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UniProtKB - Q96PV4 (PNMA5_HUMAN)
Protein
Paraneoplastic antigen-like protein 5
Gene
PNMA5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- positive regulation of apoptotic process Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q96PV4 |
SignaLinki | Q96PV4 |
Names & Taxonomyi
Protein namesi | Recommended name: Paraneoplastic antigen-like protein 5Alternative name(s): Tumor antigen BJ-HCC-25 |
Gene namesi | Name:PNMA5 Synonyms:KIAA1934 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18743, PNMA5 |
MIMi | 300916, gene |
neXtProti | NX_Q96PV4 |
VEuPathDBi | HostDB:ENSG00000198883 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198883 |
PharmGKBi | PA38668 |
Miscellaneous databases
Pharosi | Q96PV4, Tdark |
Genetic variation databases
BioMutai | PNMA5 |
DMDMi | 160419235 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311217 | 1 – 448 | Paraneoplastic antigen-like protein 5Add BLAST | 448 |
Proteomic databases
MassIVEi | Q96PV4 |
PaxDbi | Q96PV4 |
PeptideAtlasi | Q96PV4 |
PRIDEi | Q96PV4 |
ProteomicsDBi | 77773 |
PTM databases
GlyGeni | Q96PV4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96PV4 |
PhosphoSitePlusi | Q96PV4 |
Expressioni
Tissue specificityi
Expressed in the brain.1 Publication
Gene expression databases
Bgeei | ENSG00000198883, Expressed in brain and 54 other tissues |
Organism-specific databases
HPAi | ENSG00000198883, Group enriched (brain, testis) |
Interactioni
Binary interactionsi
Q96PV4
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 125374, 66 interactors |
IntActi | Q96PV4, 68 interactors |
STRINGi | 9606.ENSP00000388850 |
Miscellaneous databases
RNActi | Q96PV4, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 335 – 448 | DisorderedSequence analysisAdd BLAST | 114 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 359 – 384 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 395 – 409 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the PNMA family.Curated
Phylogenomic databases
eggNOGi | ENOG502SPHT, Eukaryota |
GeneTreei | ENSGT01030000234522 |
HOGENOMi | CLU_014694_0_1_1 |
InParanoidi | Q96PV4 |
OMAi | EGPQTAG |
OrthoDBi | 820525at2759 |
PhylomeDBi | Q96PV4 |
TreeFami | TF335054 |
Family and domain databases
InterProi | View protein in InterPro IPR026523, PNMA IPR026527, PNMA5 |
PANTHERi | PTHR23095, PTHR23095, 1 hit PTHR23095:SF4, PTHR23095:SF4, 1 hit |
Pfami | View protein in Pfam PF14893, PNMA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96PV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALTLLEDWC KGMDMDPRKA LLIVGIPMEC SEVEIQDTVK AGLQPLCAYR
60 70 80 90 100
VLGRMFRRED NAKAVFIELA DTVNYTTLPS HIPGKGGSWE VVVKPRNPDD
110 120 130 140 150
EFLSRLNYFL KDEGRSMTDV ARALGCCSLP AESLDAEVMP QVRSPPLEPP
160 170 180 190 200
KESMWYRKLK VFSGTASPSP GEETFEDWLE QVTEIMPIWQ VSEVEKRRRL
210 220 230 240 250
LESLRGPALS IMRVLQANND SITVEQCLDA LKQIFGDKED FRASQFRFLQ
260 270 280 290 300
TSPKIGEKVS TFLLRLEPLL QKAVHKSPLS VRSTDMIRLK HLLARVAMTP
310 320 330 340 350
ALRGKLELLD QRGCPPNFLE LMKLIRDEEE WENTEAVMKN KEKPSGRGRG
360 370 380 390 400
ASGRQARAEA SVSAPQATVQ ARSFSDSSPQ TIQGGLPPLV KRRRLLGSES
410 420 430 440
TRGEDHGQAT YPKAENQTPG REGPQAAGEE LGNEAGAGAM SHPKPWET
Sequence cautioni
The sequence BAB67827 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 242 | R → G in AAI01113 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 325 | I → T in BAH14475 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 359 | E → G in BAH14475 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037164 | 107 | N → H. Corresponds to variant dbSNP:rs3810655Ensembl. | 1 | |
