSVS FHCDDGFVKT QGSESITCIL QDGNVVWSST
760 770 780 790 800
VPRCEAPCGG HLTASSGVIL PPGWPGYYKD SLHCEWIIEA KPGHSIKITF
810 820 830 840 850
DRFQTEVNYD TLEVRDGPAS SSPLIGEYHG TQAPQFLIST GNFMYLLFTT
860 870 880 890 900
DNSRSSIGFL IHYESVTLES DSCLDPGIPV NGHRHGGDFG IRSTVTFSCD
910 920 930 940 950
PGYTLSDDEP LVCERNHQWN HALPSCDALC GGYIQGKSGT VLSPGFPDFY
960 970 980 990 1000
PNSLNCTWTI EVSHGKGVQM IFHTFHLESS HDYLLITEDG SFSEPVARLT
1010 1020 1030 1040 1050
GSVLPHTIKA GLFGNFTAQL RFISDFSISY EGFNITFSEY DLEPCDDPGV
1060 1070 1080 1090 1100
PAFSRRIGFH FGVGDSLTFS CFLGYRLEGA TKLTCLGGGR RVWSAPLPRC
1110 1120 1130 1140 1150
VAECGASVKG NEGTLLSPNF PSNYDNNHEC IYKIETEAGK GIHLRTRSFQ
1160 1170 1180 1190 1200
LFEGDTLKVY DGKDSSSRPL GTFTKNELLG LILNSTSNHL WLEFNTNGSD
1210 1220 1230 1240 1250
TDQGFQLTYT SFDLVKCEDP GIPNYGYRIR DEGHFTDTVV LYSCNPGYAM
1260 1270 1280 1290 1300
HGSNTLTCLS GDRRVWDKPL PSCIAECGGQ IHAATSGRIL SPGYPAPYDN
1310 1320 1330 1340 1350
NLHCTWIIEA DPGKTISLHF IVFDTEMAHD ILKVWDGPVD SDILLKEWSG
1360 1370 1380 1390 1400
SALPEDIHST FNSLTLQFDS DFFISKSGFS IQFSTSIAAT CNDPGMPQNG
1410 1420 1430 1440 1450
TRYGDSREAG DTVTFQCDPG YQLQGQAKIT CVQLNNRFFW QPDPPTCIAA
1460 1470 1480 1490 1500
CGGNLTGPAG VILSPNYPQP YPPGKECDWR VKVNPDFVIA LIFKSFNMEP
1510 1520 1530 1540 1550
SYDFLHIYEG EDSNSPLIGS YQGSQAPERI ESSGNSLFLA FRSDASVGLS
1560 1570 1580 1590 1600
GFAIEFKEKP REACFDPGNI MNGTRVGTDF KLGSTITYQC DSGYKILDPS
1610 1620 1630 1640 1650
SITCVIGADG KPSWDQVLPS CNAPCGGQYT GSEGVVLSPN YPHNYTAGQI
1660 1670 1680 1690 1700
CLYSITVPKE FVVFGQFAYF QTALNDLAEL FDGTHAQARL LSSLSGSHSG
1710 1720 1730 1740 1750
ETLPLATSNQ ILLRFSAKSG ASARGFHFVY QAVPRTSDTQ CSSVPEPRYG
1760 1770 1780 1790 1800
RRIGSEFSAG SIVRFECNPG YLLQGSTALH CQSVPNALAQ WNDTIPSCVV
1810 1820 1830 1840 1850
PCSGNFTQRR GTILSPGYPE PYGNNLNCIW KIIVTEGSGI QIQVISFATE
1860 1870 1880 1890 1900
QNWDSLEIHD GGDVTAPRLG SFSGTTVPAL LNSTSNQLYL HFQSDISVAA
1910 1920 1930 1940 1950
AGFHLEYKTV GLAACQEPAL PSNSIKIGDR YMVNDVLSFQ CEPGYTLQGR
1960 1970 1980 1990 2000
SHISCMPGTV RRWNYPSPLC IATCGGTLST LGGVILSPGF PGSYPNNLDC
2010 2020 2030 2040 2050
TWRISLPIGY GAHIQFLNFS TEANHDFLEI QNGPYHTSPM IGQFSGTDLP
2060 2070 2080 2090 2100
AALLSTTHET LIHFYSDHSQ NRQGFKLAYQ AYELQNCPDP PPFQNGYMIN
2110 2120 2130 2140 2150
SDYSVGQSVS FECYPGYILI GHPVLTCQHG INRNWNYPFP RCDAPCGYNV
2160 2170 2180 2190 2200
TSQNGTIYSP GFPDEYPILK DCIWLITVPP GHGVYINFTL LQTEAVNDYI
2210 2220 2230 2240 2250
