UniProtKB - Q96PN6 (ADCYA_HUMAN)
Protein
Adenylate cyclase type 10
Gene
ADCY10
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).By similarity5 Publications
Catalytic activityi
- EC:4.6.1.15 Publications
Cofactori
Mg2+1 Publication4 Publications, Mn2+3 PublicationsNote: Binds 2 magnesium ions per subunit (PubMed:25040695). Is also active with manganese (in vitro) (PubMed:12609998, PubMed:15659711, PubMed:24616449).1 Publication3 Publications
Activity regulationi
Activated by manganese or magnesium ions (PubMed:12609998, PubMed:24616449). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed:12609998, PubMed:15659711, PubMed:24567411). In the presence of manganese ions, the enzyme is inhibited by bicarbonate (PubMed:15659711). In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium (PubMed:15659711). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions (PubMed:15659711, PubMed:25040695).5 Publications
Kineticsi
- KM=0.8 mM for ATP-Mn2+1 Publication
- KM=2.41 mM for Mg2+1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 47 | Magnesium 1PROSITE-ProRule annotation2 Publications1 Publication | 1 | |
Metal bindingi | 47 | Magnesium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 48 | Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Binding sitei | 95 | BicarbonateCombined sources2 Publications | 1 | |
Metal bindingi | 99 | Magnesium 1PROSITE-ProRule annotation2 Publications1 Publication | 1 | |
Metal bindingi | 99 | Magnesium 2PROSITE-ProRule annotation | 1 | |
Binding sitei | 99 | ATPCombined sources2 Publications1 Publication | 1 | |
Binding sitei | 144 | ATPCombined sources2 Publications1 Publication | 1 | |
Binding sitei | 167 | Bicarbonate; via amide nitrogen and carbonyl oxygenCombined sources2 Publications | 1 | |
Binding sitei | 176 | BicarbonateCombined sources2 Publications | 1 | |
Binding sitei | 337 | Bicarbonate; via amide nitrogenCombined sources2 Publications | 1 | |
Binding sitei | 406 | ATP; via carbonyl oxygenCombined sources2 Publications1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 47 – 52 | ATPCombined sources2 Publications1 Publication | 6 | |
Nucleotide bindingi | 412 – 416 | ATP3 Publications | 5 |
GO - Molecular functioni
- adenylate cyclase activity Source: UniProtKB
- ATPase binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- bicarbonate binding Source: UniProtKB
- magnesium ion binding Source: InterPro
- manganese ion binding Source: Ensembl
GO - Biological processi
- cAMP biosynthetic process Source: UniProtKB
- cellular response to inorganic substance Source: UniProtKB
- epithelial cilium movement involved in extracellular fluid movement Source: UniProtKB
- intracellular signal transduction Source: InterPro
- positive regulation of apoptotic process Source: Ensembl
- spermatogenesis Source: InterPro
Keywordsi
Molecular function | Lyase |
Biological process | cAMP biosynthesis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 4.6.1.1, 2681 |
PathwayCommonsi | Q96PN6 |
Reactomei | R-HSA-5610787, Hedgehog 'off' state |
SABIO-RKi | Q96PN6 |
SIGNORi | Q96PN6 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenylate cyclase type 10 (EC:4.6.1.15 Publications)Alternative name(s): AH-related protein Adenylate cyclase homolog Germ cell soluble adenylyl cyclase1 Publication Short name: hsAC Short name: sAC2 Publications Testicular soluble adenylyl cyclase |
Gene namesi | Name:ADCY10 Synonyms:SAC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21285, ADCY10 |
MIMi | 605205, gene |
neXtProti | NX_Q96PN6 |
VEuPathDBi | HostDB:ENSG00000143199.17 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Nucleus
- Nucleus 2 Publications
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytoskeleton
- cytoskeleton 2 Publications
Other locations
- perinuclear region 2 Publications
- cilium 1 Publication
- Cytoplasm 1 Publication
Note: Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.2 Publications
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: GOC
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: Ensembl
Other locations
- basal part of cell Source: Ensembl
- cilium Source: UniProtKB-SubCell
- cytoplasm Source: GO_Central
- dendrite Source: Ensembl
- growth cone Source: Ensembl
- neuronal cell body Source: Ensembl
