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Entry version 158 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Potassium voltage-gated channel subfamily C member 2

Gene

KCNC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity).By similarity2 Publications1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Stichodactyla helianthus peptide ShK (PubMed:15709110). Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP) (By similarity).By similarity1 Publication1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage-dependent potassium currents, that are rapidly activated during membrane depolarization, i.e within a risetime of a few msec. After that, inactivates very slowly, i.e within about >800 msec. Their activation requires a threshold potential at about -10 mV, with a midpoint activation at about 12.1 mV and a steepness parameter of about 8.4 mV. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, the presence or absence of ancillary subunits and post-translational modifications.1 Publication1 Publication

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionIon channel, Potassium channel, Voltage-gated channel
      Biological processIon transport, Potassium transport, Transport
      LigandPotassium

      Enzyme and pathway databases

      Pathway Commons web resource for biological pathway data

      More...
      PathwayCommonsi
      Q96PR1

      Reactome - a knowledgebase of biological pathways and processes

      More...
      Reactomei
      R-HSA-1296072, Voltage gated Potassium channels
      R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Potassium voltage-gated channel subfamily C member 2Imported
      Alternative name(s):
      Shaw-like potassium channelBy similarity
      Voltage-gated potassium channel Kv3.2By similarity
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:KCNC2Imported
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

      Organism-specific databases

      Eukaryotic Pathogen Database Resources

      More...
      EuPathDBi
      HostDB:ENSG00000166006.12

      Human Gene Nomenclature Database

      More...
      HGNCi
      HGNC:6234, KCNC2

      Online Mendelian Inheritance in Man (OMIM)

      More...
      MIMi
      176256, gene

      neXtProt; the human protein knowledge platform

      More...
      neXtProti
      NX_Q96PR1

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Topology

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 229CytoplasmicSequence analysisAdd BLAST229
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei230 – 250Helical; Name=Segment S1Sequence analysisAdd BLAST21
      Transmembranei284 – 303Helical; Name=Segment S2Sequence analysisAdd BLAST20
      Topological domaini304 – 313CytoplasmicSequence analysis10
      Transmembranei314 – 334Helical; Name=Segment S3Sequence analysisAdd BLAST21
      Transmembranei346 – 368Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST23
      Topological domaini369 – 381CytoplasmicSequence analysisAdd BLAST13
      Transmembranei382 – 402Helical; Name=Segment S5Sequence analysisAdd BLAST21
      Transmembranei453 – 473Helical; Name=Segment S6Sequence analysisAdd BLAST21
      Topological domaini474 – 638CytoplasmicSequence analysisAdd BLAST165

      Keywords - Cellular componenti

      Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

      A chromosomal aberration involving KCNC2 has been found in a mother and her two children with varying degrees of neurodevelopmental delay and cerebellar ataxia. One child also exhibits episodes of unresponsiveness suggestive of absence seizures and facial dysmorphism. Deletion at 12q21.1 deletes exons 3-5 of KCNC2.1 Publication

      Organism-specific databases

      DisGeNET

      More...
      DisGeNETi
      3747

      Open Targets

      More...
      OpenTargetsi
      ENSG00000166006

      The Pharmacogenetics and Pharmacogenomics Knowledge Base

      More...
      PharmGKBi
      PA35490

      Miscellaneous databases

      Pharos NIH Druggable Genome Knowledgebase

      More...
      Pharosi
      Q96PR1, Tclin

      Chemistry databases

      ChEMBL database of bioactive drug-like small molecules

      More...
      ChEMBLi
      CHEMBL2363009

      Drug and drug target database

      More...
      DrugBanki
      DB06637, Dalfampridine
      DB01069, Promethazine

      DrugCentral

      More...
      DrugCentrali
      Q96PR1

      IUPHAR/BPS Guide to PHARMACOLOGY

      More...
      GuidetoPHARMACOLOGYi
      549

      Polymorphism and mutation databases

      BioMuta curated single-nucleotide variation and disease association database

      More...
      BioMutai
      KCNC2

      Domain mapping of disease mutations (DMDM)

