Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q96PU5 (NED4L_HUMAN)

Entry version 193 (25 May 2022)
Sequence version 2 (30 Aug 2005)
Previous versions | rss
Add a publicationFeedback
Protein

E3 ubiquitin-protein ligase NEDD4-like

Gene

NEDD4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:31959741, PubMed:33608556, PubMed:20064473).

Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141).

Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741).

Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338).

Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).

Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Involved in the regulation of TOR signaling (PubMed:27694961).

Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).

Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556).

By similarity13 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by NDFIP1- and NDFIP2-binding.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei942Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDifferentiation, Host-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.26, 2681
2.3.2.B8, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96PU5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-162588, Budding and maturation of HIV virion
R-HSA-2173788, Downregulation of TGF-beta receptor signaling
R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2672351, Stimuli-sensing channels
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96PU5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96PU5

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase NEDD4-like (EC:2.3.2.261 Publication, EC:2.3.2.361 Publication)
Alternative name(s):
HECT-type E3 ubiquitin transferase NED4L
NEDD4.2
Nedd4-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEDD4L1 Publication
Synonyms:KIAA04391 Publication, NEDL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7728, NEDD4L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606384, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96PU5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000049759

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Periventricular nodular heterotopia 7 (PVNH7)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of periventricular nodular heterotopia, a disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches. PVNH7 is an autosomal dominant disease characterized by delayed psychomotor development, intellectual disability, and seizures in some patients. Additional features include cleft palate and toe syndactyly.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077880679Y → C in PVNH7. 1 PublicationCorresponds to variant dbSNP:rs879255599Ensembl.1
Natural variantiVAR_077881694Q → H in PVNH7; increased degradation; changed function in regulation of TOR signaling. 1 PublicationCorresponds to variant dbSNP:rs879255598Ensembl.1
Natural variantiVAR_077882893E → K in PVNH7; increased degradation; changed function in regulation of TOR signaling. 1 PublicationCorresponds to variant dbSNP:rs879255597Ensembl.1
Natural variantiVAR_077883897R → Q in PVNH7; increased degradation; changed function in regulation of TOR signaling. 1 PublicationCorresponds to variant dbSNP:rs879255596Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi448S → A: Abolishes interaction with 1433F. 1 Publication1
Mutagenesisi942C → S: Abolishes activity. No effect on USP36 protein levels. 2 Publications1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		23327

MalaCards human disease database

More...MalaCardsi		NEDD4L
MIMi617201, phenotype

Open Targets

More...OpenTargetsi		ENSG00000049759

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98892, Periventricular nodular heterotopia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31534

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96PU5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NEDD4L

Domain mapping of disease mutations (DMDM)

More...DMDMi		73921204

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203232 – 975E3 ubiquitin-protein ligase NEDD4-likeAdd BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei342Phosphoserine; by WNK1 and WNK4Combined sources2 Publications1
Modified residuei367Phosphothreonine; by SGK11 Publication1
Modified residuei446PhosphoserineCombined sources1
Modified residuei448Phosphoserine; by PKA and SGK1Combined sources2 Publications1
Modified residuei449Phosphoserine; by WNK1 and WNK4Combined sources1 Publication1
Modified residuei464PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by SGK1 or PKA; which impairs interaction with SCNN. Interaction with YWHAH inhibits dephosphorylation.5 Publications
Auto-ubiquitinated (PubMed:19343052). Deubiquitinated by USP36, no effect on NEDD4L protein levels. Both proteins interact and regulate each other's ubiquitination levels (PubMed:27445338).2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96PU5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96PU5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96PU5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96PU5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96PU5

PeptideAtlas

More...PeptideAtlasi		Q96PU5

PRoteomics IDEntifications database

More...PRIDEi		Q96PU5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77752 [Q96PU5-1]
77753 [Q96PU5-2]
77754 [Q96PU5-3]
77755 [Q96PU5-4]
77756 [Q96PU5-5]
77757 [Q96PU5-6]
77758 [Q96PU5-7]
77760 [Q96PU5-9]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96PU5, 2 sites, 2 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96PU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96PU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels in prostate, pancreas, and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597). Expressed in melanocytes (PubMed:23999003).4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By androgens in prostate, and by albumin in kidney.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000049759, Expressed in forebrain and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96PU5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96PU5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000049759, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBE2E3 (By similarity).