AVWDGPDQNS PQLGVFSGNT ALETAYSSTN QVLLKFHSDF SNGGFFVLNF
2260 2270 2280 2290 2300
HAFQLKKCQP PPAVPQAEML TEDDDFEIGD FVKYQCHPGY TLVGTDILTC
2310 2320 2330 2340 2350
KLSSQLQFEG SLPTCEAQCP ANEVRTGSSG VILSPGYPGN YFNSQTCSWS
2360 2370 2380 2390 2400
IKVEPNYNIT IFVDTFQSEK QFDALEVFDG SSGQSPLLVV LSGNHTEQSN
2410 2420 2430 2440 2450
FTSRSNQLYL RWSTDHATSK KGFKIRYAAP YCSLTHPLKN GGILNRTAGA
2460 2470 2480 2490 2500
VGSKVHYFCK PGYRMVGHSN ATCRRNPLGM YQWDSLTPLC QAVSCGIPES
2510 2520 2530 2540 2550
PGNGSFTGNE FTLDSKVVYE CHEGFKLESS QQATAVCQED GLWSNKGKPP
2560 2570 2580 2590 2600
TCKPVACPSI EAQLSEHVIW RLVSGSLNEY GAQVLLSCSP GYYLEGWRLL
2610 2620 2630 2640 2650
RCQANGTWNI GDERPSCRVI SCGSLSFPPN GNKIGTLTVY GATAIFTCNT
2660 2670 2680 2690 2700
GYTLVGSHVR ECLANGLWSG SETRCLAGHC GSPDPIVNGH ISGDGFSYRD
2710 2720 2730 2740 2750
TVVYQCNPGF RLVGTSVRIC LQDHKWSGQT PVCVPITCGH PGNPAHGFTN
2760 2770 2780 2790 2800
GSEFNLNDVV NFTCNTGYLL QGVSRAQCRS NGQWSSPLPT CRVVNCSDPG
2810 2820 2830 2840 2850
FVENAIRHGQ QNFPESFEYG MSILYHCKKG FYLLGSSALT CMANGLWDRS
2860 2870 2880 2890 2900
LPKCLAISCG HPGVPANAVL TGELFTYGAV VHYSCRGSES LIGNDTRVCQ
2910 2920 2930 2940 2950
EDSHWSGALP HCTGNNPGFC GDPGTPAHGS RLGDDFKTKS LLRFSCEMGH
2960 2970 2980 2990 3000
QLRGSPERTC LLNGSWSGLQ PVCEAVSCGN PGTPTNGMIV SSDGILFSSS
3010 3020 3030 3040 3050
VIYACWEGYK TSGLMTRHCT ANGTWTGTAP DCTIISCGDP GTLANGIQFG
3060 3070 3080 3090 3100
TDFTFNKTVS YQCNPGYVME AVTSATIRCT KDGRWNPSKP VCKAVLCPQP
3110 3120 3130 3140 3150
PPVQNGTVEG SDFRWGSSIS YSCMDGYQLS HSAILSCEGR GVWKGEIPQC
3160 3170 3180 3190 3200
LPVFCGDPGI PAEGRLSGKS FTYKSEVFFQ CKSPFILVGS SRRVCQADGT
3210 3220 3230 3240 3250
WSGIQPTCID PAHNTCPDPG TPHFGIQNSS RGYEVGSTVF FRCRKGYHIQ
3260 3270 3280 3290 3300
GSTTRTCLAN LTWSGIQTEC IPHACRQPET PAHADVRAID LPTFGYTLVY
3310 3320 3330 3340 3350
TCHPGFFLAG GSEHRTCKAD MKWTGKSPVC KSKGVREVNE TVTKTPVPSD
3360 3370 3380 3390 3400
VFFVNSLWKG YYEYLGKRQP ATLTVDWFNA TSSKVNATFS EASPVELKLT
3410 3420 3430 3440 3450
GIYKKEEAHL LLKAFQIKGQ ADIFVSKFEN DNWGLDGYVS SGLERGGFTF
3460 3470 3480 3490 3500
QGDIHGKDFG KFKLERQDPL NPDQDSSSHY HGTSSGSVAA AILVPFFALI
3510 3520 3530 3540 3550
LSGFAFYLYK HRTRPKVQYN GYAGHENSNG QASFENPMYD TNLKPTEAKA
3560
VRFDTTLNTV CTVV
Length:3,564
Mass (Da):388,736
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i949BAAF5DD559A0C
GO
Isoform 2 (identifier: Q96PZ7-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     2619-2676: Missing.
     2975-3093: Missing.

