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Entry version 160 (29 Sep 2021)
Sequence version 2 (24 Jul 2013)
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Protein

Zinc finger protein 385A

Gene

ZNF385A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri74 – 98Matrin-type 1Add BLAST25
Zinc fingeri201 – 225Matrin-type 2Add BLAST25
Zinc fingeri261 – 285Matrin-type 3Add BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processDNA damage, Transcription, Transcription regulation, Translation regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96PM9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors
R-HSA-69895, Transcriptional activation of cell cycle inhibitor p21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 385A
Alternative name(s):
Hematopoietic zinc finger protein
Retinal zinc finger protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF385A
Synonyms:HZF, RZF, ZNF385
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17521, ZNF385A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609124, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96PM9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000161642

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25946

Open Targets

More...
OpenTargetsi
ENSG00000161642

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162410095

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96PM9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF385A

Domain mapping of disease mutations (DMDM)

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DMDMi
527504071

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475541 – 386Zinc finger protein 385AAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei185PhosphoserineCombined sources1
Modified residuei248PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96PM9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96PM9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PM9

PeptideAtlas

More...
PeptideAtlasi
Q96PM9

PRoteomics IDEntifications database

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PRIDEi
Q96PM9

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
77713 [Q96PM9-4]
77714 [Q96PM9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96PM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in the retina.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by p53/TP53 in response to DNA damage and oxidative stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000161642, Expressed in skin of abdomen and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96PM9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96PM9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000161642, Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ELAVL1; the interaction is indirect, mRNA-dependent and may regulate p53/TP53 expression (By similarity).

Interacts with p53/TP53; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117442, 14 interactors

Protein interaction database and analysis system

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IntActi
Q96PM9, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000338927

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96PM9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96PM9

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni90 – 193DisorderedSequence analysisAdd BLAST104
Regioni145 – 351Necessary for binding to ITPR1, CEBPA and p53/TP53 mRNAsBy similarityAdd BLAST207
Regioni279 – 309DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi100 – 118Basic and acidic residuesSequence analysisAdd BLAST19

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 98Matrin-type 1Add BLAST25
Zinc fingeri201 – 225Matrin-type 2Add BLAST25
Zinc fingeri261 – 285Matrin-type 3Add BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QWH6, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000171694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027876_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PM9

Identification of Orthologs from Complete Genome Data

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OMAi
GDKQHPP

Database of Orthologous Groups

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OrthoDBi
899600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PM9

TreeFam database of animal gene trees

More...
TreeFami
TF326622

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 3 hits
SM00451, ZnF_U1, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q96PM9-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MILGSLSRAG PLPLLRQPPI MQPPLDLKQI LPFPLEPAPT LGLFSNYSTM
60 70 80 90 100
DPVQKAVLSH TFGGPLLKTK RPVISCNICQ IRFNSQSQAE AHYKGNRHAR
110 120 130 140 150
RVKGIEAAKT RGREPGVREP GDPAPPGSTP TNGDGVAPRP VSMENGLGPA
160 170 180 190 200
PGSPEKQPGS PSPPSIPETG QGVTKGEGGT PAPASLPGGS KEEEEKAKRL
210 220 230 240 250
LYCALCKVAV NSLSQLEAHN KGTKHKTILE ARSGLGPIKA YPRLGPPTPG
260 270 280 290 300
EPEAPAQDRT FHCEICNVKV NSEVQLKQHI SSRRHRDGVA GKPNPLLSRH
310 320 330 340 350
KKSRGAGELA GTLTFSKELP KSLAGGLLPS PLAVAAVMAA AAGSPLSLRP
360 370 380
APAAPLLQGP PITHPLLHPA PGPIRTAHGP ILFSPY
Length:386
Mass (Da):40,454
Last modified:July 24, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21290C79D95CD620
GO
Isoform 1 (identifier: Q96PM9-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MILGSLSRAGPLPLLRQPPIM → M

Show »
Length:366
Mass (Da):38,342
Checksum:i8B77BAE4F921EFB6
GO
Isoform 2 (identifier: Q96PM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MILGSLSRAGPLPLLRQPPIM → M
     141-221: Missing.

