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UniProtKB - Q96PJ5 (FCRL4_HUMAN)
Protein
Fc receptor-like protein 4
Gene
FCRL4
Organism
Homo sapiens (Human)
Status
Functioni
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 17 – 18 | Breakpoint for insertion to form FCRL4-IGHA1 fusion protein | 2 |
GO - Molecular functioni
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q96PJ5 |
SignaLinki | Q96PJ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Fc receptor-like protein 4Short name: FcR-like protein 4 Short name: FcRL4 Alternative name(s): Fc receptor homolog 4 Short name: FcRH4 IFGP family protein 2 Short name: hIFGP2 Immune receptor translocation-associated protein 1 CD_antigen: CD307d |
Gene namesi | Name:FCRL4 Synonyms:FCRH4, IFGP2, IRTA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18507, FCRL4 |
MIMi | 605876, gene |
neXtProti | NX_Q96PJ5 |
VEuPathDBi | HostDB:ENSG00000163518 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell surface Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 387 | ExtracellularSequence analysisAdd BLAST | 368 | |
Transmembranei | 388 – 408 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 409 – 515 | CytoplasmicSequence analysisAdd BLAST | 107 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).1 Publication
A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 451 | Y → F: No effect on function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication | 1 | |
Mutagenesisi | 463 | Y → F: Loss of function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication | 1 | |
Mutagenesisi | 493 | Y → F: Loss of interaction with PTPN6 and PTPN11 and partial loss of function and phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 83417 |
OpenTargetsi | ENSG00000163518 |
PharmGKBi | PA142671768 |
Miscellaneous databases
Pharosi | Q96PJ5, Tbio |
Genetic variation databases
BioMutai | FCRL4 |
DMDMi | 74761029 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000331642 | 20 – 515 | Fc receptor-like protein 4Add BLAST | 496 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 85 | PROSITE-ProRule annotation | ||
Disulfide bondi | 123 ↔ 167 | PROSITE-ProRule annotation | ||
Disulfide bondi | 212 ↔ 261 | PROSITE-ProRule annotation | ||
Disulfide bondi | 310 ↔ 359 | PROSITE-ProRule annotation | ||
Glycosylationi | 374 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated on cytoplasmic tyrosines upon activation.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q96PJ5 |
PaxDbi | Q96PJ5 |
PeptideAtlasi | Q96PJ5 |
PRIDEi | Q96PJ5 |
PTM databases
GlyGeni | Q96PJ5, 1 site |
iPTMneti | Q96PJ5 |
PhosphoSitePlusi | Q96PJ5 |
SwissPalmi | Q96PJ5 |
Expressioni
Tissue specificityi
Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).6 Publications
Gene expression databases
Bgeei | ENSG00000163518, Expressed in buccal mucosa cell and 44 other tissues |
Genevisiblei | Q96PJ5, HS |
Organism-specific databases
HPAi | ENSG00000163518, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Interacts with PTPN6 and PTPN11.
1 PublicationBinary interactionsi
Q96PJ5
Protein-protein interaction databases
BioGRIDi | 123641, 15 interactors |
IntActi | Q96PJ5, 11 interactors |
STRINGi | 9606.ENSP00000271532 |
Miscellaneous databases
RNActi | Q96PJ5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 97 | Ig-like C2-type 1Add BLAST | 75 | |
Domaini | 102 – 183 | Ig-like C2-type 2Add BLAST | 82 | |
Domaini | 193 – 271 | Ig-like C2-type 3Add BLAST | 79 | |
Domaini | 275 – 374 | Ig-like C2-type 4Add BLAST | 100 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 494 – 515 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 449 – 454 | ITIM motif 1 | 6 | |
Motifi | 461 – 466 | ITIM motif 2 | 6 | |
Motifi | 491 – 496 | ITIM motif 3 | 6 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S65W, Eukaryota |
GeneTreei | ENSGT01040000240447 |
HOGENOMi | CLU_023383_7_1_1 |
InParanoidi | Q96PJ5 |
OMAi | YQHYWRE |
OrthoDBi | 53940at2759 |
PhylomeDBi | Q96PJ5 |
TreeFami | TF351107 |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96PJ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY
60 70 80 90 100
ATEKTTWYHR HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF
110 120 130 140 150
SSDSLILQAP YSVFEGDTLV LRCHRRRKEK LTAVKYTWNG NILSISNKSW
160 170 180 190 200
DLLIPQASSN NNGNYRCIGY GDENDVFRSN FKIIKIQELF PHPELKATDS
210 220 230 240 250
QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW STYPELQLPT
260 270 280 290 300
VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA
310 320 330 340 350
VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR
360 370 380 390 400
QSHAGGYYCT ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL
410 420 430 440 450
LLAVALLFHC WRRRKSGVGF LGDETRLPPA PGPGESSHSI CPAQVELQSL
460 470 480 490 500
YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS RTLLEDKDVS VVYSEVKTQH
510
PDNSAGKISS KDEES
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 179 | S → L in AAK93970 (PubMed:11493702).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042929 | 60 | R → Q. Corresponds to variant dbSNP:rs11582663Ensembl. | 1 | |
Natural variantiVAR_042930 | 255 | N → S. Corresponds to variant dbSNP:rs4561035EnsemblClinVar. | 1 | |
Natural variantiVAR_042931 | 457 | K → R. Corresponds to variant dbSNP:rs2039401EnsemblClinVar. | 1 | |
Natural variantiVAR_042932 | 493 | Y → C. Corresponds to variant dbSNP:rs3811028Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033310 | 454 – 515 | VHPKK…KDEES → GEDSLLGSCSWPQPWKDNAL SALGNAPGLPKVSQIQIFPD IMCPRRVEMMLRKRHL in isoform 2. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF343659 mRNA No translation available. AF397452 mRNA Translation: AAK93970.1 AF329490 mRNA Translation: AAL23900.1 AF329492 mRNA Translation: AAL23902.1 EF064731 Genomic DNA Translation: ABK41914.1 CH471121 Genomic DNA Translation: EAW52883.1 BC125173 mRNA Translation: AAI25174.1 BC125174 mRNA Translation: AAI25175.1 |
CCDSi | CCDS1166.1 [Q96PJ5-1] |
RefSeqi | NP_112572.1, NM_031282.2 [Q96PJ5-1] |
Genome annotation databases
Ensembli | ENST00000271532; ENSP00000271532; ENSG00000163518 |
GeneIDi | 83417 |
KEGGi | hsa:83417 |
MANE-Selecti | ENST00000271532.2; ENSP00000271532.1; NM_031282.3; NP_112572.1 |
UCSCi | uc001fqw.3, human [Q96PJ5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF343659 mRNA No translation available. AF397452 mRNA Translation: AAK93970.1 AF329490 mRNA Translation: AAL23900.1 AF329492 mRNA Translation: AAL23902.1 EF064731 Genomic DNA Translation: ABK41914.1 CH471121 Genomic DNA Translation: EAW52883.1 BC125173 mRNA Translation: AAI25174.1 BC125174 mRNA Translation: AAI25175.1 |
CCDSi | CCDS1166.1 [Q96PJ5-1] |
RefSeqi | NP_112572.1, NM_031282.2 [Q96PJ5-1] |
3D structure databases
SMRi | Q96PJ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123641, 15 interactors |
IntActi | Q96PJ5, 11 interactors |
STRINGi | 9606.ENSP00000271532 |
PTM databases
GlyGeni | Q96PJ5, 1 site |
iPTMneti | Q96PJ5 |
PhosphoSitePlusi | Q96PJ5 |
SwissPalmi | Q96PJ5 |
Genetic variation databases
BioMutai | FCRL4 |
DMDMi | 74761029 |
Proteomic databases
MassIVEi | Q96PJ5 |
PaxDbi | Q96PJ5 |
PeptideAtlasi | Q96PJ5 |
PRIDEi | Q96PJ5 |
Protocols and materials databases
Antibodypediai | 34231, 209 antibodies from 26 providers |
DNASUi | 83417 |
Genome annotation databases
Ensembli | ENST00000271532; ENSP00000271532; ENSG00000163518 |
GeneIDi | 83417 |
KEGGi | hsa:83417 |
MANE-Selecti | ENST00000271532.2; ENSP00000271532.1; NM_031282.3; NP_112572.1 |
UCSCi | uc001fqw.3, human [Q96PJ5-1] |
Organism-specific databases
CTDi | 83417 |
DisGeNETi | 83417 |
GeneCardsi | FCRL4 |
HGNCi | HGNC:18507, FCRL4 |
HPAi | ENSG00000163518, Tissue enriched (lymphoid) |
MIMi | 605876, gene |
neXtProti | NX_Q96PJ5 |
OpenTargetsi | ENSG00000163518 |
PharmGKBi | PA142671768 |
VEuPathDBi | HostDB:ENSG00000163518 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S65W, Eukaryota |
GeneTreei | ENSGT01040000240447 |
HOGENOMi | CLU_023383_7_1_1 |
InParanoidi | Q96PJ5 |
OMAi | YQHYWRE |
OrthoDBi | 53940at2759 |
PhylomeDBi | Q96PJ5 |
TreeFami | TF351107 |
Enzyme and pathway databases
PathwayCommonsi | Q96PJ5 |
SignaLinki | Q96PJ5 |
Miscellaneous databases
BioGRID-ORCSi | 83417, 6 hits in 1036 CRISPR screens |
ChiTaRSi | FCRL4, human |
GeneWikii | FCRL4 |
GenomeRNAii | 83417 |
Pharosi | Q96PJ5, Tbio |
PROi | PR:Q96PJ5 |
RNActi | Q96PJ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163518, Expressed in buccal mucosa cell and 44 other tissues |
Genevisiblei | Q96PJ5, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FCRL4_HUMAN | |
Accessioni | Q96PJ5Primary (citable) accession number: Q96PJ5 Secondary accession number(s): Q96PJ3, Q96RE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot