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Entry version 101 (18 Sep 2019)
Sequence version 3 (18 May 2010)
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Protein

Coiled-coil domain-containing protein 85A

Gene

CCDC85A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC85A
Synonyms:KIAA1912
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29400 CCDC85A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PX6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114800

Open Targets

More...
OpenTargetsi
ENSG00000055813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596452

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC85A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002711041 – 553Coiled-coil domain-containing protein 85AAdd BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei541Asymmetric dimethylarginineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96PX6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96PX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PX6

PeptideAtlas

More...
PeptideAtlasi
Q96PX6

PRoteomics IDEntifications database

More...
PRIDEi
Q96PX6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77782

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000055813 Expressed in 112 organ(s), highest expression level in anterior cingulate cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96PX6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043106
HPA057020

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125361, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96PX6, 5 interactors

Molecular INTeraction database

More...
MINTi
Q96PX6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96PX6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili43 – 109Sequence analysisAdd BLAST67
Coiled coili137 – 169Sequence analysisAdd BLAST33
Coiled coili412 – 443Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 31Ala-richAdd BLAST28
Compositional biasi224 – 374His-richAdd BLAST151

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3819 Eukaryota
ENOG410YXPD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157361

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294096

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PX6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPRACGT

Database of Orthologous Groups

More...
OrthoDBi
1393196at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PX6

TreeFam database of animal gene trees

More...
TreeFami
TF320243

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019359 CCDC85

The PANTHER Classification System

More...
PANTHERi
PTHR13546 PTHR13546, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10226 CCDC85, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96PX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKAAGGAAA AAAAAESCSP APAGSSAAPP APVEDLSKVS DEELLQWSKE
60 70 80 90 100
ELIRSLRRAE AEKVSAMLDH SNLIREVNRR LQLHLGEIRG LKDINQKLQE
110 120 130 140 150
DNQELRDLCC FLDDDRQKGK RVSREWQRLG RYTAGVMHKE VALYLQKLKD
160 170 180 190 200
LEVKQEEVVK ENMELKELCV LLDEEKGAGC AGSRCSIDSQ ASLCQLTAST
210 220 230 240 250
APYVRDVGDG SSTSSTGSTD SPDHHKHHAS SGSPEHLQKP RSEGSPEHSK
260 270 280 290 300
HRSASPEHPQ KPRACGTPDR PKALKGPSPE HHKPLCKGSP EQQRHPHPGS
310 320 330 340 350
SPETLPKHVL SGSPEHFQKH RSGSSPEHAR HSGGSPEHLQ KHALGGSLEH
360 370 380 390 400
LPRARGTSPE HLKQHYGGSP DHKHGGGSGG SGGSGGGSRE GTLRRQAQED
410 420 430 440 450
GSPHHRNVYS GMNESTLSYV RQLEARVRQL EEENRMLPQA SQNRRQPPTR
460 470 480 490 500
NSSNMEKGWG SRARRVLQWW QGCRGIGRCL PTLPGSFRLS SGADGSNSSP
510 520 530 540 550
NSAASFSGHA TPSQQPEPVV HSLKVVWRKL GDAAGSCPGI RQHLSGNQYK

GPM
Length:553
Mass (Da):59,976
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE620905745A556A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB67805 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20P → S in BAB67805 (PubMed:11572484).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB067499 mRNA Translation: BAB67805.1 Different initiation.
AC007743 Genomic DNA No translation available.
AC007744 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46290.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073902.1, NM_001080433.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000407595; ENSP00000384040; ENSG00000055813

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114800

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114800

UCSC genome browser

More...
UCSCi
uc002rzn.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067499 mRNA Translation: BAB67805.1 Different initiation.
AC007743 Genomic DNA No translation available.
AC007744 Genomic DNA No translation available.
CCDSiCCDS46290.1
RefSeqiNP_001073902.1, NM_001080433.1

3D structure databases

SMRiQ96PX6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125361, 3 interactors
IntActiQ96PX6, 5 interactors
MINTiQ96PX6
STRINGi9606.ENSP00000384040

PTM databases

iPTMnetiQ96PX6
PhosphoSitePlusiQ96PX6

Polymorphism and mutation databases

BioMutaiCCDC85A
DMDMi296439418

Proteomic databases

EPDiQ96PX6
MassIVEiQ96PX6
PaxDbiQ96PX6
PeptideAtlasiQ96PX6
PRIDEiQ96PX6
ProteomicsDBi77782

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407595; ENSP00000384040; ENSG00000055813
GeneIDi114800
KEGGihsa:114800
UCSCiuc002rzn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114800
DisGeNETi114800

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC85A
HGNCiHGNC:29400 CCDC85A
HPAiHPA043106
HPA057020
neXtProtiNX_Q96PX6
OpenTargetsiENSG00000055813
PharmGKBiPA144596452

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3819 Eukaryota
ENOG410YXPD LUCA
GeneTreeiENSGT00940000157361
HOGENOMiHOG000294096
InParanoidiQ96PX6
OMAiKPRACGT
OrthoDBi1393196at2759
PhylomeDBiQ96PX6
TreeFamiTF320243

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC85A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114800

Pharos

More...
Pharosi
Q96PX6

Protein Ontology

More...
PROi
PR:Q96PX6

Gene expression databases

BgeeiENSG00000055813 Expressed in 112 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiQ96PX6 HS

Family and domain databases

InterProiView protein in InterPro
IPR019359 CCDC85
PANTHERiPTHR13546 PTHR13546, 1 hit
PfamiView protein in Pfam
PF10226 CCDC85, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC85A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 101 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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