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Protein

Adenylate cyclase type 10

Gene

ADCY10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication4 Publications, Mn2+3 PublicationsNote: Binds 2 magnesium ions per subunit (PubMed:25040695). Is also active with manganese (in vitro) (PubMed:12609998, PubMed:15659711, PubMed:24616449).1 Publication3 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by manganese or magnesium ions (PubMed:12609998, PubMed:24616449). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed:12609998, PubMed:15659711, PubMed:24567411). In the presence of manganese ions, the enzyme is inhibited by bicarbonate (PubMed:15659711). In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium (PubMed:15659711). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions (PubMed:15659711, PubMed:25040695).5 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.8 mM for ATP-Mn2+1 Publication
  2. KM=2.41 mM for Mg2+1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi47Magnesium 1PROSITE-ProRule annotation2 Publications1 Publication1
    Metal bindingi47Magnesium 2PROSITE-ProRule annotation1
    Metal bindingi48Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei95BicarbonateCombined sources2 Publications1
    Metal bindingi99Magnesium 1PROSITE-ProRule annotation2 Publications1 Publication1
    Metal bindingi99Magnesium 2PROSITE-ProRule annotation1
    Binding sitei99ATPCombined sources2 Publications1 Publication1
    Binding sitei144ATPCombined sources2 Publications1 Publication1
    Binding sitei167Bicarbonate; via amide nitrogen and carbonyl oxygenCombined sources2 Publications1
    Binding sitei176BicarbonateCombined sources2 Publications1
    Binding sitei337Bicarbonate; via amide nitrogenCombined sources2 Publications1
    Binding sitei406ATP; via carbonyl oxygenCombined sources2 Publications1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi47 – 52ATPCombined sources2 Publications1 Publication6
    Nucleotide bindingi412 – 416ATP3 Publications5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processcAMP biosynthesis
    LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    4.6.1.1 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-5610787 Hedgehog 'off' state

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q96PN6

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Adenylate cyclase type 10 (EC:4.6.1.15 Publications)
    Alternative name(s):
    AH-related protein
    Adenylate cyclase homolog
    Germ cell soluble adenylyl cyclase1 Publication
    Short name:
    hsAC
    Short name:
    sAC2 Publications
    Testicular soluble adenylyl cyclase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ADCY10
    Synonyms:SAC
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000143199.17

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:21285 ADCY10

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605205 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q96PN6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Hypercalciuria absorptive 2 (HCA2)1 Publication
    Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Disease descriptionA common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis.
    See also OMIM:143870

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi95K → A: Nearly abolishes bicarbonate-mediated increase of enzyme activity. Abolishes bicarbonate-mediated increase of enzyme activity; when associated with A-176. 1 Publication1
    Mutagenesisi176R → A: Reduces bicarbonate-mediated increase of enzyme activity. Abolishes bicarbonate-mediated increase of enzyme activity; when associated with A-95. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    55811

    MalaCards human disease database

    More...
    MalaCardsi
    ADCY10
    MIMi143870 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000143199

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    2197 Idiopathic hypercalciuria

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162375618

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5854

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ADCY10

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    308153637

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003171011 – 1610Adenylate cyclase type 10Add BLAST1610

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Cleavage may occur to generate the active 48 kDa form.Curated

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q96PN6

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q96PN6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q96PN6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q96PN6

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    77715
    77716 [Q96PN6-2]
    77717 [Q96PN6-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q96PN6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q96PN6

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q96PN6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000143199 Expressed in 80 organ(s), highest expression level in sperm

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_ADCY10

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q96PN6 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q96PN6 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA015243
    HPA017749

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000356825

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q96PN6

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    11610
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q96PN6

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q96PN6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 179Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST138
    Domaini293 – 418Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST126

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments or isoforms containing the first 470 amino acid residues are fully active.3 Publications

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IEPA Eukaryota
    ENOG410ZFMC LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000001322

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000060149

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG103835

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q96PN6

    KEGG Orthology (KO)

    More...
    KOi
    K11265

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MRVNILD

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G00BV

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q96PN6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF329284

