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Entry version 151 (13 Feb 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Transcriptional-regulating factor 1

Gene

TRERF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri512 – 534C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1013 – 1037C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1086 – 1108C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding, bending Source: UniProtKB
  • DNA-binding transcription factor activity Source: UniProtKB
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW
  • nuclear receptor transcription coactivator activity Source: UniProtKB
  • transcription coregulator activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional-regulating factor 1
Alternative name(s):
Breast cancer anti-estrogen resistance 2
Transcriptional-regulating protein 132
Zinc finger protein rapa
Zinc finger transcription factor TReP-132
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRERF1
Synonyms:BCAR2, RAPA, TREP132
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124496.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18273 TRERF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610322 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PN7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55809

Open Targets

More...
OpenTargetsi
ENSG00000124496

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134923539

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRERF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762683

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001971341 – 1200Transcriptional-regulating factor 1Add BLAST1200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei491PhosphoserineCombined sources1
Modified residuei633N6-acetyllysineBy similarity1
Modified residuei640N6-acetyllysineBy similarity1
Modified residuei767PhosphothreonineCombined sources1
Modified residuei954PhosphothreonineCombined sources1
Modified residuei955PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96PN7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96PN7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96PN7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PN7

PeptideAtlas

More...
PeptideAtlasi
Q96PN7

PRoteomics IDEntifications database

More...
PRIDEi
Q96PN7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77718
77719 [Q96PN7-2]
77720 [Q96PN7-3]
77721 [Q96PN7-4]
77722 [Q96PN7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124496 Expressed in 167 organ(s), highest expression level in primary visual cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96PN7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96PN7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027771
HPA051273
HPA059943

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CREBBP and EP300 (PubMed:11349124). Interacts with DNTTIP1 (PubMed:16371131, PubMed:21573134). Interacts with DNTT (PubMed:16371131).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120919, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q96PN7, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362013

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96PN7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96PN7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini779 – 870ELM2PROSITE-ProRule annotationAdd BLAST92
Domaini885 – 936SANTPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni439 – 1200Interaction with CREBBP1 PublicationAdd BLAST762

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi202 – 417Gln-richAdd BLAST216
Compositional biasi553 – 749Pro-richAdd BLAST197
Compositional biasi956 – 982Glu-richAdd BLAST27

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri512 – 534C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1013 – 1037C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1086 – 1108C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4167 Eukaryota
ENOG4110BKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160303

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082398

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PN7

Database of Orthologous Groups

More...
OrthoDBi
165439at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PN7

