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Protein

Serine/threonine-protein kinase Nek1

Gene

NEK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: CACAO
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central
  • protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological processCell cycle, Cell division, Cilium biogenesis/degradation, Mitosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96PY6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96PY6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek1 (EC:2.7.11.11 Publication)
Alternative name(s):
Never in mitosis A-related kinase 1
Short name:
NimA-related protein kinase 1
Renal carcinoma antigen NY-REN-55
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEK1
Synonyms:KIAA1901
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137601.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7744 NEK1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604588 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PY6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Short-rib thoracic dysplasia 6 with or without polydactyly (SRTD6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. In some cases NEK1 mutations result in disease phenotype in the presence of mutations in DYNC2H1 indicating digenic inheritance (digenic short rib-polydactyly syndrome 3/6 with polydactyly) (PubMed:21211617).1 Publication
Disease descriptionA form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome.
See also OMIM:263520
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069617145G → R in SRTD6. 1 PublicationCorresponds to variant dbSNP:rs431905508EnsemblClinVar.1
Natural variantiVAR_069618253L → S in SRTD6. 1 Publication1
Amyotrophic lateral sclerosis 24 (ALS24)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
See also OMIM:617892
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080694261R → H in ALS24; associated with disease susceptibility. 1 Publication1
Natural variantiVAR_080695550 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST709
Natural variantiVAR_080696784 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST475
Natural variantiVAR_0806971008 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST251

Keywords - Diseasei

Amyotrophic lateral sclerosis, Ciliopathy, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
4750

MalaCards human disease database

More...
MalaCardsi
NEK1
MIMi263520 phenotype
617892 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137601

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
803 Amyotrophic lateral sclerosis
2751 Orofaciodigital syndrome type 2
93269 Short rib-polydactyly syndrome, Majewski type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31545

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5855

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2114

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NEK1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22256934

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000864181 – 1258Serine/threonine-protein kinase Nek1Add BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei156PhosphothreonineCombined sources1
Modified residuei162Phosphothreonine; by autocatalysisBy similarity1
Modified residuei414PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei438PhosphoserineBy similarity1
Modified residuei653PhosphoserineCombined sources1
Modified residuei661PhosphothreonineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei798PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei1052PhosphoserineCombined sources1
Modified residuei1126PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96PY6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96PY6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96PY6

PeptideAtlas

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PeptideAtlasi
Q96PY6

PRoteomics IDEntifications database

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PRIDEi
Q96PY6

ProteomicsDB human proteome resource

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ProteomicsDBi
77788
77789 [Q96PY6-2]
77790 [Q96PY6-3]
77791 [Q96PY6-4]
77792 [Q96PY6-5]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q96PY6-3 [Q96PY6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96PY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96PY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High fetal expression in the brain and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137601 Expressed in 231 organ(s), highest expression level in trigeminal ganglion

CleanEx database of gene expression profiles

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CleanExi
HS_NEK1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96PY6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96PY6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020873
HPA040413

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to SPERT (By similarity). Found in a complex with CFAP410, NEK1 and SPATA7 (PubMed:26167768). Interacts with CFAP410 (PubMed:26167768). Interacts (via Ser-1052 phosphorylated form) with 14-3-3 proteins (By similarity).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110825, 36 interactors

Protein interaction database and analysis system

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IntActi
Q96PY6, 28 interactors

Molecular INTeraction database

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MINTi
Q96PY6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000424757

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96PY6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96PY6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96PY6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 258Protein kinasePROSITE-ProRule annotationAdd BLAST255

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0589 Eukaryota
ENOG410Y7JF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158460

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006460

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96PY6

KEGG Orthology (KO)