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.70.1230, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001054 A/G_cyclase
    IPR016577 Adenylate_cyclase_typ10
    IPR029787 Nucleotide_cyclase
    IPR027417 P-loop_NTPase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00211 Guanylate_cyc, 2 hits

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF011131 Soluble_adenylyl_cyclase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 1 hit
    SSF55073 SSF55073, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50125 GUANYLATE_CYCLASE_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q96PN6-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG
    60 70 80 90 100
    FTAMTEKFSS AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA
    110 120 130 140 150
    LLALWRVERK QLKNIITVVI KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG
    160 170 180 190 200
    HISMLVFGDE THSHFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS
    210 220 230 240 250
    MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY PSGEHKNLLR
    260 270 280 290 300
    LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM
    310 320 330 340 350
    FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF
    360 370 380 390 400
    PGEKVPDELT HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV
    410 420 430 440 450
    RHEYTVIGQK VNLAARMMMY YPGIVTCDSV TYNGSNLPAY FFKELPKKVM
    460 470 480 490 500
    KGVADSGPLY QYWGRTEKVM FGMACLICNR KEDYPLLGRN KEINYFMYTM
    510 520 530 540 550
    KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI IAISLNKISF
    560 570 580 590 600
    HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF
    610 620 630 640 650
    HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD
    660 670 680 690 700
    STSWRFMEKL IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV
    710 720 730 740 750
    QPNDISNKIC LDLNVSCISK ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL
    760 770 780 790 800
    VFQQTESEEK TNRTWNNLFK YSIKLTEKLN MVTLHSDKES EEVCHLTSGV
    810 820 830 840 850
    RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF TTELLFEILP
    860 870 880 890 900
    CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK
    910 920 930 940 950
    PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH
    960 970 980 990 1000
    LKCARFLEED AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG
    1010 1020 1030 1040 1050
    FKTEEKLILS NSEIPETSAF FPENRSPEEI REKILNFFDH VLTKMKTSDE
    1060 1070 1080 1090 1100
    DIIPLESCQC EEILEIVILP LAHHFLALGE NDKALYYFLE IASAYLIFCD
    1110 1120 1130 1140 1150
    NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV CFNMGQIVLA
    1160 1170 1180 1190 1200
    KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK
    1210 1220 1230 1240 1250
    RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ
    1260 1270 1280 1290 1300
    IIKAYLDYSL YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE
    1310 1320 1330 1340 1350
    TLVFNKLIMG HLDLAIELGS RALQMWALLQ NPNRHYQSLC RLSRCLLLNS
    1360 1370 1380 1390 1400
    RYPQLIQVLG RLWELSVTQE HIFSKAFFYF VCLDILLYSG FVYRTFEECL
    1410 1420 1430 1440 1450
    EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY KFSNRAKNLL
    1460 1470 1480 1490 1500
    PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV
    1510 1520 1530 1540 1550
    AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK
    1560 1570 1580 1590 1600
    CWLNMNKESW YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL
    1610
    MRANTVDNHF
    Length:1,610
    Mass (Da):187,149
    Last modified:October 5, 2010 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0E205747120EFE0
    GO
    Isoform 2 (identifier: Q96PN6-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: MNTPKEEFQD...IFGGDILKFA → MSLSE

    Note: No experimental confirmation available.
    Show »
    Length:1,518
    Mass (Da):176,591
    Checksum:iA533D2474085BF7E
    GO
    Isoform 3 (identifier: Q96PN6-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1099: Missing.
         1100-1103: DNYM → MLFK
         1430-1471: YARLQEWDNF...GISRYMEGQV → ECEAGVGRRL...ELKIFCQEEP
         1472-1610: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:372
    Mass (Da):43,900
    Checksum:iE645DCFBE8E415A6
    GO
    Isoform 4 (identifier: Q96PN6-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:1,457
    Mass (Da):169,750
    Checksum:iB148D881126ED9A7
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    V9GY51V9GY51_HUMAN
    Adenylate cyclase type 10
    ADCY10
    250Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    U3KPS9U3KPS9_HUMAN
    Adenylate cyclase type 10
    ADCY10
    73Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti942L → P in BAG64062 (PubMed:14702039).Curated1
    Sequence conflicti1359L → P in AAK96045 (Ref. 4) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038476234T → M. Corresponds to variant dbSNP:rs16859886Ensembl.1
    Natural variantiVAR_038477697I → V3 PublicationsCorresponds to variant dbSNP:rs2071921Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0308661 – 1099Missing in isoform 3. 1 PublicationAdd BLAST1099
    Alternative sequenceiVSP_0463291 – 153Missing in isoform 4. 1 PublicationAdd BLAST153
    Alternative sequenceiVSP_0308671 – 97MNTPK…ILKFA → MSLSE in isoform 2. 1 PublicationAdd BLAST97
    Alternative sequenceiVSP_0308681100 – 1103DNYM → MLFK in isoform 3. 1 Publication4
    Alternative sequenceiVSP_0308691430 – 1471YARLQ…MEGQV → ECEAGVGRRLHTSRDPGMPD FRNGTTFTNFPIELKIFCQE EP in isoform 3. 1 PublicationAdd BLAST42
    Alternative sequenceiVSP_0308701472 – 1610Missing in isoform 3. 1 PublicationAdd BLAST139

