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Protein

Leukocyte receptor cluster member 8

Gene

LENG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 8
Gene namesi
Name:LENG8
Synonyms:KIAA1932
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167615.16
HGNCiHGNC:15500 LENG8
MIMi616575 gene
neXtProtiNX_Q96PV6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167615
PharmGKBiPA134903953

Polymorphism and mutation databases

BioMutaiLENG8
DMDMi158705886

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003063912 – 800Leukocyte receptor cluster member 8Add BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei351PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ96PV6
PRIDEiQ96PV6
ProteomicsDBi77774
77775 [Q96PV6-2]
77776 [Q96PV6-3]

PTM databases

iPTMnetiQ96PV6
PhosphoSitePlusiQ96PV6

Expressioni

Gene expression databases

BgeeiENSG00000167615 Expressed in 187 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_LENG8
ExpressionAtlasiQ96PV6 baseline and differential
GenevisibleiQ96PV6 HS

Organism-specific databases

HPAiHPA042004
HPA042056
HPA061571

Interactioni

Subunit structurei

May be part of a SEM1-containing complex.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi125373, 48 interactors
CORUMiQ96PV6
IntActiQ96PV6, 68 interactors
MINTiQ96PV6

Structurei

3D structure databases

ProteinModelPortaliQ96PV6
SMRiQ96PV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini636 – 800PCIPROSITE-ProRule annotationAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 168Gln-richPROSITE-ProRule annotationAdd BLAST98
Compositional biasi412 – 446Ser-richPROSITE-ProRule annotationAdd BLAST35

Phylogenomic databases

GeneTreeiENSGT00390000008006
HOGENOMiHOG000001575
HOVERGENiHBG070702
InParanoidiQ96PV6
OrthoDBiEOG091G08LT
PhylomeDBiQ96PV6
TreeFamiTF312927

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PV6-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANVGDQRS TDWSSQYSMV AGAGRENGME TPMHENPEWE KARQALASIS
60 70 80 90 100
KSGAAGGSAK SSSNGPVASA QYVSQAEASA LQQQQYYQWY QQYNYAYPYS
110 120 130 140 150
YYYPMSMYQS YGSPSQYGMA GSYGSATPQQ PSAPQHQGTL NQPPVPGMDE
160 170 180 190 200
SMSYQAPPQQ LPSAQPPQPS NPPHGAHTLN SGPQPGTAPA TQHSQAGPAT
210 220 230 240 250
GQAYGPHTYT EPAKPKKGQQ LWNRMKPAPG TGGLKFNIQK RPFAVTTQSF
260 270 280 290 300
GSNAEGQHSG FGPQPNPEKV QNHSGSSARG NLSGKPDDWP QDMKEYVERC
310 320 330 340 350
FTACESEEDK DRTEKLLKEV LQARLQDGSA YTIDWSREPL PGLTREPVAE
360 370 380 390 400
SPKKKRWEAA SSLHPPRGAG SATRGGGAPS QRGTPGAGGA GRARGNSFTK
410 420 430 440 450
FGNRNVFMKD NSSSSSTDSR SRSSSRSPTR HFRRSDSHSD SDSSYSGNEC
460 470 480 490 500
HPVGRRNPPP KGRGGRGAHM DRGRGRAQRG KRHDLAPTKR SRKKMAALEC
510 520 530 540 550
EDPERELKKQ KRAARFQHGH SRRLRLEPLV LQMSSLESSG ADPDWQELQI
560 570 580 590 600
VGTCPDITKH YLRLTCAPDP STVRPVAVLK KSLCMVKCHW KEKQDYAFAC
610 620 630 640 650
EQMKSIRQDL TVQGIRTEFT VEVYETHARI ALEKGDHEEF NQCQTQLKSL
660 670 680 690 700
YAENLPGNVG EFTAYRILYY IFTKNSGDIT TELAYLTREL KADPCVAHAL
710 720 730 740 750
ALRTAWALGN YHRFFRLYCH APCMSGYLVD KFADRERKVA LKAMIKTFRP
760 770 780 790 800
ALPVSYLQAE LAFEGEAACR AFLEPLGLAY TGPDNSSIDC RLSLAQLSAF
Length:800
Mass (Da):88,157
Last modified:March 28, 2018 - v3
Checksum:iDCD37905D54D1544
GO
Isoform 2 (identifier: Q96PV6-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-142: Missing.
     748-800: FRPALPVSYL...RLSLAQLSAF → YVVPSSLLPL...PPSLPPSSAM

Show »
Length:781
Mass (Da):86,313
Checksum:i0FBA7339B5A13976
GO
Isoform 3 (identifier: Q96PV6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-783: Missing.

