UniProtKB - Q96PQ6 (ZN317_HUMAN)
Protein
Zinc finger protein 317
Gene
ZNF317
Organism
Homo sapiens (Human)
Status
Functioni
May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96PQ6 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 317 |
Gene namesi | Name:ZNF317 Synonyms:KIAA1588 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13507, ZNF317 |
MIMi | 613864, gene |
neXtProti | NX_Q96PQ6 |
VEuPathDBi | HostDB:ENSG00000130803.14 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57693 |
OpenTargetsi | ENSG00000130803 |
PharmGKBi | PA37793 |
Miscellaneous databases
Pharosi | Q96PQ6, Tdark |
Genetic variation databases
BioMutai | ZNF317 |
DMDMi | 229462794 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047526 | 1 – 595 | Zinc finger protein 317Add BLAST | 595 |
Proteomic databases
jPOSTi | Q96PQ6 |
MassIVEi | Q96PQ6 |
MaxQBi | Q96PQ6 |
PaxDbi | Q96PQ6 |
PeptideAtlasi | Q96PQ6 |
PRIDEi | Q96PQ6 |
ProteomicsDBi | 77731 [Q96PQ6-1] 77732 [Q96PQ6-2] 77733 [Q96PQ6-3] 77734 [Q96PQ6-4] |
PTM databases
iPTMneti | Q96PQ6 |
PhosphoSitePlusi | Q96PQ6 |
Expressioni
Tissue specificityi
Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.1 Publication
Gene expression databases
Bgeei | ENSG00000130803, Expressed in metanephros and 202 other tissues |
ExpressionAtlasi | Q96PQ6, baseline and differential |
Genevisiblei | Q96PQ6, HS |
Organism-specific databases
HPAi | ENSG00000130803, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96PQ6
Isoform 4 [Q96PQ6-4]
With | #Exp. | IntAct |
---|---|---|
KRT40 [Q6A162] | 3 | EBI-10292528,EBI-10171697 |
KRTAP10-9 [P60411] | 3 | EBI-10292528,EBI-10172052 |
Protein-protein interaction databases
BioGRIDi | 121719, 31 interactors |
IntActi | Q96PQ6, 25 interactors |
MINTi | Q96PQ6 |
STRINGi | 9606.ENSP00000247956 |
Miscellaneous databases
RNActi | Q96PQ6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 128 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162241 |
HOGENOMi | CLU_002678_72_0_1 |
InParanoidi | Q96PQ6 |
OMAi | TQQMGRH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96PQ6 |
TreeFami | TF338497 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: Q96PQ6-1) [UniParc]FASTAAdd to basket
Also known as: ZNF317-2
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAALSPTFAT STQDSTCLQD SEFPVSSKDH SCPQNLDLFV CSGLEPHTPS
60 70 80 90 100
VGSQESVTFQ DVAVDFTEKE WPLLDSSQRK LYKDVMLENY SNLTSLGYQV
110 120 130 140 150
GKPSLISHLE QEEEPRTEER GAHQGACADW ETPSKTKWSL LMEDIFGKET
160 170 180 190 200
PSGVTMERAG LGEKSTEYAH LFEVFGMDPH LTQPMGRHAG KRPYHRRDYG
210 220 230 240 250
VAFKGRPHLT QHMSMYDGRK MHECHQCQKA FTTSASLTRH RRIHTGEKPY
260 270 280 290 300
ECSDCGKAFN DPSALRSHAR THLKEKPFDC SQCGNAFRTL SALKIHMRVH
310 320 330 340 350
TGERPYKCDQ CGKAYGRSCH LIAHKRTHTG ERPYECHDCG KAFQHPSHLK
360 370 380 390 400
EHVRNHTGEK PYACTQCGKA FRWKSNFNLH KKNHMVEKTY ECKECGKSFG
410 420 430 440 450
DLVSRRKHMR IHIVKKPVEC RQCGKTFRNQ SILKTHMNSH TGEKPYGCDL
460 470 480 490 500
CGKAFSASSN LTAHRKIHTQ ERRYECAACG KVFGDYLSRR RHMSVHLVKK
510 520 530 540 550
RVECRQCGKA FRNQSTLKTH MRSHTGEKPY ECDHCGKAFS IGSNLNVHRR
560 570 580 590
IHTGEKPYEC LVCGKAFSDH SSLRSHVKTH RGEKLFVSSV WKRLQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EKT9 | K7EKT9_HUMAN | Zinc finger protein 317 | ZNF317 | 106 | Annotation score: | ||
K7ERD6 | K7ERD6_HUMAN | Zinc finger protein 317 | ZNF317 | 44 | Annotation score: |
Sequence cautioni
The sequence BAB13414 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 409 | M → I in AAL29182 (PubMed:11688974).Curated | 1 | |
Sequence conflicti | 409 | M → I in AAL29188 (PubMed:11688974).Curated | 1 | |
Sequence conflicti | 409 | M → I in AAL29190 (PubMed:11688974).Curated | 1 | |