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF271058 mRNA Translation: AAF74296.1
    AF331033 mRNA Translation: AAL57036.1
    AF176813 mRNA Translation: AAF65931.1
    AF299350 mRNA Translation: AAK96045.1
    AL035122 mRNA Translation: CAA22684.1
    AK302884 mRNA Translation: BAG64062.1
    Z97876 Genomic DNA No translation available.
    Z99943 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW90804.1
    CH471067 Genomic DNA Translation: EAW90807.1
    BC117366 mRNA Translation: AAI17367.1
    BC117372 mRNA Translation: AAI17373.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1265.1 [Q96PN6-1]
    CCDS53426.1 [Q96PN6-4]
    CCDS72977.1 [Q96PN6-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001161221.1, NM_001167749.2 [Q96PN6-4]
    NP_001284701.1, NM_001297772.1 [Q96PN6-2]
    NP_060887.2, NM_018417.5 [Q96PN6-1]
    XP_011508062.1, XM_011509760.2 [Q96PN6-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.320892

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000367848; ENSP00000356822; ENSG00000143199 [Q96PN6-2]
    ENST00000367851; ENSP00000356825; ENSG00000143199 [Q96PN6-1]
    ENST00000545172; ENSP00000441992; ENSG00000143199 [Q96PN6-4]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    55811

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:55811

    UCSC genome browser

    More...
    UCSCi
    uc001ger.4 human [Q96PN6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF271058 mRNA Translation: AAF74296.1
    AF331033 mRNA Translation: AAL57036.1
    AF176813 mRNA Translation: AAF65931.1
    AF299350 mRNA Translation: AAK96045.1
    AL035122 mRNA Translation: CAA22684.1
    AK302884 mRNA Translation: BAG64062.1
    Z97876 Genomic DNA No translation available.
    Z99943 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW90804.1
    CH471067 Genomic DNA Translation: EAW90807.1
    BC117366 mRNA Translation: AAI17367.1
    BC117372 mRNA Translation: AAI17373.1
    CCDSiCCDS1265.1 [Q96PN6-1]
    CCDS53426.1 [Q96PN6-4]
    CCDS72977.1 [Q96PN6-2]
    RefSeqiNP_001161221.1, NM_001167749.2 [Q96PN6-4]
    NP_001284701.1, NM_001297772.1 [Q96PN6-2]
    NP_060887.2, NM_018417.5 [Q96PN6-1]
    XP_011508062.1, XM_011509760.2 [Q96PN6-1]
    UniGeneiHs.320892