Show »
Length:3,387
Mass (Da):370,184
Checksum:iE6EE874843E007FE
GO
Isoform 3 (identifier: Q96PZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2081-2109: AYELQNCPDPPPFQNGYMINSDYSVGQSV → GGSGNIGPAFPCLDTPFQARCQGEERTFN
     2110-3564: Missing.

Note: No experimental confirmation available.
Show »
Length:2,109
Mass (Da):230,014
Checksum:i2262BE081DA9699B
GO
Isoform 4 (identifier: Q96PZ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2012-2012: A → K
     2013-3564: Missing.

Show »
Length:2,012
Mass (Da):219,272
Checksum:i8D64EF6A39655337
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIG2E5RIG2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,565Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9C3F8W9C3_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,388Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ18F5GZ18_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXU2H7BXU2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
2,967Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88541 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82D → N in AAK73475 (PubMed:11472063).Curated1
Sequence conflicti82D → N in AAG52948 (PubMed:11472063).Curated1
Sequence conflicti347 – 350DMCP → HMCL in AAK73475 (PubMed:11472063).Curated4
Sequence conflicti347 – 350DMCP → HMCL in AAG52948 (PubMed:11472063).Curated4
Sequence conflicti365F → FS in AAK73475 (PubMed:11472063).Curated1
Sequence conflicti365F → FS in AAG52948 (PubMed:11472063).Curated1
Sequence conflicti643D → N in AAG52948 (PubMed:11472063).Curated1
Sequence conflicti798I → M in AAK73475 (PubMed:11472063).Curated1
Sequence conflicti798I → M in AAG52948 (PubMed:11472063).Curated1
Sequence conflicti1461V → I in AK126936 (PubMed:14702039).Curated1
Sequence conflicti1842 – 1856IQVIS…NWDSL → DPSDQFCHGAELGLPF in AAK73475 (PubMed:11472063).CuratedAdd BLAST15
Sequence conflicti1842 – 1856IQVIS…NWDSL → DPSDQFCHGAELGLPF in AAG52948 (PubMed:11472063).CuratedAdd BLAST15
Sequence conflicti2061L → F in AK126936 (PubMed:14702039).Curated1
Sequence conflicti2551T → M in AAK73475 (PubMed:11472063).Curated1
Sequence conflicti2551T → M in AAG52948 (PubMed:11472063).Curated1
Sequence conflicti2832Y → H in AAK73475 (PubMed:11472063).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0596342040M → I. Corresponds to variant dbSNP:rs6995799Ensembl.1
Natural variantiVAR_0764442260P → A1 PublicationCorresponds to variant dbSNP:rs1254099921Ensembl.1
Natural variantiVAR_0568463311G → W. Corresponds to variant dbSNP:rs34079122Ensembl.1
Natural variantiVAR_0596353369Q → H. Corresponds to variant dbSNP:rs34337712Ensembl.1
Natural variantiVAR_0596363478S → N. Corresponds to variant dbSNP:rs11984691Ensembl.1
Natural variantiVAR_0764453539Y → C1 PublicationCorresponds to variant dbSNP:rs573209145Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0090322012A → K in isoform 4. 2 Publications1
Alternative sequenceiVSP_0090332013 – 3564Missing in isoform 4. 2 PublicationsAdd BLAST1552
Alternative sequenceiVSP_0090302081 – 2109AYELQ…VGQSV → GGSGNIGPAFPCLDTPFQAR CQGEERTFN in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0090312110 – 3564Missing in isoform 3. 1 PublicationAdd BLAST1455
Alternative sequenceiVSP_0090342619 – 2676Missing in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_0090352975 – 3093Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF333704 mRNA Translation: AAK73475.2
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
AY017307 mRNA Translation: AAG52948.1
DQ384438 Genomic DNA Translation: ABD48881.1
DQ384439 Genomic DNA Translation: ABD48882.1
DQ384440 Genomic DNA Translation: ABD48883.1
DQ384441 Genomic DNA Translation: ABD48884.1
DQ384442 Genomic DNA Translation: ABD48885.1
KF458667 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
AY358174 mRNA Translation: AAQ88541.1 Different initiation.
AB067477 mRNA Translation: BAB67783.1
AK126936 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55189.1 [Q96PZ7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_150094.5, NM_033225.5 [Q96PZ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000635120; ENSP00000489225; ENSG00000183117 [Q96PZ7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64478