Interacts with NDFIP1; this interaction activates the E3 ubiquitin-protein ligase (PubMed:11748237, PubMed:26363003).

Interacts with NDFIP2; this interaction activates the E3 ubiquitin-protein ligase (PubMed:26363003).

Interacts (via WW domains) with SCNN1A (PubMed:11696533, PubMed:11244092, PubMed:14556380).

Interacts (via WW domains) with SCNN1B (PubMed:11244092, PubMed:14556380).

Interacts (via WW domains) with SCNN1G (PubMed:11244092, PubMed:14556380).

Interacts (via WW domains) with SCN1A (By similarity).

Interacts (via WW domains) with SCN2A (PubMed:15548568).

Interacts (via WW domains) with SCN3A (PubMed:15548568).

Interacts (via WW domains) with SCN5A (PubMed:15217910, PubMed:15548568).

Interacts (via WW domains) with SCN8A (By similarity).

Interacts (via WW domains) with SCN9A (By similarity).

Interacts (via WW domains) with SCN10A (By similarity).

Interacts (via WW domains) with CLCN5 (PubMed:15489223).

Interacts with SMAD2 (PubMed:15496141).

Interacts with SMAD3 (PubMed:15496141).

Interacts with SMAD6 (PubMed:15496141).

Interacts with SMAD7 (PubMed:15496141). The phosphorylated form interacts with 14-3-3 proteins (PubMed:15677482).

Interacts with TNK2 (PubMed:19144635, PubMed:20086093).

Interacts with WNK1 (PubMed:20525693).

Interacts with SGK1 (PubMed:11696533, PubMed:20730100).

Interacts (via C2 domain) with NPC2 (PubMed:19664597).

Interacts with ARRDC4 (PubMed:23236378).

Interacts with KCNQ1; promotes internalization of KCNQ1 (PubMed:22024150).

Interacts (via domains WW1, 3 and 4) with USP36; the interaction inhibits ubiquitination of, at least, NTRK1, KCNQ2 and KCNQ3 by NEDD4L (PubMed:27445338).

Interacts with PRRG4 (via cytoplasmic domain) (PubMed:23873930).

Interacts with LDLRAD3; the interaction is direct (PubMed:26854353).

Interacts with UBE2D2 (PubMed:20064473).

By similarity21 Publications

(Microbial infection) Interacts with Epstein-Barr virus LMP2A.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116915, 294 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96PU5

Database of interacting proteins

More...DIPi		DIP-41935N

Protein interaction database and analysis system

More...IntActi		Q96PU5, 52 interactors

Molecular INTeraction database

More...MINTi		Q96PU5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000383199

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96PU5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1975
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96PU5

Biological Magnetic Resonance Data Bank

More...BMRBi		Q96PU5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96PU5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96PU5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 126C2PROSITE-ProRule annotationAdd BLAST123
Domaini193 – 226WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini385 – 418WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini497 – 530WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini548 – 581WW 4PROSITE-ProRule annotationAdd BLAST34
Domaini640 – 974HECTPROSITE-ProRule annotationAdd BLAST335

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni178 – 202DisorderedSequence analysisAdd BLAST25
Regioni244 – 272DisorderedSequence analysisAdd BLAST29
Regioni285 – 312DisorderedSequence analysisAdd BLAST28
Regioni349 – 393DisorderedSequence analysisAdd BLAST45
Regioni424 – 496DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 261Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi424 – 455Polar residuesSequence analysisAdd BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0940, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156873

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96PU5

Identification of Orthologs from Complete Genome Data

More...OMAi		PAHIAMQ

Database of Orthologous Groups

More...OrthoDBi		271539at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96PU5