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4CLFX-ray1.70A1-469[»]
    4CLKX-ray2.20A1-469[»]
    4CLLX-ray1.70A1-469[»]
    4CLPX-ray1.90A1-469[»]
    4CLSX-ray1.85A1-469[»]
    4CLTX-ray1.95A1-469[»]
    4CLUX-ray1.90A1-469[»]
    4CLWX-ray2.15A1-469[»]
    4CLYX-ray2.05A1-469[»]
    4CLZX-ray1.90A1-469[»]
    4CM0X-ray3.20A1-469[»]
    4CM2X-ray1.80A1-469[»]
    4OYAX-ray2.03A1-469[»]
    4OYBX-ray1.70A1-469[»]
    4OYIX-ray1.70A1-469[»]
    4OYMX-ray1.70A1-469[»]
    4OYOX-ray1.75A1-469[»]
    4OYPX-ray2.28A1-469[»]
    4OYWX-ray1.70A1-469[»]
    4OYXX-ray1.89A1-469[»]
    4OYZX-ray1.74A1-469[»]
    4OZ2X-ray2.10A1-469[»]
    4OZ3X-ray1.70A1-469[»]
    4USTX-ray1.90A1-469[»]
    4USUX-ray1.95A1-469[»]
    4USVX-ray2.00A1-469[»]
    4USWX-ray2.05A1-469[»]
    5D0RX-ray2.24A1-469[»]
    5IV3X-ray1.86A1-469[»]
    5IV4X-ray1.79A1-469[»]
    ProteinModelPortaliQ96PN6
    SMRiQ96PN6
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356825

    Chemistry databases

    BindingDBiQ96PN6
    ChEMBLiCHEMBL5854

    PTM databases

    iPTMnetiQ96PN6
    PhosphoSitePlusiQ96PN6
    SwissPalmiQ96PN6

    Polymorphism and mutation databases

    BioMutaiADCY10
    DMDMi308153637

    Proteomic databases

    EPDiQ96PN6
    PaxDbiQ96PN6
    PeptideAtlasiQ96PN6
    PRIDEiQ96PN6
    ProteomicsDBi77715
    77716 [Q96PN6-2]
    77717 [Q96PN6-3]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000367848; ENSP00000356822; ENSG00000143199 [Q96PN6-2]
    ENST00000367851; ENSP00000356825; ENSG00000143199 [Q96PN6-1]
    ENST00000545172; ENSP00000441992; ENSG00000143199 [Q96PN6-4]
    GeneIDi55811
    KEGGihsa:55811
    UCSCiuc001ger.4 human [Q96PN6-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    55811
    DisGeNETi55811
    EuPathDBiHostDB:ENSG00000143199.17

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ADCY10

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0200024
    HGNCiHGNC:21285 ADCY10
    HPAiHPA015243
    HPA017749
    MalaCardsiADCY10
    MIMi143870 phenotype
    605205 gene
    neXtProtiNX_Q96PN6
    OpenTargetsiENSG00000143199
    Orphaneti2197 Idiopathic hypercalciuria
    PharmGKBiPA162375618

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG410IEPA Eukaryota
    ENOG410ZFMC LUCA
    GeneTreeiENSGT00390000001322
    HOGENOMiHOG000060149
    HOVERGENiHBG103835
    InParanoidiQ96PN6
    KOiK11265
    OMAiMRVNILD
    OrthoDBiEOG091G00BV
    PhylomeDBiQ96PN6
    TreeFamiTF329284

    Enzyme and pathway databases

    BRENDAi4.6.1.1 2681
    ReactomeiR-HSA-5610787 Hedgehog 'off' state
    SIGNORiQ96PN6

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ADCY10 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ADCY10

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    55811

    Protein Ontology

    More...
    PROi
    PR:Q96PN6

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000143199 Expressed in 80 organ(s), highest expression level in sperm
    CleanExiHS_ADCY10
    ExpressionAtlasiQ96PN6 baseline and differential
    GenevisibleiQ96PN6 HS

    Family and domain databases

    Gene3Di3.30.70.1230, 2 hits
    InterProiView protein in InterPro
    IPR001054 A/G_cyclase
    IPR016577 Adenylate_cyclase_typ10
    IPR029787 Nucleotide_cyclase
    IPR027417 P-loop_NTPase
    PfamiView protein in Pfam
    PF00211 Guanylate_cyc, 2 hits
    PIRSFiPIRSF011131 Soluble_adenylyl_cyclase, 1 hit
    SUPFAMiSSF52540 SSF52540, 1 hit
    SSF55073 SSF55073, 2 hits
    PROSITEiView protein in PROSITE
    PS50125 GUANYLATE_CYCLASE_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADCYA_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PN6
    Secondary accession number(s): B4DZF0
    , F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q9NNX0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 5, 2010
    Last modified: December 5, 2018
    This is version 144 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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