TreeFam database of animal gene trees

More...
TreeFami
TF106431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448 ELM2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA
60 70 80 90 100
SPISPHFPQD TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN
110 120 130 140 150
LANSNMMWGA PAQAEPTDGY QYTYSQASEI RTQKLTSGVL HKLDSFTQVF
160 170 180 190 200
ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA LRQLLSQKPM EPPAPAIPSR
210 220 230 240 250
YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL AQVPVQGGQP
260 270 280 290 300
LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP
310 320 330 340 350
QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS
360 370 380 390 400
YHRDPHQYTP EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ
410 420 430 440 450
QREDSQLKTY SSDRQAQAML SSHGDLGPPD TGMGDPASSD LTRVSSTLPH
460 470 480 490 500
RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM HLPDGRAQPG SPESSGQPKG
510 520 530 540 550
AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS PNLKQEEGEK
560 570 580 590 600
VLPPQPQPPL PPPPPPPPPP QLPPEAESLT PMVMPVSVPV KLLPPKPSSQ
610 620 630 640 650
GFTNSTVAAP SARDKPASSM SDDEMPVLEI PRKHQPSVPK AEEPLKTVQE
660 670 680 690 700
KKKFRHRPEP LFIPPPPSYN PNPAASYSGA TLYQSQLRSP RVLGDHLLLD
710 720 730 740 750
PTHELPPYTP PPMLSPVRQG SGLFSNVLIS GHGPGAHPQL PLTPLTPTPR
760 770 780 790 800
VLLCRSNSID GSNVTVTPGP GEQTVDVEPR INIGLRFQAE IPELQDISAL
810 820 830 840 850
AQDTHKATLV WKPWPELENH DLQQRVENLL NLCCSSALPG GGTNSEFALH
860 870 880 890 900
SLFEAKGDVM VALEMLLLRK PVRLKCHPLA NYHYAGSDKW TSLERKLFNK
910 920 930 940 950
ALATYSKDFI FVQKMVKSKT VAQCVEYYYT WKKIMRLGRK HRTRLAEIID
960 970 980 990 1000
DCVTSEEEEE LEEEEEEDPE EDRKSTKEEE SEVPKSPEPP PVPVLAPTEG
1010 1020 1030 1040 1050
PPLQALGQPS GSFICEMPNC GAVFSSRQAL NGHARIHGGT NQVTKARGAI
1060 1070 1080 1090 1100
PSGKQKPGGT QSGYCSVKSS PSHSTTSGET DPTTIFPCKE CGKVFFKIKS
1110 1120 1130 1140 1150
RNAHMKTHRQ QEEQQRQKAQ KAAFAAEMAA TIERTTGPVG APGLLPLDQL
1160 1170 1180 1190 1200
SLIKPIKDVD ILDDDVVQQL GGVMEEAEVV DTDLLLDDQD SVLLQGDAEL
Length:1,200
Mass (Da):132,256
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB77057F46A73404F
GO
Isoform 2 (identifier: Q96PN7-2) [UniParc]FASTAAdd to basket
Also known as: Rapa-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     546-628: Missing.

Show »
Length:956
Mass (Da):106,264
Checksum:i7BE77C8D7B10CCF9
GO
Isoform 3 (identifier: Q96PN7-3) [UniParc]FASTAAdd to basket
Also known as: Rapa-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.
     546-628: Missing.
     1022-1022: A → ADCRCHVTPFLPQ

Show »
Length:968
Mass (Da):107,662
Checksum:iAC9777B930C5BD82
GO
Isoform 4 (identifier: Q96PN7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-628: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,117
Mass (Da):123,601
Checksum:iF0325B9D6F297BBB
GO
Isoform 5 (identifier: Q96PN7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-628: Missing.
     1022-1022: A → ADCRCHVTPFLPQ

Note: Gene prediction based on EST data.
Show »
Length:1,129
Mass (Da):124,999
Checksum:iBDE472412D3DFF89
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q05GC8Q05GC8_HUMAN
Breast cancer anti-estrogen resista...
TRERF1 BCAR2
1,220Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92082 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti658P → S in CAB88206 (Ref. 2) Curated1
Sequence conflicti658P → S in CAB88207 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050197431T → A. Corresponds to variant dbSNP:rs35162277Ensembl.1
Natural variantiVAR_061362766V → I. Corresponds to variant dbSNP:rs59159203Ensembl.1
Natural variantiVAR_050198834C → S. Corresponds to variant dbSNP:rs2295275Ensembl.1
Natural variantiVAR_0501991019N → T. Corresponds to variant dbSNP:rs35978318Ensembl.1
Natural variantiVAR_0502001187D → N. Corresponds to variant dbSNP:rs11751765Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0156441 – 161Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_015645546 – 628Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_0156461022A → ADCRCHVTPFLPQ in isoform 3 and isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF297872 mRNA Translation: AAL01653.1
AJ277275 mRNA Translation: CAB88206.1
AJ277276 mRNA Translation: CAB88207.1
AM404259 mRNA Translation: CAL49295.1
AM404183 mRNA Translation: CAL49297.1
AL096814 Genomic DNA No translation available.
AK002096 mRNA Translation: BAA92082.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS4867.1 [Q96PN7-1]

