Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase Nek1

Gene

NEK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617).By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: CACAO
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central
  • protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological processCell cycle, Cell division, Cilium biogenesis/degradation, Mitosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96PY6
SIGNORiQ96PY6

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek1 (EC:2.7.11.11 Publication)
Alternative name(s):
Never in mitosis A-related kinase 1
Short name:
NimA-related protein kinase 1
Renal carcinoma antigen NY-REN-55
Gene namesi
Name:NEK1
Synonyms:KIAA1901
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000137601.15
HGNCiHGNC:7744 NEK1
MIMi604588 gene
neXtProtiNX_Q96PY6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Short-rib thoracic dysplasia 6 with or without polydactyly (SRTD6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. In some cases NEK1 mutations result in disease phenotype in the presence of mutations in DYNC2H1 indicating digenic inheritance (digenic short rib-polydactyly syndrome 3/6 with polydactyly) (PubMed:21211617).1 Publication
Disease descriptionA form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome.
See also OMIM:263520
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069617145G → R in SRTD6. 1 PublicationCorresponds to variant dbSNP:rs431905508EnsemblClinVar.1
Natural variantiVAR_069618253L → S in SRTD6. 1 Publication1
Amyotrophic lateral sclerosis 24 (ALS24)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
See also OMIM:617892
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080694261R → H in ALS24; associated with disease susceptibility. 1 Publication1
Natural variantiVAR_080695550 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST709
Natural variantiVAR_080696784 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST475
Natural variantiVAR_0806971008 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST251

Keywords - Diseasei

Amyotrophic lateral sclerosis, Ciliopathy, Neurodegeneration

Organism-specific databases

DisGeNETi4750
MalaCardsiNEK1
MIMi263520 phenotype
617892 phenotype
OpenTargetsiENSG00000137601
Orphaneti93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBiPA31545

Chemistry databases

ChEMBLiCHEMBL5855
GuidetoPHARMACOLOGYi2114

Polymorphism and mutation databases

BioMutaiNEK1
DMDMi22256934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864181 – 1258Serine/threonine-protein kinase Nek1Add BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156PhosphothreonineCombined sources1
Modified residuei162Phosphothreonine; by autocatalysisBy similarity1
Modified residuei414PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei438PhosphoserineBy similarity1
Modified residuei653PhosphoserineCombined sources1
Modified residuei661PhosphothreonineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei798PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei1052PhosphoserineCombined sources1
Modified residuei1126PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96PY6
MaxQBiQ96PY6
PaxDbiQ96PY6
PeptideAtlasiQ96PY6
PRIDEiQ96PY6
ProteomicsDBi77788
77789 [Q96PY6-2]
77790 [Q96PY6-3]
77791 [Q96PY6-4]
77792 [Q96PY6-5]
TopDownProteomicsiQ96PY6-3 [Q96PY6-3]

PTM databases

iPTMnetiQ96PY6
PhosphoSitePlusiQ96PY6

Expressioni

Tissue specificityi

High fetal expression in the brain and kidney.1 Publication

Gene expression databases

BgeeiENSG00000137601 Expressed in 231 organ(s), highest expression level in trigeminal ganglion
CleanExiHS_NEK1
ExpressionAtlasiQ96PY6 baseline and differential
GenevisibleiQ96PY6 HS

Organism-specific databases

HPAiHPA020873
HPA040413

Interactioni

Subunit structurei

Binds to SPERT (By similarity). Found in a complex with C21orf2, NEK1 and SPATA7 (PubMed:26167768). Interacts with C21orf2 (PubMed:26167768). Interacts (via Ser-1052 phosphorylated form) with 14-3-3 proteins (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110825, 36 interactors
IntActiQ96PY6, 28 interactors
MINTiQ96PY6
STRINGi9606.ENSP00000424757

Chemistry databases

BindingDBiQ96PY6

Structurei

Secondary structure

11258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96PY6
SMRiQ96PY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 258Protein kinasePROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00760000118997
HOVERGENiHBG006460
InParanoidiQ96PY6
KOiK08857
OMAiEHYHAIF
OrthoDBiEOG091G0GU4
PhylomeDBiQ96PY6
TreeFamiTF333575