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KOi
K08857

Identification of Orthologs from Complete Genome Data

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OMAi
VRQDNLE

Database of Orthologous Groups

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OrthoDBi
EOG091G0GU4

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96PY6

TreeFam database of animal gene trees

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TreeFami
TF333575

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKYVRLQKI GEGSFGKAIL VKSTEDGRQY VIKEINISRM SSKEREESRR
60 70 80 90 100
EVAVLANMKH PNIVQYRESF EENGSLYIVM DYCEGGDLFK RINAQKGVLF
110 120 130 140 150
QEDQILDWFV QICLALKHVH DRKILHRDIK SQNIFLTKDG TVQLGDFGIA
160 170 180 190 200
RVLNSTVELA RTCIGTPYYL SPEICENKPY NNKSDIWALG CVLYELCTLK
210 220 230 240 250
HAFEAGSMKN LVLKIISGSF PPVSLHYSYD LRSLVSQLFK RNPRDRPSVN
260 270 280 290 300
SILEKGFIAK RIEKFLSPQL IAEEFCLKTF SKFGSQPIPA KRPASGQNSI
310 320 330 340 350
SVMPAQKITK PAAKYGIPLA YKKYGDKKLH EKKPLQKHKQ AHQTPEKRVN
360 370 380 390 400
TGEERRKISE EAARKRRLEF IEKEKKQKDQ IISLMKAEQM KRQEKERLER
410 420 430 440 450
INRAREQGWR NVLSAGGSGE VKAPFLGSGG TIAPSSFSSR GQYEHYHAIF
460 470 480 490 500
DQMQQQRAED NEAKWKREIY GRGLPERGIL PGVRPGFPYG AAGHHHFPDA
510 520 530 540 550
DDIRKTLKRL KAVSKQANAN RQKGQLAVER AKQVEEFLQR KREAMQNKAR
560 570 580 590 600
AEGHMVYLAR LRQIRLQNFN ERQQIKAKLR GEKKEANHSE GQEGSEEADM
610 620 630 640 650
RRKKIESLKA HANARAAVLK EQLERKRKEA YEREKKVWEE HLVAKGVKSS
660 670 680 690 700
DVSPPLGQHE TGGSPSKQQM RSVISVTSAL KEVGVDSSLT DTRETSEEMQ
710 720 730 740 750
KTNNAISSKR EILRRLNENL KAQEDEKGKQ NLSDTFEINV HEDAKEHEKE
760 770 780 790 800
KSVSSDRKKW EAGGQLVIPL DELTLDTSFS TTERHTVGEV IKLGPNGSPR
810 820 830 840 850
RAWGKSPTDS VLKILGEAEL QLQTELLENT TIRSEISPEG EKYKPLITGE
860 870 880 890 900
KKVQCISHEI NPSAIVDSPV ETKSPEFSEA SPQMSLKLEG NLEEPDDLET
910 920 930 940 950
EILQEPSGTN KDESLPCTIT DVWISEEKET KETQSADRIT IQENEVSEDG
960 970 980 990 1000
VSSTVDQLSD IHIEPGTNDS QHSKCDVDKS VQPEPFFHKV VHSEHLNLVP
1010 1020 1030 1040 1050
QVQSVQCSPE ESFAFRSHSH LPPKNKNKNS LLIGLSTGLF DANNPKMLRT
1060 1070 1080 1090 1100
CSLPDLSKLF RTLMDVPTVG DVRQDNLEID EIEDENIKEG PSDSEDIVFE
1110 1120 1130 1140 1150
ETDTDLQELQ ASMEQLLREQ PGEEYSEEEE SVLKNSDVEP TANGTDVADE
1160 1170 1180 1190 1200
DDNPSSESAL NEEWHSDNSD GEIASECECD SVFNHLEELR LHLEQEMGFE
1210 1220 1230 1240 1250
KFFEVYEKIK AIHEDEDENI EICSKIVQNI LGNEHQHLYA KILHLVMADG

AYQEDNDE
Length:1,258
Mass (Da):142,828
Last modified:August 13, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i339C4BFA56612530
GO
Isoform 2 (identifier: Q96PY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-521: Missing.

Note: No experimental confirmation available.
Show »
Length:1,214
Mass (Da):138,068
Checksum:i347246AED3D9FD79
GO
Isoform 3 (identifier: Q96PY6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.
Show »
Length:1,286
Mass (Da):145,814
Checksum:iF94B3F9C0666059D
GO
Isoform 4 (identifier: Q96PY6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-422: Missing.
     477-520: Missing.

