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UniProtKB - Q96PV6 (LENG8_HUMAN)
Protein
Leukocyte receptor cluster member 8
Gene
LENG8
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte receptor cluster member 8 |
Gene namesi | Name:LENG8 Synonyms:KIAA1932 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15500, LENG8 |
MIMi | 616575, gene |
neXtProti | NX_Q96PV6 |
VEuPathDBi | HostDB:ENSG00000167615 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 114823 |
OpenTargetsi | ENSG00000167615 |
PharmGKBi | PA134903953 |
Miscellaneous databases
Pharosi | Q96PV6, Tdark |
Genetic variation databases
BioMutai | LENG8 |
DMDMi | 158705886 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000306391 | 2 – 800 | Leukocyte receptor cluster member 8Add BLAST | 799 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96PV6 |
jPOSTi | Q96PV6 |
MassIVEi | Q96PV6 |
MaxQBi | Q96PV6 |
PeptideAtlasi | Q96PV6 |
PRIDEi | Q96PV6 |
ProteomicsDBi | 77774 [Q96PV6-1] 77775 [Q96PV6-2] 77776 [Q96PV6-3] |
PTM databases
GlyGeni | Q96PV6, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q96PV6 |
PhosphoSitePlusi | Q96PV6 |
SwissPalmi | Q96PV6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167615, Expressed in left lobe of thyroid gland and 202 other tissues |
ExpressionAtlasi | Q96PV6, baseline and differential |
Genevisiblei | Q96PV6, HS |
Organism-specific databases
HPAi | ENSG00000167615, Low tissue specificity |
Interactioni
Subunit structurei
May be part of a SEM1-containing complex.
1 PublicationBinary interactionsi
Q96PV6
Protein-protein interaction databases
BioGRIDi | 125373, 132 interactors |
CORUMi | Q96PV6 |
IntActi | Q96PV6, 96 interactors |
MINTi | Q96PV6 |
STRINGi | 9606.ENSP00000318374 |
Miscellaneous databases
RNActi | Q96PV6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 636 – 800 | PCIPROSITE-ProRule annotationAdd BLAST | 165 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 66 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 118 – 291 | DisorderedSequence analysisAdd BLAST | 174 | |
Regioni | 328 – 506 | DisorderedSequence analysisAdd BLAST | 179 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 118 – 159 | Polar residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 174 – 201 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 241 – 281 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 398 – 423 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 465 – 506 | Basic and acidic residuesSequence analysisAdd BLAST | 42 |
Phylogenomic databases
eggNOGi | KOG1861, Eukaryota |
GeneTreei | ENSGT00390000008006 |
HOGENOMi | CLU_014160_1_0_1 |
InParanoidi | Q96PV6 |
OMAi | DYAYACE |
PhylomeDBi | Q96PV6 |
TreeFami | TF312927 |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR045107, SAC3/GANP/THP3 IPR005062, SAC3/GANP/THP3_conserved |
PANTHERi | PTHR12436, PTHR12436, 1 hit |
Pfami | View protein in Pfam PF03399, SAC3_GANP, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96PV6-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAANVGDQRS TDWSSQYSMV AGAGRENGME TPMHENPEWE KARQALASIS
60 70 80 90 100
KSGAAGGSAK SSSNGPVASA QYVSQAEASA LQQQQYYQWY QQYNYAYPYS
110 120 130 140 150
YYYPMSMYQS YGSPSQYGMA GSYGSATPQQ PSAPQHQGTL NQPPVPGMDE
160 170 180 190 200
SMSYQAPPQQ LPSAQPPQPS NPPHGAHTLN SGPQPGTAPA TQHSQAGPAT
210 220 230 240 250
GQAYGPHTYT EPAKPKKGQQ LWNRMKPAPG TGGLKFNIQK RPFAVTTQSF
260 270 280 290 300
GSNAEGQHSG FGPQPNPEKV QNHSGSSARG NLSGKPDDWP QDMKEYVERC
310 320 330 340 350
FTACESEEDK DRTEKLLKEV LQARLQDGSA YTIDWSREPL PGLTREPVAE