      More...
      DMDMi
      74752079

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003104161 – 638Potassium voltage-gated channel subfamily C member 2Add BLAST638

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
      Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
      <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei600PhosphoserineBy similarity1

      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

      Phosphorylated by PKA in cortical synaptosomes. cAMP-dependent phosphorylation inhibits channel activity (By similarity). Histamine H2 receptor- and PKA-induced phosphorylation extends action potential spike duration, reduces action potential spike amplitude, sustains maximum firing frequency in hippocampal interneurons; also reduces the incidence of high-frequency oscillations in hippocampal CA3 pyramidal cell layers.By similarity

      Keywords - PTMi

      Glycoprotein, Phosphoprotein

      Proteomic databases

      MassIVE - Mass Spectrometry Interactive Virtual Environment

      More...
      MassIVEi
      Q96PR1

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      Q96PR1

      PeptideAtlas

      More...
      PeptideAtlasi
      Q96PR1

      PRoteomics IDEntifications database

      More...
      PRIDEi
      Q96PR1

      ProteomicsDB: a multi-organism proteome resource

      More...
      ProteomicsDBi
      25209
      77738 [Q96PR1-1]
      77739 [Q96PR1-2]
      77740 [Q96PR1-3]
      77741 [Q96PR1-4]

      Consortium for Top Down Proteomics

      More...
      TopDownProteomicsi
      Q96PR1-4 [Q96PR1-4]

      PTM databases

      GlyGen: Computational and Informatics Resources for Glycoscience

      More...
      GlyGeni
      Q96PR1, 2 sites

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      Q96PR1

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      Q96PR1

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...
      Bgeei
      ENSG00000166006, Expressed in dorsolateral prefrontal cortex and 67 other tissues

      ExpressionAtlas, Differential and Baseline Expression

      More...
      ExpressionAtlasi
      Q96PR1, baseline and differential

      Genevisible search portal to normalized and curated expression data from Genevestigator

      More...
      Genevisiblei
      Q96PR1, HS

      Organism-specific databases

      Human Protein Atlas

      More...
      HPAi
      ENSG00000166006, Tissue enriched (brain)

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNC1.

      Interacts with KCNC1. Homotetramer or heterotetramer channel activity is regulated by association with modulating ancillary subunits such as KCNE1, KCNE2 and KCNE3, creating a functionally diverse range of channel complexes.

      Interacts with KCNE1, KCNE2 and KCNE3.

      By similarity

      GO - Molecular functioni

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGRID)

      More...
      BioGRIDi
      109949, 1 interactor

      STRING: functional protein association networks

      More...
      STRINGi
      9606.ENSP00000449253

      Miscellaneous databases

      RNAct, Protein-RNA interaction predictions for model organisms.

      More...
      RNActi
      Q96PR1, protein

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Region

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni437 – 442Selectivity filterBy similarity6

      Compositional bias

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 99Gly/Pro-rich (insert)Add BLAST44

      <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

      The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

      <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Keywords - Domaini

      Transmembrane, Transmembrane helix

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      KOG3713, Eukaryota

      Ensembl GeneTree

      More...
      GeneTreei
      ENSGT00940000157371

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      CLU_011722_4_3_1

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      Q96PR1

      KEGG Orthology (KO)

      More...
      KOi
      K04888

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      DMCLGKD

      Database of Orthologous Groups

      More...
      OrthoDBi
      1123666at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      Q96PR1

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF352511

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      1.20.120.350, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR000210, BTB/POZ_dom
      IPR005821, Ion_trans_dom
      IPR003968, K_chnl_volt-dep_Kv
      IPR003974, K_chnl_volt-dep_Kv3
      IPR011333, SKP1/BTB/POZ_sf
      IPR003131, T1-type_BTB
      IPR028325, VG_K_chnl
      IPR027359, Volt_channel_dom_sf

      The PANTHER Classification System

      More...
      PANTHERi
      PTHR11537, PTHR11537, 1 hit

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF02214, BTB_2, 1 hit
      PF00520, Ion_trans, 1 hit

