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UniProtKB - Q96PM5 (ZN363_HUMAN)

Protein

RING finger and CHY zinc finger domain-containing protein 1

Gene

RCHY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri13 – 80CHY-typePROSITE-ProRule annotationAdd BLAST68
Zinc fingeri82 – 144CTCHY-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri145 – 189RING-typePROSITE-ProRule annotationAdd BLAST45

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • p53 binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.B10 2681
6.3.2.19 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110320 Translesion Synthesis by POLH
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96PM5

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING finger and CHY zinc finger domain-containing protein 1 (EC:2.3.2.27)
Alternative name(s):
Androgen receptor N-terminal-interacting protein
CH-rich-interacting match with PLAG1
E3 ubiquitin-protein ligase Pirh2
RING finger protein 199
RING-type E3 ubiquitin transferase RCHY1
Zinc finger protein 363
p53-induced RING-H2 protein
Short name:
hPirh2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RCHY1
Synonyms:ARNIP, CHIMP, PIRH2, RNF199, ZNF363
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163743.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:17479 RCHY1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607680 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96PM5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi176M → E: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication1
Mutagenesisi186C → A: Abolishes E3 ubiquitin-protein ligase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		25898

Open Targets

More...OpenTargetsi		ENSG00000163743

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38240

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RCHY1

Domain mapping of disease mutations (DMDM)

More...DMDMi		32700008

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000563121 – 261RING finger and CHY zinc finger domain-containing protein 1Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei257PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96PM5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96PM5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96PM5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96PM5

PeptideAtlas

More...PeptideAtlasi		Q96PM5

PRoteomics IDEntifications database

More...PRIDEi		Q96PM5

ProteomicsDB human proteome resource

More...ProteomicsDBi		77709
77710 [Q96PM5-2]
77711 [Q96PM5-3]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		Q96PM5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96PM5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96PM5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163743 Expressed in 236 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...CleanExi		HS_RCHY1

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96PM5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96PM5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA030339

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1.8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117406, 84 interactors

Database of interacting proteins

More...DIPi		DIP-43981N

Protein interaction database and analysis system

More...IntActi		Q96PM5, 51 interactors

Molecular INTeraction database

More...MINTi		Q96PM5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000321239

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRJNMR-A138-189[»]
2K2CNMR-A1-137[»]
2K2DNMR-A187-261[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q96PM5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96PM5

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96PM5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 80CHY-typePROSITE-ProRule annotationAdd BLAST68
Zinc fingeri82 – 144CTCHY-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri145 – 189RING-typePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1940 Eukaryota
ENOG410XXHF LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008853

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231827

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG062959

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96PM5

KEGG Orthology (KO)

More...KOi		K10144

Identification of Orthologs from Complete Genome Data

More...OMAi		GMKCNIC

Database of Orthologous Groups

More...OrthoDBi		1303946at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96PM5

TreeFam database of animal gene trees

More...TreeFami		TF323762

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039512 RCHY1_zinc-ribbon
IPR008913 Znf_CHY
IPR037274 Znf_CHY_sf
IPR017921 Znf_CTCHY
IPR037275 Znf_CTCHY_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05495 zf-CHY, 1 hit
PF13639 zf-RING_2, 1 hit
PF14599 zinc_ribbon_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161219 SSF161219, 1 hit
SSF161245 SSF161245, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51266 ZF_CHY, 1 hit
PS51270 ZF_CTCHY, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PM5-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH 
        60         70         80         90        100
QLDRFKVKEV QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY 
       110        120        130        140        150
HCENCGICRI GPKEDFFHCL KCNLCLAMNL QGRHKCIENV SRQNCPICLE 
       160        170        180        190        200
DIHTSRVVAH VLPCGHLLHR TCYEEMLKEG YRCPLCMHSA LDMTRYWRQL 
       210        220        230        240        250
DDEVAQTPMP SEYQNMTVDI LCNDCNGRST VQFHILGMKC KICESYNTAQ 
       260 
AGGRRISLDQ Q
Length:261
Mass (Da):30,110
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC03786F6B42A03D
GO
Isoform 2 (identifier: Q96PM5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     171-179: Missing.

Show »
Length:252
Mass (Da):28,983
Checksum:i0079B97723751278
GO
Isoform 3 (identifier: Q96PM5-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     180-261: Missing.

Show »
Length:179
Mass (Da):20,720
Checksum:iB38F75D4374FA2F8
GO
Isoform 4 (identifier: Q96PM5-4) [UniParc]FASTAAdd to basket
Also known as: Pirh2b

The sequence of this isoform differs from the canonical sequence as follows:
     180-261: GYRCPLCMHS...GGRRISLDQQ → YDQVLETAG

Note: No ubiquitin protein ligase activity. Down-regulated in hepatocellular carcinoma.
Show »
Length:188
Mass (Da):21,697
Checksum:i0DEFC07DCEDBA3A7
GO
Isoform 5 (identifier: Q96PM5-5) [UniParc]FASTAAdd to basket
Also known as: Pirh2D

The sequence of this isoform differs from the canonical sequence as follows:
     68-75: IQHAQQTC → NSTCPTDL
     76-261: Missing.

Show »
Length:75
Mass (Da):8,494
Checksum:i2FE97DE89608DE6D
GO
Isoform 6 (identifier: Q96PM5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MAATAREDGASGQERGQRGCEHYDRGCLLK → MAPAVKSE

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:239
Mass (Da):27,676
Checksum:i0DD872A14E2E217A
GO
Isoform 7 (identifier: Q96PM5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-70: Missing.

Note: No experimental confirmation available. Gene prediction based on partial mRNA data.
Show »
Length:221
Mass (Da):25,337
Checksum:i7B96797039B25C4D
GO
Isoform 8 (identifier: Q96PM5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-70: Missing.
     171-179: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:212
Mass (Da):24,210
Checksum:iA4EA203D3FBB7F21
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAF6D6RAF6_HUMAN
RING finger and CHY zinc finger dom...
RCHY1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAI4H0YAI4_HUMAN
RING finger and CHY zinc finger dom...
RCHY1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92309 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11 – 13SGQ → TGE in ACT35531 (PubMed:19483087).Curated3
Sequence conflicti11 – 13SGQ → TGE in ACT35532 (PubMed:19483087).Curated3
Sequence conflicti11 – 13SGQ → TGE in ACT35533 (PubMed:19483087).Curated3
Sequence conflicti11 – 13SGQ → TGE in AAK96896 (Ref. 3) Curated3
Sequence conflicti142R → Q in AAH47393 (PubMed:15489334).Curated1
Sequence conflicti220I → F in BAD92309 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537871 – 30MAATA…GCLLK → MAPAVKSE in isoform 6. CuratedAdd BLAST30
Alternative sequenceiVSP_05378831 – 70Missing in isoform 7 and isoform 8. CuratedAdd BLAST40
Alternative sequenceiVSP_05338568 – 75IQHAQQTC → NSTCPTDL in isoform 5. 1 Publication8
Alternative sequenceiVSP_05338676 – 261Missing in isoform 5. 1 PublicationAdd BLAST186
Alternative sequenceiVSP_038467171 – 179Missing in isoform 2 and isoform 8. 1 Publication9
Alternative sequenceiVSP_038468180 – 261Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_044085180 – 261GYRCP…SLDQQ → YDQVLETAG in isoform 4. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GQ250944 mRNA Translation: ACT35531.1
GQ250945 mRNA Translation: ACT35532.1
GQ250946 mRNA Translation: ACT35533.1
AF247041 mRNA Translation: AAL76101.1
AF255666 mRNA Translation: AAK96896.1
AF305424 mRNA Translation: AAL09356.1
AB209072 mRNA Translation: BAD92309.1 Different initiation.
AY888047 mRNA Translation: AAX78233.1
GU937000 mRNA Translation: ADD21555.1
AK091501 mRNA Translation: BAG52375.1
AC096759 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05725.1
BC047393 mRNA Translation: AAH47393.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34012.1 [Q96PM5-2]
CCDS3567.1 [Q96PM5-1]
CCDS63990.1 [Q96PM5-8]
CCDS63991.1 [Q96PM5-7]
CCDS63992.1 [Q96PM5-6]

NCBI Reference Sequences

More...RefSeqi		NP_001009922.1, NM_001009922.2 [Q96PM5-2]
NP_001265465.1, NM_001278536.1 [Q96PM5-7]
NP_001265466.1, NM_001278537.1 [Q96PM5-8]
NP_001265467.1, NM_001278538.1 [Q96PM5-6]
NP_056251.2, NM_015436.3 [Q96PM5-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.48297

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324439; ENSP00000321239; ENSG00000163743 [Q96PM5-1]
ENST00000380840; ENSP00000370220; ENSG00000163743 [Q96PM5-7]
ENST00000505105; ENSP00000424631; ENSG00000163743 [Q96PM5-4]
ENST00000507014; ENSP00000424472; ENSG00000163743 [Q96PM5-8]
ENST00000512706; ENSP00000423976; ENSG00000163743 [Q96PM5-6]
ENST00000513257; ENSP00000421084; ENSG00000163743 [Q96PM5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25898