NCBI Reference Sequences

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RefSeqi
NP_001284502.1, NM_001297573.1
NP_277037.1, NM_033502.3 [Q96PN7-1]
XP_016866538.1, XM_017011049.1 [Q96PN7-1]
XP_016866541.1, XM_017011052.1 [Q96PN7-5]
XP_016866542.1, XM_017011053.1 [Q96PN7-5]
XP_016866543.1, XM_017011054.1 [Q96PN7-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.485392

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000340840; ENSP00000339438; ENSG00000124496 [Q96PN7-5]
ENST00000354325; ENSP00000346285; ENSG00000124496 [Q96PN7-4]
ENST00000372917; ENSP00000362008; ENSG00000124496 [Q96PN7-2]
ENST00000372922; ENSP00000362013; ENSG00000124496 [Q96PN7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55809

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55809

UCSC genome browser

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UCSCi
uc003osc.3 human [Q96PN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297872 mRNA Translation: AAL01653.1
AJ277275 mRNA Translation: CAB88206.1
AJ277276 mRNA Translation: CAB88207.1
AM404259 mRNA Translation: CAL49295.1
AM404183 mRNA Translation: CAL49297.1
AL096814 Genomic DNA No translation available.
AK002096 mRNA Translation: BAA92082.1 Different initiation.
CCDSiCCDS4867.1 [Q96PN7-1]
RefSeqiNP_001284502.1, NM_001297573.1
NP_277037.1, NM_033502.3 [Q96PN7-1]
XP_016866538.1, XM_017011049.1 [Q96PN7-1]
XP_016866541.1, XM_017011052.1 [Q96PN7-5]
XP_016866542.1, XM_017011053.1 [Q96PN7-5]
XP_016866543.1, XM_017011054.1 [Q96PN7-4]
UniGeneiHs.485392

3D structure databases

ProteinModelPortaliQ96PN7
SMRiQ96PN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120919, 11 interactors
IntActiQ96PN7, 4 interactors
STRINGi9606.ENSP00000362013

PTM databases

iPTMnetiQ96PN7
PhosphoSitePlusiQ96PN7

Polymorphism and mutation databases

BioMutaiTRERF1
DMDMi74762683

Proteomic databases

EPDiQ96PN7
jPOSTiQ96PN7
MaxQBiQ96PN7
PaxDbiQ96PN7
PeptideAtlasiQ96PN7
PRIDEiQ96PN7
ProteomicsDBi77718
77719 [Q96PN7-2]
77720 [Q96PN7-3]
77721 [Q96PN7-4]
77722 [Q96PN7-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55809
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340840; ENSP00000339438; ENSG00000124496 [Q96PN7-5]
ENST00000354325; ENSP00000346285; ENSG00000124496 [Q96PN7-4]
ENST00000372917; ENSP00000362008; ENSG00000124496 [Q96PN7-2]
ENST00000372922; ENSP00000362013; ENSG00000124496 [Q96PN7-1]
GeneIDi55809
KEGGihsa:55809
UCSCiuc003osc.3 human [Q96PN7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55809
DisGeNETi55809
EuPathDBiHostDB:ENSG00000124496.12

GeneCards: human genes, protein and diseases

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GeneCardsi
TRERF1
HGNCiHGNC:18273 TRERF1
HPAiHPA027771
HPA051273
HPA059943
MIMi610322 gene
neXtProtiNX_Q96PN7
OpenTargetsiENSG00000124496
PharmGKBiPA134923539

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4167 Eukaryota
ENOG4110BKZ LUCA
GeneTreeiENSGT00940000160303
HOVERGENiHBG082398
InParanoidiQ96PN7
OrthoDBi165439at2759
PhylomeDBiQ96PN7
TreeFamiTF106431

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRERF1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRERF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55809

Protein Ontology

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PROi
PR:Q96PN7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124496 Expressed in 167 organ(s), highest expression level in primary visual cortex
ExpressionAtlasiQ96PN7 baseline and differential
GenevisibleiQ96PN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTREF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PN7
Secondary accession number(s): Q05GC6
, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: February 13, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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