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKYVRLQKI GEGSFGKAIL VKSTEDGRQY VIKEINISRM SSKEREESRR
60 70 80 90 100
EVAVLANMKH PNIVQYRESF EENGSLYIVM DYCEGGDLFK RINAQKGVLF
110 120 130 140 150
QEDQILDWFV QICLALKHVH DRKILHRDIK SQNIFLTKDG TVQLGDFGIA
160 170 180 190 200
RVLNSTVELA RTCIGTPYYL SPEICENKPY NNKSDIWALG CVLYELCTLK
210 220 230 240 250
HAFEAGSMKN LVLKIISGSF PPVSLHYSYD LRSLVSQLFK RNPRDRPSVN
260 270 280 290 300
SILEKGFIAK RIEKFLSPQL IAEEFCLKTF SKFGSQPIPA KRPASGQNSI
310 320 330 340 350
SVMPAQKITK PAAKYGIPLA YKKYGDKKLH EKKPLQKHKQ AHQTPEKRVN
360 370 380 390 400
TGEERRKISE EAARKRRLEF IEKEKKQKDQ IISLMKAEQM KRQEKERLER
410 420 430 440 450
INRAREQGWR NVLSAGGSGE VKAPFLGSGG TIAPSSFSSR GQYEHYHAIF
460 470 480 490 500
DQMQQQRAED NEAKWKREIY GRGLPERGIL PGVRPGFPYG AAGHHHFPDA
510 520 530 540 550
DDIRKTLKRL KAVSKQANAN RQKGQLAVER AKQVEEFLQR KREAMQNKAR
560 570 580 590 600
AEGHMVYLAR LRQIRLQNFN ERQQIKAKLR GEKKEANHSE GQEGSEEADM
610 620 630 640 650
RRKKIESLKA HANARAAVLK EQLERKRKEA YEREKKVWEE HLVAKGVKSS
660 670 680 690 700
DVSPPLGQHE TGGSPSKQQM RSVISVTSAL KEVGVDSSLT DTRETSEEMQ
710 720 730 740 750
KTNNAISSKR EILRRLNENL KAQEDEKGKQ NLSDTFEINV HEDAKEHEKE
760 770 780 790 800
KSVSSDRKKW EAGGQLVIPL DELTLDTSFS TTERHTVGEV IKLGPNGSPR
810 820 830 840 850
RAWGKSPTDS VLKILGEAEL QLQTELLENT TIRSEISPEG EKYKPLITGE
860 870 880 890 900
KKVQCISHEI NPSAIVDSPV ETKSPEFSEA SPQMSLKLEG NLEEPDDLET
910 920 930 940 950
EILQEPSGTN KDESLPCTIT DVWISEEKET KETQSADRIT IQENEVSEDG
960 970 980 990 1000
VSSTVDQLSD IHIEPGTNDS QHSKCDVDKS VQPEPFFHKV VHSEHLNLVP
1010 1020 1030 1040 1050
QVQSVQCSPE ESFAFRSHSH LPPKNKNKNS LLIGLSTGLF DANNPKMLRT
1060 1070 1080 1090 1100
CSLPDLSKLF RTLMDVPTVG DVRQDNLEID EIEDENIKEG PSDSEDIVFE
1110 1120 1130 1140 1150
ETDTDLQELQ ASMEQLLREQ PGEEYSEEEE SVLKNSDVEP TANGTDVADE
1160 1170 1180 1190 1200
DDNPSSESAL NEEWHSDNSD GEIASECECD SVFNHLEELR LHLEQEMGFE
1210 1220 1230 1240 1250
KFFEVYEKIK AIHEDEDENI EICSKIVQNI LGNEHQHLYA KILHLVMADG

AYQEDNDE
Length:1,258
Mass (Da):142,828
Last modified:August 13, 2002 - v2
Checksum:i339C4BFA56612530
GO
Isoform 2 (identifier: Q96PY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-521: Missing.

Note: No experimental confirmation available.
Show »
Length:1,214
Mass (Da):138,068
Checksum:i347246AED3D9FD79
GO
Isoform 3 (identifier: Q96PY6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.
Show »
Length:1,286
Mass (Da):145,814
Checksum:iF94B3F9C0666059D
GO
Isoform 4 (identifier: Q96PY6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-422: Missing.
     477-520: Missing.