UCSC genome browser

More...UCSCi		uc003hik.4 human [Q96PM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ250944 mRNA Translation: ACT35531.1
GQ250945 mRNA Translation: ACT35532.1
GQ250946 mRNA Translation: ACT35533.1
AF247041 mRNA Translation: AAL76101.1
AF255666 mRNA Translation: AAK96896.1
AF305424 mRNA Translation: AAL09356.1
AB209072 mRNA Translation: BAD92309.1 Different initiation.
AY888047 mRNA Translation: AAX78233.1
GU937000 mRNA Translation: ADD21555.1
AK091501 mRNA Translation: BAG52375.1
AC096759 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05725.1
BC047393 mRNA Translation: AAH47393.1
CCDSiCCDS34012.1 [Q96PM5-2]
CCDS3567.1 [Q96PM5-1]
CCDS63990.1 [Q96PM5-8]
CCDS63991.1 [Q96PM5-7]
CCDS63992.1 [Q96PM5-6]
RefSeqiNP_001009922.1, NM_001009922.2 [Q96PM5-2]
NP_001265465.1, NM_001278536.1 [Q96PM5-7]
NP_001265466.1, NM_001278537.1 [Q96PM5-8]
NP_001265467.1, NM_001278538.1 [Q96PM5-6]
NP_056251.2, NM_015436.3 [Q96PM5-1]
UniGeneiHs.48297

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRJNMR-A138-189[»]
2K2CNMR-A1-137[»]
2K2DNMR-A187-261[»]
ProteinModelPortaliQ96PM5
SMRiQ96PM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117406, 84 interactors
DIPiDIP-43981N
IntActiQ96PM5, 51 interactors
MINTiQ96PM5
STRINGi9606.ENSP00000321239

PTM databases

iPTMnetiQ96PM5
PhosphoSitePlusiQ96PM5

Polymorphism and mutation databases

BioMutaiRCHY1
DMDMi32700008

2D gel databases

REPRODUCTION-2DPAGEiQ96PM5

Proteomic databases

EPDiQ96PM5
jPOSTiQ96PM5
MaxQBiQ96PM5
PaxDbiQ96PM5
PeptideAtlasiQ96PM5
PRIDEiQ96PM5
ProteomicsDBi77709
77710 [Q96PM5-2]
77711 [Q96PM5-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		25898
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324439; ENSP00000321239; ENSG00000163743 [Q96PM5-1]
ENST00000380840; ENSP00000370220; ENSG00000163743 [Q96PM5-7]
ENST00000505105; ENSP00000424631; ENSG00000163743 [Q96PM5-4]
ENST00000507014; ENSP00000424472; ENSG00000163743 [Q96PM5-8]
ENST00000512706; ENSP00000423976; ENSG00000163743 [Q96PM5-6]
ENST00000513257; ENSP00000421084; ENSG00000163743 [Q96PM5-2]
GeneIDi25898
KEGGihsa:25898
UCSCiuc003hik.4 human [Q96PM5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25898
DisGeNETi25898
EuPathDBiHostDB:ENSG00000163743.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		RCHY1
HGNCiHGNC:17479 RCHY1
HPAiHPA030339
MIMi607680 gene
neXtProtiNX_Q96PM5
OpenTargetsiENSG00000163743
PharmGKBiPA38240

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1940 Eukaryota
ENOG410XXHF LUCA
GeneTreeiENSGT00390000008853
HOGENOMiHOG000231827
HOVERGENiHBG062959
InParanoidiQ96PM5
KOiK10144
OMAiGMKCNIC
OrthoDBi1303946at2759
PhylomeDBiQ96PM5
TreeFamiTF323762

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi2.3.2.B10 2681
6.3.2.19 2681
ReactomeiR-HSA-110320 Translesion Synthesis by POLH
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ96PM5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RCHY1 human
EvolutionaryTraceiQ96PM5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RCHY1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25898

Protein Ontology

More...PROi		PR:Q96PM5

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163743 Expressed in 236 organ(s), highest expression level in sperm
CleanExiHS_RCHY1
ExpressionAtlasiQ96PM5 baseline and differential
GenevisibleiQ96PM5 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039512 RCHY1_zinc-ribbon
IPR008913 Znf_CHY
IPR037274 Znf_CHY_sf
IPR017921 Znf_CTCHY
IPR037275 Znf_CTCHY_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05495 zf-CHY, 1 hit
PF13639 zf-RING_2, 1 hit
PF14599 zinc_ribbon_6, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF161219 SSF161219, 1 hit
SSF161245 SSF161245, 1 hit
PROSITEiView protein in PROSITE
PS51266 ZF_CHY, 1 hit
PS51270 ZF_CTCHY, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN363_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PM5
Secondary accession number(s): B3KRG3
, C7E541, C7E542, C7E543, D3YRV2, E7EMC8, E7ETW5, J3KPI0, Q2KN33, Q59GN7, Q86X26, Q96PR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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