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Protein

Zinc finger protein 317

Gene

ZNF317

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 317
Gene namesi
Name:ZNF317
Synonyms:KIAA1588
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130803.14
HGNCiHGNC:13507 ZNF317
MIMi613864 gene
neXtProtiNX_Q96PQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130803
PharmGKBiPA37793

Polymorphism and mutation databases

BioMutaiZNF317
DMDMi229462794

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475261 – 595Zinc finger protein 317Add BLAST595

Proteomic databases

MaxQBiQ96PQ6
PaxDbiQ96PQ6
PeptideAtlasiQ96PQ6
PRIDEiQ96PQ6
ProteomicsDBi77731
77732 [Q96PQ6-2]
77733 [Q96PQ6-3]
77734 [Q96PQ6-4]

PTM databases

iPTMnetiQ96PQ6
PhosphoSitePlusiQ96PQ6

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.1 Publication

Gene expression databases

BgeeiENSG00000130803 Expressed in 188 organ(s), highest expression level in metanephros
CleanExiHS_ZNF317
ExpressionAtlasiQ96PQ6 baseline and differential
GenevisibleiQ96PQ6 HS

Organism-specific databases

HPAiHPA042075
HPA048625

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121719, 18 interactors
IntActiQ96PQ6, 16 interactors
MINTiQ96PQ6
STRINGi9606.ENSP00000247956

Structurei

3D structure databases

ProteinModelPortaliQ96PQ6
SMRiQ96PQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 128KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129830
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96PQ6
KOiK09228
OMAiWSILMED
OrthoDBiEOG091G02KC
PhylomeDBiQ96PQ6
TreeFamiTF338497

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q96PQ6-1) [UniParc]FASTAAdd to basket
Also known as: ZNF317-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALSPTFAT STQDSTCLQD SEFPVSSKDH SCPQNLDLFV CSGLEPHTPS
60 70 80 90 100
VGSQESVTFQ DVAVDFTEKE WPLLDSSQRK LYKDVMLENY SNLTSLGYQV
110 120 130 140 150
GKPSLISHLE QEEEPRTEER GAHQGACADW ETPSKTKWSL LMEDIFGKET
160 170 180 190 200
PSGVTMERAG LGEKSTEYAH LFEVFGMDPH LTQPMGRHAG KRPYHRRDYG
210 220 230 240 250
VAFKGRPHLT QHMSMYDGRK MHECHQCQKA FTTSASLTRH RRIHTGEKPY
260 270 280 290 300
ECSDCGKAFN DPSALRSHAR THLKEKPFDC SQCGNAFRTL SALKIHMRVH
310 320 330 340 350
TGERPYKCDQ CGKAYGRSCH LIAHKRTHTG ERPYECHDCG KAFQHPSHLK
360 370 380 390 400
EHVRNHTGEK PYACTQCGKA FRWKSNFNLH KKNHMVEKTY ECKECGKSFG
410 420 430 440 450
DLVSRRKHMR IHIVKKPVEC RQCGKTFRNQ SILKTHMNSH TGEKPYGCDL
460 470 480 490 500
CGKAFSASSN LTAHRKIHTQ ERRYECAACG KVFGDYLSRR RHMSVHLVKK
510 520 530 540 550
RVECRQCGKA FRNQSTLKTH MRSHTGEKPY ECDHCGKAFS IGSNLNVHRR
560 570 580 590
IHTGEKPYEC LVCGKAFSDH SSLRSHVKTH RGEKLFVSSV WKRLQ
Length:595
Mass (Da):67,959
Last modified:May 5, 2009 - v2
Checksum:i9AF99586A1882A9D
GO
Isoform 1 (identifier: Q96PQ6-2) [UniParc]FASTAAdd to basket
Also known as: ZNF317-1

The sequence of this isoform differs from the canonical sequence as follows:
     97-128: Missing.

Show »
Length:563
Mass (Da):64,469
Checksum:i33D88D90C952AC9B
GO
Isoform 3 (identifier: Q96PQ6-3) [UniParc]FASTAAdd to basket
Also known as: ZNF317-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     97-128: Missing.

