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Entry version 163 (25 May 2022)
Sequence version 1 (01 Dec 2001)
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Protein

NADPH oxidase 5

Gene

NOX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.

3 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by calcium which induces conformational changes and interaction between the N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.06 µM for calcium1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi42Calcium 1Curated1
Metal bindingi44Calcium 1Curated1
Metal bindingi49Calcium 1Curated1
Metal bindingi70Calcium 2PROSITE-ProRule annotation1
Metal bindingi72Calcium 2PROSITE-ProRule annotation1
Metal bindingi74Calcium 2PROSITE-ProRule annotation1
Metal bindingi76Calcium 2PROSITE-ProRule annotation1
Metal bindingi81Calcium 2PROSITE-ProRule annotation1
Metal bindingi106Calcium 3; first partCurated1
Metal bindingi108Calcium 3; first partCurated1
Metal bindingi138Calcium 3; second partCurated1
Metal bindingi140Calcium 3; second partCurated1
Metal bindingi145Calcium 3; second partCurated1
Metal bindingi178Calcium 4PROSITE-ProRule annotation1
Metal bindingi180Calcium 4PROSITE-ProRule annotation1
Metal bindingi182Calcium 4PROSITE-ProRule annotation1
Metal bindingi189Calcium 4PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Oxidoreductase
Biological processAngiogenesis, Electron transport, Ion transport, Transport
LigandCalcium, FAD, Flavoprotein, Metal-binding, NADP

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96PH1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3299685, Detoxification of Reactive Oxygen Species

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q96PH1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96PH1

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96PH1

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
6024, HsNOx05

Transport Classification Database

More...
TCDBi
5.B.1.1.5, the phagocyte (gp91(phox)) nadph oxidase family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADPH oxidase 5 (EC:1.6.3.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOX5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14874, NOX5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606572, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PH1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000255346

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 238CytoplasmicSequence analysisAdd BLAST238
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 266ExtracellularSequence analysis7
Transmembranei267 – 289HelicalSequence analysisAdd BLAST23
Topological domaini290 – 317CytoplasmicSequence analysisAdd BLAST28
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 362ExtracellularSequence analysisAdd BLAST24
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 394CytoplasmicSequence analysisAdd BLAST11
Transmembranei395 – 417HelicalSequence analysisAdd BLAST23
Topological domaini418 – 434ExtracellularSequence analysisAdd BLAST17
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Topological domaini456 – 583CytoplasmicSequence analysisAdd BLAST128
Transmembranei584 – 604HelicalSequence analysisAdd BLAST21
Topological domaini605 – 765ExtracellularSequence analysisAdd BLAST161

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49E → Q: Loss of binding of 1 calcium molecule. No effect on catalytic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79400

Open Targets

More...
OpenTargetsi
ENSG00000255346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31693

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96PH1, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1926497

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
3005

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOX5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74717091

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002249951 – 765NADPH oxidase 5Add BLAST765

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96PH1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96PH1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PH1

PeptideAtlas

More...
PeptideAtlasi
Q96PH1

PRoteomics IDEntifications database

More...
PRIDEi
Q96PH1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
77694 [Q96PH1-1]
77695 [Q96PH1-2]
77696 [Q96PH1-3]
77697 [Q96PH1-4]
77698 [Q96PH1-5]
77699 [Q96PH1-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PH1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal tissues.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by TGFB1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000255346, Expressed in cingulate cortex and 127 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96PH1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96PH1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000255346, Group enriched (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122660, 47 interactors

Protein interaction database and analysis system

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IntActi
Q96PH1, 9 interactors

Molecular INTeraction database

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MINTi
Q96PH1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373518

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q96PH1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96PH1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1765
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q96PH1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96PH1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 56EF-hand 1CuratedAdd BLAST31
Domaini57 – 92EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini93 – 156EF-hand 3; atypical; contains an insert of 28 residuesPROSITE-ProRule annotationAdd BLAST64
Domaini165 – 200EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini293 – 440Ferric oxidoreductaseAdd BLAST148
Domaini441 – 577FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 169N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent mannerAdd BLAST169
Regioni122 – 141DisorderedSequence analysisAdd BLAST20
Regioni449 – 565C-terminal catalytic regionAdd BLAST117

