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Protein

Testis-specific serine/threonine-protein kinase 3

Gene

TSSK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in a signaling pathway during male germ cell development or mature sperm function.

Miscellaneous

The mouse homolog is Stk22d.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Activity regulationi

Activated by phosphorylation on Thr-168, potentially by autophosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39ATPPROSITE-ProRule annotation1
Active sitei134Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96PN8

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 3 (EC:2.7.11.1)
Short name:
TSK-3
Short name:
TSSK-3
Short name:
Testis-specific kinase 3
Alternative name(s):
Serine/threonine-protein kinase 22C
Gene namesi
Name:TSSK3
Synonyms:SPOGA3, STK22C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162526.6
HGNCiHGNC:15473 TSSK3
MIMi607660 gene
neXtProtiNX_Q96PN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162526
PharmGKBiPA37964

Chemistry databases

ChEMBLiCHEMBL3414416

Polymorphism and mutation databases

BioMutaiTSSK3
DMDMi30316270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867701 – 268Testis-specific serine/threonine-protein kinase 3Add BLAST268

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96PN8
PaxDbiQ96PN8
PeptideAtlasiQ96PN8
PRIDEiQ96PN8
ProteomicsDBi77723

PTM databases

iPTMnetiQ96PN8
PhosphoSitePlusiQ96PN8

Expressioni

Gene expression databases

BgeeiENSG00000162526 Expressed in 92 organ(s), highest expression level in sperm
CleanExiHS_TSSK3
ExpressionAtlasiQ96PN8 baseline and differential
GenevisibleiQ96PN8 HS

Organism-specific databases

HPAiHPA037516

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123564, 19 interactors
IntActiQ96PN8, 64 interactors
STRINGi9606.ENSP00000362634

Chemistry databases

BindingDBiQ96PN8

Structurei

3D structure databases

ProteinModelPortaliQ96PN8
SMRiQ96PN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 265Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00770000120521
HOGENOMiHOG000233016
HOVERGENiHBG101110
InParanoidiQ96PN8
KOiK08811
OMAiIIRVYEM
OrthoDBiEOG091G0EZI
PhylomeDBiQ96PN8
TreeFamiTF352374

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96PN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDFLLSNGY QLGKTIGEGT YSKVKEAFSK KHQRKVAIKV IDKMGGPEEF
60 70 80 90 100
IQRFLPRELQ IVRTLDHKNI IQVYEMLESA DGKICLVMEL AEGGDVFDCV
110 120 130 140 150
LNGGPLPESR AKALFRQMVE AIRYCHGCGV AHRDLKCENA LLQGFNLKLT
160 170 180 190 200
DFGFAKVLPK SHRELSQTFC GSTAYAAPEV LQGIPHDSKK GDVWSMGVVL
210 220 230 240 250
YVMLCASLPF DDTDIPKMLW QQQKGVSFPT HLSISADCQD LLKRLLEPDM
260
ILRPSIEEVS WHPWLAST
Length:268
Mass (Da):30,102
Last modified:December 1, 2001 - v1
Checksum:iEF91F91DD216F671
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1X4I3L1X4_HUMAN
Testis-specific serine/threonine-pr...
TSSK3
35Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05167871I → V. Corresponds to variant dbSNP:rs35508255Ensembl.1
Natural variantiVAR_041245140A → T1 PublicationCorresponds to variant dbSNP:rs55786268Ensembl.1
Natural variantiVAR_041246235S → L1 PublicationCorresponds to variant dbSNP:rs35457991Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296450 mRNA Translation: AAK97141.1
AY048701 Transcribed RNA Translation: AAL02128.1
AL109945 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07532.1
BC035354 mRNA Translation: AAH35354.1
CCDSiCCDS362.1
RefSeqiNP_443073.1, NM_052841.3
UniGeneiHs.512763

Genome annotation databases

EnsembliENST00000373534; ENSP00000362634; ENSG00000162526
GeneIDi81629
KEGGihsa:81629
UCSCiuc001bvf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296450 mRNA Translation: AAK97141.1
AY048701 Transcribed RNA Translation: AAL02128.1
AL109945 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07532.1
BC035354 mRNA Translation: AAH35354.1
CCDSiCCDS362.1
RefSeqiNP_443073.1, NM_052841.3
UniGeneiHs.512763

3D structure databases

ProteinModelPortaliQ96PN8
SMRiQ96PN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123564, 19 interactors
IntActiQ96PN8, 64 interactors
STRINGi9606.ENSP00000362634

Chemistry databases

BindingDBiQ96PN8
ChEMBLiCHEMBL3414416

PTM databases

iPTMnetiQ96PN8
PhosphoSitePlusiQ96PN8

Polymorphism and mutation databases

BioMutaiTSSK3
DMDMi30316270

Proteomic databases

MaxQBiQ96PN8
PaxDbiQ96PN8
PeptideAtlasiQ96PN8
PRIDEiQ96PN8
ProteomicsDBi77723

Protocols and materials databases

DNASUi81629
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373534; ENSP00000362634; ENSG00000162526
GeneIDi81629
KEGGihsa:81629
UCSCiuc001bvf.4 human

Organism-specific databases

CTDi81629
EuPathDBiHostDB:ENSG00000162526.6
GeneCardsiTSSK3
H-InvDBiHIX0000372
HGNCiHGNC:15473 TSSK3
HPAiHPA037516
MIMi607660 gene
neXtProtiNX_Q96PN8
OpenTargetsiENSG00000162526
PharmGKBiPA37964
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00770000120521
HOGENOMiHOG000233016
HOVERGENiHBG101110
InParanoidiQ96PN8
KOiK08811
OMAiIIRVYEM
OrthoDBiEOG091G0EZI
PhylomeDBiQ96PN8
TreeFamiTF352374

Enzyme and pathway databases

SignaLinkiQ96PN8

Miscellaneous databases

ChiTaRSiTSSK3 human
GenomeRNAii81629
PROiPR:Q96PN8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162526 Expressed in 92 organ(s), highest expression level in sperm
CleanExiHS_TSSK3
ExpressionAtlasiQ96PN8 baseline and differential
GenevisibleiQ96PN8 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSSK3_HUMAN
AccessioniPrimary (citable) accession number: Q96PN8
Secondary accession number(s): Q5TEE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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