Show »
Length:478
Mass (Da):55,131
Checksum:i3BD1D9ED463B7522
GO
Isoform 4 (identifier: Q96PQ6-4) [UniParc]FASTAAdd to basket
Also known as: ZNF317-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:510
Mass (Da):58,621
Checksum:i3E2AEC20E5B2174B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKT9K7EKT9_HUMAN
Zinc finger protein 317
ZNF317
106Annotation score:
K7ERD6K7ERD6_HUMAN
Zinc finger protein 317
ZNF317
44Annotation score:

Sequence cautioni

The sequence BAB13414 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti409M → I in AAL29182 (PubMed:11688974).Curated1
Sequence conflicti409M → I in AAL29188 (PubMed:11688974).Curated1
Sequence conflicti409M → I in AAL29190 (PubMed:11688974).Curated1
Sequence conflicti409M → I in AAL29191 (PubMed:11688974).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01998019Q → H. Corresponds to variant dbSNP:rs3752199Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069151 – 85Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_00691697 – 128Missing in isoform 1 and isoform 3. 3 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275255 mRNA Translation: AAL29188.1
AF148135 mRNA Translation: AAL29182.1
AF307096 mRNA Translation: AAL29190.1
AF307097 mRNA Translation: AAL29191.1
AB046808 mRNA Translation: BAB13414.1 Different initiation.
CH471106 Genomic DNA Translation: EAW84011.1
BC078154 mRNA Translation: AAH78154.1
CCDSiCCDS12210.1 [Q96PQ6-1]
CCDS54213.1 [Q96PQ6-2]
PIRiJC7779
RefSeqiNP_001177720.1, NM_001190791.1 [Q96PQ6-2]
NP_065984.3, NM_020933.4 [Q96PQ6-1]
UniGeneiHs.465829

Genome annotation databases

EnsembliENST00000247956; ENSP00000247956; ENSG00000130803 [Q96PQ6-1]
ENST00000360385; ENSP00000353554; ENSG00000130803 [Q96PQ6-2]
GeneIDi57693
KEGGihsa:57693
UCSCiuc002mku.4 human [Q96PQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275255 mRNA Translation: AAL29188.1
AF148135 mRNA Translation: AAL29182.1
AF307096 mRNA Translation: AAL29190.1
AF307097 mRNA Translation: AAL29191.1
AB046808 mRNA Translation: BAB13414.1 Different initiation.
CH471106 Genomic DNA Translation: EAW84011.1
BC078154 mRNA Translation: AAH78154.1
CCDSiCCDS12210.1 [Q96PQ6-1]
CCDS54213.1 [Q96PQ6-2]
PIRiJC7779
RefSeqiNP_001177720.1, NM_001190791.1 [Q96PQ6-2]
NP_065984.3, NM_020933.4 [Q96PQ6-1]
UniGeneiHs.465829

3D structure databases

ProteinModelPortaliQ96PQ6
SMRiQ96PQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121719, 18 interactors
IntActiQ96PQ6, 16 interactors
MINTiQ96PQ6
STRINGi9606.ENSP00000247956

PTM databases

iPTMnetiQ96PQ6
PhosphoSitePlusiQ96PQ6

Polymorphism and mutation databases

BioMutaiZNF317
DMDMi229462794

Proteomic databases

MaxQBiQ96PQ6
PaxDbiQ96PQ6
PeptideAtlasiQ96PQ6
PRIDEiQ96PQ6
ProteomicsDBi77731
77732 [Q96PQ6-2]
77733 [Q96PQ6-3]
77734 [Q96PQ6-4]

Protocols and materials databases

DNASUi57693
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247956; ENSP00000247956; ENSG00000130803 [Q96PQ6-1]
ENST00000360385; ENSP00000353554; ENSG00000130803 [Q96PQ6-2]
GeneIDi57693
KEGGihsa:57693
UCSCiuc002mku.4 human [Q96PQ6-1]

Organism-specific databases

CTDi57693
EuPathDBiHostDB:ENSG00000130803.14
GeneCardsiZNF317
HGNCiHGNC:13507 ZNF317
HPAiHPA042075
HPA048625
MIMi613864 gene
neXtProtiNX_Q96PQ6
OpenTargetsiENSG00000130803
PharmGKBiPA37793
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129830
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96PQ6
KOiK09228
OMAiWSILMED
OrthoDBiEOG091G02KC
PhylomeDBiQ96PQ6
TreeFamiTF338497

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF317 human
GenomeRNAii57693
PROiPR:Q96PQ6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130803 Expressed in 188 organ(s), highest expression level in metanephros
CleanExiHS_ZNF317
ExpressionAtlasiQ96PQ6 baseline and differential
GenevisibleiQ96PQ6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN317_HUMAN
AccessioniPrimary (citable) accession number: Q96PQ6
Secondary accession number(s): Q6DCA9
, Q96PM0, Q96PM1, Q96PT2, Q9HCI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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