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Protein

Fc receptor-like protein 4

Gene

FCRL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17 – 18Breakpoint for insertion to form FCRL4-IGHA1 fusion protein2

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 4
Short name:
FcR-like protein 4
Short name:
FcRL4
Alternative name(s):
Fc receptor homolog 4
Short name:
FcRH4
IFGP family protein 2
Short name:
hIFGP2
Immune receptor translocation-associated protein 1
CD_antigen: CD307d
Gene namesi
Name:FCRL4
Synonyms:FCRH4, IFGP2, IRTA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163518.10
HGNCiHGNC:18507 FCRL4
MIMi605876 gene
neXtProtiNX_Q96PJ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 387ExtracellularSequence analysisAdd BLAST368
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 515CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).1 Publication
A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi451Y → F: No effect on function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication1
Mutagenesisi463Y → F: Loss of function, phosphorylation and interaction with PTPN6 and PTPN11. 1 Publication1
Mutagenesisi493Y → F: Loss of interaction with PTPN6 and PTPN11 and partial loss of function and phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi83417
OpenTargetsiENSG00000163518
PharmGKBiPA142671768

Polymorphism and mutation databases

BioMutaiFCRL4
DMDMi74761029

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000033164220 – 515Fc receptor-like protein 4Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 85PROSITE-ProRule annotation
Disulfide bondi123 ↔ 167PROSITE-ProRule annotation
Disulfide bondi212 ↔ 261PROSITE-ProRule annotation
Disulfide bondi310 ↔ 359PROSITE-ProRule annotation
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosines upon activation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96PJ5
PeptideAtlasiQ96PJ5
PRIDEiQ96PJ5
ProteomicsDBi77702
77703 [Q96PJ5-2]

PTM databases

iPTMnetiQ96PJ5
PhosphoSitePlusiQ96PJ5
SwissPalmiQ96PJ5

Expressioni

Tissue specificityi

Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).6 Publications

Gene expression databases

BgeeiENSG00000163518 Expressed in 35 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_FCRL4
GenevisibleiQ96PJ5 HS

Organism-specific databases

HPAiHPA054030

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123641, 7 interactors
IntActiQ96PJ5, 7 interactors
STRINGi9606.ENSP00000271532

Structurei

3D structure databases

ProteinModelPortaliQ96PJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 97Ig-like C2-type 1Add BLAST75
Domaini102 – 183Ig-like C2-type 2Add BLAST82
Domaini193 – 271Ig-like C2-type 3Add BLAST79
Domaini275 – 374Ig-like C2-type 4Add BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi449 – 454ITIM motif 16
Motifi461 – 466ITIM motif 26
Motifi491 – 496ITIM motif 36

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXWJ Eukaryota
ENOG410Z11U LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036945
InParanoidiQ96PJ5
KOiK06727
OMAiHFIFFRD
OrthoDBiEOG091G03OP
PhylomeDBiQ96PJ5
TreeFamiTF351107

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96PJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY
60 70 80 90 100
ATEKTTWYHR HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF
110 120 130 140 150
SSDSLILQAP YSVFEGDTLV LRCHRRRKEK LTAVKYTWNG NILSISNKSW
160 170 180 190 200
DLLIPQASSN NNGNYRCIGY GDENDVFRSN FKIIKIQELF PHPELKATDS
210 220 230 240 250
QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW STYPELQLPT
260 270 280 290 300
VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA
310 320 330 340 350
VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR
360 370 380 390 400
QSHAGGYYCT ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL
410 420 430 440 450
LLAVALLFHC WRRRKSGVGF LGDETRLPPA PGPGESSHSI CPAQVELQSL
460 470 480 490 500
YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS RTLLEDKDVS VVYSEVKTQH
510
PDNSAGKISS KDEES
Length:515
Mass (Da):57,224
Last modified:December 1, 2001 - v1
Checksum:iF3B7AD14FB1B449A
GO
Isoform 2 (identifier: Q96PJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-515: VHPKKGDLVY...GKISSKDEES → GEDSLLGSCS...VEMMLRKRHL

