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Protein

Secretoglobin family 3A member 2

Gene

SCGB3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).By similarity2 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-3000480 Scavenging by Class A Receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 3A member 2
Alternative name(s):
Pneumo secretory protein 1
Short name:
PnSP-1
Uteroglobin-related protein 1
Gene namesi
Name:SCGB3A2
Synonyms:PNSP1, UGRP1
ORF Names:UNQ566/PRO1128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164265.8
HGNCiHGNC:18391 SCGB3A2
MIMi606531 gene
neXtProtiNX_Q96PL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi117156
MalaCardsiSCGB3A2
OpenTargetsiENSG00000164265
PharmGKBiPA34995

Polymorphism and mutation databases

BioMutaiSCGB3A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003638122 – 93Secretoglobin family 3A member 2Add BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96PL1
PeptideAtlasiQ96PL1
PRIDEiQ96PL1
ProteomicsDBi77706

PTM databases

iPTMnetiQ96PL1
PhosphoSitePlusiQ96PL1

Expressioni

Tissue specificityi

Highly expressed in lung and trachea (PubMed:12406855, PubMed:12175512, PubMed:12847263). Detected throughout the airway epithelium in lung, with slightly higher expression in large airways (PubMed:12406855). Found in lung submucosal gland acinus where it localizes to serous-like cells (PubMed:12406855). Probably expressed in club/Clara cells of the bronchioles (PubMed:12847263). Not detected in other tissues tested (PubMed:12847263).3 Publications

Developmental stagei

Expressed in fetal lung.1 Publication

Gene expression databases

BgeeiENSG00000164265 Expressed in 83 organ(s), highest expression level in lung
CleanExiHS_SCGB3A2
ExpressionAtlasiQ96PL1 baseline and differential
GenevisibleiQ96PL1 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked (PubMed:24213919). Monomer (PubMed:24213919). Interacts with APOA1 (PubMed:12847263).2 Publications

Protein-protein interaction databases

BioGridi125562, 1 interactor
STRINGi9606.ENSP00000296694

Structurei

3D structure databases

ProteinModelPortaliQ96PL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family. UGRP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1Y3 Eukaryota
ENOG4111402 LUCA
GeneTreeiENSGT00420000029848
HOGENOMiHOG000128185
HOVERGENiHBG079305
InParanoidiQ96PL1
OMAiICSYSAT
OrthoDBiEOG091G10V3
PhylomeDBiQ96PL1
TreeFamiTF336928

Family and domain databases

InterProiView protein in InterPro
IPR016126 Secretoglobin
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96PL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLVTIFLLV TISLCSYSAT AFLINKVPLP VDKLAPLPLD NILPFMDPLK
60 70 80 90
LLLKTLGISV EHLVEGLRKC VNELGPEASE AVKKLLEALS HLV
Length:93
Mass (Da):10,161
Last modified:December 1, 2001 - v1
Checksum:iFBD4BFAC2BF33718
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBX5D6RBX5_HUMAN
Secretoglobin family 3A member 2
SCGB3A2
48Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03618533K → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313455 mRNA Translation: AAL26215.1
AF439544 Genomic DNA Translation: AAQ04559.1
AF439545 mRNA Translation: AAQ04560.1
AY358979 mRNA Translation: AAQ89338.1
BC024232 mRNA Translation: AAH24232.1
CCDSiCCDS4287.1
RefSeqiNP_473364.1, NM_054023.4
UniGeneiHs.483765

Genome annotation databases

EnsembliENST00000296694; ENSP00000296694; ENSG00000164265
GeneIDi117156
KEGGihsa:117156
UCSCiuc003lot.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313455 mRNA Translation: AAL26215.1
AF439544 Genomic DNA Translation: AAQ04559.1
AF439545 mRNA Translation: AAQ04560.1
AY358979 mRNA Translation: AAQ89338.1
BC024232 mRNA Translation: AAH24232.1
CCDSiCCDS4287.1
RefSeqiNP_473364.1, NM_054023.4
UniGeneiHs.483765

3D structure databases

ProteinModelPortaliQ96PL1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125562, 1 interactor
STRINGi9606.ENSP00000296694

PTM databases

iPTMnetiQ96PL1
PhosphoSitePlusiQ96PL1

Polymorphism and mutation databases

BioMutaiSCGB3A2

Proteomic databases

PaxDbiQ96PL1
PeptideAtlasiQ96PL1
PRIDEiQ96PL1
ProteomicsDBi77706

Protocols and materials databases

DNASUi117156
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296694; ENSP00000296694; ENSG00000164265
GeneIDi117156
KEGGihsa:117156
UCSCiuc003lot.3 human

Organism-specific databases

CTDi117156
DisGeNETi117156
EuPathDBiHostDB:ENSG00000164265.8
GeneCardsiSCGB3A2
HGNCiHGNC:18391 SCGB3A2
MalaCardsiSCGB3A2
MIMi606531 gene
neXtProtiNX_Q96PL1
OpenTargetsiENSG00000164265
PharmGKBiPA34995
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1Y3 Eukaryota
ENOG4111402 LUCA
GeneTreeiENSGT00420000029848
HOGENOMiHOG000128185
HOVERGENiHBG079305
InParanoidiQ96PL1
OMAiICSYSAT
OrthoDBiEOG091G10V3
PhylomeDBiQ96PL1
TreeFamiTF336928

Enzyme and pathway databases

ReactomeiR-HSA-3000480 Scavenging by Class A Receptors

Miscellaneous databases

ChiTaRSiSCGB3A2 human
GeneWikiiSCGB3A2
GenomeRNAii117156
PROiPR:Q96PL1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164265 Expressed in 83 organ(s), highest expression level in lung
CleanExiHS_SCGB3A2
ExpressionAtlasiQ96PL1 baseline and differential
GenevisibleiQ96PL1 HS

Family and domain databases

InterProiView protein in InterPro
IPR016126 Secretoglobin
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSG3A2_HUMAN
AccessioniPrimary (citable) accession number: Q96PL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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