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Entry version 126 (02 Jun 2021)
Sequence version 3 (26 Jun 2013)
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Protein

Protein FAM193B

Gene

FAM193B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96PV7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96PV7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM193B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM193B
Synonyms:IRIZIO, KIAA1931
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25524, FAM193B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615813, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PV7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000146067.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54540

Open Targets

More...
OpenTargetsi
ENSG00000146067

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660336

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96PV7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM193B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
519668676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003444571 – 902Protein FAM193BAdd BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei773PhosphoserineBy similarity1
Modified residuei785PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96PV7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96PV7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96PV7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96PV7

PeptideAtlas

More...
PeptideAtlasi
Q96PV7

PRoteomics IDEntifications database

More...
PRIDEi
Q96PV7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19959
77777 [Q96PV7-1]
77778 [Q96PV7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PV7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PV7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96PV7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is up-regulated in both embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146067, Expressed in left lobe of thyroid gland and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96PV7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96PV7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000146067, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120027, 23 interactors

Protein interaction database and analysis system

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IntActi
Q96PV7, 13 interactors

Molecular INTeraction database

More...
MINTi
Q96PV7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000422131

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96PV7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96PV7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 79DisorderedSequence analysisAdd BLAST79
Regioni159 – 192DisorderedSequence analysisAdd BLAST34
Regioni210 – 319DisorderedSequence analysisAdd BLAST110
Regioni382 – 409DisorderedSequence analysisAdd BLAST28
Regioni581 – 655DisorderedSequence analysisAdd BLAST75
Regioni679 – 854DisorderedSequence analysisAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili490 – 524Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 40Pro residuesSequence analysisAdd BLAST16
Compositional biasi242 – 267Polar residuesSequence analysisAdd BLAST26
Compositional biasi268 – 282Pro residuesSequence analysisAdd BLAST15
Compositional biasi594 – 628Polar residuesSequence analysisAdd BLAST35
Compositional biasi636 – 653Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM193 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QV04, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000000973

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012556_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PV7

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGTSCHP

Database of Orthologous Groups

More...
OrthoDBi
171147at2759

TreeFam database of animal gene trees

More...
TreeFami
TF330223

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029717, FAM193
IPR031802, FAM193_C
IPR029722, FAM193B

The PANTHER Classification System

More...
PANTHERi
PTHR15109, PTHR15109, 1 hit
PTHR15109:SF3, PTHR15109:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15914, FAM193_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRRRSRPSG GAGRRERARA AGPQKPQAPE PPPPPSLEAG AGAGPPEAPA
60 70 80 90 100
EPDHDGPRED DEPNLVPGPQ VPPASSQPVQ TCCLLCHRER KGWEEGPSQN
110 120 130 140 150
GLVLQGEKLP PDFMPKLVKN LLGEMPLWVC QSCRKSMEED ERQTGREHAV
160 170 180 190 200
AISLSHTSCK SQSCGDDSHS SSSSSSSSSS SSSSSCPGNS GDWDPSSFLS
210 220 230 240 250
AHKLSGLWNS PHSSGAMPGS SLGSPPTIPG EAFPVSEHHQ HSDLTAPPNS
260 270 280 290 300
PTGHHPQPAS LIPSHPSSFG SPPHPHLLPT TPAAPFPAQA SECPVAAATA
310 320 330 340 350
PHTPGPCQSS HLPSTSMPLL KMPPPFSGCS HPCSGHCGGH CSGPLLPPPS
360 370 380 390 400
SQPLPSTHRD PGCKGHKFAH SGLACQLPQP CEADEGLGEE EDSSSERSSC
410 420 430 440 450
TSSSTHQRDG KFCDCCYCEF FGHNAPPAAP TSRNYTEIRE KLRSRLTRRK
460 470 480 490 500
EELPMKGGTL GGIPGEPAVD HRDVDELLEF INSTEPKVPN SARAAKRARH
510 520 530 540 550
KLKKKEKEKA QLAAEALKQA NRVSGSREPR PARERLLEWP DRELDRVNSF
560 570 580 590 600
LSSRLQEIKN TVKDSIRASF SVCELSMDSN GFSKEGAAEP EPQSLPPSNL
610 620 630 640 650
SGSSEQQPDI NLDLSPLTLG SPQNHTLQAP GEPAPPWAEM RGPHPPWTEV
660 670 680 690 700
RGPPPGIVPE NGLVRRLNTV PNLSRVIWVK TPKPGYPSSE EPSSKEVPSC
710 720 730 740 750
KQELPEPVSS GGKPQKGKRQ GSQAKKSEAS PAPRPPASLE VPSAKGQVAG
760 770 780 790 800
PKQPGRVLEL PKVGSCAEAG EGSRGSRPGP GWAGSPKTEK EKGSSWRNWP
810 820 830 840 850
GEAKARPQEQ ESVQPSGPAR PQSLPQGKGR SRRSRNKQEK PASSLDDVFL
860 870 880 890 900
PKDMDGVEMD ETDREVEYFK RFCLDSAKQT RQKVAVNWTN FSLKKTTPST

AQ
Length:902
Mass (Da):96,543
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i584AF8E0C8F8DF74
GO
Isoform 2 (identifier: Q96PV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.

Show »
Length:448
Mass (Da):48,767
Checksum:i93A459EB3786A876
GO
Isoform 3 (identifier: Q96PV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-505: Missing.