TreeFam database of animal gene trees

More...TreeFami		TF323658

Family and domain databases

Conserved Domains Database

More...CDDi		cd00078, HECTc, 1 hit
cd00201, WW, 4 hits

Database of protein disorder

More...DisProti		DP02292

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00114

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR024928, E3_ub_ligase_SMURF1
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF00632, HECT, 1 hit
PF00397, WW, 4 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001569, E3_ub_ligase_SMURF1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00360, C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00119, HECTc, 1 hit
SM00456, WW, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 1 hit
SSF51045, SSF51045, 4 hits
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 4 hits
PS50020, WW_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PU5-1) [UniParc]FASTAAdd to basket
Also known as: Nedd4-2c

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATGLGEPVY GLSEDEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY 
        60         70         80         90        100
VADENRELAL VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT 
       110        120        130        140        150
RDDFLGQVDV PLSHLPTEDP TMERPYTFKD FLLRPRSHKS RVKGFLRLKM 
       160        170        180        190        200
AYMPKNGGQD EENSDQRDDM EHGWEVVDSN DSASQHQEEL PPPPLPPGWE 
       210        220        230        240        250
EKVDNLGRTY YVNHNNRTTQ WHRPSLMDVS SESDNNIRQI NQEAAHRRFR 
       260        270        280        290        300
SRRHISEDLE PEPSEGGDVP EPWETISEEV NIAGDSLGLA LPPPPASPGS 
       310        320        330        340        350
RTSPQELSEE LSRRLQITPD SNGEQFSSLI QREPSSRLRS CSVTDAVAEQ 
       360        370        380        390        400
GHLPPPSAPA GRARSSTVTG GEEPTPSVAY VHTTPGLPSG WEERKDAKGR 
       410        420        430        440        450
TYYVNHNNRT TTWTRPIMQL AEDGASGSAT NSNNHLIEPQ IRRPRSLSSP 
       460        470        480        490        500
TVTLSAPLEG AKDSPVRRAV KDTLSNPQSP QPSPYNSPKP QHKVTQSFLP 
       510        520        530        540        550
PGWEMRIAPN GRPFFIDHNT KTTTWEDPRL KFPVHMRSKT SLNPNDLGPL 
       560        570        580        590        600
PPGWEERIHL DGRTFYIDHN SKITQWEDPR LQNPAITGPA VPYSREFKQK 
       610        620        630        640        650
YDYFRKKLKK PADIPNRFEM KLHRNNIFEE SYRRIMSVKR PDVLKARLWI 
       660        670        680        690        700
EFESEKGLDY GGVAREWFFL LSKEMFNPYY GLFEYSATDN YTLQINPNSG 
       710        720        730        740        750
LCNEDHLSYF TFIGRVAGLA VFHGKLLDGF FIRPFYKMML GKQITLNDME 
       760        770        780        790        800
SVDSEYYNSL KWILENDPTE LDLMFCIDEE NFGQTYQVDL KPNGSEIMVT 
       810        820        830        840        850
NENKREYIDL VIQWRFVNRV QKQMNAFLEG FTELLPIDLI KIFDENELEL 
       860        870        880        890        900
LMCGLGDVDV NDWRQHSIYK NGYCPNHPVI QWFWKAVLLM DAEKRIRLLQ 
       910        920        930        940        950
FVTGTSRVPM NGFAELYGSN GPQLFTIEQW GSPEKLPRAH TCFNRLDLPP 
       960        970 
YETFEDLREK LLMAVENAQG FEGVD
Length:975
Mass (Da):111,932
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C958625B4A1AB3F
GO
Isoform 2 (identifier: Q96PU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-419: Missing.

Show »
Length:911
Mass (Da):104,922
Checksum:iCE04AAED677AA506
GO
Isoform 3 (identifier: Q96PU5-3) [UniParc]FASTAAdd to basket
Also known as: NEDD4Le

The sequence of this isoform differs from the canonical sequence as follows:
     356-459: Missing.

