RCHY1

Functionⁱ

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.7 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	13 – 80	CHY-typePROSITE-ProRule annotationAdd BLAST	68
Zinc fingerⁱ	82 – 144	CTCHY-typePROSITE-ProRule annotationAdd BLAST	63
Zinc fingerⁱ	145 – 189	RING-typePROSITE-ProRule annotationAdd BLAST	45

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	2.3.2.B10, 2681 6.3.2.19, 2681
PathwayCommonsⁱ	Q96PM5
Reactomeⁱ	R-HSA-110320, Translesion Synthesis by POLH R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q96PM5
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RING finger and CHY zinc finger domain-containing protein 1 (EC:2.3.2.27) Alternative name(s): Androgen receptor N-terminal-interacting protein CH-rich-interacting match with PLAG1 E3 ubiquitin-protein ligase Pirh2 RING finger protein 199 RING-type E3 ubiquitin transferase RCHY1 Zinc finger protein 363 p53-induced RING-H2 protein Short name: hPirh2
Gene namesⁱ	Name:RCHY1 Synonyms:ARNIP, CHIMP, PIRH2, RNF199, ZNF363
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163743.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17479, RCHY1
MIMⁱ	607680, gene
neXtProtⁱ	NX_Q96PM5

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	176	M → E: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication		1
Mutagenesisⁱ	186	C → A: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25898
Open Targets More...OpenTargetsⁱ	ENSG00000163743
PharmGKBⁱ	PA38240

Miscellaneous databases

Pharosⁱ	Q96PM5, Tbio

Pharosⁱ

Q96PM5, Tbio

Polymorphism and mutation databases

BioMutaⁱ	RCHY1
DMDMⁱ	32700008

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056312	1 – 261	RING finger and CHY zinc finger domain-containing protein 1Add BLAST		261

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	257	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.2 Publications

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96PM5
jPOSTⁱ	Q96PM5
MassIVEⁱ	Q96PM5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96PM5
PaxDbⁱ	Q96PM5
PeptideAtlas More...PeptideAtlasⁱ	Q96PM5
PRIDEⁱ	Q96PM5
ProteomicsDBⁱ	16915 18304 61327 77709 [Q96PM5-1] 77710 [Q96PM5-2] 77711 [Q96PM5-3]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q96PM5

REPRODUCTION-2DPAGEⁱ

Q96PM5

PTM databases

iPTMnetⁱ	Q96PM5
PhosphoSitePlusⁱ	Q96PM5

Expressionⁱ

Inductionⁱ

Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase.

Gene expression databases

Bgeeⁱ	ENSG00000163743, Expressed in sperm and 250 other tissues
ExpressionAtlasⁱ	Q96PM5, baseline and differential
Genevisibleⁱ	Q96PM5, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000163743, Low tissue specificity

HPAⁱ

ENSG00000163743, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer.

Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1.

8 Publications

Binary interactionsⁱ

Hide details

Q96PM5

With	#Exp.	IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]	3	EBI-947779,EBI-10173507
AIG1 [Q9NVV5]	4	EBI-947779,EBI-3942989
ANGPTL8 [Q6UXH0]	2	EBI-947779,EBI-3943039
ARF4 [P18085]	3	EBI-947779,EBI-1237085
CALM3 [P0DP25]	2	EBI-947779,EBI-397435
CREB5 - isoform 3 [Q02930-3]	3	EBI-947779,EBI-10192698
HRG [P04196]	3	EBI-947779,EBI-3915012
KLHL41 [O60662]	6	EBI-947779,EBI-5353084
KRTAP9-2 [Q9BYQ4]	3	EBI-947779,EBI-1044640
LIMS2 - isoform 5 [Q7Z4I7-5]	3	EBI-947779,EBI-10257651
MEOX2 [P50222]	3	EBI-947779,EBI-748397
NKD2 [Q969F2]	2	EBI-947779,EBI-1538629
NLK [Q9UBE8]	5	EBI-947779,EBI-366978
NOTCH2NLA [Q7Z3S9]	4	EBI-947779,EBI-945833
SEMA4C [Q9C0C4]	3	EBI-947779,EBI-10303490
TP53 [P04637]	11	EBI-947779,EBI-366083
UBASH3B [Q8TF42]	6	EBI-947779,EBI-1380492
WDR74 [Q6RFH5]	3	EBI-947779,EBI-722366

