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Protein

Beta-tectorin

Gene

TECTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-tectorin
Gene namesi
Name:TECTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119913.4
HGNCiHGNC:11721 TECTB
MIMi602653 gene
neXtProtiNX_Q96PL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6975
OpenTargetsiENSG00000119913
PharmGKBiPA36438

Polymorphism and mutation databases

DMDMi48428669

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000004174118 – 305Beta-tectorinAdd BLAST288
PropeptideiPRO_0000041742306 – 329Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 264By similarity
Lipidationi305GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ96PL2
PRIDEiQ96PL2
ProteomicsDBi77707

Expressioni

Gene expression databases

BgeeiENSG00000119913 Expressed in 33 organ(s), highest expression level in right lobe of liver
CleanExiHS_TECTB
GenevisibleiQ96PL2 HS

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

Protein-protein interaction databases

BioGridi112835, 1 interactor
STRINGi9606.ENSP00000358430

Structurei

3D structure databases

ProteinModelPortaliQ96PL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 283ZPPROSITE-ProRule annotationAdd BLAST265

Domaini

Zona pellucida domain may enable to form filaments.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJKZ Eukaryota
ENOG410XSHJ LUCA
GeneTreeiENSGT00530000063315
HOGENOMiHOG000124070
HOVERGENiHBG056825
InParanoidiQ96PL2
OMAiNNCWATP
OrthoDBiEOG091G09WN
PhylomeDBiQ96PL2
TreeFamiTF330284

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96PL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV
60 70 80 90 100
HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH
110 120 130 140 150
IVSNDTTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT
160 170 180 190 200
FESQLSLNFY TNAKFSIKKE APFVLEASEI GSDLFAGVEA KGLSIRFKVV
210 220 230 240 250
LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH RATFQFNAFR
260 270 280 290 300
FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS
310 320
LRSRGFSSLY SFSDVLHHLI MMLGICAVL
Length:329
Mass (Da):36,956
Last modified:December 1, 2001 - v1
Checksum:i0B4D379624F488D0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6R9A0A2R8Y6R9_HUMAN
Beta-tectorin
TECTB
332Annotation score:
A0A2R8YGB5A0A2R8YGB5_HUMAN
Beta-tectorin
TECTB
342Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312827 mRNA Translation: AAL12829.1
AL391986 Genomic DNA No translation available.
BC113497 mRNA Translation: AAI13498.1
BC113499 mRNA Translation: AAI13500.1
CCDSiCCDS7571.1
RefSeqiNP_478129.1, NM_058222.2
UniGeneiHs.345485
Hs.348615

Genome annotation databases

EnsembliENST00000369422; ENSP00000358430; ENSG00000119913
ENST00000646139; ENSP00000494896; ENSG00000119913
GeneIDi6975
KEGGihsa:6975
UCSCiuc001kzr.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312827 mRNA Translation: AAL12829.1
AL391986 Genomic DNA No translation available.
BC113497 mRNA Translation: AAI13498.1
BC113499 mRNA Translation: AAI13500.1
CCDSiCCDS7571.1
RefSeqiNP_478129.1, NM_058222.2
UniGeneiHs.345485
Hs.348615

3D structure databases

ProteinModelPortaliQ96PL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112835, 1 interactor
STRINGi9606.ENSP00000358430

Polymorphism and mutation databases

DMDMi48428669

Proteomic databases

PaxDbiQ96PL2
PRIDEiQ96PL2
ProteomicsDBi77707

Protocols and materials databases

DNASUi6975
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369422; ENSP00000358430; ENSG00000119913
ENST00000646139; ENSP00000494896; ENSG00000119913
GeneIDi6975
KEGGihsa:6975
UCSCiuc001kzr.3 human

Organism-specific databases

CTDi6975
DisGeNETi6975
EuPathDBiHostDB:ENSG00000119913.4
GeneCardsiTECTB
HGNCiHGNC:11721 TECTB
MIMi602653 gene
neXtProtiNX_Q96PL2
OpenTargetsiENSG00000119913
PharmGKBiPA36438
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJKZ Eukaryota
ENOG410XSHJ LUCA
GeneTreeiENSGT00530000063315
HOGENOMiHOG000124070
HOVERGENiHBG056825
InParanoidiQ96PL2
OMAiNNCWATP
OrthoDBiEOG091G09WN
PhylomeDBiQ96PL2
TreeFamiTF330284

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

GeneWikiiTECTB
GenomeRNAii6975
PROiPR:Q96PL2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119913 Expressed in 33 organ(s), highest expression level in right lobe of liver
CleanExiHS_TECTB
GenevisibleiQ96PL2 HS

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTECTB_HUMAN
AccessioniPrimary (citable) accession number: Q96PL2
Secondary accession number(s): Q5VW53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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