Natural variantiVAR_037165 | 349 | R → W. Corresponds to variant dbSNP:rs3810654Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY121806 mRNA Translation: AAM82754.1 AB067521 mRNA Translation: BAB67827.1 Different initiation. AK295446 mRNA Translation: BAG58384.1 AK316104 mRNA Translation: BAH14475.1 CH471172 Genomic DNA Translation: EAW72892.1 BC101111 mRNA Translation: AAI01112.1 BC101112 mRNA Translation: AAI01113.1 BC101113 mRNA Translation: AAI01114.1 |
CCDSi | CCDS14718.1 |
RefSeqi | NP_001096620.1, NM_001103150.1 NP_001096621.1, NM_001103151.1 NP_001171853.1, NM_001184924.1 NP_443158.1, NM_052926.2 XP_016884741.1, XM_017029252.1 XP_016884742.1, XM_017029253.1 |
Genome annotation databases
Ensembli | ENST00000361887; ENSP00000354834; ENSG00000198883 ENST00000439251; ENSP00000388850; ENSG00000198883 ENST00000452693; ENSP00000392342; ENSG00000198883 ENST00000535214; ENSP00000445775; ENSG00000198883 |
GeneIDi | 114824 |
KEGGi | hsa:114824 |
MANE-Selecti | ENST00000535214.6; ENSP00000445775.1; NM_001184924.2; NP_001171853.1 |
UCSCi | uc004fgy.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY121806 mRNA Translation: AAM82754.1 AB067521 mRNA Translation: BAB67827.1 Different initiation. AK295446 mRNA Translation: BAG58384.1 AK316104 mRNA Translation: BAH14475.1 CH471172 Genomic DNA Translation: EAW72892.1 BC101111 mRNA Translation: AAI01112.1 BC101112 mRNA Translation: AAI01113.1 BC101113 mRNA Translation: AAI01114.1 |
CCDSi | CCDS14718.1 |
RefSeqi | NP_001096620.1, NM_001103150.1 NP_001096621.1, NM_001103151.1 NP_001171853.1, NM_001184924.1 NP_443158.1, NM_052926.2 XP_016884741.1, XM_017029252.1 XP_016884742.1, XM_017029253.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125374, 66 interactors |
IntActi | Q96PV4, 68 interactors |
STRINGi | 9606.ENSP00000388850 |
PTM databases
GlyGeni | Q96PV4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96PV4 |
PhosphoSitePlusi | Q96PV4 |
Genetic variation databases
BioMutai | PNMA5 |
DMDMi | 160419235 |
Proteomic databases
MassIVEi | Q96PV4 |
PaxDbi | Q96PV4 |
PeptideAtlasi | Q96PV4 |
PRIDEi | Q96PV4 |
ProteomicsDBi | 77773 |
Protocols and materials databases
Antibodypediai | 63837, 108 antibodies from 16 providers |
DNASUi | 114824 |
Genome annotation databases
Ensembli | ENST00000361887; ENSP00000354834; ENSG00000198883 ENST00000439251; ENSP00000388850; ENSG00000198883 ENST00000452693; ENSP00000392342; ENSG00000198883 ENST00000535214; ENSP00000445775; ENSG00000198883 |
GeneIDi | 114824 |
KEGGi | hsa:114824 |
MANE-Selecti | ENST00000535214.6; ENSP00000445775.1; NM_001184924.2; NP_001171853.1 |
UCSCi | uc004fgy.5, human |
Organism-specific databases
CTDi | 114824 |
GeneCardsi | PNMA5 |
HGNCi | HGNC:18743, PNMA5 |
HPAi | ENSG00000198883, Group enriched (brain, testis) |
MIMi | 300916, gene |
neXtProti | NX_Q96PV4 |
OpenTargetsi | ENSG00000198883 |
PharmGKBi | PA38668 |
VEuPathDBi | HostDB:ENSG00000198883 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SPHT, Eukaryota |
GeneTreei | ENSGT01030000234522 |
HOGENOMi | CLU_014694_0_1_1 |
InParanoidi | Q96PV4 |
OMAi | EGPQTAG |
OrthoDBi | 820525at2759 |
PhylomeDBi | Q96PV4 |
TreeFami | TF335054 |
Enzyme and pathway databases
PathwayCommonsi | Q96PV4 |
SignaLinki | Q96PV4 |
Miscellaneous databases
BioGRID-ORCSi | 114824, 5 hits in 660 CRISPR screens |
ChiTaRSi | PNMA5, human |
GenomeRNAii | 114824 |
Pharosi | Q96PV4, Tdark |
PROi | PR:Q96PV4 |
RNActi | Q96PV4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198883, Expressed in brain and 54 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR026523, PNMA IPR026527, PNMA5 |
PANTHERi | PTHR23095, PTHR23095, 1 hit PTHR23095:SF4, PTHR23095:SF4, 1 hit |
Pfami | View protein in Pfam PF14893, PNMA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PNMA5_HUMAN | |
Accessioni | Q96PV4Primary (citable) accession number: Q96PV4 Secondary accession number(s): B4DI72 Q8NET3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families