Sequence conflicti | 409 | M → I in AAL29191 (PubMed:11688974).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019980 | 19 | Q → H. Corresponds to variant dbSNP:rs3752199Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006915 | 1 – 85 | Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_006916 | 97 – 128 | Missing in isoform 1 and isoform 3. 3 PublicationsAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF275255 mRNA Translation: AAL29188.1 AF148135 mRNA Translation: AAL29182.1 AF307096 mRNA Translation: AAL29190.1 AF307097 mRNA Translation: AAL29191.1 AB046808 mRNA Translation: BAB13414.1 Different initiation. CH471106 Genomic DNA Translation: EAW84011.1 BC078154 mRNA Translation: AAH78154.1 |
CCDSi | CCDS12210.1 [Q96PQ6-1] CCDS54213.1 [Q96PQ6-2] |
PIRi | JC7779 |
RefSeqi | NP_001177720.1, NM_001190791.1 [Q96PQ6-2] NP_065984.3, NM_020933.4 [Q96PQ6-1] |
Genome annotation databases
Ensembli | ENST00000247956; ENSP00000247956; ENSG00000130803 [Q96PQ6-1] ENST00000360385; ENSP00000353554; ENSG00000130803 [Q96PQ6-2] |
GeneIDi | 57693 |
KEGGi | hsa:57693 |
UCSCi | uc002mku.4, human [Q96PQ6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF275255 mRNA Translation: AAL29188.1 AF148135 mRNA Translation: AAL29182.1 AF307096 mRNA Translation: AAL29190.1 AF307097 mRNA Translation: AAL29191.1 AB046808 mRNA Translation: BAB13414.1 Different initiation. CH471106 Genomic DNA Translation: EAW84011.1 BC078154 mRNA Translation: AAH78154.1 |
CCDSi | CCDS12210.1 [Q96PQ6-1] CCDS54213.1 [Q96PQ6-2] |
PIRi | JC7779 |
RefSeqi | NP_001177720.1, NM_001190791.1 [Q96PQ6-2] NP_065984.3, NM_020933.4 [Q96PQ6-1] |
3D structure databases
SMRi | Q96PQ6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121719, 31 interactors |
IntActi | Q96PQ6, 25 interactors |
MINTi | Q96PQ6 |
STRINGi | 9606.ENSP00000247956 |
PTM databases
iPTMneti | Q96PQ6 |
PhosphoSitePlusi | Q96PQ6 |
Genetic variation databases
BioMutai | ZNF317 |
DMDMi | 229462794 |
Proteomic databases
jPOSTi | Q96PQ6 |
MassIVEi | Q96PQ6 |
MaxQBi | Q96PQ6 |
PaxDbi | Q96PQ6 |
PeptideAtlasi | Q96PQ6 |
PRIDEi | Q96PQ6 |
ProteomicsDBi | 77731 [Q96PQ6-1] 77732 [Q96PQ6-2] 77733 [Q96PQ6-3] 77734 [Q96PQ6-4] |
Protocols and materials databases
Antibodypediai | 24999, 105 antibodies |
DNASUi | 57693 |
Genome annotation databases
Ensembli | ENST00000247956; ENSP00000247956; ENSG00000130803 [Q96PQ6-1] ENST00000360385; ENSP00000353554; ENSG00000130803 [Q96PQ6-2] |
GeneIDi | 57693 |
KEGGi | hsa:57693 |
UCSCi | uc002mku.4, human [Q96PQ6-1] |
Organism-specific databases
CTDi | 57693 |
DisGeNETi | 57693 |
GeneCardsi | ZNF317 |
HGNCi | HGNC:13507, ZNF317 |
HPAi | ENSG00000130803, Low tissue specificity |
MIMi | 613864, gene |
neXtProti | NX_Q96PQ6 |
OpenTargetsi | ENSG00000130803 |
PharmGKBi | PA37793 |
VEuPathDBi | HostDB:ENSG00000130803.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162241 |
HOGENOMi | CLU_002678_72_0_1 |
InParanoidi | Q96PQ6 |
OMAi | TQQMGRH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96PQ6 |
TreeFami | TF338497 |
Enzyme and pathway databases
PathwayCommonsi | Q96PQ6 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 57693, 255 hits in 1017 CRISPR screens |
ChiTaRSi | ZNF317, human |
GenomeRNAii | 57693 |
Pharosi | Q96PQ6, Tdark |
PROi | PR:Q96PQ6 |
RNActi | Q96PQ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130803, Expressed in metanephros and 202 other tissues |
ExpressionAtlasi | Q96PQ6, baseline and differential |
Genevisiblei | Q96PQ6, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN317_HUMAN | |
Accessioni | Q96PQ6Primary (citable) accession number: Q96PQ6 Secondary accession number(s): Q6DCA9 Q9HCI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | May 5, 2009 | |
Last modified: | April 7, 2021 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families