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Hypercalciuria absorptive 2 (HCA2)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 95 | K → A: Nearly abolishes bicarbonate-mediated increase of enzyme activity. Abolishes bicarbonate-mediated increase of enzyme activity; when associated with A-176. 1 Publication | 1 | |
Mutagenesisi | 176 | R → A: Reduces bicarbonate-mediated increase of enzyme activity. Abolishes bicarbonate-mediated increase of enzyme activity; when associated with A-95. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55811 |
MalaCardsi | ADCY10 |
MIMi | 143870, phenotype |
OpenTargetsi | ENSG00000143199 |
Orphaneti | 2197, Idiopathic hypercalciuria |
PharmGKBi | PA162375618 |
Miscellaneous databases
Pharosi | Q96PN6, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5854 |
GuidetoPHARMACOLOGYi | 3068 |
Genetic variation databases
BioMutai | ADCY10 |
DMDMi | 308153637 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317101 | 1 – 1610 | Adenylate cyclase type 10Add BLAST | 1610 |
Post-translational modificationi
Cleavage may occur to generate the active 48 kDa form.Curated
Proteomic databases
EPDi | Q96PN6 |
MassIVEi | Q96PN6 |
PaxDbi | Q96PN6 |
PeptideAtlasi | Q96PN6 |
PRIDEi | Q96PN6 |
ProteomicsDBi | 24204 77715 [Q96PN6-1] 77716 [Q96PN6-2] 77717 [Q96PN6-3] |
PTM databases
iPTMneti | Q96PN6 |
PhosphoSitePlusi | Q96PN6 |
SwissPalmi | Q96PN6 |
Expressioni
Tissue specificityi
Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.3 Publications
Gene expression databases
Bgeei | ENSG00000143199, Expressed in testis and 97 other tissues |
ExpressionAtlasi | Q96PN6, baseline and differential |
Genevisiblei | Q96PN6, HS |
Organism-specific databases
HPAi | ENSG00000143199, Group enriched (liver, testis) |
Interactioni
GO - Molecular functioni
- ATPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 120921, 2 interactors |
IntActi | Q96PN6, 1 interactor |
STRINGi | 9606.ENSP00000356825 |
Chemistry databases
BindingDBi | Q96PN6 |
Miscellaneous databases
RNActi | Q96PN6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96PN6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 179 | Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST | 138 | |
Domaini | 293 – 418 | Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST | 126 |
Domaini
The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments or isoforms containing the first 470 amino acid residues are fully active.3 Publications
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QPPT, Eukaryota |
GeneTreei | ENSGT00390000001322 |
HOGENOMi | CLU_004055_1_0_1 |
InParanoidi | Q96PN6 |
OMAi | TVDIRLN |
PhylomeDBi | Q96PN6 |
TreeFami | TF329284 |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR016577, Adenylate_cyclase_typ10 IPR029787, Nucleotide_cyclase IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF011131, Soluble_adenylyl_cyclase, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS50125, GUANYLATE_CYCLASE_2, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96PN6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG
60 70 80 90 100
FTAMTEKFSS AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA
110 120 130 140 150
LLALWRVERK QLKNIITVVI KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG
160 170 180 190 200
HISMLVFGDE THSHFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS
210 220 230 240 250
MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY PSGEHKNLLR
260 270 280 290 300
LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM
310 320 330 340 350
FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF
360 370 380 390 400
PGEKVPDELT HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV
410 420 430 440 450
RHEYTVIGQK VNLAARMMMY YPGIVTCDSV TYNGSNLPAY FFKELPKKVM
460 470 480 490 500
KGVADSGPLY QYWGRTEKVM FGMACLICNR KEDYPLLGRN KEINYFMYTM
510 520 530 540 550
KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI IAISLNKISF
560 570 580 590 600
HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF
610 620 630 640 650
HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD
660 670 680 690 700
STSWRFMEKL IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV
710 720 730 740 750
QPNDISNKIC LDLNVSCISK ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL
760 770 780 790 800
VFQQTESEEK TNRTWNNLFK YSIKLTEKLN MVTLHSDKES EEVCHLTSGV
810 820 830 840 850
RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF TTELLFEILP
860 870 880 890 900
CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK
910 920 930 940 950
PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH
960 970 980 990 1000
LKCARFLEED AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG
1010 1020 1030 1040 1050
FKTEEKLILS NSEIPETSAF FPENRSPEEI REKILNFFDH VLTKMKTSDE
1060 1070 1080 1090 1100
DIIPLESCQC EEILEIVILP LAHHFLALGE NDKALYYFLE IASAYLIFCD
1110 1120 1130 1140 1150
NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV CFNMGQIVLA
1160 1170 1180 1190 1200
KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK
1210 1220 1230 1240 1250
RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ
1260 1270 1280 1290 1300
IIKAYLDYSL YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE
1310 1320 1330 1340 1350
TLVFNKLIMG HLDLAIELGS RALQMWALLQ NPNRHYQSLC RLSRCLLLNS
1360 1370 1380 1390 1400
RYPQLIQVLG RLWELSVTQE HIFSKAFFYF VCLDILLYSG FVYRTFEECL
1410 1420 1430 1440 1450
EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY KFSNRAKNLL
1460 1470 1480 1490 1500
PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV
1510 1520 1530 1540 1550
AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK
1560 1570 1580 1590 1600
CWLNMNKESW YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL
1610
MRANTVDNHF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3KPS9 | U3KPS9_HUMAN | Adenylate cyclase type 10 | ADCY10 | 73 | Annotation score: | ||
V9GY51 | V9GY51_HUMAN | Adenylate cyclase type 10 | ADCY10 | 250 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 942 | L → P in BAG64062 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1359 | L → P in AAK96045 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038476 | 234 | T → M. Corresponds to variant dbSNP:rs16859886Ensembl. | 1 | |
Natural variantiVAR_038477 | 697 | I → V3 PublicationsCorresponds to variant dbSNP:rs2071921Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030866 | 1 – 1099 | Missing in isoform 3. 1 PublicationAdd BLAST | 1099 | |
Alternative sequenceiVSP_046329 | 1 – 153 | Missing in isoform 4. 1 PublicationAdd BLAST | 153 | |
Alternative sequenceiVSP_030867 | 1 – 97 | MNTPK…ILKFA → MSLSE in isoform 2. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_030868 | 1100 – 1103 | DNYM → MLFK in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_030869 | 1430 – 1471 | YARLQ…MEGQV → ECEAGVGRRLHTSRDPGMPD FRNGTTFTNFPIELKIFCQE EP in isoform 3. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_030870 | 1472 – 1610 | Missing in isoform 3. 1 PublicationAdd BLAST | 139 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF271058 mRNA Translation: AAF74296.1 AF331033 mRNA Translation: AAL57036.1 AF176813 mRNA Translation: AAF65931.1 AF299350 mRNA Translation: AAK96045.1 AL035122 mRNA Translation: CAA22684.1 AK302884 mRNA Translation: BAG64062.1 Z97876 Genomic DNA No translation available. Z99943 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90804.1 CH471067 Genomic DNA Translation: EAW90807.1 BC117366 mRNA Translation: AAI17367.1 BC117372 mRNA Translation: AAI17373.1 |
CCDSi | CCDS1265.1 [Q96PN6-1] CCDS53426.1 [Q96PN6-4] CCDS72977.1 [Q96PN6-2] |
RefSeqi | NP_001161221.1, NM_001167749.2 [Q96PN6-4] NP_001284701.1, NM_001297772.1 [Q96PN6-2] NP_060887.2, NM_018417.5 [Q96PN6-1] XP_011508062.1, XM_011509760.2 [Q96PN6-1] |
Genome annotation databases
Ensembli | ENST00000367848; ENSP00000356822; ENSG00000143199 [Q96PN6-2] ENST00000367851; ENSP00000356825; ENSG00000143199 [Q96PN6-1] ENST00000545172; ENSP00000441992; ENSG00000143199 [Q96PN6-4] |
GeneIDi | 55811 |
KEGGi | hsa:55811 |
UCSCi | uc001ger.4, human [Q96PN6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF271058 mRNA Translation: AAF74296.1 AF331033 mRNA Translation: AAL57036.1 AF176813 mRNA Translation: AAF65931.1 AF299350 mRNA Translation: AAK96045.1 AL035122 mRNA Translation: CAA22684.1 AK302884 mRNA Translation: BAG64062.1 Z97876 Genomic DNA No translation available. Z99943 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90804.1 CH471067 Genomic DNA Translation: EAW90807.1 BC117366 mRNA Translation: AAI17367.1 BC117372 mRNA Translation: AAI17373.1 |
