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UniProtKB - Q96PV6 (LENG8_HUMAN)

Entry version 133 (16 Oct 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Leukocyte receptor cluster member 8

Gene

LENG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte receptor cluster member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LENG8
Synonyms:KIAA1932
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15500 LENG8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616575 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96PV6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000167615

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134903953

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96PV6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LENG8

Domain mapping of disease mutations (DMDM)

More...DMDMi		158705886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003063912 – 800Leukocyte receptor cluster member 8Add BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei351PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96PV6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96PV6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96PV6

PeptideAtlas

More...PeptideAtlasi		Q96PV6

PRoteomics IDEntifications database

More...PRIDEi		Q96PV6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77774 [Q96PV6-1]
77775 [Q96PV6-2]
77776 [Q96PV6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96PV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96PV6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96PV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167615 Expressed in 187 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96PV6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96PV6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA042004
HPA042056
HPA061571

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be part of a SEM1-containing complex.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125373, 52 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96PV6

Protein interaction database and analysis system

More...IntActi		Q96PV6, 87 interactors

Molecular INTeraction database

More...MINTi		Q96PV6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000318374

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini636 – 800PCIPROSITE-ProRule annotationAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 168Gln-richPROSITE-ProRule annotationAdd BLAST98
Compositional biasi412 – 446Ser-richPROSITE-ProRule annotationAdd BLAST35

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008006

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000001575

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96PV6

Database of Orthologous Groups

More...OrthoDBi		1503267at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96PV6

TreeFam database of animal gene trees

More...TreeFami		TF312927

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03399 SAC3_GANP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50250 PCI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PV6-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANVGDQRS TDWSSQYSMV AGAGRENGME TPMHENPEWE KARQALASIS 
        60         70         80         90        100
KSGAAGGSAK SSSNGPVASA QYVSQAEASA LQQQQYYQWY QQYNYAYPYS 
       110        120        130        140        150
YYYPMSMYQS YGSPSQYGMA GSYGSATPQQ PSAPQHQGTL NQPPVPGMDE 
       160        170        180        190        200
SMSYQAPPQQ LPSAQPPQPS NPPHGAHTLN SGPQPGTAPA TQHSQAGPAT 
       210        220        230        240        250
GQAYGPHTYT EPAKPKKGQQ LWNRMKPAPG TGGLKFNIQK RPFAVTTQSF 
       260        270        280        290        300
GSNAEGQHSG FGPQPNPEKV QNHSGSSARG NLSGKPDDWP QDMKEYVERC 
       310        320        330        340        350
FTACESEEDK DRTEKLLKEV LQARLQDGSA YTIDWSREPL PGLTREPVAE 
       360        370        380        390        400
SPKKKRWEAA SSLHPPRGAG SATRGGGAPS QRGTPGAGGA GRARGNSFTK 
       410        420        430        440        450
FGNRNVFMKD NSSSSSTDSR SRSSSRSPTR HFRRSDSHSD SDSSYSGNEC 
       460        470        480        490        500
HPVGRRNPPP KGRGGRGAHM DRGRGRAQRG KRHDLAPTKR SRKKMAALEC 
       510        520        530        540        550
EDPERELKKQ KRAARFQHGH SRRLRLEPLV LQMSSLESSG ADPDWQELQI 
       560        570        580        590        600
VGTCPDITKH YLRLTCAPDP STVRPVAVLK KSLCMVKCHW KEKQDYAFAC 
       610        620        630        640        650
EQMKSIRQDL TVQGIRTEFT VEVYETHARI ALEKGDHEEF NQCQTQLKSL 
       660        670        680        690        700
YAENLPGNVG EFTAYRILYY IFTKNSGDIT TELAYLTREL KADPCVAHAL 
       710        720        730        740        750
ALRTAWALGN YHRFFRLYCH APCMSGYLVD KFADRERKVA LKAMIKTFRP 
       760        770        780        790        800
ALPVSYLQAE LAFEGEAACR AFLEPLGLAY TGPDNSSIDC RLSLAQLSAF
Length:800
Mass (Da):88,157
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCD37905D54D1544
GO
Isoform 2 (identifier: Q96PV6-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-142: Missing.
     748-800: FRPALPVSYL...RLSLAQLSAF → YVVPSSLLPL...PPSLPPSSAM

Show »
Length:781
Mass (Da):86,313
Checksum:i0FBA7339B5A13976
GO
Isoform 3 (identifier: Q96PV6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-783: Missing.