Show »
Length:871
Mass (Da):100,752
Checksum:i5E2AB9B510060D4A
GO
Isoform 4 (identifier: Q96PU5-4) [UniParc]FASTAAdd to basket
Also known as: NEDD4La, NEDD4Lb, NEDD4Lf

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Show »
Length:854
Mass (Da):98,181
Checksum:i00C74E1661F52E7F
GO
Isoform 5 (identifier: Q96PU5-5) [UniParc]FASTAAdd to basket
Also known as: NEDD4Ld

The sequence of this isoform differs from the canonical sequence as follows:
     356-375: Missing.

Show »
Length:955
Mass (Da):110,022
Checksum:iA8BB278A37F6A6B5
GO
Isoform 6 (identifier: Q96PU5-6) [UniParc]FASTAAdd to basket
Also known as: NEDD4Lh

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MATGLGEPVYGLSEDE → MRRLAFEQ
     356-375: Missing.

Show »
Length:947
Mass (Da):109,404
Checksum:iF107E5A8E0C3BB8D
GO
Isoform 7 (identifier: Q96PU5-7) [UniParc]FASTAAdd to basket
Also known as: NEDD4Lg

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MATGLGEPVYGLSEDE → MRRLAFEQ

Show »
Length:967
Mass (Da):111,314
Checksum:i9786AC67C8CD165F
GO
Isoform 8 (identifier: Q96PU5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     356-375: Missing.

Show »
Length:834
Mass (Da):96,271
Checksum:i47C33C4FB577C3DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6Q8PG51A0A6Q8PG51_HUMAN
E3 ubiquitin-protein ligase
NEDD4L
863Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERN1K7ERN1_HUMAN
HECT-type E3 ubiquitin transferase
NEDD4L
639Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFI7A0A6Q8PFI7_HUMAN
E3 ubiquitin-protein ligase
NEDD4L
948Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGP5A0A6Q8PGP5_HUMAN
E3 ubiquitin-protein ligase
NEDD4L
942Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHJ5A0A6Q8PHJ5_HUMAN
E3 ubiquitin-protein ligase
NEDD4L
930Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVY1A0A1B0GVY1_HUMAN
HECT-type E3 ubiquitin transferase
NEDD4L
1,254Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0Z498A0A7P0Z498_HUMAN
HECT-type E3 ubiquitin transferase
NEDD4L
618Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENS6K7ENS6_HUMAN
E3 ubiquitin-protein ligase NEDD4-l...
NEDD4L
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKL1K7EKL1_HUMAN
E3 ubiquitin-protein ligase NEDD4-l...
NEDD4L
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG81A0A6Q8PG81_HUMAN
E3 ubiquitin-protein ligase NEDD4-l...
NEDD4L
394Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23711 differs from that shown. Probable cloning artifact.Curated
The sequence BAA23711 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52A → P in AAM76729 (PubMed:14615060).Curated1
Sequence conflicti52A → P in AAM76730 (PubMed:14615060).Curated1
Sequence conflicti188E → K in AAP75706 (PubMed:14556380).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023415355P → L Impaired ability to inhibit SCNN. 1 PublicationCorresponds to variant dbSNP:rs767136811EnsemblClinVar.1
Natural variantiVAR_023416497S → R1 Publication1
Natural variantiVAR_077880679Y → C in PVNH7. 1 PublicationCorresponds to variant dbSNP:rs879255599Ensembl.1
Natural variantiVAR_077881694Q → H in PVNH7; increased degradation; changed function in regulation of TOR signaling. 1 PublicationCorresponds to variant dbSNP:rs879255598Ensembl.1
Natural variantiVAR_077882893E → K in PVNH7; increased degradation; changed function in regulation of TOR signaling. 1 PublicationCorresponds to variant dbSNP:rs879255597Ensembl.1
Natural variantiVAR_077883897R → Q in PVNH7; increased degradation; changed function in regulation of TOR signaling. 1 PublicationCorresponds to variant dbSNP:rs879255596Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0154441 – 121Missing in isoform 4 and isoform 8. 4 PublicationsAdd BLAST121
Alternative sequenceiVSP_0154461 – 16MATGL…LSEDE → MRRLAFEQ in isoform 6 and isoform 7. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_015447356 – 459Missing in isoform 3. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_015448356 – 419Missing in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_043848356 – 375Missing in isoform 5, isoform 6 and isoform 8. 5 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF210730 mRNA Translation: AAG43524.1
AF385931 mRNA Translation: AAM46208.1
AY312514 mRNA Translation: AAP75706.1
AY112983 mRNA Translation: AAM76728.1
AY112984 mRNA Translation: AAM76729.1
AY112985 mRNA Translation: AAM76730.1
AB071179 mRNA Translation: BAB69424.1
DQ181796 mRNA Translation: ABA10330.1
AC015988 Genomic DNA No translation available.
AC090236 Genomic DNA No translation available.
AC107896 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63065.1
BC000621 mRNA Translation: AAH00621.2
BC019345 mRNA Translation: AAH19345.1
BC032597 mRNA Translation: AAH32597.1
AB007899 mRNA Translation: BAA23711.1 Different initiation.
AL137469 mRNA Translation: CAB70754.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45872.1 [Q96PU5-1]
CCDS45873.1 [Q96PU5-5]
CCDS45874.1 [Q96PU5-7]
CCDS45875.1 [Q96PU5-4]
CCDS45876.1 [Q96PU5-9]
CCDS58632.1 [Q96PU5-2]
CCDS59323.1 [Q96PU5-6]