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	117406, 96 interactors
Database of interacting proteins More...DIPⁱ	DIP-43981N
IntActⁱ	Q96PM5, 53 interactors
Molecular INTeraction database More...MINTⁱ	Q96PM5
STRINGⁱ	9606.ENSP00000321239

Miscellaneous databases

RNActⁱ	Q96PM5, protein

RNActⁱ

Q96PM5, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	26 – 30	Combined sources	5
Turnⁱ	32 – 34	Combined sources	3
Beta strandⁱ	37 – 40	Combined sources	4
Helixⁱ	41 – 47	Combined sources	7
Beta strandⁱ	48 – 50	Combined sources	3
Turnⁱ	54 – 56	Combined sources	3
Beta strandⁱ	59 – 62	Combined sources	4
Turnⁱ	63 – 65	Combined sources	3
Beta strandⁱ	68 – 71	Combined sources	4
Turnⁱ	76 – 78	Combined sources	3
Beta strandⁱ	84 – 87	Combined sources	4
Turnⁱ	88 – 91	Combined sources	4
Beta strandⁱ	92 – 94	Combined sources	3
Beta strandⁱ	100 – 102	Combined sources	3
Turnⁱ	103 – 106	Combined sources	4
Beta strandⁱ	107 – 110	Combined sources	4
Turnⁱ	113 – 115	Combined sources	3
Beta strandⁱ	116 – 119	Combined sources	4
Turnⁱ	120 – 123	Combined sources	4
Beta strandⁱ	124 – 127	Combined sources	4
Turnⁱ	128 – 132	Combined sources	5
Turnⁱ	146 – 149	Combined sources	4
Turnⁱ	156 – 158	Combined sources	3
Beta strandⁱ	159 – 161	Combined sources	3
Beta strandⁱ	167 – 169	Combined sources	3
Helixⁱ	170 – 179	Combined sources	10
Helixⁱ	184 – 187	Combined sources	4
Beta strandⁱ	217 – 225	Combined sources	9
Beta strandⁱ	228 – 232	Combined sources	5
Turnⁱ	241 – 243	Combined sources	3
Beta strandⁱ	248 – 251	Combined sources	4

Show more details

3D structure databases

BMRBⁱ	Q96PM5
SMRⁱ	Q96PM5
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96PM5

EvolutionaryTraceⁱ

Q96PM5

Family & Domainsⁱ

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	13 – 80	CHY-typePROSITE-ProRule annotationAdd BLAST	68
Zinc fingerⁱ	82 – 144	CTCHY-typePROSITE-ProRule annotationAdd BLAST	63
Zinc fingerⁱ	145 – 189	RING-typePROSITE-ProRule annotationAdd BLAST	45

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1940, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008853
HOGENOMⁱ	CLU_013368_3_0_1
InParanoidⁱ	Q96PM5
OMAⁱ	TCFDDMV
Database of Orthologous Groups More...OrthoDBⁱ	1303946at2759
PhylomeDBⁱ	Q96PM5
TreeFamⁱ	TF323762

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR039512, RCHY1_zinc-ribbon IPR008913, Znf_CHY IPR037274, Znf_CHY_sf IPR017921, Znf_CTCHY IPR037275, Znf_CTCHY_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05495, zf-CHY, 1 hit PF13639, zf-RING_2, 1 hit PF14599, zinc_ribbon_6, 1 hit
SMARTⁱ	View protein in SMART SM00184, RING, 1 hit
SUPFAMⁱ	SSF161219, SSF161219, 1 hit SSF161245, SSF161245, 1 hit
PROSITEⁱ	View protein in PROSITE PS51266, ZF_CHY, 1 hit PS51270, ZF_CTCHY, 1 hit PS50089, ZF_RING_2, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96PM5-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH 
        60         70         80         90        100
QLDRFKVKEV QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY 
       110        120        130        140        150
HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV SRQNCPICLE 
       160        170        180        190        200
DIHTSRVVAH VLPCGHLLHR TCYEEMLKEG YRCPLCMHSA LDMTRYWRQL 
       210        220        230        240        250
DDEVAQTPMP SEYQNMTVDI LCNDCNGRST VQFHILGMKC KICESYNTAQ 
       260 
AGGRRISLDQ Q

