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UniProtKB - Q96PV4 (PNMA5_HUMAN)

Entry version 110 (31 Jul 2019)
Sequence version 2 (13 Nov 2007)
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Protein

Paraneoplastic antigen-like protein 5

Gene

PNMA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paraneoplastic antigen-like protein 5
Alternative name(s):
Tumor antigen BJ-HCC-25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNMA5
Synonyms:KIAA1934
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18743 PNMA5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300916 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96PV4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000198883

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38668

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PNMA5

Domain mapping of disease mutations (DMDM)

More...DMDMi		160419235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112171 – 448Paraneoplastic antigen-like protein 5Add BLAST448

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96PV4

PeptideAtlas

More...PeptideAtlasi		Q96PV4

PRoteomics IDEntifications database

More...PRIDEi		Q96PV4

ProteomicsDB human proteome resource

More...ProteomicsDBi		77773

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96PV4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96PV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198883 Expressed in 37 organ(s), highest expression level in hypothalamus

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA044690

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125374, 38 interactors

Protein interaction database and analysis system

More...IntActi		Q96PV4, 60 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000388850

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96PV4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JBGG Eukaryota
ENOG4111E9E LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013079

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96PV4

Identification of Orthologs from Complete Genome Data

More...OMAi		WYRKLKV

Database of Orthologous Groups

More...OrthoDBi		820525at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96PV4

TreeFam database of animal gene trees

More...TreeFami		TF335054

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026523 PNMA
IPR026527 PNMA5

The PANTHER Classification System

More...PANTHERi		PTHR23095 PTHR23095, 1 hit
PTHR23095:SF4 PTHR23095:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14893 PNMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96PV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTLLEDWC KGMDMDPRKA LLIVGIPMEC SEVEIQDTVK AGLQPLCAYR 
        60         70         80         90        100
VLGRMFRRED NAKAVFIELA DTVNYTTLPS HIPGKGGSWE VVVKPRNPDD 
       110        120        130        140        150
EFLSRLNYFL KDEGRSMTDV ARALGCCSLP AESLDAEVMP QVRSPPLEPP 
       160        170        180        190        200
KESMWYRKLK VFSGTASPSP GEETFEDWLE QVTEIMPIWQ VSEVEKRRRL 
       210        220        230        240        250
LESLRGPALS IMRVLQANND SITVEQCLDA LKQIFGDKED FRASQFRFLQ 
       260        270        280        290        300
TSPKIGEKVS TFLLRLEPLL QKAVHKSPLS VRSTDMIRLK HLLARVAMTP 
       310        320        330        340        350
ALRGKLELLD QRGCPPNFLE LMKLIRDEEE WENTEAVMKN KEKPSGRGRG 
       360        370        380        390        400
ASGRQARAEA SVSAPQATVQ ARSFSDSSPQ TIQGGLPPLV KRRRLLGSES 
       410        420        430        440 
TRGEDHGQAT YPKAENQTPG REGPQAAGEE LGNEAGAGAM SHPKPWET
Length:448
Mass (Da):49,934
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F6BC8A15B457A89
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB67827 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242R → G in AAI01113 (PubMed:15489334).Curated1
Sequence conflicti325I → T in BAH14475 (PubMed:14702039).Curated1
Sequence conflicti359E → G in BAH14475 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037164107N → H. Corresponds to variant dbSNP:rs3810655Ensembl.1
Natural variantiVAR_037165349R → W. Corresponds to variant dbSNP:rs3810654Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY121806 mRNA Translation: AAM82754.1
AB067521 mRNA Translation: BAB67827.1 Different initiation.
AK295446 mRNA Translation: BAG58384.1
AK316104 mRNA Translation: BAH14475.1
CH471172 Genomic DNA Translation: EAW72892.1
BC101111 mRNA Translation: AAI01112.1
BC101112 mRNA Translation: AAI01113.1
BC101113 mRNA Translation: AAI01114.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14718.1

NCBI Reference Sequences

More...RefSeqi		NP_001096620.1, NM_001103150.1
NP_001096621.1, NM_001103151.1
NP_001171853.1, NM_001184924.1
NP_443158.1, NM_052926.2
XP_016884741.1, XM_017029252.1
XP_016884742.1, XM_017029253.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361887; ENSP00000354834; ENSG00000198883
ENST00000439251; ENSP00000388850; ENSG00000198883
ENST00000452693; ENSP00000392342; ENSG00000198883
ENST00000535214; ENSP00000445775; ENSG00000198883

Database of genes from NCBI RefSeq genomes

More...GeneIDi		114824

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:114824

UCSC genome browser

More...UCSCi		uc004fgy.5 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY121806 mRNA Translation: AAM82754.1
AB067521 mRNA Translation: BAB67827.1 Different initiation.
AK295446 mRNA Translation: BAG58384.1
AK316104 mRNA Translation: BAH14475.1
CH471172 Genomic DNA Translation: EAW72892.1
BC101111 mRNA Translation: AAI01112.1
BC101112 mRNA Translation: AAI01113.1
BC101113 mRNA Translation: AAI01114.1
CCDSiCCDS14718.1
RefSeqiNP_001096620.1, NM_001103150.1
NP_001096621.1, NM_001103151.1
NP_001171853.1, NM_001184924.1
NP_443158.1, NM_052926.2
XP_016884741.1, XM_017029252.1
XP_016884742.1, XM_017029253.1

3D structure databases

SMRiQ96PV4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125374, 38 interactors
IntActiQ96PV4, 60 interactors
STRINGi9606.ENSP00000388850

PTM databases

iPTMnetiQ96PV4
PhosphoSitePlusiQ96PV4

Polymorphism and mutation databases

BioMutaiPNMA5
DMDMi160419235

Proteomic databases

PaxDbiQ96PV4
PeptideAtlasiQ96PV4
PRIDEiQ96PV4
ProteomicsDBi77773

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		114824
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361887; ENSP00000354834; ENSG00000198883
ENST00000439251; ENSP00000388850; ENSG00000198883
ENST00000452693; ENSP00000392342; ENSG00000198883
ENST00000535214; ENSP00000445775; ENSG00000198883
GeneIDi114824
KEGGihsa:114824
UCSCiuc004fgy.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		114824

GeneCards: human genes, protein and diseases

More...GeneCardsi		PNMA5
HGNCiHGNC:18743 PNMA5
HPAiHPA044690
MIMi300916 gene
neXtProtiNX_Q96PV4
OpenTargetsiENSG00000198883
PharmGKBiPA38668

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JBGG Eukaryota
ENOG4111E9E LUCA
GeneTreeiENSGT00950000182785
HOGENOMiHOG000013079
InParanoidiQ96PV4
OMAiWYRKLKV
OrthoDBi820525at2759
PhylomeDBiQ96PV4
TreeFamiTF335054

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PNMA5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		114824

Protein Ontology

More...PROi		PR:Q96PV4

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198883 Expressed in 37 organ(s), highest expression level in hypothalamus

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR026527 PNMA5
PANTHERiPTHR23095 PTHR23095, 1 hit
PTHR23095:SF4 PTHR23095:SF4, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNMA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PV4
Secondary accession number(s): B4DI72
, B7Z9Y9, Q495L5, Q8NET3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 31, 2019
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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