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):56,636
Checksum:i2810BA15A2BA5405
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179S → L in AAK93970 (PubMed:11493702).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04292960R → Q. Corresponds to variant dbSNP:rs11582663Ensembl.1
Natural variantiVAR_042930255N → S. Corresponds to variant dbSNP:rs4561035Ensembl.1
Natural variantiVAR_042931457K → R. Corresponds to variant dbSNP:rs2039401Ensembl.1
Natural variantiVAR_042932493Y → C. Corresponds to variant dbSNP:rs3811028Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033310454 – 515VHPKK…KDEES → GEDSLLGSCSWPQPWKDNAL SALGNAPGLPKVSQIQIFPD IMCPRRVEMMLRKRHL in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343659 mRNA No translation available.
AF397452 mRNA Translation: AAK93970.1
AF329490 mRNA Translation: AAL23900.1
AF329492 mRNA Translation: AAL23902.1
EF064731 Genomic DNA Translation: ABK41914.1
CH471121 Genomic DNA Translation: EAW52883.1
BC125173 mRNA Translation: AAI25174.1
BC125174 mRNA Translation: AAI25175.1
CCDSiCCDS1166.1 [Q96PJ5-1]
RefSeqiNP_112572.1, NM_031282.2 [Q96PJ5-1]
UniGeneiHs.120260

Genome annotation databases

EnsembliENST00000271532; ENSP00000271532; ENSG00000163518 [Q96PJ5-1]
GeneIDi83417
KEGGihsa:83417
UCSCiuc001fqw.3 human [Q96PJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343659 mRNA No translation available.
AF397452 mRNA Translation: AAK93970.1
AF329490 mRNA Translation: AAL23900.1
AF329492 mRNA Translation: AAL23902.1
EF064731 Genomic DNA Translation: ABK41914.1
CH471121 Genomic DNA Translation: EAW52883.1
BC125173 mRNA Translation: AAI25174.1
BC125174 mRNA Translation: AAI25175.1
CCDSiCCDS1166.1 [Q96PJ5-1]
RefSeqiNP_112572.1, NM_031282.2 [Q96PJ5-1]
UniGeneiHs.120260

3D structure databases

ProteinModelPortaliQ96PJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123641, 7 interactors
IntActiQ96PJ5, 7 interactors
STRINGi9606.ENSP00000271532

PTM databases

iPTMnetiQ96PJ5
PhosphoSitePlusiQ96PJ5
SwissPalmiQ96PJ5

Polymorphism and mutation databases

BioMutaiFCRL4
DMDMi74761029

Proteomic databases

PaxDbiQ96PJ5
PeptideAtlasiQ96PJ5
PRIDEiQ96PJ5
ProteomicsDBi77702
77703 [Q96PJ5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271532; ENSP00000271532; ENSG00000163518 [Q96PJ5-1]
GeneIDi83417
KEGGihsa:83417
UCSCiuc001fqw.3 human [Q96PJ5-1]

Organism-specific databases

CTDi83417
DisGeNETi83417
EuPathDBiHostDB:ENSG00000163518.10
GeneCardsiFCRL4
HGNCiHGNC:18507 FCRL4
HPAiHPA054030
MIMi605876 gene
neXtProtiNX_Q96PJ5
OpenTargetsiENSG00000163518
PharmGKBiPA142671768
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXWJ Eukaryota
ENOG410Z11U LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036945
InParanoidiQ96PJ5
KOiK06727
OMAiHFIFFRD
OrthoDBiEOG091G03OP
PhylomeDBiQ96PJ5
TreeFamiTF351107

Miscellaneous databases

ChiTaRSiFCRL4 human
GeneWikiiFCRL4
GenomeRNAii83417
PROiPR:Q96PJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163518 Expressed in 35 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_FCRL4
GenevisibleiQ96PJ5 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCRL4_HUMAN
AccessioniPrimary (citable) accession number: Q96PJ5
Secondary accession number(s): Q96PJ3, Q96RE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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