Show »
Length:54
Mass (Da):5,835
Checksum:i53D37F914A53FF36
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUE4A0A087WUE4_HUMAN
Leukocyte receptor cluster member 8
LENG8
874Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMY0C9JMY0_HUMAN
Leukocyte receptor cluster member 8
LENG8
837Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0VJY8B0VJY8_HUMAN
Leukocyte receptor cluster member 8
LENG8
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1N5C9J1N5_HUMAN
Leukocyte receptor cluster member 8
LENG8
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWC7E7EWC7_HUMAN
Leukocyte receptor cluster member 8
LENG8
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNN3A0A0G2JNN3_HUMAN
Leukocyte receptor cluster member 8
LENG8
726Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JN70A0A0G2JN70_HUMAN
Leukocyte receptor cluster member 8
LENG8
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPW6A0A0G2JPW6_HUMAN
Leukocyte receptor cluster member 8
LENG8
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZP5H7BZP5_HUMAN
Leukocyte receptor cluster member 8
LENG8
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB67825 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035294279R → P. Corresponds to variant dbSNP:rs35061854Ensembl.1
Natural variantiVAR_035295557I → V. Corresponds to variant dbSNP:rs35336528Ensembl.1
Natural variantiVAR_082146661E → K Found in a patient with developmental delay, hypotonia since birth and dysmorphic features such as triangular face, brachycephaly epicanthal fold, hypertelorism, broad nasal bridge and strabismus; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05945538 – 783Missing in isoform 3. 1 PublicationAdd BLAST746
Alternative sequenceiVSP_059456106 – 142Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_059457748 – 800FRPAL…QLSAF → YVVPSSLLPLLFPSFRLVSS CIKLSPCPLLPLPPVFLLIF FSPFPPSLSAFFPWFSTGKT VPPSLPPSSAM in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB067519 mRNA Translation: BAB67825.1 Different initiation.
AL834532 mRNA Translation: CAD39188.2
AC008746 Genomic DNA No translation available.
AC245884 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CU467002 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72248.1
BC028048 mRNA Translation: AAH28048.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12894.1 [Q96PV6-2]

NCBI Reference Sequences

More...RefSeqi		NP_443157.1, NM_052925.3 [Q96PV6-2]
XP_011524717.1, XM_011526415.2 [Q96PV6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000326764; ENSP00000318374; ENSG00000167615 [Q96PV6-2]
ENST00000610314; ENSP00000484494; ENSG00000274305 [Q96PV6-1]
ENST00000611866; ENSP00000479293; ENSG00000276681 [Q96PV6-1]
ENST00000616932; ENSP00000477813; ENSG00000167615 [Q96PV6-1]
ENST00000617180; ENSP00000480663; ENSG00000276681 [Q96PV6-2]
ENST00000617420; ENSP00000481040; ENSG00000276458 [Q96PV6-1]
ENST00000621306; ENSP00000478337; ENSG00000276458 [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305 [Q96PV6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		114823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:114823

UCSC genome browser

More...UCSCi		uc032iea.2 human [Q96PV6-2]
uc061cqz.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067519 mRNA Translation: BAB67825.1 Different initiation.
AL834532 mRNA Translation: CAD39188.2
AC008746 Genomic DNA No translation available.
AC245884 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CU467002 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72248.1
BC028048 mRNA Translation: AAH28048.1
CCDSiCCDS12894.1 [Q96PV6-2]
RefSeqiNP_443157.1, NM_052925.3 [Q96PV6-2]
XP_011524717.1, XM_011526415.2 [Q96PV6-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi125373, 52 interactors
CORUMiQ96PV6
IntActiQ96PV6, 87 interactors
MINTiQ96PV6
STRINGi9606.ENSP00000318374

PTM databases

iPTMnetiQ96PV6
PhosphoSitePlusiQ96PV6
SwissPalmiQ96PV6

Polymorphism and mutation databases

BioMutaiLENG8
DMDMi158705886

Proteomic databases

EPDiQ96PV6
jPOSTiQ96PV6
MassIVEiQ96PV6
PeptideAtlasiQ96PV6
PRIDEiQ96PV6
ProteomicsDBi77774 [Q96PV6-1]
77775 [Q96PV6-2]
77776 [Q96PV6-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		114823

Genome annotation databases

EnsembliENST00000326764; ENSP00000318374; ENSG00000167615 [Q96PV6-2]
ENST00000610314; ENSP00000484494; ENSG00000274305 [Q96PV6-1]
ENST00000611866; ENSP00000479293; ENSG00000276681 [Q96PV6-1]
ENST00000616932; ENSP00000477813; ENSG00000167615 [Q96PV6-1]
ENST00000617180; ENSP00000480663; ENSG00000276681 [Q96PV6-2]
ENST00000617420; ENSP00000481040; ENSG00000276458 [Q96PV6-1]
ENST00000621306; ENSP00000478337; ENSG00000276458 [Q96PV6-2]
ENST00000622672; ENSP00000478975; ENSG00000274305 [Q96PV6-2]
GeneIDi114823
KEGGihsa:114823
UCSCiuc032iea.2 human [Q96PV6-2]
uc061cqz.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		114823

GeneCards: human genes, protein and diseases

More...GeneCardsi		LENG8
HGNCiHGNC:15500 LENG8
HPAiHPA042004
HPA042056
HPA061571
MIMi616575 gene
neXtProtiNX_Q96PV6
OpenTargetsiENSG00000167615
PharmGKBiPA134903953

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00390000008006
HOGENOMiHOG000001575
InParanoidiQ96PV6
OrthoDBi1503267at2759
PhylomeDBiQ96PV6
TreeFamiTF312927

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LENG8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		114823
PharosiQ96PV6

Protein Ontology

More...PROi		PR:Q96PV6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167615 Expressed in 187 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ96PV6 baseline and differential
GenevisibleiQ96PV6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLENG8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PV6
Secondary accession number(s): A0A087WTE7
, B0VJY9, Q8IZ27, Q8NCX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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