Show »
Length:822
Mass (Da):87,548
Checksum:i8FA394CAE3BE417B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCX2H0YCX2_HUMAN
Protein FAM193B
FAM193B
508Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9G1H0Y9G1_HUMAN
Protein FAM193B
FAM193B
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REQ2D6REQ2_HUMAN
Protein FAM193B
FAM193B
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9J9H0Y9J9_HUMAN
Protein FAM193B
FAM193B
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAX9D6RAX9_HUMAN
Protein FAM193B
FAM193B
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC29D6RC29_HUMAN
Protein FAM193B
FAM193B
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDZ2D6RDZ2_HUMAN
Protein FAM193B
FAM193B
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REE6D6REE6_HUMAN
Protein FAM193B
FAM193B
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9W8H0Y9W8_HUMAN
Protein FAM193B
FAM193B
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9D3H0Y9D3_HUMAN
Protein FAM193B
FAM193B
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB67824 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045619816S → P5 PublicationsCorresponds to variant dbSNP:rs337382Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0347801 – 454Missing in isoform 2. 4 PublicationsAdd BLAST454
Alternative sequenceiVSP_047164426 – 505Missing in isoform 3. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB067518 mRNA Translation: BAB67824.1 Different initiation.
AK001266 mRNA Translation: BAA91589.1
BX647587 mRNA Translation: CAI46078.1
AC145098 Genomic DNA No translation available.
AC139795 Genomic DNA No translation available.
CH471195 Genomic DNA Translation: EAW84969.1
BC008784 mRNA Translation: AAH08784.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54954.1 [Q96PV7-3]

NCBI Reference Sequences

More...
RefSeqi
XP_006714938.1, XM_006714875.2 [Q96PV7-1]
XP_006714947.1, XM_006714884.1
XP_006714948.1, XM_006714885.1 [Q96PV7-2]
XP_011532884.1, XM_011534582.1
XP_011532885.1, XM_011534583.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000514747; ENSP00000422131; ENSG00000146067 [Q96PV7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54540

UCSC genome browser

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UCSCi
uc003mhu.4, human [Q96PV7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067518 mRNA Translation: BAB67824.1 Different initiation.
AK001266 mRNA Translation: BAA91589.1
BX647587 mRNA Translation: CAI46078.1
AC145098 Genomic DNA No translation available.
AC139795 Genomic DNA No translation available.
CH471195 Genomic DNA Translation: EAW84969.1
BC008784 mRNA Translation: AAH08784.1
CCDSiCCDS54954.1 [Q96PV7-3]
RefSeqiXP_006714938.1, XM_006714875.2 [Q96PV7-1]
XP_006714947.1, XM_006714884.1
XP_006714948.1, XM_006714885.1 [Q96PV7-2]
XP_011532884.1, XM_011534582.1
XP_011532885.1, XM_011534583.1

3D structure databases

SMRiQ96PV7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120027, 23 interactors
IntActiQ96PV7, 13 interactors
MINTiQ96PV7
STRINGi9606.ENSP00000422131

PTM databases

iPTMnetiQ96PV7
PhosphoSitePlusiQ96PV7
SwissPalmiQ96PV7

Genetic variation databases

BioMutaiFAM193B
DMDMi519668676

Proteomic databases

EPDiQ96PV7
MassIVEiQ96PV7
MaxQBiQ96PV7
PaxDbiQ96PV7
PeptideAtlasiQ96PV7
PRIDEiQ96PV7
ProteomicsDBi19959
77777 [Q96PV7-1]
77778 [Q96PV7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29329, 39 antibodies

The DNASU plasmid repository

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DNASUi
54540

Genome annotation databases

EnsembliENST00000514747; ENSP00000422131; ENSG00000146067 [Q96PV7-3]
GeneIDi54540
UCSCiuc003mhu.4, human [Q96PV7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54540
DisGeNETi54540

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM193B
HGNCiHGNC:25524, FAM193B
HPAiENSG00000146067, Low tissue specificity
MIMi615813, gene
neXtProtiNX_Q96PV7
OpenTargetsiENSG00000146067
PharmGKBiPA165660336
VEuPathDBiHostDB:ENSG00000146067.15

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QV04, Eukaryota
GeneTreeiENSGT00390000000973
HOGENOMiCLU_012556_0_0_1
InParanoidiQ96PV7
OMAiNGTSCHP
OrthoDBi171147at2759
TreeFamiTF330223

Enzyme and pathway databases

PathwayCommonsiQ96PV7
SignaLinkiQ96PV7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54540, 6 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM193B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54540
PharosiQ96PV7, Tdark

Protein Ontology

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PROi
PR:Q96PV7
RNActiQ96PV7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146067, Expressed in left lobe of thyroid gland and 235 other tissues
ExpressionAtlasiQ96PV7, baseline and differential
GenevisibleiQ96PV7, HS

Family and domain databases

InterProiView protein in InterPro
IPR029717, FAM193
IPR031802, FAM193_C
IPR029722, FAM193B
PANTHERiPTHR15109, PTHR15109, 1 hit
PTHR15109:SF3, PTHR15109:SF3, 1 hit
PfamiView protein in Pfam
PF15914, FAM193_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF193B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PV7
Secondary accession number(s): E9PET5, Q9NW00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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