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Isoform v1 and isoform v2 of this protein have four functional EF-hand calcium-binding domains. Isoform v3 and isoform v4 have the third EF-hand domain interrupted by an insert.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0039, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000162591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009773_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PH1

Identification of Orthologs from Complete Genome Data

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OMAi
NFWKWFM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PH1

TreeFam database of animal gene trees

More...
TreeFami
TF324099

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR017938, Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13202, EF-hand_5, 1 hit
PF13405, EF-hand_6, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform v3 (identifier: Q96PH1-1) [UniParc]FASTAAdd to basket
Also known as: NOX5gamma

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTSGDPAQT GPEGCRGTMS AEEDARWLRW VTQQFKTIAG EDGEISLQEF
60 70 80 90 100
KAALHVKESF FAERFFALFD SDRSGTITLQ ELQEALTLLI HGSPMDKLKF
110 120 130 140 150
LFQVYDIDVC ARQGASAGTE WGAGAGPHWA SSPLGTGSGS IDPDELRTVL
160 170 180 190 200
QSCLRESAIS LPDEKLDQLT LALFESADAD GNGAITFEEL RDELQRFPGV
210 220 230 240 250
MENLTISAAH WLTAPAPRPR PRRPRQLTRA YWHNHRSQLF CLATYAGLHV
260 270 280 290 300
LLFGLAASAH RDLGASVMVA KGCGQCLNFD CSFIAVLMLR RCLTWLRATW
310 320 330 340 350
LAQVLPLDQN IQFHQLMGYV VVGLSLVHTV AHTVNFVLQA QAEASPFQFW
360 370 380 390 400
ELLLTTRPGI GWVHGSASPT GVALLLLLLL MFICSSSCIR RSGHFEVFYW
410 420 430 440 450
THLSYLLVWL LLIFHGPNFW KWLLVPGILF FLEKAIGLAV SRMAAVCIME
460 470 480 490 500
VNLLPSKVTH LLIKRPPFFH YRPGDYLYLN IPTIARYEWH PFTISSAPEQ
510 520 530 540 550
KDTIWLHIRS QGQWTNRLYE SFKASDPLGR GSKRLSRSVT MRKSQRSSKG
560 570 580 590 600
SEILLEKHKF CNIKCYIDGP YGTPTRRIFA SEHAVLIGAG IGITPFASIL
610 620 630 640 650
QSIMYRHQKR KHTCPSCQHS WIEGVQDNMK LHKVDFIWIN RDQRSFEWFV
660 670 680 690 700
SLLTKLEMDQ AEEAQYGRFL ELHMYMTSAL GKNDMKAIGL QMALDLLANK
710 720 730 740 750
EKKDSITGLQ TRTQPGRPDW SKVFQKVAAE KKGKVQVFFC GSPALAKVLK
760
GHCEKFGFRF FQENF
Length:765
Mass (Da):86,439
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96B57225BF919682
GO
Isoform v1 (identifier: Q96PH1-3) [UniParc]FASTAAdd to basket
Also known as: NOX5alpha

The sequence of this isoform differs from the canonical sequence as follows:
     109-136: Missing.

Show »
Length:737
Mass (Da):83,774
Checksum:i33B3AC250C36F6E9
GO
Isoform v2 (identifier: Q96PH1-4) [UniParc]FASTAAdd to basket
Also known as: NOX5beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     109-136: Missing.

Show »
Length:719
Mass (Da):82,013
Checksum:i04F7BA7C78B1AEDB
GO
Isoform v4 (identifier: Q96PH1-2) [UniParc]FASTAAdd to basket
Also known as: NOX5delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:747
Mass (Da):84,678
Checksum:i86B46366672B6E4A
GO
Isoform v5 (identifier: Q96PH1-5) [UniParc]FASTAAdd to basket
Also known as: NOX5epsilon, NOX5S

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Show »
Length:565
Mass (Da):64,652
Checksum:i94785B98A61214F6
GO
Isoform v6 (identifier: Q96PH1-6) [UniParc]FASTAAdd to basket
Also known as: NOX5zeta

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MNTSGDPAQTGPEGCRG → MAFVCAGLSD
     109-136: Missing.