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333704 mRNA Translation: AAK73475.2
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
AY017307 mRNA Translation: AAG52948.1
DQ384438 Genomic DNA Translation: ABD48881.1
DQ384439 Genomic DNA Translation: ABD48882.1
DQ384440 Genomic DNA Translation: ABD48883.1
DQ384441 Genomic DNA Translation: ABD48884.1
DQ384442 Genomic DNA Translation: ABD48885.1
KF458667 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
AY358174 mRNA Translation: AAQ88541.1 Different initiation.
AB067477 mRNA Translation: BAB67783.1
AK126936 mRNA No translation available.
CCDSiCCDS55189.1 [Q96PZ7-1]
RefSeqiNP_150094.5, NM_033225.5 [Q96PZ7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EHFNMR-A521-580[»]
SMRiQ96PZ7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122185, 4 interactors
IntActiQ96PZ7, 3 interactors
STRINGi9606.ENSP00000430733

PTM databases

iPTMnetiQ96PZ7
PhosphoSitePlusiQ96PZ7

Polymorphism and mutation databases

BioMutaiCSMD1
DMDMi38604975

Proteomic databases

jPOSTiQ96PZ7
MassIVEiQ96PZ7
PaxDbiQ96PZ7
PeptideAtlasiQ96PZ7
PRIDEiQ96PZ7
ProteomicsDBi77795 [Q96PZ7-1]
77796 [Q96PZ7-2]
77797 [Q96PZ7-3]
77798 [Q96PZ7-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64478
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000635120; ENSP00000489225; ENSG00000183117 [Q96PZ7-1]
GeneIDi64478
KEGGihsa:64478

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64478
DisGeNETi64478

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CSMD1
HGNCiHGNC:14026 CSMD1
HPAiHPA074707
MIMi608397 gene
neXtProtiNX_Q96PZ7
OpenTargetsiENSG00000183117
PharmGKBiPA26947

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00940000155701
HOGENOMiHOG000112015
InParanoidiQ96PZ7
KOiK17495
OrthoDBi2377at2759
PhylomeDBiQ96PZ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSMD1 human
EvolutionaryTraceiQ96PZ7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CSMD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64478

Pharos

More...
Pharosi
Q96PZ7

Protein Ontology

More...
PROi
PR:Q96PZ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiQ96PZ7 baseline and differential

Family and domain databases

CDDicd00033 CCP, 28 hits
cd00041 CUB, 14 hits
Gene3Di2.60.120.290, 14 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 14 hits
PF00084 Sushi, 28 hits
SMARTiView protein in SMART
SM00032 CCP, 28 hits
SM00042 CUB, 14 hits
SUPFAMiSSF49854 SSF49854, 14 hits
SSF57535 SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 14 hits
PS50923 SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSMD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PZ7
Secondary accession number(s): A0A0U1RQY1
, Q0H0J5, Q96QU9, Q96RM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 28, 2018
Last modified: September 18, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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