360 370 380 390 400
SPKKKRWEAA SSLHPPRGAG SATRGGGAPS QRGTPGAGGA GRARGNSFTK
410 420 430 440 450
FGNRNVFMKD NSSSSSTDSR SRSSSRSPTR HFRRSDSHSD SDSSYSGNEC
460 470 480 490 500
HPVGRRNPPP KGRGGRGAHM DRGRGRAQRG KRHDLAPTKR SRKKMAALEC
510 520 530 540 550
EDPERELKKQ KRAARFQHGH SRRLRLEPLV LQMSSLESSG ADPDWQELQI
560 570 580 590 600
VGTCPDITKH YLRLTCAPDP STVRPVAVLK KSLCMVKCHW KEKQDYAFAC
610 620 630 640 650
EQMKSIRQDL TVQGIRTEFT VEVYETHARI ALEKGDHEEF NQCQTQLKSL
660 670 680 690 700
YAENLPGNVG EFTAYRILYY IFTKNSGDIT TELAYLTREL KADPCVAHAL
710 720 730 740 750
ALRTAWALGN YHRFFRLYCH APCMSGYLVD KFADRERKVA LKAMIKTFRP
760 770 780 790 800
ALPVSYLQAE LAFEGEAACR AFLEPLGLAY TGPDNSSIDC RLSLAQLSAF
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JMY0 | C9JMY0_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 837 | Annotation score: | ||
A0A087WUE4 | A0A087WUE4_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 874 | Annotation score: | ||
A0A0G2JNN3 | A0A0G2JNN3_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 726 | Annotation score: | ||
C9J1N5 | C9J1N5_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 75 | Annotation score: | ||
E7EWC7 | E7EWC7_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 300 | Annotation score: | ||
B0VJY8 | B0VJY8_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 91 | Annotation score: | ||
A0A0G2JN70 | A0A0G2JN70_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 151 | Annotation score: | ||
A0A0G2JPW6 | A0A0G2JPW6_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 199 | Annotation score: | ||
H7BZP5 | H7BZP5_HUMAN | Leukocyte receptor cluster member 8 | LENG8 | 111 | Annotation score: |
Sequence cautioni
The sequence BAB67825 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035294 | 279 | R → P. Corresponds to variant dbSNP:rs35061854Ensembl. | 1 | |
Natural variantiVAR_035295 | 557 | I → V. Corresponds to variant dbSNP:rs35336528Ensembl. | 1 | |
Natural variantiVAR_082146 | 661 | E → K Found in a patient with developmental delay, hypotonia since birth and dysmorphic features such as triangular face, brachycephaly epicanthal fold, hypertelorism, broad nasal bridge and strabismus; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059455 | 38 – 783 | Missing in isoform 3. 1 PublicationAdd BLAST | 746 | |
Alternative sequenceiVSP_059456 | 106 – 142 | Missing in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_059457 | 748 – 800 | FRPAL…QLSAF → YVVPSSLLPLLFPSFRLVSS CIKLSPCPLLPLPPVFLLIF FSPFPPSLSAFFPWFSTGKT VPPSLPPSSAM in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB067519 mRNA Translation: BAB67825.1 Different initiation. AL834532 mRNA Translation: CAD39188.2 AC008746 Genomic DNA No translation available. AC245884 Genomic DNA No translation available. CU207370 Genomic DNA No translation available. CU467002 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72248.1 BC028048 mRNA Translation: AAH28048.1 |
CCDSi | CCDS12894.1 [Q96PV6-2] |
RefSeqi | NP_443157.1, NM_052925.3 [Q96PV6-2] XP_011524717.1, XM_011526415.2 [Q96PV6-2] |
Genome annotation databases
Ensembli | ENST00000326764; ENSP00000318374; ENSG00000167615 ENST00000610314; ENSP00000484494; ENSG00000274305 [Q96PV6-1] ENST00000611866; ENSP00000479293; ENSG00000276681 [Q96PV6-1] ENST00000616932; ENSP00000477813; ENSG00000167615 [Q96PV6-1] ENST00000617180; ENSP00000480663; ENSG00000276681 ENST00000617420; ENSP00000481040; ENSG00000276458 [Q96PV6-1] ENST00000621306; ENSP00000478337; ENSG00000276458 ENST00000622672; ENSP00000478975; ENSG00000274305 |