Note: No experimental confirmation available.
Show »
Length:1,189
Mass (Da):135,303
Checksum:iCAE13631DC2A2151
GO
Isoform 5 (identifier: Q96PY6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     522-527: QKGQLA → LDCDDP
     528-1258: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):60,250
Checksum:i47E0707A533EE57C
GO
Isoform 6 (identifier: Q96PY6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-520: Missing.
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.
Show »
Length:1,242
Mass (Da):141,053
Checksum:i5CB4B464CF15573C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBG5D6RBG5_HUMAN
Serine/threonine-protein kinase Nek...
NEK1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8M6H0Y8M6_HUMAN
Serine/threonine-protein kinase Nek...
NEK1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15147 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15207 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55209 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB67794 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250N → D in CAI45943 (PubMed:17974005).Curated1
Sequence conflicti602R → RK in CAI45943 (PubMed:17974005).Curated1
Sequence conflicti1232G → E in AAD42879 (PubMed:10508479).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04090010I → F1 PublicationCorresponds to variant dbSNP:rs34214559Ensembl.1
Natural variantiVAR_04090125E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04090276L → V1 PublicationCorresponds to variant dbSNP:rs35093214Ensembl.1
Natural variantiVAR_069617145G → R in SRTD6. 1 PublicationCorresponds to variant dbSNP:rs431905508EnsemblClinVar.1
Natural variantiVAR_069618253L → S in SRTD6. 1 Publication1
Natural variantiVAR_080694261R → H in ALS24; associated with disease susceptibility. 1 Publication1
Natural variantiVAR_040903294A → P in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040904355R → G1 PublicationCorresponds to variant dbSNP:rs35763578Ensembl.1
Natural variantiVAR_040905463A → V1 PublicationCorresponds to variant dbSNP:rs34540355EnsemblClinVar.1
Natural variantiVAR_080695550 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST709
Natural variantiVAR_046486598A → T1 PublicationCorresponds to variant dbSNP:rs33933790EnsemblClinVar.1
Natural variantiVAR_061743717N → K. Corresponds to variant dbSNP:rs34324114EnsemblClinVar.1
Natural variantiVAR_051651724E → G2 PublicationsCorresponds to variant dbSNP:rs34099167EnsemblClinVar.1
Natural variantiVAR_040906745K → N1 Publication1
Natural variantiVAR_080696784 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST475
Natural variantiVAR_046488883Q → E1 PublicationCorresponds to variant dbSNP:rs6828134EnsemblClinVar.1
Natural variantiVAR_0806971008 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST251
Natural variantiVAR_0464891180D → N1 PublicationCorresponds to variant dbSNP:rs35503975EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035435398 – 422Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_035436477 – 520Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_004870478 – 521Missing in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_035437522 – 527QKGQLA → LDCDDP in isoform 5. 1 Publication6
Alternative sequenceiVSP_035438528 – 1258Missing in isoform 5. 1 PublicationAdd BLAST731
Alternative sequenceiVSP_035439555M → MGILQNLAAMYGGRPSSSRG GKPRNKEEE in isoform 3 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB067488 mRNA Translation: BAB67794.1 Different initiation.
CR933642 mRNA Translation: CAI45943.1
AC116615 Genomic DNA No translation available.
AC116621 Genomic DNA No translation available.
AC084724 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04791.1
BC015147 mRNA Translation: AAH15147.1 Sequence problems.
BC037790 mRNA Translation: AAH37790.1
BC114491 mRNA Translation: AAI14492.1
AK025658 mRNA Translation: BAB15207.1 Different initiation.
AK027580 mRNA Translation: BAB55209.1 Different initiation.
AF155113 mRNA Translation: AAD42879.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47162.1 [Q96PY6-1]
CCDS56348.1 [Q96PY6-4]
CCDS56349.1 [Q96PY6-2]
CCDS56350.1 [Q96PY6-6]
CCDS56351.1 [Q96PY6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001186326.1, NM_001199397.1 [Q96PY6-3]
NP_001186327.1, NM_001199398.1 [Q96PY6-6]
NP_001186328.1, NM_001199399.1 [Q96PY6-4]
NP_001186329.1, NM_001199400.1 [Q96PY6-2]
NP_036356.1, NM_012224.2 [Q96PY6-1]
XP_011530305.1, XM_011532003.1 [Q96PY6-1]
XP_011530306.1, XM_011532004.1 [Q96PY6-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.481181

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000439128; ENSP00000408020; ENSG00000137601 [Q96PY6-1]
ENST00000507142; ENSP00000424757; ENSG00000137601 [Q96PY6-3]
ENST00000510533; ENSP00000427653; ENSG00000137601 [Q96PY6-2]
ENST00000511633; ENSP00000423332; ENSG00000137601 [Q96PY6-6]
ENST00000512193; ENSP00000424938; ENSG00000137601 [Q96PY6-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4750