Show »
Length:730
Mass (Da):83,109
Checksum:i93B21AF3A0A1CE79
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J289A0A0B4J289_HUMAN
NADPH oxidase 5
NOX5
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG33638 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15319 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB84897 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti208A → T in AAG33638 (PubMed:15994299).Curated1
Sequence conflicti272G → S in AAI25099 (PubMed:15489334).Curated1
Sequence conflicti375L → P in BAG37241 (PubMed:14702039).Curated1
Sequence conflicti380L → F in BAB84884 (Ref. 2) Curated1
Sequence conflicti380L → F in BAB84897 (Ref. 2) Curated1
Sequence conflicti380L → F in BAB15319 (PubMed:14702039).Curated1
Sequence conflicti380L → F in BAG37241 (PubMed:14702039).Curated1
Sequence conflicti380L → F in EAW77830 (Ref. 6) Curated1
Sequence conflicti380L → F in AAI25098 (PubMed:15489334).Curated1
Sequence conflicti380L → F in AAI25099 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055820576R → H. Corresponds to variant dbSNP:rs2277552Ensembl.1
Natural variantiVAR_055821759R → G. Corresponds to variant dbSNP:rs7168025EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173261 – 200Missing in isoform v5. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_0173271 – 18Missing in isoform v2 and isoform v4. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_0416191 – 17MNTSG…EGCRG → MAFVCAGLSD in isoform v6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_017328109 – 136Missing in isoform v1, isoform v2 and isoform v6. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF325189 mRNA Translation: AAK57193.1
AF325190 mRNA Translation: AAK57194.1
AF353088 mRNA Translation: AAK57338.1
AF353089 mRNA Translation: AAK57339.1
AK074058 mRNA Translation: BAB84884.1
AK074071 mRNA Translation: BAB84897.1 Different initiation.
AK026011 mRNA Translation: BAB15319.1 Different initiation.
AK314689 mRNA Translation: BAG37241.1
DQ314884 Genomic DNA Translation: ABC40743.1
AC027088 Genomic DNA No translation available.
AC087639 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77830.1
BC125097 mRNA Translation: AAI25098.1
BC125098 mRNA Translation: AAI25099.1
AF317889 mRNA Translation: AAG33638.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32276.2 [Q96PH1-1]
CCDS53953.1 [Q96PH1-6]
CCDS53954.1 [Q96PH1-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001171708.1, NM_001184779.1 [Q96PH1-3]
NP_001171709.1, NM_001184780.1 [Q96PH1-6]
NP_078781.3, NM_024505.3 [Q96PH1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260364.9; ENSP00000454143.1; ENSG00000255346.10 [Q96PH1-2]
ENST00000388866.8; ENSP00000373518.3; ENSG00000255346.10
ENST00000448182.7; ENSP00000410887.3; ENSG00000255346.10 [Q96PH1-4]
ENST00000455873.7; ENSP00000416828.3; ENSG00000255346.10 [Q96PH1-6]
ENST00000530406.6; ENSP00000432440.2; ENSG00000255346.10 [Q96PH1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79400

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000388866.8; ENSP00000373518.3; NM_024505.4; NP_078781.3

UCSC genome browser

More...
UCSCi
uc002arp.3, human [Q96PH1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325189 mRNA Translation: AAK57193.1
AF325190 mRNA Translation: AAK57194.1
AF353088 mRNA Translation: AAK57338.1
AF353089 mRNA Translation: AAK57339.1
AK074058 mRNA Translation: BAB84884.1
AK074071 mRNA Translation: BAB84897.1 Different initiation.
AK026011 mRNA Translation: BAB15319.1 Different initiation.
AK314689 mRNA Translation: BAG37241.1
DQ314884 Genomic DNA Translation: ABC40743.1
AC027088 Genomic DNA No translation available.
AC087639 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77830.1
BC125097 mRNA Translation: AAI25098.1
BC125098 mRNA Translation: AAI25099.1
AF317889 mRNA Translation: AAG33638.1 Different initiation.
CCDSiCCDS32276.2 [Q96PH1-1]
CCDS53953.1 [Q96PH1-6]
CCDS53954.1 [Q96PH1-3]
RefSeqiNP_001171708.1, NM_001184779.1 [Q96PH1-3]
NP_001171709.1, NM_001184780.1 [Q96PH1-6]
NP_078781.3, NM_024505.3 [Q96PH1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6SZ5X-ray2.23B/C19-765[»]
AlphaFoldDBiQ96PH1
SMRiQ96PH1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122660, 47 interactors
IntActiQ96PH1, 9 interactors
MINTiQ96PH1
STRINGi9606.ENSP00000373518