      Protein Motif fingerprint database; a protein domain database

      More...
      PRINTSi
      PR01491, KVCHANNEL
      PR01498, SHAWCHANNEL

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00225, BTB, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF54695, SSF54695, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

      This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

      Isoform 1 (identifier: Q96PR1-1) [UniParc]FASTAAdd to basket
      Also known as: Kv3.2b

      This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

      « Hide
              10         20         30         40         50
      MGKIENNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPPGDCLTTA
      60 70 80 90 100
      GDKLQPSPPP LSPPPRAPPL SPGPGGCFEG GAGNCSSRGG RASDHPGGGR
      110 120 130 140 150
      EFFFDRHPGV FAYVLNYYRT GKLHCPADVC GPLFEEELAF WGIDETDVEP
      160 170 180 190 200
      CCWMTYRQHR DAEEALDIFE TPDLIGGDPG DDEDLAAKRL GIEDAAGLGG
      210 220 230 240 250
      PDGKSGRWRR LQPRMWALFE DPYSSRAARF IAFASLFFIL VSITTFCLET
      260 270 280 290 300
      HEAFNIVKNK TEPVINGTSV VLQYEIETDP ALTYVEGVCV VWFTFEFLVR
      310 320 330 340 350
      IVFSPNKLEF IKNLLNIIDF VAILPFYLEV GLSGLSSKAA KDVLGFLRVV
      360 370 380 390 400
      RFVRILRIFK LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI
      410 420 430 440 450
      YYAERVGAQP NDPSASEHTQ FKNIPIGFWW AVVTMTTLGY GDMYPQTWSG
      460 470 480 490 500
      MLVGALCALA GVLTIAMPVP VIVNNFGMYY SLAMAKQKLP RKRKKHIPPA
      510 520 530 540 550
      PQASSPTFCK TELNMACNST QSDTCLGKDN RLLEHNRSVL SGDDSTGSEP
      560 570 580 590 600
      PLSPPERLPI RRSSTRDKNR RGETCFLLTT GDYTCASDGG IRKGYEKSRS
      610 620 630
      LNNIAGLAGN ALRLSPVTSP YNSPCPLRRS RSPIPSIL
      Length:638
      Mass (Da):70,226
      Last modified:December 1, 2001 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i211CAF8395A58C5D
      GO
      Isoform 2 (identifier: Q96PR1-2) [UniParc]FASTAAdd to basket
      Also known as: Kv3.2d

      The sequence of this isoform differs from the canonical sequence as follows:
           594-638: GYEKSRSLNN...RSRSPIPSIL → VLYRIYHGLL...GNRLLLLNVP

      Show »
      Length:629
      Mass (Da):69,534
      Checksum:iBDDBF6DB6FA0A510
      GO
      Isoform 3 (identifier: Q96PR1-3) [UniParc]FASTAAdd to basket
      Also known as: Kv3.2a

      The sequence of this isoform differs from the canonical sequence as follows:
           594-638: GYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → DNCKEVVITGYTQAEARSLT

      Show »
      Length:613
      Mass (Da):67,600
      Checksum:iD6F4DA8E0659682D
      GO
      Isoform 4 (identifier: Q96PR1-4) [UniParc]FASTAAdd to basket
      Also known as: Kv3.2c

      The sequence of this isoform differs from the canonical sequence as follows:
           539-558: VLSGDDSTGSEPPLSPPERL → DNCKEVVITGYTQAEARSLT
           559-638: Missing.

      Show »
      Length:558
      Mass (Da):61,650
      Checksum:i86AC5B2DAF84AF1B
      GO
      Isoform 5 (identifier: Q96PR1-5) [UniParc]FASTAAdd to basket

      The sequence of this isoform differs from the canonical sequence as follows:
           539-593: Missing.