Length:261

Mass (Da):30,110

Last modified:December 1, 2001 - v1

Checksum:ⁱAC03786F6B42A03D

GO

Isoform 2 (identifier: Q96PM5-2) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
171-179: Missing.

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH 
        60         70         80         90        100
QLDRFKVKEV QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY 
       110        120        130        140        150
HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV SRQNCPICLE 
       160        170        180        190        200
DIHTSRVVAH VLPCGHLLHR GYRCPLCMHS ALDMTRYWRQ LDDEVAQTPM 
       210        220        230        240        250
PSEYQNMTVD ILCNDCNGRS TVQFHILGMK CKICESYNTA QAGGRRISLD 

QQ

Show »

Length:252

Mass (Da):28,983

Checksum:ⁱ0079B97723751278

GO

Isoform 3 (identifier: Q96PM5-3) [UniParc]FASTA Add to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
180-261: Missing.

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH 
        60         70         80         90        100
QLDRFKVKEV QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY 
       110        120        130        140        150
HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV SRQNCPICLE 
       160        170 
DIHTSRVVAH VLPCGHLLHR TCYEEMLKE

Show »

Length:179

Mass (Da):20,720

Checksum:ⁱB38F75D4374FA2F8

GO

Isoform 4 (identifier: Q96PM5-4) [UniParc]FASTA Add to basket

Also known as: Pirh2b

The sequence of this isoform differs from the canonical sequence as follows:
180-261: GYRCPLCMHS...GGRRISLDQQ → YDQVLETAG

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH 
        60         70         80         90        100
QLDRFKVKEV QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY 
       110        120        130        140        150
HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV SRQNCPICLE 
       160        170        180 
DIHTSRVVAH VLPCGHLLHR TCYEEMLKEY DQVLETAG

Note: No ubiquitin protein ligase activity. Down-regulated in hepatocellular carcinoma.Curated

Show »

Length:188

Mass (Da):21,697

Checksum:ⁱ0DEFC07DCEDBA3A7

GO

Isoform 5 (identifier: Q96PM5-5) [UniParc]FASTA Add to basket

Also known as: Pirh2D

The sequence of this isoform differs from the canonical sequence as follows:
68-75: IQHAQQTC → NSTCPTDL
76-261: Missing.

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH 
        60         70 
QLDRFKVKEV QCINCEKNST CPTDL

Show »

Length:75

Mass (Da):8,494

Checksum:ⁱ2FE97DE89608DE6D

GO

Isoform 6 (identifier: Q96PM5-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-30: MAATAREDGASGQERGQRGCEHYDRGCLLK → MAPAVKSE

« Hide

        10         20         30         40         50
MAPAVKSEAP CCDKLYTCRL CHDNNEDHQL DRFKVKEVQC INCEKIQHAQ 
        60         70         80         90        100
QTCEECSTLF GEYYCDICHL FDKDKKQYHC ENCGICRIGP KEDFFHCLKC 
       110        120        130        140        150
NLCLAMNLQG RHKCIENVSR QNCPICLEDI HTSRVVAHVL PCGHLLHRTC 
       160        170        180        190        200
YEEMLKEGYR CPLCMHSALD MTRYWRQLDD EVAQTPMPSE YQNMTVDILC 
       210        220        230 
NDCNGRSTVQ FHILGMKCKI CESYNTAQAG GRRISLDQQ

Show »

Length:239

Mass (Da):27,676

Checksum:ⁱ0DD872A14E2E217A

GO

Isoform 7 (identifier: Q96PM5-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
31-70: Missing.