Show »
Length:285
Mass (Da):30,180
Checksum:i75E46290CA710469
GO
Isoform 3 (identifier: Q96PM9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-221: Missing.

Show »
Length:305
Mass (Da):32,291
Checksum:iB92B9EB18DA73F19
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VRY0F8VRY0_HUMAN
Zinc finger protein 385A
ZNF385A
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI55H0YI55_HUMAN
Zinc finger protein 385A
ZNF385A
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWV6F8VWV6_HUMAN
Zinc finger protein 385A
ZNF385A
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSJ1F8VSJ1_HUMAN
Zinc finger protein 385A
ZNF385A
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQ24F8VQ24_HUMAN
Zinc finger protein 385A
ZNF385A
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VY43F8VY43_HUMAN
Zinc finger protein 385A
ZNF385A
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIX3H0YIX3_HUMAN
Zinc finger protein 385A
ZNF385A
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0474481 – 21MILGS…QPPIM → M in isoform 1 and isoform 2. 4 PublicationsAdd BLAST21
Alternative sequenceiVSP_047449141 – 221Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY461717 mRNA Translation: AAS19275.1
AF304052 mRNA Translation: AAL08625.1
AK024404 mRNA Translation: BAB14910.1
AK296564 mRNA Translation: BAG59184.1
AK315613 mRNA Translation: BAG37982.1
CR457327 mRNA Translation: CAG33608.1
AB593085 mRNA Translation: BAJ84025.1
AC078778 Genomic DNA No translation available.
AC079313 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96777.1
BC029752 mRNA Translation: AAH29752.1
AL117462 mRNA Translation: CAB55938.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44910.1 [Q96PM9-3]
CCDS44911.1 [Q96PM9-4]
CCDS76563.1 [Q96PM9-2]
CCDS8879.1 [Q96PM9-1]

Protein sequence database of the Protein Information Resource

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PIRi
T17248

NCBI Reference Sequences

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RefSeqi
NP_001124439.1, NM_001130967.2 [Q96PM9-4]
NP_001124440.1, NM_001130968.2 [Q96PM9-3]
NP_001276930.1, NM_001290001.1 [Q96PM9-2]
NP_001276931.1, NM_001290002.1 [Q96PM9-1]
NP_001276933.1, NM_001290004.1 [Q96PM9-1]
NP_056296.1, NM_015481.2 [Q96PM9-1]
XP_005268840.1, XM_005268783.4 [Q96PM9-1]
XP_006719405.1, XM_006719342.2 [Q96PM9-1]
XP_016874663.1, XM_017019174.1 [Q96PM9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338010; ENSP00000338927; ENSG00000161642 [Q96PM9-4]
ENST00000352268; ENSP00000293385; ENSG00000161642 [Q96PM9-3]
ENST00000394313; ENSP00000377849; ENSG00000161642 [Q96PM9-1]
ENST00000546970; ENSP00000446913; ENSG00000161642 [Q96PM9-1]
ENST00000551109; ENSP00000449161; ENSG00000161642 [Q96PM9-1]
ENST00000551771; ENSP00000447162; ENSG00000161642 [Q96PM9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25946