      Show »
      Length:583
      Mass (Da):64,276
      Checksum:i65A3F7DFA2B7448D
      GO
      Isoform 6 (identifier: Q96PR1-6) [UniParc]FASTAAdd to basket

      The sequence of this isoform differs from the canonical sequence as follows:
           595-638: YEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL → IRNGHSILHHLDNGTKCHYLRIIF

      Show »
      Length:618
      Mass (Da):68,317
      Checksum:i6C333D045C6325C1
      GO

      <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

      There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
      EntryEntry nameProtein names
      Gene namesLengthAnnotation
      A0A3B3ISR9A0A3B3ISR9_HUMAN
      Potassium voltage-gated channel sub...
      KCNC2
      612Annotation score:

      Annotation score:2 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

      <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

      The sequence BAE06076 differs from that shown. Reason: Erroneous initiation.Curated

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31G → V in AK309245 (PubMed:14702039).Curated1
      Sequence conflicti305P → S in BAE06076 (Ref. 4) Curated1
      Sequence conflicti476F → S in BAH11717 (PubMed:14702039).Curated1
      Sequence conflicti487Q → H in AK309245 (PubMed:14702039).Curated1

      Alternative sequence

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044742539 – 593Missing in isoform 5. 1 PublicationAdd BLAST55
      Alternative sequenceiVSP_029269539 – 558VLSGD…PPERL → DNCKEVVITGYTQAEARSLT in isoform 4. 2 PublicationsAdd BLAST20
      Alternative sequenceiVSP_029270559 – 638Missing in isoform 4. 2 PublicationsAdd BLAST80
      Alternative sequenceiVSP_029271594 – 638GYEKS…IPSIL → VLYRIYHGLLTAEKGTVEFS HTKDYTGNRLLLLNVP in isoform 2. 1 PublicationAdd BLAST45
      Alternative sequenceiVSP_029272594 – 638GYEKS…IPSIL → DNCKEVVITGYTQAEARSLT in isoform 3. 1 PublicationAdd BLAST45
      Alternative sequenceiVSP_046002595 – 638YEKSR…IPSIL → IRNGHSILHHLDNGTKCHYL RIIF in isoform 6. 1 PublicationAdd BLAST44

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      AF268896 mRNA Translation: AAL27272.1
      AF268897 mRNA Translation: AAL27273.1
      AY243473 mRNA Translation: AAO89503.1
      AY118169 mRNA Translation: AAM81577.1
      AK094720 mRNA Translation: BAC04407.1
      AK294269 mRNA Translation: BAH11717.1
      AK309245 mRNA No translation available.
      AB209994 mRNA Translation: BAE06076.1 Different initiation.
      AC073525 Genomic DNA No translation available.
      AC091534 Genomic DNA No translation available.
      AC130405 Genomic DNA No translation available.
      CH471054 Genomic DNA Translation: EAW97287.1
      CH471054 Genomic DNA Translation: EAW97288.1
      CH471054 Genomic DNA Translation: EAW97289.1
      CH471054 Genomic DNA Translation: EAW97291.1
      BC093635 mRNA Translation: AAH93635.1
      BC111991 mRNA Translation: AAI11992.1

      The Consensus CDS (CCDS) project

      More...
      CCDSi
      CCDS58255.1 [Q96PR1-5]
      CCDS58256.1 [Q96PR1-2]
      CCDS58257.1 [Q96PR1-6]
      CCDS9005.1 [Q96PR1-3]
      CCDS9006.1 [Q96PR1-4]
      CCDS9007.1 [Q96PR1-1]

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_001247426.1, NM_001260497.1 [Q96PR1-6]
      NP_001247427.1, NM_001260498.1 [Q96PR1-2]
      NP_001247428.1, NM_001260499.1 [Q96PR1-5]
      NP_631874.1, NM_139136.3 [Q96PR1-3]
      NP_631875.1, NM_139137.3 [Q96PR1-1]
      NP_715624.1, NM_153748.2 [Q96PR1-4]
      XP_006719445.1, XM_006719382.3 [Q96PR1-3]