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK AQQTCEECST LFGEYYCDIC 
        60         70         80         90        100
HLFDKDKKQY HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV 
       110        120        130        140        150
SRQNCPICLE DIHTSRVVAH VLPCGHLLHR TCYEEMLKEG YRCPLCMHSA 
       160        170        180        190        200
LDMTRYWRQL DDEVAQTPMP SEYQNMTVDI LCNDCNGRST VQFHILGMKC 
       210        220 
KICESYNTAQ AGGRRISLDQ Q

Note: Gene prediction based on partial mRNA data.Curated

Show »

Length:221

Mass (Da):25,337

Checksum:ⁱ7B96797039B25C4D

GO

Isoform 8 (identifier: Q96PM5-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
31-70: Missing.
171-179: Missing.

« Hide

        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK AQQTCEECST LFGEYYCDIC 
        60         70         80         90        100
HLFDKDKKQY HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV 
       110        120        130        140        150
SRQNCPICLE DIHTSRVVAH VLPCGHLLHR GYRCPLCMHS ALDMTRYWRQ 
       160        170        180        190        200
LDDEVAQTPM PSEYQNMTVD ILCNDCNGRS TVQFHILGMK CKICESYNTA 
       210 
QAGGRRISLD QQ

Show »

Length:212

Mass (Da):24,210

Checksum:ⁱA4EA203D3FBB7F21

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YAI4	H0YAI4_HUMAN	RING finger and CHY zinc finger dom... RING finger and CHY zinc finger domain-containing protein 1	RCHY1	111	Annotation score:
D6RAF6	D6RAF6_HUMAN	RING finger and CHY zinc finger dom... RING finger and CHY zinc finger domain-containing protein 1	RCHY1	107	Annotation score:

Sequence cautionⁱ

The sequence BAD92309 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	11 – 13	SGQ → TGE in ACT35531 (PubMed:19483087).Curated	3
Sequence conflictⁱ	11 – 13	SGQ → TGE in ACT35532 (PubMed:19483087).Curated	3
Sequence conflictⁱ	11 – 13	SGQ → TGE in ACT35533 (PubMed:19483087).Curated	3
Sequence conflictⁱ	11 – 13	SGQ → TGE in AAK96896 (Ref. 3) Curated	3
Sequence conflictⁱ	142	R → Q in AAH47393 (PubMed:15489334).Curated	1
Sequence conflictⁱ	220	I → F in BAD92309 (Ref. 8) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053787	1 – 30	MAATA…GCLLK → MAPAVKSE in isoform 6. CuratedAdd BLAST	30
Alternative sequenceⁱVSP_053788	31 – 70	Missing in isoform 7 and isoform 8. CuratedAdd BLAST	40
Alternative sequenceⁱVSP_053385	68 – 75	IQHAQQTC → NSTCPTDL in isoform 5. 1 Publication	8
Alternative sequenceⁱVSP_053386	76 – 261	Missing in isoform 5. 1 PublicationAdd BLAST	186
Alternative sequenceⁱVSP_038467	171 – 179	Missing in isoform 2 and isoform 8. 1 Publication	9
Alternative sequenceⁱVSP_038468	180 – 261	Missing in isoform 3. 1 PublicationAdd BLAST	82
Alternative sequenceⁱVSP_044085	180 – 261	GYRCP…SLDQQ → YDQVLETAG in isoform 4. 1 PublicationAdd BLAST	82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ250944 mRNA Translation: ACT35531.1 GQ250945 mRNA Translation: ACT35532.1 GQ250946 mRNA Translation: ACT35533.1 AF247041 mRNA Translation: AAL76101.1 AF255666 mRNA Translation: AAK96896.1 AF305424 mRNA Translation: AAL09356.1 AB209072 mRNA Translation: BAD92309.1 Different initiation. AY888047 mRNA Translation: AAX78233.1 GU937000 mRNA Translation: ADD21555.1 AK091501 mRNA Translation: BAG52375.1 AC096759 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05725.1 BC047393 mRNA Translation: AAH47393.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34012.1 [Q96PM5-2] CCDS3567.1 [Q96PM5-1] CCDS63990.1 [Q96PM5-8] CCDS63991.1 [Q96PM5-7] CCDS63992.1 [Q96PM5-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001009922.1, NM_001009922.2 [Q96PM5-2] NP_001265465.1, NM_001278536.1 [Q96PM5-7] NP_001265466.1, NM_001278537.1 [Q96PM5-8] NP_001265467.1, NM_001278538.1 [Q96PM5-6] NP_056251.2, NM_015436.3 [Q96PM5-1]