Protein sequence database of the Protein Information Resource

More...PIRi		T46412

NCBI Reference Sequences

More...RefSeqi		NP_001138436.1, NM_001144964.1 [Q96PU5-4]
NP_001138437.1, NM_001144965.1 [Q96PU5-4]
NP_001138438.1, NM_001144966.2 [Q96PU5-4]
NP_001138439.1, NM_001144967.2 [Q96PU5-1]
NP_001138440.1, NM_001144968.1 [Q96PU5-7]
NP_001138441.1, NM_001144969.1 [Q96PU5-6]
NP_001138442.1, NM_001144970.2 [Q96PU5-9]
NP_001138443.1, NM_001144971.1 [Q96PU5-9]
NP_001230889.1, NM_001243960.1 [Q96PU5-2]
NP_056092.2, NM_015277.5 [Q96PU5-5]
XP_016881168.1, XM_017025679.1 [Q96PU5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256830.13; ENSP00000256830.8; ENSG00000049759.20 [Q96PU5-3]
ENST00000356462.10; ENSP00000348847.5; ENSG00000049759.20 [Q96PU5-2]
ENST00000357895.9; ENSP00000350569.4; ENSG00000049759.20 [Q96PU5-7]
ENST00000382850.8; ENSP00000372301.3; ENSG00000049759.20 [Q96PU5-5]
ENST00000400345.8; ENSP00000383199.2; ENSG00000049759.20
ENST00000431212.6; ENSP00000389406.1; ENSG00000049759.20 [Q96PU5-4]
ENST00000435432.6; ENSP00000393395.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000456173.6; ENSP00000405440.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000456986.5; ENSP00000411947.1; ENSG00000049759.20 [Q96PU5-4]
ENST00000586263.5; ENSP00000468546.1; ENSG00000049759.20 [Q96PU5-6]
ENST00000674517.1; ENSP00000501665.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000675502.1; ENSP00000502428.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000675801.1; ENSP00000502688.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000675865.1; ENSP00000502003.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000676226.1; ENSP00000502325.1; ENSG00000049759.20 [Q96PU5-9]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23327

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23327

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000400345.8; ENSP00000383199.2; NM_001144967.3; NP_001138439.1