Show »
Length:54
Mass (Da):5,835
Checksum:i53D37F914A53FF36
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUE4A0A087WUE4_HUMAN
Leukocyte receptor cluster member 8
LENG8
874Annotation score:
C9JMY0C9JMY0_HUMAN
Leukocyte receptor cluster member 8
LENG8
837Annotation score:
B0VJY8B0VJY8_HUMAN
Leukocyte receptor cluster member 8
LENG8
91Annotation score:
C9J1N5C9J1N5_HUMAN
Leukocyte receptor cluster member 8
LENG8
75Annotation score:
E7EWC7E7EWC7_HUMAN
Leukocyte receptor cluster member 8
LENG8
300Annotation score:
H7BZP5H7BZP5_HUMAN
Leukocyte receptor cluster member 8
LENG8
111Annotation score:
A0A0G2JNN3A0A0G2JNN3_HUMAN
Leukocyte receptor cluster member 8
LENG8
726Annotation score:
A0A0G2JPW6A0A0G2JPW6_HUMAN
Leukocyte receptor cluster member 8
LENG8
199Annotation score:
A0A0G2JN70A0A0G2JN70_HUMAN
Leukocyte receptor cluster member 8
LENG8
151Annotation score:

Sequence cautioni

The sequence BAB67825 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035294279R → P. Corresponds to variant dbSNP:rs35061854Ensembl.1
Natural variantiVAR_035295557I → V. Corresponds to variant dbSNP:rs35336528Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05945538 – 783Missing in isoform 3. 1 PublicationAdd BLAST746
Alternative sequenceiVSP_059456106 – 142Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_059457748 – 800FRPAL…QLSAF → YVVPSSLLPLLFPSFRLVSS CIKLSPCPLLPLPPVFLLIF FSPFPPSLSAFFPWFSTGKT VPPSLPPSSAM in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067519 mRNA Translation: BAB67825.1 Different initiation.
AL834532 mRNA Translation: CAD39188.2
AC008746 Genomic DNA No translation available.
AC245884 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CU467002 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72248.1
BC028048 mRNA Translation: AAH28048.1
CCDSiCCDS12894.1 [Q96PV6-2]
RefSeqiNP_443157.1, NM_052925.3 [Q96PV6-2]
XP_011524717.1, XM_011526415.2 [Q96PV6-2]
UniGeneiHs.502378
Hs.744596

Genome annotation databases

EnsembliENST00000326764; ENSP00000318374; ENSG00000167615 [Q96PV6-2]
ENST00000610314; ENSP00000484494; ENSG00000274305 [Q96PV6-1]
ENST00000611866; ENSP00000479293; ENSG00000276681 [Q96PV6-1]
ENST00000616932; ENSP00000477813; ENSG00000167615 [Q96PV6-1]
ENST00000617180; ENSP00000480663; ENSG00000276681 [Q96PV6-2]
ENST00000617420; ENSP00000481040; ENSG00000276458 [Q96PV6-1]
ENST00000621306; ENSP00000478337; ENSG00000276458 [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305 [Q96PV6-2]
GeneIDi114823
KEGGihsa:114823
UCSCiuc032iea.2 human [Q96PV6-2]
uc061cqz.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067519 mRNA Translation: BAB67825.1 Different initiation.
AL834532 mRNA Translation: CAD39188.2
AC008746 Genomic DNA No translation available.
AC245884 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CU467002 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72248.1
BC028048 mRNA Translation: AAH28048.1
CCDSiCCDS12894.1 [Q96PV6-2]
RefSeqiNP_443157.1, NM_052925.3 [Q96PV6-2]
XP_011524717.1, XM_011526415.2 [Q96PV6-2]
UniGeneiHs.502378
Hs.744596

3D structure databases

ProteinModelPortaliQ96PV6
SMRiQ96PV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125373, 48 interactors
CORUMiQ96PV6
IntActiQ96PV6, 68 interactors
MINTiQ96PV6

PTM databases

iPTMnetiQ96PV6
PhosphoSitePlusiQ96PV6

Polymorphism and mutation databases

BioMutaiLENG8
DMDMi158705886

Proteomic databases

PeptideAtlasiQ96PV6
PRIDEiQ96PV6
ProteomicsDBi77774
77775 [Q96PV6-2]
77776 [Q96PV6-3]

Protocols and materials databases

DNASUi114823
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326764; ENSP00000318374; ENSG00000167615 [Q96PV6-2]
ENST00000610314; ENSP00000484494; ENSG00000274305 [Q96PV6-1]
ENST00000611866; ENSP00000479293; ENSG00000276681 [Q96PV6-1]
ENST00000616932; ENSP00000477813; ENSG00000167615 [Q96PV6-1]
ENST00000617180; ENSP00000480663; ENSG00000276681 [Q96PV6-2]
ENST00000617420; ENSP00000481040; ENSG00000276458 [Q96PV6-1]
ENST00000621306; ENSP00000478337; ENSG00000276458 [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305 [Q96PV6-2]
GeneIDi114823
KEGGihsa:114823
UCSCiuc032iea.2 human [Q96PV6-2]
uc061cqz.1 human

Organism-specific databases

CTDi114823
EuPathDBiHostDB:ENSG00000167615.16
GeneCardsiLENG8
HGNCiHGNC:15500 LENG8
HPAiHPA042004
HPA042056
HPA061571
MIMi616575 gene
neXtProtiNX_Q96PV6
OpenTargetsiENSG00000167615
PharmGKBiPA134903953
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000008006
HOGENOMiHOG000001575
HOVERGENiHBG070702
InParanoidiQ96PV6
OrthoDBiEOG091G08LT
PhylomeDBiQ96PV6
TreeFamiTF312927

Miscellaneous databases

ChiTaRSiLENG8 human
GenomeRNAii114823
PROiPR:Q96PV6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167615 Expressed in 187 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_LENG8
ExpressionAtlasiQ96PV6 baseline and differential
GenevisibleiQ96PV6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLENG8_HUMAN
AccessioniPrimary (citable) accession number: Q96PV6
Secondary accession number(s): A0A087WTE7
, B0VJY9, Q8IZ27, Q8NCX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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