CCDSi | CCDS1265.1 [Q96PN6-1] CCDS53426.1 [Q96PN6-4] CCDS72977.1 [Q96PN6-2] |
RefSeqi | NP_001161221.1, NM_001167749.2 [Q96PN6-4] NP_001284701.1, NM_001297772.1 [Q96PN6-2] NP_060887.2, NM_018417.5 [Q96PN6-1] XP_011508062.1, XM_011509760.2 [Q96PN6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4CLF | X-ray | 1.70 | A | 1-469 | [»] | |
4CLK | X-ray | 2.20 | A | 1-469 | [»] | |
4CLL | X-ray | 1.70 | A | 1-469 | [»] | |
4CLP | X-ray | 1.90 | A | 1-469 | [»] | |
4CLS | X-ray | 1.85 | A | 1-469 | [»] | |
4CLT | X-ray | 1.95 | A | 1-469 | [»] | |
4CLU | X-ray | 1.90 | A | 1-469 | [»] | |
4CLW | X-ray | 2.15 | A | 1-469 | [»] | |
4CLY | X-ray | 2.05 | A | 1-469 | [»] | |
4CLZ | X-ray | 1.90 | A | 1-469 | [»] | |
4CM0 | X-ray | 3.20 | A | 1-469 | [»] | |
4CM2 | X-ray | 1.80 | A | 1-469 | [»] | |
4OYA | X-ray | 2.03 | A | 1-469 | [»] | |
4OYB | X-ray | 1.70 | A | 1-469 | [»] | |
4OYI | X-ray | 1.70 | A | 1-469 | [»] | |
4OYM | X-ray | 1.70 | A | 1-469 | [»] | |
4OYO | X-ray | 1.75 | A | 1-469 | [»] | |
4OYP | X-ray | 2.28 | A | 1-469 | [»] | |
4OYW | X-ray | 1.70 | A | 1-469 | [»] | |
4OYX | X-ray | 1.89 | A | 1-469 | [»] | |
4OYZ | X-ray | 1.74 | A | 1-469 | [»] | |
4OZ2 | X-ray | 2.10 | A | 1-469 | [»] | |
4OZ3 | X-ray | 1.70 | A | 1-469 | [»] | |
4UST | X-ray | 1.90 | A | 1-469 | [»] | |
4USU | X-ray | 1.95 | A | 1-469 | [»] | |
4USV | X-ray | 2.00 | A | 1-469 | [»] | |
4USW | X-ray | 2.05 | A | 1-469 | [»] | |
5D0R | X-ray | 2.24 | A | 1-469 | [»] | |
5IV3 | X-ray | 1.86 | A | 1-469 | [»] | |
5IV4 | X-ray | 1.79 | A | 1-469 | [»] | |
SMRi | Q96PN6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120921, 2 interactors |
IntActi | Q96PN6, 1 interactor |
STRINGi | 9606.ENSP00000356825 |
Chemistry databases
BindingDBi | Q96PN6 |
ChEMBLi | CHEMBL5854 |
GuidetoPHARMACOLOGYi | 3068 |
PTM databases
iPTMneti | Q96PN6 |
PhosphoSitePlusi | Q96PN6 |
SwissPalmi | Q96PN6 |
Genetic variation databases
BioMutai | ADCY10 |
DMDMi | 308153637 |
Proteomic databases
EPDi | Q96PN6 |
MassIVEi | Q96PN6 |
PaxDbi | Q96PN6 |
PeptideAtlasi | Q96PN6 |
PRIDEi | Q96PN6 |
ProteomicsDBi | 24204 77715 [Q96PN6-1] 77716 [Q96PN6-2] 77717 [Q96PN6-3] |
Protocols and materials databases
Antibodypediai | 3017, 139 antibodies |
Genome annotation databases
Ensembli | ENST00000367848; ENSP00000356822; ENSG00000143199 [Q96PN6-2] ENST00000367851; ENSP00000356825; ENSG00000143199 [Q96PN6-1] ENST00000545172; ENSP00000441992; ENSG00000143199 [Q96PN6-4] |
GeneIDi | 55811 |
KEGGi | hsa:55811 |
UCSCi | uc001ger.4, human [Q96PN6-1] |
Organism-specific databases
CTDi | 55811 |
DisGeNETi | 55811 |
GeneCardsi | ADCY10 |
HGNCi | HGNC:21285, ADCY10 |
HPAi | ENSG00000143199, Group enriched (liver, testis) |
MalaCardsi | ADCY10 |
MIMi | 143870, phenotype 605205, gene |
neXtProti | NX_Q96PN6 |
OpenTargetsi | ENSG00000143199 |
Orphaneti | 2197, Idiopathic hypercalciuria |
PharmGKBi | PA162375618 |
VEuPathDBi | HostDB:ENSG00000143199.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPPT, Eukaryota |
GeneTreei | ENSGT00390000001322 |
HOGENOMi | CLU_004055_1_0_1 |
InParanoidi | Q96PN6 |
OMAi | TVDIRLN |
PhylomeDBi | Q96PN6 |
TreeFami | TF329284 |
Enzyme and pathway databases
BRENDAi | 4.6.1.1, 2681 |
PathwayCommonsi | Q96PN6 |
Reactomei | R-HSA-5610787, Hedgehog 'off' state |
SABIO-RKi | Q96PN6 |
SIGNORi | Q96PN6 |
Miscellaneous databases
BioGRID-ORCSi | 55811, 5 hits in 872 CRISPR screens |
ChiTaRSi | ADCY10, human |
GeneWikii | ADCY10 |
GenomeRNAii | 55811 |
Pharosi | Q96PN6, Tchem |
PROi | PR:Q96PN6 |
RNActi | Q96PN6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143199, Expressed in testis and 97 other tissues |
ExpressionAtlasi | Q96PN6, baseline and differential |
Genevisiblei | Q96PN6, HS |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR016577, Adenylate_cyclase_typ10 IPR029787, Nucleotide_cyclase IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF011131, Soluble_adenylyl_cyclase, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS50125, GUANYLATE_CYCLASE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCYA_HUMAN | |
Accessioni | Q96PN6Primary (citable) accession number: Q96PN6 Secondary accession number(s): B4DZF0 Q9NNX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families