UCSC genome browser

More...
UCSCi
uc003isb.3 human [Q96PY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067488 mRNA Translation: BAB67794.1 Different initiation.
CR933642 mRNA Translation: CAI45943.1
AC116615 Genomic DNA No translation available.
AC116621 Genomic DNA No translation available.
AC084724 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04791.1
BC015147 mRNA Translation: AAH15147.1 Sequence problems.
BC037790 mRNA Translation: AAH37790.1
BC114491 mRNA Translation: AAI14492.1
AK025658 mRNA Translation: BAB15207.1 Different initiation.
AK027580 mRNA Translation: BAB55209.1 Different initiation.
AF155113 mRNA Translation: AAD42879.1
CCDSiCCDS47162.1 [Q96PY6-1]
CCDS56348.1 [Q96PY6-4]
CCDS56349.1 [Q96PY6-2]
CCDS56350.1 [Q96PY6-6]
CCDS56351.1 [Q96PY6-3]
RefSeqiNP_001186326.1, NM_001199397.1 [Q96PY6-3]
NP_001186327.1, NM_001199398.1 [Q96PY6-6]
NP_001186328.1, NM_001199399.1 [Q96PY6-4]
NP_001186329.1, NM_001199400.1 [Q96PY6-2]
NP_036356.1, NM_012224.2 [Q96PY6-1]
XP_011530305.1, XM_011532003.1 [Q96PY6-1]
XP_011530306.1, XM_011532004.1 [Q96PY6-2]
UniGeneiHs.481181

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4APCX-ray2.10A/B1-328[»]
4B9DX-ray1.90A/B1-328[»]
ProteinModelPortaliQ96PY6
SMRiQ96PY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110825, 36 interactors
IntActiQ96PY6, 28 interactors
MINTiQ96PY6
STRINGi9606.ENSP00000424757

Chemistry databases

BindingDBiQ96PY6
ChEMBLiCHEMBL5855
GuidetoPHARMACOLOGYi2114

PTM databases

iPTMnetiQ96PY6
PhosphoSitePlusiQ96PY6

Polymorphism and mutation databases

BioMutaiNEK1
DMDMi22256934

Proteomic databases

EPDiQ96PY6
MaxQBiQ96PY6
PaxDbiQ96PY6
PeptideAtlasiQ96PY6
PRIDEiQ96PY6
ProteomicsDBi77788
77789 [Q96PY6-2]
77790 [Q96PY6-3]
77791 [Q96PY6-4]
77792 [Q96PY6-5]
TopDownProteomicsiQ96PY6-3 [Q96PY6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439128; ENSP00000408020; ENSG00000137601 [Q96PY6-1]
ENST00000507142; ENSP00000424757; ENSG00000137601 [Q96PY6-3]
ENST00000510533; ENSP00000427653; ENSG00000137601 [Q96PY6-2]
ENST00000511633; ENSP00000423332; ENSG00000137601 [Q96PY6-6]
ENST00000512193; ENSP00000424938; ENSG00000137601 [Q96PY6-4]
GeneIDi4750
KEGGihsa:4750
UCSCiuc003isb.3 human [Q96PY6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4750
DisGeNETi4750
EuPathDBiHostDB:ENSG00000137601.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NEK1
HGNCiHGNC:7744 NEK1
HPAiHPA020873
HPA040413
MalaCardsiNEK1
MIMi263520 phenotype
604588 gene
617892 phenotype
neXtProtiNX_Q96PY6
OpenTargetsiENSG00000137601
Orphaneti803 Amyotrophic lateral sclerosis
2751 Orofaciodigital syndrome type 2
93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBiPA31545

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00940000158460
HOVERGENiHBG006460
InParanoidiQ96PY6
KOiK08857
OMAiVRQDNLE
OrthoDBiEOG091G0GU4
PhylomeDBiQ96PY6
TreeFamiTF333575

Enzyme and pathway databases

SignaLinkiQ96PY6
SIGNORiQ96PY6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NEK1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NEK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4750

Protein Ontology

More...
PROi
PR:Q96PY6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137601 Expressed in 231 organ(s), highest expression level in trigeminal ganglion
CleanExiHS_NEK1
ExpressionAtlasiQ96PY6 baseline and differential
GenevisibleiQ96PY6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PY6
Secondary accession number(s): G5E9Z3
, Q05DG5, Q14CB7, Q5H9T1, Q6PIB8, Q96SS2, Q9H6P7, Q9Y594
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: December 5, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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