Chemistry databases

BindingDBiQ96PH1
ChEMBLiCHEMBL1926497
GuidetoPHARMACOLOGYi3005

Protein family/group databases

PeroxiBasei6024, HsNOx05
TCDBi5.B.1.1.5, the phagocyte (gp91(phox)) nadph oxidase family

PTM databases

iPTMnetiQ96PH1
PhosphoSitePlusiQ96PH1

Genetic variation databases

BioMutaiNOX5
DMDMi74717091

Proteomic databases

jPOSTiQ96PH1
MassIVEiQ96PH1
PaxDbiQ96PH1
PeptideAtlasiQ96PH1
PRIDEiQ96PH1
ProteomicsDBi77694 [Q96PH1-1]
77695 [Q96PH1-2]
77696 [Q96PH1-3]
77697 [Q96PH1-4]
77698 [Q96PH1-5]
77699 [Q96PH1-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
57978, 253 antibodies from 30 providers

The DNASU plasmid repository

More...
DNASUi
79400

Genome annotation databases

EnsembliENST00000260364.9; ENSP00000454143.1; ENSG00000255346.10 [Q96PH1-2]
ENST00000388866.8; ENSP00000373518.3; ENSG00000255346.10
ENST00000448182.7; ENSP00000410887.3; ENSG00000255346.10 [Q96PH1-4]
ENST00000455873.7; ENSP00000416828.3; ENSG00000255346.10 [Q96PH1-6]
ENST00000530406.6; ENSP00000432440.2; ENSG00000255346.10 [Q96PH1-3]
GeneIDi79400
KEGGihsa:79400
MANE-SelectiENST00000388866.8; ENSP00000373518.3; NM_024505.4; NP_078781.3
UCSCiuc002arp.3, human [Q96PH1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79400
DisGeNETi79400

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NOX5
HGNCiHGNC:14874, NOX5
HPAiENSG00000255346, Group enriched (lymphoid tissue, testis)
MIMi606572, gene
neXtProtiNX_Q96PH1
OpenTargetsiENSG00000255346
PharmGKBiPA31693
VEuPathDBiHostDB:ENSG00000255346

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0039, Eukaryota
GeneTreeiENSGT00940000162591
HOGENOMiCLU_009773_0_0_1
InParanoidiQ96PH1
OMAiNFWKWFM
PhylomeDBiQ96PH1
TreeFamiTF324099

Enzyme and pathway databases

PathwayCommonsiQ96PH1
ReactomeiR-HSA-3299685, Detoxification of Reactive Oxygen Species
SABIO-RKiQ96PH1
SignaLinkiQ96PH1
SIGNORiQ96PH1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79400, 12 hits in 1068 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOX5, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NOX5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79400
PharosiQ96PH1, Tchem

Protein Ontology

More...
PROi
PR:Q96PH1
RNActiQ96PH1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000255346, Expressed in cingulate cortex and 127 other tissues
ExpressionAtlasiQ96PH1, baseline and differential
GenevisibleiQ96PH1, HS

Family and domain databases

CDDicd00051, EFh, 2 hits
Gene3Di3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR017938, Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF13202, EF-hand_5, 1 hit
PF13405, EF-hand_6, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOX5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PH1
Secondary accession number(s): B2RBJ4
, Q08AN2, Q08AN3, Q8TEQ1, Q8TER4, Q96PH2, Q96PJ8, Q96PJ9, Q9H6E0, Q9HAM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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