UCSC genome browser

More...UCSCi		uc002lgx.4, human [Q96PU5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210730 mRNA Translation: AAG43524.1
AF385931 mRNA Translation: AAM46208.1
AY312514 mRNA Translation: AAP75706.1
AY112983 mRNA Translation: AAM76728.1
AY112984 mRNA Translation: AAM76729.1
AY112985 mRNA Translation: AAM76730.1
AB071179 mRNA Translation: BAB69424.1
DQ181796 mRNA Translation: ABA10330.1
AC015988 Genomic DNA No translation available.
AC090236 Genomic DNA No translation available.
AC107896 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63065.1
BC000621 mRNA Translation: AAH00621.2
BC019345 mRNA Translation: AAH19345.1
BC032597 mRNA Translation: AAH32597.1
AB007899 mRNA Translation: BAA23711.1 Different initiation.
AL137469 mRNA Translation: CAB70754.1
CCDSiCCDS45872.1 [Q96PU5-1]
CCDS45873.1 [Q96PU5-5]
CCDS45874.1 [Q96PU5-7]
CCDS45875.1 [Q96PU5-4]
CCDS45876.1 [Q96PU5-9]
CCDS58632.1 [Q96PU5-2]
CCDS59323.1 [Q96PU5-6]
PIRiT46412
RefSeqiNP_001138436.1, NM_001144964.1 [Q96PU5-4]
NP_001138437.1, NM_001144965.1 [Q96PU5-4]
NP_001138438.1, NM_001144966.2 [Q96PU5-4]
NP_001138439.1, NM_001144967.2 [Q96PU5-1]
NP_001138440.1, NM_001144968.1 [Q96PU5-7]
NP_001138441.1, NM_001144969.1 [Q96PU5-6]
NP_001138442.1, NM_001144970.2 [Q96PU5-9]
NP_001138443.1, NM_001144971.1 [Q96PU5-9]
NP_001230889.1, NM_001243960.1 [Q96PU5-2]
NP_056092.2, NM_015277.5 [Q96PU5-5]
XP_016881168.1, XM_017025679.1 [Q96PU5-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LAJNMR-A496-535[»]
2LB2NMR-A386-420[»]
2LTYNMR-A385-417[»]
2MPTNMR-A496-539[»]
B945-957[»]
2NSQX-ray1.85A1-154[»]
2ONIX-ray2.20A594-967[»]
3JVZX-ray3.30C/D596-975[»]
3JW0X-ray3.10C/D596-975[»]
5HPKX-ray2.43A594-975[»]
6ZBTX-ray1.80E/F/G/H338-347[»]
6ZC9X-ray1.90E/F/G/H444-453[»]
7LP1X-ray1.35A494-532[»]
7LP3X-ray1.61A/C193-226[»]
7LP4NMR-A493-539[»]
7LP5NMR-A493-539[»]
7NMZX-ray2.30C335-455[»]
AlphaFoldDBiQ96PU5
BMRBiQ96PU5
SMRiQ96PU5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116915, 294 interactors
CORUMiQ96PU5
DIPiDIP-41935N
IntActiQ96PU5, 52 interactors
MINTiQ96PU5
STRINGi9606.ENSP00000383199

PTM databases

GlyGeniQ96PU5, 2 sites, 2 O-linked glycans (2 sites)
iPTMnetiQ96PU5
PhosphoSitePlusiQ96PU5

Genetic variation databases

BioMutaiNEDD4L
DMDMi73921204

Proteomic databases

EPDiQ96PU5
jPOSTiQ96PU5
MassIVEiQ96PU5
MaxQBiQ96PU5
PaxDbiQ96PU5
PeptideAtlasiQ96PU5
PRIDEiQ96PU5
ProteomicsDBi77752 [Q96PU5-1]
77753 [Q96PU5-2]
77754 [Q96PU5-3]
77755 [Q96PU5-4]
77756 [Q96PU5-5]
77757 [Q96PU5-6]
77758 [Q96PU5-7]
77760 [Q96PU5-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5421, 259 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		23327