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25946

UCSC genome browser

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UCSCi
uc001sfw.2, human [Q96PM9-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461717 mRNA Translation: AAS19275.1
AF304052 mRNA Translation: AAL08625.1
AK024404 mRNA Translation: BAB14910.1
AK296564 mRNA Translation: BAG59184.1
AK315613 mRNA Translation: BAG37982.1
CR457327 mRNA Translation: CAG33608.1
AB593085 mRNA Translation: BAJ84025.1
AC078778 Genomic DNA No translation available.
AC079313 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96777.1
BC029752 mRNA Translation: AAH29752.1
AL117462 mRNA Translation: CAB55938.1
CCDSiCCDS44910.1 [Q96PM9-3]
CCDS44911.1 [Q96PM9-4]
CCDS76563.1 [Q96PM9-2]
CCDS8879.1 [Q96PM9-1]
PIRiT17248
RefSeqiNP_001124439.1, NM_001130967.2 [Q96PM9-4]
NP_001124440.1, NM_001130968.2 [Q96PM9-3]
NP_001276930.1, NM_001290001.1 [Q96PM9-2]
NP_001276931.1, NM_001290002.1 [Q96PM9-1]
NP_001276933.1, NM_001290004.1 [Q96PM9-1]
NP_056296.1, NM_015481.2 [Q96PM9-1]
XP_005268840.1, XM_005268783.4 [Q96PM9-1]
XP_006719405.1, XM_006719342.2 [Q96PM9-1]
XP_016874663.1, XM_017019174.1 [Q96PM9-1]

3D structure databases

SMRiQ96PM9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117442, 14 interactors
IntActiQ96PM9, 3 interactors
STRINGi9606.ENSP00000338927

PTM databases

iPTMnetiQ96PM9
PhosphoSitePlusiQ96PM9

Genetic variation databases

BioMutaiZNF385A
DMDMi527504071

Proteomic databases

jPOSTiQ96PM9
MassIVEiQ96PM9
PaxDbiQ96PM9
PeptideAtlasiQ96PM9
PRIDEiQ96PM9
ProteomicsDBi77713 [Q96PM9-4]
77714 [Q96PM9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
15350, 112 antibodies

The DNASU plasmid repository

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DNASUi
25946

Genome annotation databases

EnsembliENST00000338010; ENSP00000338927; ENSG00000161642 [Q96PM9-4]
ENST00000352268; ENSP00000293385; ENSG00000161642 [Q96PM9-3]
ENST00000394313; ENSP00000377849; ENSG00000161642 [Q96PM9-1]
ENST00000546970; ENSP00000446913; ENSG00000161642 [Q96PM9-1]
ENST00000551109; ENSP00000449161; ENSG00000161642 [Q96PM9-1]
ENST00000551771; ENSP00000447162; ENSG00000161642 [Q96PM9-2]
GeneIDi25946
KEGGihsa:25946
UCSCiuc001sfw.2, human [Q96PM9-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25946
DisGeNETi25946

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF385A
HGNCiHGNC:17521, ZNF385A
HPAiENSG00000161642, Tissue enhanced (skin)
MIMi609124, gene
neXtProtiNX_Q96PM9
OpenTargetsiENSG00000161642
PharmGKBiPA162410095
VEuPathDBiHostDB:ENSG00000161642

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QWH6, Eukaryota
GeneTreeiENSGT00940000171694
HOGENOMiCLU_027876_1_0_1
InParanoidiQ96PM9
OMAiGDKQHPP
OrthoDBi899600at2759
PhylomeDBiQ96PM9
TreeFamiTF326622

Enzyme and pathway databases

PathwayCommonsiQ96PM9
ReactomeiR-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors
R-HSA-69895, Transcriptional activation of cell cycle inhibitor p21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
25946, 10 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF385A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25946
PharosiQ96PM9, Tbio

Protein Ontology

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PROi
PR:Q96PM9
RNActiQ96PM9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161642, Expressed in skin of abdomen and 209 other tissues
ExpressionAtlasiQ96PM9, baseline and differential
GenevisibleiQ96PM9, HS

Family and domain databases

InterProiView protein in InterPro
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 3 hits
SM00451, ZnF_U1, 3 hits
SUPFAMiSSF57667, SSF57667, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ385A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PM9
Secondary accession number(s): B2RDN5
, B4DKH2, F1T0F1, J3KNS3, Q5VH53, Q9H7R6, Q9UFU3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 24, 2013
Last modified: September 29, 2021
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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