Genome annotation databases

Ensemblⁱ	ENST00000324439; ENSP00000321239; ENSG00000163743 [Q96PM5-1] ENST00000380840; ENSP00000370220; ENSG00000163743 [Q96PM5-7] ENST00000505105; ENSP00000424631; ENSG00000163743 [Q96PM5-4] ENST00000507014; ENSP00000424472; ENSG00000163743 [Q96PM5-8] ENST00000512706; ENSP00000423976; ENSG00000163743 [Q96PM5-6] ENST00000513257; ENSP00000421084; ENSG00000163743 [Q96PM5-2]
GeneIDⁱ	25898
KEGGⁱ	hsa:25898
UCSC genome browser More...UCSCⁱ	uc003hik.4, human [Q96PM5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96PM5	RING finger and CHY zinc finger domain-containing protein 1 isoform 1		MACMU		261	UniRef100_Q96PM5
RCHY1 isoform 1		PONAB		261
Uncharacterized protein		CERAT		261
Uncharacterized protein		PAPAN		261
Uncharacterized protein		AOTNA		261
+12
Q96PM5-2	RING finger and CHY zinc finger domain-containing protein 1 isoform 3		MACMU		252	UniRef100_A0A1D5QPM7
RCHY1 isoform 9		PONAB		252
Uncharacterized protein		CERAT		252
Uncharacterized protein		PAPAN		252
Uncharacterized protein		AOTNA		252
+6
Q96PM5-3	RING finger and CHY zinc finger domain-containing protein 1		HUMAN		107	UniRef100_D6RAF6
RING finger and CHY zinc finger domain-containing protein 1 isoform X1		SAPAP		264
Uncharacterized protein		Cebus capucinus imitator		261
RCHY1 isoform 6		PONAB		107
RING finger and CHY zinc finger domain-containing protein 1 isoform X3		SAPAP		134
Q96PM5-4	RCHY1 isoform 4		PONAB		188	UniRef100_A0A2J8UU18
Q96PM5-6	RCHY1 isoform 7		PONAB		239	UniRef100_A0A2J8UU12
RCHY1 isoform 7		PANTR		239
Q96PM5-7	RCHY1 isoform 2		PONAB		221	UniRef100_A0A2J8UU21
Uncharacterized protein		CERAT		221
Uncharacterized protein		AOTNA		221
Uncharacterized protein		PAPAN		221
Uncharacterized protein		MANLE		221
+5
Q96PM5-8	RCHY1 isoform 8		PONAB		212	UniRef100_A0A2J8UU09

Protein	Similar proteins		Species	Score	Length	Source
Q96PM5	RING finger and CHY zinc finger domain-containing protein 1 isoform 1		MACMU		261	UniRef90_Q96PM5
RCHY1 isoform 1		PONAB		261
Uncharacterized protein		CERAT		261
Uncharacterized protein		PAPAN		261
Uncharacterized protein		AOTNA		261
+85
Q96PM5-2	Ring finger and CHY zinc finger domain containing 1		OTOGA		252	UniRef90_H0XWN1
RING finger and CHY zinc finger domain-containing protein 1 isoform 1		CALJA		270
RING finger and CHY zinc finger domain-containing protein 1		CAMDR		261
RING finger and CHY zinc finger domain-containing protein 1 isoform X2		VICPA		134
Ring finger and CHY zinc finger domain containing 1		PANTR		252
+23
Q96PM5-4	RCHY1 isoform 4		PONAB		188	UniRef90_A0A2J8UU18
RCHY1 isoform 4		PANTR		188
Q96PM5-6	Uncharacterized protein		PROCO		231	UniRef90_A0A2K6GIV1
RCHY1 isoform 7		PONAB		239
RCHY1 isoform 7		PANTR		239
RING finger and CHY zinc finge domain-containing protein 1-like protein (Fragment)		HORSE		233
+8
Q96PM5-7	Ring finger and CHY zinc finger domain containing 1		CANLF		219	UniRef90_J9P7H1
Ring finger and CHY zinc finger domain containing 1		FELCA		221
RING finger and CHY zinc finger domain-containing protein 1 isoform X3		PUMCO		224
RING finger and CHY zinc finger domain-containing protein 1 isoform X2		PANPR		224
Uncharacterized protein		LYNCA		221
+57