Note: No experimental confirmation available.
Show »
Length:1,189
Mass (Da):135,303
Checksum:iCAE13631DC2A2151
GO
Isoform 5 (identifier: Q96PY6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     522-527: QKGQLA → LDCDDP
     528-1258: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):60,250
Checksum:i47E0707A533EE57C
GO
Isoform 6 (identifier: Q96PY6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-520: Missing.
     555-555: M → MGILQNLAAMYGGRPSSSRGGKPRNKEEE

Note: No experimental confirmation available.
Show »
Length:1,242
Mass (Da):141,053
Checksum:i5CB4B464CF15573C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBG5D6RBG5_HUMAN
Serine/threonine-protein kinase Nek...
NEK1
45Annotation score:
H0Y8M6H0Y8M6_HUMAN
Serine/threonine-protein kinase Nek...
NEK1
123Annotation score:

Sequence cautioni

The sequence AAH15147 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15207 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55209 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB67794 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250N → D in CAI45943 (PubMed:17974005).Curated1
Sequence conflicti602R → RK in CAI45943 (PubMed:17974005).Curated1
Sequence conflicti1232G → E in AAD42879 (PubMed:10508479).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04090010I → F1 PublicationCorresponds to variant dbSNP:rs34214559Ensembl.1
Natural variantiVAR_04090125E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04090276L → V1 PublicationCorresponds to variant dbSNP:rs35093214Ensembl.1
Natural variantiVAR_069617145G → R in SRTD6. 1 PublicationCorresponds to variant dbSNP:rs431905508EnsemblClinVar.1
Natural variantiVAR_069618253L → S in SRTD6. 1 Publication1
Natural variantiVAR_080694261R → H in ALS24; associated with disease susceptibility. 1 Publication1
Natural variantiVAR_040903294A → P in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040904355R → G1 PublicationCorresponds to variant dbSNP:rs35763578Ensembl.1
Natural variantiVAR_040905463A → V1 PublicationCorresponds to variant dbSNP:rs34540355EnsemblClinVar.1
Natural variantiVAR_080695550 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST709
Natural variantiVAR_046486598A → T1 PublicationCorresponds to variant dbSNP:rs33933790EnsemblClinVar.1
Natural variantiVAR_061743717N → K. Corresponds to variant dbSNP:rs34324114EnsemblClinVar.1
Natural variantiVAR_051651724E → G2 PublicationsCorresponds to variant dbSNP:rs34099167EnsemblClinVar.1
Natural variantiVAR_040906745K → N1 Publication1
Natural variantiVAR_080696784 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST475
Natural variantiVAR_046488883Q → E1 PublicationCorresponds to variant dbSNP:rs6828134EnsemblClinVar.1
Natural variantiVAR_0806971008 – 1258Missing in ALS24; associated with disease susceptibility. 1 PublicationAdd BLAST251
Natural variantiVAR_0464891180D → N1 PublicationCorresponds to variant dbSNP:rs35503975EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035435398 – 422Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_035436477 – 520Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_004870478 – 521Missing in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_035437522 – 527QKGQLA → LDCDDP in isoform 5. 1 Publication6
Alternative sequenceiVSP_035438528 – 1258Missing in isoform 5. 1 PublicationAdd BLAST731
Alternative sequenceiVSP_035439555M → MGILQNLAAMYGGRPSSSRG GKPRNKEEE in isoform 3 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067488 mRNA Translation: BAB67794.1 Different initiation.
CR933642 mRNA Translation: CAI45943.1
AC116615 Genomic DNA No translation available.
AC116621 Genomic DNA No translation available.
AC084724 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04791.1
BC015147 mRNA Translation: AAH15147.1 Sequence problems.
BC037790 mRNA Translation: AAH37790.1
BC114491 mRNA Translation: AAI14492.1
AK025658 mRNA Translation: BAB15207.1 Different initiation.
AK027580 mRNA Translation: BAB55209.1 Different initiation.
AF155113 mRNA Translation: AAD42879.1
CCDSiCCDS47162.1 [Q96PY6-1]
CCDS56348.1 [Q96PY6-4]
CCDS56349.1 [Q96PY6-2]
CCDS56350.1 [Q96PY6-6]
CCDS56351.1 [Q96PY6-3]
RefSeqiNP_001186326.1, NM_001199397.1 [Q96PY6-3]
NP_001186327.1, NM_001199398.1 [Q96PY6-6]
NP_001186328.1, NM_001199399.1 [Q96PY6-4]
NP_001186329.1, NM_001199400.1 [Q96PY6-2]
NP_036356.1, NM_012224.2 [Q96PY6-1]
XP_011530305.1, XM_011532003.1 [Q96PY6-1]
XP_011530306.1, XM_011532004.1 [Q96PY6-2]
UniGeneiHs.481181