Genome annotation databases

EnsembliENST00000256830.13; ENSP00000256830.8; ENSG00000049759.20 [Q96PU5-3]
ENST00000356462.10; ENSP00000348847.5; ENSG00000049759.20 [Q96PU5-2]
ENST00000357895.9; ENSP00000350569.4; ENSG00000049759.20 [Q96PU5-7]
ENST00000382850.8; ENSP00000372301.3; ENSG00000049759.20 [Q96PU5-5]
ENST00000400345.8; ENSP00000383199.2; ENSG00000049759.20
ENST00000431212.6; ENSP00000389406.1; ENSG00000049759.20 [Q96PU5-4]
ENST00000435432.6; ENSP00000393395.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000456173.6; ENSP00000405440.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000456986.5; ENSP00000411947.1; ENSG00000049759.20 [Q96PU5-4]
ENST00000586263.5; ENSP00000468546.1; ENSG00000049759.20 [Q96PU5-6]
ENST00000674517.1; ENSP00000501665.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000675502.1; ENSP00000502428.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000675801.1; ENSP00000502688.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000675865.1; ENSP00000502003.1; ENSG00000049759.20 [Q96PU5-9]
ENST00000676226.1; ENSP00000502325.1; ENSG00000049759.20 [Q96PU5-9]
GeneIDi23327
KEGGihsa:23327
MANE-SelectiENST00000400345.8; ENSP00000383199.2; NM_001144967.3; NP_001138439.1
UCSCiuc002lgx.4, human [Q96PU5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23327
DisGeNETi23327

GeneCards: human genes, protein and diseases

More...GeneCardsi		NEDD4L
HGNCiHGNC:7728, NEDD4L
HPAiENSG00000049759, Low tissue specificity
MalaCardsiNEDD4L
MIMi606384, gene
617201, phenotype
neXtProtiNX_Q96PU5
OpenTargetsiENSG00000049759
Orphaneti98892, Periventricular nodular heterotopia
PharmGKBiPA31534
VEuPathDBiHostDB:ENSG00000049759

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0940, Eukaryota
GeneTreeiENSGT00940000156873
InParanoidiQ96PU5
OMAiPAHIAMQ
OrthoDBi271539at2759
PhylomeDBiQ96PU5
TreeFamiTF323658

Enzyme and pathway databases

UniPathwayiUPA00143
BRENDAi2.3.2.26, 2681
2.3.2.B8, 2681
PathwayCommonsiQ96PU5
ReactomeiR-HSA-162588, Budding and maturation of HIV virion
R-HSA-2173788, Downregulation of TGF-beta receptor signaling
R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2672351, Stimuli-sensing channels
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ96PU5
SIGNORiQ96PU5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23327, 13 hits in 1118 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NEDD4L, human
EvolutionaryTraceiQ96PU5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NEDD4L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23327
PharosiQ96PU5, Tbio

Protein Ontology

More...PROi		PR:Q96PU5
RNActiQ96PU5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000049759, Expressed in forebrain and 226 other tissues
ExpressionAtlasiQ96PU5, baseline and differential
GenevisibleiQ96PU5, HS

Family and domain databases

CDDicd00078, HECTc, 1 hit
cd00201, WW, 4 hits
DisProtiDP02292
Gene3Di2.60.40.150, 1 hit
IDEALiIID00114
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR024928, E3_ub_ligase_SMURF1
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00632, HECT, 1 hit
PF00397, WW, 4 hits
PIRSFiPIRSF001569, E3_ub_ligase_SMURF1, 1 hit
PRINTSiPR00360, C2DOMAIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00119, HECTc, 1 hit
SM00456, WW, 4 hits
SUPFAMiSSF49562, SSF49562, 1 hit
SSF51045, SSF51045, 4 hits
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 4 hits
PS50020, WW_DOMAIN_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNED4L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PU5
Secondary accession number(s): O43165
, Q3LSM7, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 25, 2022
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again