Protein	Similar proteins		Species	Score	Length	Source
Q96PM5	RING finger and CHY zinc finger domain-containing protein 1	)	MOUSE		261	UniRef50_Q96PM5
RING finger and CHY zinc finger domain-containing protein 1 isoform 1		MACMU		261
RCHY1 isoform 1		PONAB		261
Uncharacterized protein		CERAT		261
Uncharacterized protein		PAPAN		261
+339
Q96PM5-4	RING finger and CHY zinc finger domain-containing protein 1		ERIEU		179	UniRef50_A0A1S2ZII0
RCHY1 isoform 4		PANTR		188
RCHY1 isoform 4		PONAB		188
+2
Q96PM5-7	Ring finger and CHY zinc finger domain containing 1		CANLF		259	UniRef50_J9NZR5
RING finger and CHY zinc finger domain-containing protein 1		PTEAL		261
RING finger and CHY zinc finger domain-containing protein 1 isoform X1		PTEVA		261
Uncharacterized protein		LATCH		238
Uncharacterized protein		OREAU		264
+239

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ250944 mRNA Translation: ACT35531.1 GQ250945 mRNA Translation: ACT35532.1 GQ250946 mRNA Translation: ACT35533.1 AF247041 mRNA Translation: AAL76101.1 AF255666 mRNA Translation: AAK96896.1 AF305424 mRNA Translation: AAL09356.1 AB209072 mRNA Translation: BAD92309.1 Different initiation. AY888047 mRNA Translation: AAX78233.1 GU937000 mRNA Translation: ADD21555.1 AK091501 mRNA Translation: BAG52375.1 AC096759 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05725.1 BC047393 mRNA Translation: AAH47393.1
CCDSⁱ	CCDS34012.1 [Q96PM5-2] CCDS3567.1 [Q96PM5-1] CCDS63990.1 [Q96PM5-8] CCDS63991.1 [Q96PM5-7] CCDS63992.1 [Q96PM5-6]
RefSeqⁱ	NP_001009922.1, NM_001009922.2 [Q96PM5-2] NP_001265465.1, NM_001278536.1 [Q96PM5-7] NP_001265466.1, NM_001278537.1 [Q96PM5-8] NP_001265467.1, NM_001278538.1 [Q96PM5-6] NP_056251.2, NM_015436.3 [Q96PM5-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JRJ	NMR	-	A	138-189	[»]
	2K2C	NMR	-	A	1-137	[»]
	2K2D	NMR	-	A	187-261	[»]
BMRBⁱ	Q96PM5
SMRⁱ	Q96PM5
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	117406, 96 interactors
DIPⁱ	DIP-43981N
IntActⁱ	Q96PM5, 53 interactors
MINTⁱ	Q96PM5
STRINGⁱ	9606.ENSP00000321239

PTM databases

iPTMnetⁱ	Q96PM5
PhosphoSitePlusⁱ	Q96PM5

Polymorphism and mutation databases

BioMutaⁱ	RCHY1
DMDMⁱ	32700008

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q96PM5

REPRODUCTION-2DPAGEⁱ

Q96PM5

Proteomic databases

EPDⁱ	Q96PM5
jPOSTⁱ	Q96PM5
MassIVEⁱ	Q96PM5
MaxQBⁱ	Q96PM5
PaxDbⁱ	Q96PM5
PeptideAtlasⁱ	Q96PM5
PRIDEⁱ	Q96PM5
ProteomicsDBⁱ	16915 18304 61327 77709 [Q96PM5-1] 77710 [Q96PM5-2] 77711 [Q96PM5-3]