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...
      Ensembli
      ENST00000298972; ENSP00000298972; ENSG00000166006 [Q96PR1-3]
      ENST00000350228; ENSP00000319877; ENSG00000166006 [Q96PR1-4]
      ENST00000393288; ENSP00000376966; ENSG00000166006 [Q96PR1-6]
      ENST00000540018; ENSP00000438423; ENSG00000166006 [Q96PR1-5]
      ENST00000548513; ENSP00000449941; ENSG00000166006 [Q96PR1-3]
      ENST00000549446; ENSP00000449253; ENSG00000166006 [Q96PR1-1]
      ENST00000550433; ENSP00000448301; ENSG00000166006 [Q96PR1-2]

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      3747

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      hsa:3747

      UCSC genome browser

      More...
      UCSCi
      uc001sxe.5, human [Q96PR1-1]

      Keywords - Coding sequence diversityi

      Alternative splicing, Chromosomal rearrangement

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      AF268896 mRNA Translation: AAL27272.1
      AF268897 mRNA Translation: AAL27273.1
      AY243473 mRNA Translation: AAO89503.1
      AY118169 mRNA Translation: AAM81577.1
      AK094720 mRNA Translation: BAC04407.1
      AK294269 mRNA Translation: BAH11717.1
      AK309245 mRNA No translation available.
      AB209994 mRNA Translation: BAE06076.1 Different initiation.
      AC073525 Genomic DNA No translation available.
      AC091534 Genomic DNA No translation available.
      AC130405 Genomic DNA No translation available.
      CH471054 Genomic DNA Translation: EAW97287.1
      CH471054 Genomic DNA Translation: EAW97288.1
      CH471054 Genomic DNA Translation: EAW97289.1
      CH471054 Genomic DNA Translation: EAW97291.1
      BC093635 mRNA Translation: AAH93635.1
      BC111991 mRNA Translation: AAI11992.1
      CCDSiCCDS58255.1 [Q96PR1-5]
      CCDS58256.1 [Q96PR1-2]
      CCDS58257.1 [Q96PR1-6]
      CCDS9005.1 [Q96PR1-3]
      CCDS9006.1 [Q96PR1-4]
      CCDS9007.1 [Q96PR1-1]
      RefSeqiNP_001247426.1, NM_001260497.1 [Q96PR1-6]
      NP_001247427.1, NM_001260498.1 [Q96PR1-2]
      NP_001247428.1, NM_001260499.1 [Q96PR1-5]
      NP_631874.1, NM_139136.3 [Q96PR1-3]
      NP_631875.1, NM_139137.3 [Q96PR1-1]
      NP_715624.1, NM_153748.2 [Q96PR1-4]
      XP_006719445.1, XM_006719382.3 [Q96PR1-3]

      3D structure databases

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      SWISS-MODEL Interactive Workspace

      More...
      SWISS-MODEL-Workspacei
      Submit a new modelling project...

      Protein-protein interaction databases

      BioGRIDi109949, 1 interactor
      STRINGi9606.ENSP00000449253

      Chemistry databases

      ChEMBLiCHEMBL2363009
      DrugBankiDB06637, Dalfampridine
      DB01069, Promethazine
      DrugCentraliQ96PR1
      GuidetoPHARMACOLOGYi549

      PTM databases

      GlyGeniQ96PR1, 2 sites
      iPTMnetiQ96PR1
      PhosphoSitePlusiQ96PR1

      Polymorphism and mutation databases

      BioMutaiKCNC2
      DMDMi74752079

      Proteomic databases

      MassIVEiQ96PR1
      PaxDbiQ96PR1
      PeptideAtlasiQ96PR1
      PRIDEiQ96PR1
      ProteomicsDBi25209
      77738 [Q96PR1-1]
      77739 [Q96PR1-2]
      77740 [Q96PR1-3]
      77741 [Q96PR1-4]
      TopDownProteomicsiQ96PR1-4 [Q96PR1-4]