GeneIDi | 114823 |
KEGGi | hsa:114823 |
MANE-Selecti | ENST00000326764.10; ENSP00000318374.5; NM_052925.4; NP_443157.1 |
UCSCi | uc032iea.2, human [Q96PV6-2] uc061cqz.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB067519 mRNA Translation: BAB67825.1 Different initiation. AL834532 mRNA Translation: CAD39188.2 AC008746 Genomic DNA No translation available. AC245884 Genomic DNA No translation available. CU207370 Genomic DNA No translation available. CU467002 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72248.1 BC028048 mRNA Translation: AAH28048.1 |
CCDSi | CCDS12894.1 [Q96PV6-2] |
RefSeqi | NP_443157.1, NM_052925.3 [Q96PV6-2] XP_011524717.1, XM_011526415.2 [Q96PV6-2] |
3D structure databases
SMRi | Q96PV6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125373, 132 interactors |
CORUMi | Q96PV6 |
IntActi | Q96PV6, 96 interactors |
MINTi | Q96PV6 |
STRINGi | 9606.ENSP00000318374 |
PTM databases
GlyGeni | Q96PV6, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q96PV6 |
PhosphoSitePlusi | Q96PV6 |
SwissPalmi | Q96PV6 |
Genetic variation databases
BioMutai | LENG8 |
DMDMi | 158705886 |
Proteomic databases
EPDi | Q96PV6 |
jPOSTi | Q96PV6 |
MassIVEi | Q96PV6 |
MaxQBi | Q96PV6 |
PeptideAtlasi | Q96PV6 |
PRIDEi | Q96PV6 |
ProteomicsDBi | 77774 [Q96PV6-1] 77775 [Q96PV6-2] 77776 [Q96PV6-3] |
Protocols and materials databases
Antibodypediai | 46360, 53 antibodies from 18 providers |
DNASUi | 114823 |
Genome annotation databases
Ensembli | ENST00000326764; ENSP00000318374; ENSG00000167615 ENST00000610314; ENSP00000484494; ENSG00000274305 [Q96PV6-1] ENST00000611866; ENSP00000479293; ENSG00000276681 [Q96PV6-1] ENST00000616932; ENSP00000477813; ENSG00000167615 [Q96PV6-1] ENST00000617180; ENSP00000480663; ENSG00000276681 ENST00000617420; ENSP00000481040; ENSG00000276458 [Q96PV6-1] ENST00000621306; ENSP00000478337; ENSG00000276458 ENST00000622672; ENSP00000478975; ENSG00000274305 |
GeneIDi | 114823 |
KEGGi | hsa:114823 |
MANE-Selecti | ENST00000326764.10; ENSP00000318374.5; NM_052925.4; NP_443157.1 |
UCSCi | uc032iea.2, human [Q96PV6-2] uc061cqz.1, human |
Organism-specific databases
CTDi | 114823 |
DisGeNETi | 114823 |
GeneCardsi | LENG8 |
HGNCi | HGNC:15500, LENG8 |
HPAi | ENSG00000167615, Low tissue specificity |
MIMi | 616575, gene |
neXtProti | NX_Q96PV6 |
OpenTargetsi | ENSG00000167615 |
PharmGKBi | PA134903953 |
VEuPathDBi | HostDB:ENSG00000167615 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1861, Eukaryota |
GeneTreei | ENSGT00390000008006 |
HOGENOMi | CLU_014160_1_0_1 |
InParanoidi | Q96PV6 |
OMAi | DYAYACE |
PhylomeDBi | Q96PV6 |
TreeFami | TF312927 |
Enzyme and pathway databases
PathwayCommonsi | Q96PV6 |
SignaLinki | Q96PV6 |
Miscellaneous databases
BioGRID-ORCSi | 114823, 430 hits in 1050 CRISPR screens |
ChiTaRSi | LENG8, human |
GenomeRNAii | 114823 |
Pharosi | Q96PV6, Tdark |
PROi | PR:Q96PV6 |
RNActi | Q96PV6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167615, Expressed in left lobe of thyroid gland and 202 other tissues |
ExpressionAtlasi | Q96PV6, baseline and differential |
Genevisiblei | Q96PV6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR045107, SAC3/GANP/THP3 IPR005062, SAC3/GANP/THP3_conserved |
PANTHERi | PTHR12436, PTHR12436, 1 hit |
Pfami | View protein in Pfam PF03399, SAC3_GANP, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LENG8_HUMAN | |
Accessioni | Q96PV6Primary (citable) accession number: Q96PV6 Secondary accession number(s): A0A087WTE7 Q8NCX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot