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Protein

Transcriptional-regulating factor 1

Gene

TRERF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri512 – 534C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1013 – 1037C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1086 – 1108C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding, bending Source: UniProtKB
  • DNA-binding transcription factor activity Source: UniProtKB
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW
  • nuclear receptor transcription coactivator activity Source: UniProtKB
  • transcription coregulator activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional-regulating factor 1
Alternative name(s):
Breast cancer anti-estrogen resistance 2
Transcriptional-regulating protein 132
Zinc finger protein rapa
Zinc finger transcription factor TReP-132
Gene namesi
Name:TRERF1
Synonyms:BCAR2, RAPA, TREP132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124496.12
HGNCiHGNC:18273 TRERF1
MIMi610322 gene
neXtProtiNX_Q96PN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55809
OpenTargetsiENSG00000124496
PharmGKBiPA134923539

Polymorphism and mutation databases

BioMutaiTRERF1
DMDMi74762683

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971341 – 1200Transcriptional-regulating factor 1Add BLAST1200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei491PhosphoserineCombined sources1
Modified residuei633N6-acetyllysineBy similarity1
Modified residuei640N6-acetyllysineBy similarity1
Modified residuei767PhosphothreonineCombined sources1
Modified residuei954PhosphothreonineCombined sources1
Modified residuei955PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96PN7
MaxQBiQ96PN7
PaxDbiQ96PN7
PeptideAtlasiQ96PN7
PRIDEiQ96PN7
ProteomicsDBi77718
77719 [Q96PN7-2]
77720 [Q96PN7-3]
77721 [Q96PN7-4]
77722 [Q96PN7-5]

PTM databases

iPTMnetiQ96PN7
PhosphoSitePlusiQ96PN7

Expressioni

Tissue specificityi

Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells.1 Publication

Gene expression databases

BgeeiENSG00000124496 Expressed in 167 organ(s), highest expression level in primary visual cortex
CleanExiHS_TRERF1
ExpressionAtlasiQ96PN7 baseline and differential
GenevisibleiQ96PN7 HS

Organism-specific databases

HPAiHPA027771
HPA051273
HPA059943

Interactioni

Subunit structurei

Interacts with CREBBP and EP300 (PubMed:11349124). Interacts with DNTTIP1 (PubMed:16371131, PubMed:21573134). Interacts with DNTT (PubMed:16371131).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120919, 11 interactors
IntActiQ96PN7, 4 interactors
STRINGi9606.ENSP00000362013

Structurei

3D structure databases

ProteinModelPortaliQ96PN7
SMRiQ96PN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini779 – 870ELM2PROSITE-ProRule annotationAdd BLAST92
Domaini885 – 936SANTPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni439 – 1200Interaction with CREBBP1 PublicationAdd BLAST762

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi202 – 417Gln-richAdd BLAST216
Compositional biasi553 – 749Pro-richAdd BLAST197
Compositional biasi956 – 982Glu-richAdd BLAST27

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri512 – 534C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1013 – 1037C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1086 – 1108C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4167 Eukaryota
ENOG4110BKZ LUCA
GeneTreeiENSGT00530000063277
HOVERGENiHBG082398
InParanoidiQ96PN7
PhylomeDBiQ96PN7
TreeFamiTF106431

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA
60 70 80 90 100
SPISPHFPQD TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN
110 120 130 140 150
LANSNMMWGA PAQAEPTDGY QYTYSQASEI RTQKLTSGVL HKLDSFTQVF
160 170 180 190 200
ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA LRQLLSQKPM EPPAPAIPSR
210 220 230 240 250
YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL AQVPVQGGQP
260 270 280 290 300
LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP
310 320 330 340 350
QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS
360 370 380 390 400
YHRDPHQYTP EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ
410 420 430 440 450
QREDSQLKTY SSDRQAQAML SSHGDLGPPD TGMGDPASSD LTRVSSTLPH
460 470 480 490 500
RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM HLPDGRAQPG SPESSGQPKG
510 520 530 540 550
AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS PNLKQEEGEK
560 570 580 590 600
VLPPQPQPPL PPPPPPPPPP QLPPEAESLT PMVMPVSVPV KLLPPKPSSQ
610 620 630 640 650
GFTNSTVAAP SARDKPASSM SDDEMPVLEI PRKHQPSVPK AEEPLKTVQE
660 670 680 690 700
KKKFRHRPEP LFIPPPPSYN PNPAASYSGA TLYQSQLRSP RVLGDHLLLD
710 720 730 740 750
PTHELPPYTP PPMLSPVRQG SGLFSNVLIS GHGPGAHPQL PLTPLTPTPR
760 770 780 790 800
VLLCRSNSID GSNVTVTPGP GEQTVDVEPR INIGLRFQAE IPELQDISAL
810 820 830 840 850
AQDTHKATLV WKPWPELENH DLQQRVENLL NLCCSSALPG GGTNSEFALH
860 870 880 890 900
SLFEAKGDVM VALEMLLLRK PVRLKCHPLA NYHYAGSDKW TSLERKLFNK
910 920 930 940 950
ALATYSKDFI FVQKMVKSKT VAQCVEYYYT WKKIMRLGRK HRTRLAEIID
960 970 980 990 1000
DCVTSEEEEE LEEEEEEDPE EDRKSTKEEE SEVPKSPEPP PVPVLAPTEG
1010 1020 1030 1040 1050
PPLQALGQPS GSFICEMPNC GAVFSSRQAL NGHARIHGGT NQVTKARGAI
1060 1070 1080 1090 1100
PSGKQKPGGT QSGYCSVKSS PSHSTTSGET DPTTIFPCKE CGKVFFKIKS
1110 1120 1130 1140 1150
RNAHMKTHRQ QEEQQRQKAQ KAAFAAEMAA TIERTTGPVG APGLLPLDQL
1160 1170 1180 1190 1200
SLIKPIKDVD ILDDDVVQQL GGVMEEAEVV DTDLLLDDQD SVLLQGDAEL
Length:1,200
Mass (Da):132,256
Last modified:December 1, 2001 - v1
Checksum:iB77057F46A73404F
GO
Isoform 2 (identifier: Q96PN7-2) [UniParc]FASTAAdd to basket
Also known as: Rapa-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     546-628: Missing.

Show »
Length:956
Mass (Da):106,264
Checksum:i7BE77C8D7B10CCF9
GO
Isoform 3 (identifier: Q96PN7-3) [UniParc]FASTAAdd to basket
Also known as: Rapa-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     546-628: Missing.
     1022-1022: A → ADCRCHVTPFLPQ

Show »
Length:968
Mass (Da):107,662
Checksum:iAC9777B930C5BD82
GO
Isoform 4 (identifier: Q96PN7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-628: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,117
Mass (Da):123,601
Checksum:iF0325B9D6F297BBB
GO
Isoform 5 (identifier: Q96PN7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-628: Missing.
     1022-1022: A → ADCRCHVTPFLPQ

Note: Gene prediction based on EST data.
Show »
Length:1,129
Mass (Da):124,999
Checksum:iBDE472412D3DFF89
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q05GC8Q05GC8_HUMAN
Breast cancer anti-estrogen resista...
TRERF1 BCAR2
1,220Annotation score:

Sequence cautioni

The sequence BAA92082 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti658P → S in CAB88206 (Ref. 2) Curated1
Sequence conflicti658P → S in CAB88207 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050197431T → A. Corresponds to variant dbSNP:rs35162277Ensembl.1
Natural variantiVAR_061362766V → I. Corresponds to variant dbSNP:rs59159203Ensembl.1
Natural variantiVAR_050198834C → S. Corresponds to variant dbSNP:rs2295275Ensembl.1
Natural variantiVAR_0501991019N → T. Corresponds to variant dbSNP:rs35978318Ensembl.1
Natural variantiVAR_0502001187D → N. Corresponds to variant dbSNP:rs11751765Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156441 – 161Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_015645546 – 628Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_0156461022A → ADCRCHVTPFLPQ in isoform 3 and isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297872 mRNA Translation: AAL01653.1
AJ277275 mRNA Translation: CAB88206.1
AJ277276 mRNA Translation: CAB88207.1
AM404259 mRNA Translation: CAL49295.1
AM404183 mRNA Translation: CAL49297.1
AL096814 Genomic DNA No translation available.
AK002096 mRNA Translation: BAA92082.1 Different initiation.
CCDSiCCDS4867.1 [Q96PN7-1]
RefSeqiNP_001284502.1, NM_001297573.1
NP_277037.1, NM_033502.3 [Q96PN7-1]
XP_016866538.1, XM_017011049.1 [Q96PN7-1]
XP_016866541.1, XM_017011052.1 [Q96PN7-5]
XP_016866542.1, XM_017011053.1 [Q96PN7-5]
XP_016866543.1, XM_017011054.1 [Q96PN7-4]
UniGeneiHs.485392

Genome annotation databases

EnsembliENST00000340840; ENSP00000339438; ENSG00000124496 [Q96PN7-5]
ENST00000354325; ENSP00000346285; ENSG00000124496 [Q96PN7-4]
ENST00000372917; ENSP00000362008; ENSG00000124496 [Q96PN7-2]
ENST00000372922; ENSP00000362013; ENSG00000124496 [Q96PN7-1]
GeneIDi55809
KEGGihsa:55809
UCSCiuc003osc.3 human [Q96PN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297872 mRNA Translation: AAL01653.1
AJ277275 mRNA Translation: CAB88206.1
AJ277276 mRNA Translation: CAB88207.1
AM404259 mRNA Translation: CAL49295.1
AM404183 mRNA Translation: CAL49297.1
AL096814 Genomic DNA No translation available.
AK002096 mRNA Translation: BAA92082.1 Different initiation.
CCDSiCCDS4867.1 [Q96PN7-1]
RefSeqiNP_001284502.1, NM_001297573.1
NP_277037.1, NM_033502.3 [Q96PN7-1]
XP_016866538.1, XM_017011049.1 [Q96PN7-1]
XP_016866541.1, XM_017011052.1 [Q96PN7-5]
XP_016866542.1, XM_017011053.1 [Q96PN7-5]
XP_016866543.1, XM_017011054.1 [Q96PN7-4]
UniGeneiHs.485392

3D structure databases

ProteinModelPortaliQ96PN7
SMRiQ96PN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120919, 11 interactors
IntActiQ96PN7, 4 interactors
STRINGi9606.ENSP00000362013

PTM databases

iPTMnetiQ96PN7
PhosphoSitePlusiQ96PN7

Polymorphism and mutation databases

BioMutaiTRERF1
DMDMi74762683

Proteomic databases

EPDiQ96PN7
MaxQBiQ96PN7
PaxDbiQ96PN7
PeptideAtlasiQ96PN7
PRIDEiQ96PN7
ProteomicsDBi77718
77719 [Q96PN7-2]
77720 [Q96PN7-3]
77721 [Q96PN7-4]
77722 [Q96PN7-5]

Protocols and materials databases

DNASUi55809
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340840; ENSP00000339438; ENSG00000124496 [Q96PN7-5]
ENST00000354325; ENSP00000346285; ENSG00000124496 [Q96PN7-4]
ENST00000372917; ENSP00000362008; ENSG00000124496 [Q96PN7-2]
ENST00000372922; ENSP00000362013; ENSG00000124496 [Q96PN7-1]
GeneIDi55809
KEGGihsa:55809
UCSCiuc003osc.3 human [Q96PN7-1]

Organism-specific databases

CTDi55809
DisGeNETi55809
EuPathDBiHostDB:ENSG00000124496.12
GeneCardsiTRERF1
HGNCiHGNC:18273 TRERF1
HPAiHPA027771
HPA051273
HPA059943
MIMi610322 gene
neXtProtiNX_Q96PN7
OpenTargetsiENSG00000124496
PharmGKBiPA134923539
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4167 Eukaryota
ENOG4110BKZ LUCA
GeneTreeiENSGT00530000063277
HOVERGENiHBG082398
InParanoidiQ96PN7
PhylomeDBiQ96PN7
TreeFamiTF106431

Miscellaneous databases

ChiTaRSiTRERF1 human
GeneWikiiTRERF1
GenomeRNAii55809
PROiPR:Q96PN7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124496 Expressed in 167 organ(s), highest expression level in primary visual cortex
CleanExiHS_TRERF1
ExpressionAtlasiQ96PN7 baseline and differential
GenevisibleiQ96PN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTREF1_HUMAN
AccessioniPrimary (citable) accession number: Q96PN7
Secondary accession number(s): Q05GC6
, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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