Genome annotation databases

EnsembliENST00000439128; ENSP00000408020; ENSG00000137601 [Q96PY6-1]
ENST00000507142; ENSP00000424757; ENSG00000137601 [Q96PY6-3]
ENST00000510533; ENSP00000427653; ENSG00000137601 [Q96PY6-2]
ENST00000511633; ENSP00000423332; ENSG00000137601 [Q96PY6-6]
ENST00000512193; ENSP00000424938; ENSG00000137601 [Q96PY6-4]
GeneIDi4750
KEGGihsa:4750
UCSCiuc003isb.3 human [Q96PY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067488 mRNA Translation: BAB67794.1 Different initiation.
CR933642 mRNA Translation: CAI45943.1
AC116615 Genomic DNA No translation available.
AC116621 Genomic DNA No translation available.
AC084724 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04791.1
BC015147 mRNA Translation: AAH15147.1 Sequence problems.
BC037790 mRNA Translation: AAH37790.1
BC114491 mRNA Translation: AAI14492.1
AK025658 mRNA Translation: BAB15207.1 Different initiation.
AK027580 mRNA Translation: BAB55209.1 Different initiation.
AF155113 mRNA Translation: AAD42879.1
CCDSiCCDS47162.1 [Q96PY6-1]
CCDS56348.1 [Q96PY6-4]
CCDS56349.1 [Q96PY6-2]
CCDS56350.1 [Q96PY6-6]
CCDS56351.1 [Q96PY6-3]
RefSeqiNP_001186326.1, NM_001199397.1 [Q96PY6-3]
NP_001186327.1, NM_001199398.1 [Q96PY6-6]
NP_001186328.1, NM_001199399.1 [Q96PY6-4]
NP_001186329.1, NM_001199400.1 [Q96PY6-2]
NP_036356.1, NM_012224.2 [Q96PY6-1]
XP_011530305.1, XM_011532003.1 [Q96PY6-1]
XP_011530306.1, XM_011532004.1 [Q96PY6-2]
UniGeneiHs.481181

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4APCX-ray2.10A/B1-328[»]
4B9DX-ray1.90A/B1-328[»]
ProteinModelPortaliQ96PY6
SMRiQ96PY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110825, 36 interactors
IntActiQ96PY6, 28 interactors
MINTiQ96PY6
STRINGi9606.ENSP00000424757

Chemistry databases

BindingDBiQ96PY6
ChEMBLiCHEMBL5855
GuidetoPHARMACOLOGYi2114

PTM databases

iPTMnetiQ96PY6
PhosphoSitePlusiQ96PY6

Polymorphism and mutation databases

BioMutaiNEK1
DMDMi22256934

Proteomic databases

EPDiQ96PY6
MaxQBiQ96PY6
PaxDbiQ96PY6
PeptideAtlasiQ96PY6
PRIDEiQ96PY6
ProteomicsDBi77788
77789 [Q96PY6-2]
77790 [Q96PY6-3]
77791 [Q96PY6-4]
77792 [Q96PY6-5]
TopDownProteomicsiQ96PY6-3 [Q96PY6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439128; ENSP00000408020; ENSG00000137601 [Q96PY6-1]
ENST00000507142; ENSP00000424757; ENSG00000137601 [Q96PY6-3]
ENST00000510533; ENSP00000427653; ENSG00000137601 [Q96PY6-2]
ENST00000511633; ENSP00000423332; ENSG00000137601 [Q96PY6-6]
ENST00000512193; ENSP00000424938; ENSG00000137601 [Q96PY6-4]
GeneIDi4750
KEGGihsa:4750
UCSCiuc003isb.3 human [Q96PY6-1]

Organism-specific databases

CTDi4750
DisGeNETi4750
EuPathDBiHostDB:ENSG00000137601.15
GeneCardsiNEK1
HGNCiHGNC:7744 NEK1
HPAiHPA020873
HPA040413
MalaCardsiNEK1
MIMi263520 phenotype
604588 gene
617892 phenotype
neXtProtiNX_Q96PY6
OpenTargetsiENSG00000137601
Orphaneti93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBiPA31545
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00760000118997
HOVERGENiHBG006460
InParanoidiQ96PY6
KOiK08857
OMAiEHYHAIF
OrthoDBiEOG091G0GU4
PhylomeDBiQ96PY6
TreeFamiTF333575

Enzyme and pathway databases

SignaLinkiQ96PY6
SIGNORiQ96PY6

Miscellaneous databases

ChiTaRSiNEK1 human
GeneWikiiNEK1
GenomeRNAii4750
PROiPR:Q96PY6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137601 Expressed in 231 organ(s), highest expression level in trigeminal ganglion
CleanExiHS_NEK1
ExpressionAtlasiQ96PY6 baseline and differential
GenevisibleiQ96PY6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEK1_HUMAN
AccessioniPrimary (citable) accession number: Q96PY6
Secondary accession number(s): G5E9Z3
, Q05DG5, Q14CB7, Q5H9T1, Q6PIB8, Q96SS2, Q9H6P7, Q9Y594
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: September 12, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again