Protocols and materials databases

Antibodypediaⁱ	24650, 184 antibodies
The DNASU plasmid repository More...DNASUⁱ	25898

Genome annotation databases

Ensemblⁱ	ENST00000324439; ENSP00000321239; ENSG00000163743 [Q96PM5-1] ENST00000380840; ENSP00000370220; ENSG00000163743 [Q96PM5-7] ENST00000505105; ENSP00000424631; ENSG00000163743 [Q96PM5-4] ENST00000507014; ENSP00000424472; ENSG00000163743 [Q96PM5-8] ENST00000512706; ENSP00000423976; ENSG00000163743 [Q96PM5-6] ENST00000513257; ENSP00000421084; ENSG00000163743 [Q96PM5-2]
GeneIDⁱ	25898
KEGGⁱ	hsa:25898
UCSCⁱ	uc003hik.4, human [Q96PM5-1]

Organism-specific databases

CTDⁱ	25898
DisGeNETⁱ	25898
EuPathDBⁱ	HostDB:ENSG00000163743.13
GeneCardsⁱ	RCHY1
HGNCⁱ	HGNC:17479, RCHY1
HPAⁱ	ENSG00000163743, Low tissue specificity
MIMⁱ	607680, gene
neXtProtⁱ	NX_Q96PM5
OpenTargetsⁱ	ENSG00000163743
PharmGKBⁱ	PA38240
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1940, Eukaryota
GeneTreeⁱ	ENSGT00390000008853
HOGENOMⁱ	CLU_013368_3_0_1
InParanoidⁱ	Q96PM5
OMAⁱ	TCFDDMV
OrthoDBⁱ	1303946at2759
PhylomeDBⁱ	Q96PM5
TreeFamⁱ	TF323762

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BRENDAⁱ	2.3.2.B10, 2681 6.3.2.19, 2681
PathwayCommonsⁱ	Q96PM5
Reactomeⁱ	R-HSA-110320, Translesion Synthesis by POLH R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q96PM5

Miscellaneous databases

BioGRID-ORCSⁱ	25898, 6 hits in 850 CRISPR screens
ChiTaRSⁱ	RCHY1, human
EvolutionaryTraceⁱ	Q96PM5
GeneWikiⁱ	RCHY1
GenomeRNAiⁱ	25898
Pharosⁱ	Q96PM5, Tbio
Protein Ontology More...PROⁱ	PR:Q96PM5
RNActⁱ	Q96PM5, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163743, Expressed in sperm and 250 other tissues
ExpressionAtlasⁱ	Q96PM5, baseline and differential
Genevisibleⁱ	Q96PM5, HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR039512, RCHY1_zinc-ribbon IPR008913, Znf_CHY IPR037274, Znf_CHY_sf IPR017921, Znf_CTCHY IPR037275, Znf_CTCHY_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF05495, zf-CHY, 1 hit PF13639, zf-RING_2, 1 hit PF14599, zinc_ribbon_6, 1 hit
SMARTⁱ	View protein in SMART SM00184, RING, 1 hit
SUPFAMⁱ	SSF161219, SSF161219, 1 hit SSF161245, SSF161245, 1 hit
PROSITEⁱ	View protein in PROSITE PS51266, ZF_CHY, 1 hit PS51270, ZF_CTCHY, 1 hit PS50089, ZF_RING_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN363_HUMAN
Accessionⁱ	Q96PM5Primary (citable) accession number: Q96PM5 Secondary accession number(s): B3KRG3 Q96PR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	December 1, 2001
	Last modified:	December 2, 2020
	This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q96PM5 (ZN363_HUMAN)

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RING finger and CHY zinc finger domain-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q96PM5

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