      Protocols and materials databases

      Antibodypedia a portal for validated antibodies

      More...
      Antibodypediai
      17155, 258 antibodies

      Genome annotation databases

      EnsembliENST00000298972; ENSP00000298972; ENSG00000166006 [Q96PR1-3]
      ENST00000350228; ENSP00000319877; ENSG00000166006 [Q96PR1-4]
      ENST00000393288; ENSP00000376966; ENSG00000166006 [Q96PR1-6]
      ENST00000540018; ENSP00000438423; ENSG00000166006 [Q96PR1-5]
      ENST00000548513; ENSP00000449941; ENSG00000166006 [Q96PR1-3]
      ENST00000549446; ENSP00000449253; ENSG00000166006 [Q96PR1-1]
      ENST00000550433; ENSP00000448301; ENSG00000166006 [Q96PR1-2]
      GeneIDi3747
      KEGGihsa:3747
      UCSCiuc001sxe.5, human [Q96PR1-1]

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      3747
      DisGeNETi3747
      EuPathDBiHostDB:ENSG00000166006.12

      GeneCards: human genes, protein and diseases

      More...
      GeneCardsi
      KCNC2
      HGNCiHGNC:6234, KCNC2
      HPAiENSG00000166006, Tissue enriched (brain)
      MIMi176256, gene
      neXtProtiNX_Q96PR1
      OpenTargetsiENSG00000166006
      PharmGKBiPA35490

      GenAtlas: human gene database

      More...
      GenAtlasi
      Search...

      Phylogenomic databases

      eggNOGiKOG3713, Eukaryota
      GeneTreeiENSGT00940000157371
      HOGENOMiCLU_011722_4_3_1
      InParanoidiQ96PR1
      KOiK04888
      OMAiDMCLGKD
      OrthoDBi1123666at2759
      PhylomeDBiQ96PR1
      TreeFamiTF352511

      Enzyme and pathway databases

      PathwayCommonsiQ96PR1
      ReactomeiR-HSA-1296072, Voltage gated Potassium channels
      R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

      Miscellaneous databases

      BioGRID ORCS database of CRISPR phenotype screens

      More...
      BioGRID-ORCSi
      3747, 9 hits in 866 CRISPR screens

      ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

      More...
      ChiTaRSi
      KCNC2, human

      The Gene Wiki collection of pages on human genes and proteins

      More...
      GeneWikii
      KCNC2

      Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

      More...
      GenomeRNAii
      3747
      PharosiQ96PR1, Tclin

      Protein Ontology

      More...
      PROi
      PR:Q96PR1
      RNActiQ96PR1, protein

      The Stanford Online Universal Resource for Clones and ESTs

      More...
      SOURCEi
      Search...

      Gene expression databases

      BgeeiENSG00000166006, Expressed in dorsolateral prefrontal cortex and 67 other tissues
      ExpressionAtlasiQ96PR1, baseline and differential
      GenevisibleiQ96PR1, HS

      Family and domain databases

      Gene3Di1.20.120.350, 1 hit
      InterProiView protein in InterPro
      IPR000210, BTB/POZ_dom
      IPR005821, Ion_trans_dom
      IPR003968, K_chnl_volt-dep_Kv
      IPR003974, K_chnl_volt-dep_Kv3
      IPR011333, SKP1/BTB/POZ_sf
      IPR003131, T1-type_BTB
      IPR028325, VG_K_chnl
      IPR027359, Volt_channel_dom_sf
      PANTHERiPTHR11537, PTHR11537, 1 hit
      PfamiView protein in Pfam
      PF02214, BTB_2, 1 hit
      PF00520, Ion_trans, 1 hit
      PRINTSiPR01491, KVCHANNEL
      PR01498, SHAWCHANNEL
      SMARTiView protein in SMART
      SM00225, BTB, 1 hit
      SUPFAMiSSF54695, SSF54695, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNC2_HUMAN
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PR1
      Secondary accession number(s): B7Z231
      , F5H030, J3KPP5, Q4LE77, Q86W09, Q8N1V9, Q96PR0
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
      Last sequence update: December 1, 2001
      Last modified: August 12, 2020
      This is version 158 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Reference proteome

      Documents

      1. Human chromosome 12
        Human chromosome 12: entries, gene names and cross-references to MIM
      2. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      3. SIMILARITY comments
        Index of protein domains and families
      UniProt is an ELIXIR core data resource
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