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Protein

Bcl-2-binding component 3

Gene

BBC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 3: Does not affect cell growth.1 Publication

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ96PG8

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-binding component 3
Alternative name(s):
JFY-1
p53 up-regulated modulator of apoptosis
Gene namesi
Name:BBC3
Synonyms:PUMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105327.15
HGNCiHGNC:17868 BBC3
MIMi605854 gene
neXtProtiNX_Q96PG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi27113
OpenTargetsiENSG00000105327
PharmGKBiPA38471

Polymorphism and mutation databases

BioMutaiUSPL1
DMDMi391738062

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004175721 – 261Bcl-2-binding component 3Add BLAST261

Proteomic databases

PaxDbiQ96PG8
PeptideAtlasiQ96PG8
PRIDEiQ96PG8
ProteomicsDBi77692
77693 [Q96PG8-1]

PTM databases

iPTMnetiQ96PG8
PhosphoSitePlusiQ96PG8

Expressioni

Inductioni

Up-regulated by TP53.1 Publication

Gene expression databases

BgeeiENSG00000105327 Expressed in 218 organ(s), highest expression level in dorsal plus ventral thalamus
ExpressionAtlasiQ96PG8 baseline and differential
GenevisibleiQ96PG8 HS

Organism-specific databases

HPAiCAB007752

Interactioni

Subunit structurei

Isoform 3: Does not interact with BCL2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118009, 7 interactors
IntActiQ96PG8, 8 interactors
STRINGi9606.ENSP00000404503

Structurei

3D structure databases

ProteinModelPortaliQ96PG8
SMRiQ96PG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contrary to isoforms 1 and 2, isoforms 3 and 4 do not contain any BH3 motif.1 Publication

Phylogenomic databases

eggNOGiENOG410IW36 Eukaryota
ENOG41119TR LUCA
GeneTreeiENSGT00710000107236
HOGENOMiHOG000151283
InParanoidiQ96PG8
KOiK10132
OMAiCHQPNPG
OrthoDBiEOG091G12PL
PhylomeDBiQ96PG8

Family and domain databases

InterProiView protein in InterPro
IPR031661 Bbc3
PANTHERiPTHR28639 PTHR28639, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 4 (identifier: Q96PG8-2) [UniParc]FASTAAdd to basket
Also known as: PUMA gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKFGMGSAQA CPCQVPRAAS TTWVPCQICG PRERHGPRTP GGQLPGARRG
60 70 80 90 100
PGPRRPAPLP ARPPGALGSV LRPLRARPGC RPRRPHPAAR CLPLRPHRPT
110 120 130 140 150
RRHRRPGGFP LAWGSPQPAP RPAPGRSSAL ALAGGAAPGV ARAQRPGGSG
160 170 180 190 200
GRSHPGGPGS PRGGGTVGPG DRGPAAADGG RPQRTVRAAE TRGAAAAPPL
210 220 230 240 250
TLEGPVQSHH GTPALTQGPQ SPRDGAQLGA CTRPVDVRDS GGRPLPPPDT
260
LASAGDFLCT M
Length:261
Mass (Da):26,498
Last modified:June 13, 2012 - v2
Checksum:i47BE86F942BD0452
GO
Isoform 3 (identifier: Q96PG8-1) [UniParc]FASTAAdd to basket
Also known as: PUMA delta

The sequence of this isoform differs from the canonical sequence as follows:
     30-189: Missing.

Show »
Length:101
Mass (Da):10,326
Checksum:i87EE064B28C97F14
GO
Isoform 1 (identifier: Q9BXH1-1) [UniParc]FASTAAdd to basket
Also known as: PUMA alpha
The sequence of this isoform can be found in the external entry Q9BXH1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:193
Mass (Da):20,532
GO
Isoform 2 (identifier: Q9BXH1-2) [UniParc]FASTAAdd to basket
Also known as: PUMA beta
The sequence of this isoform can be found in the external entry Q9BXH1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:131
Mass (Da):14,459
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04378130 – 189Missing in isoform 3. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354656 mRNA Translation: AAK39544.1
AC008532 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57467.1
CCDSiCCDS46128.1 [Q96PG8-1]
CCDS46129.1 [Q96PG8-2]
RefSeqiNP_001120712.1, NM_001127240.2 [Q96PG8-2]
NP_001120714.1, NM_001127242.2 [Q96PG8-1]
UniGeneiHs.467020

Genome annotation databases

EnsembliENST00000300880; ENSP00000300880; ENSG00000105327 [Q96PG8-1]
ENST00000449228; ENSP00000404503; ENSG00000105327 [Q96PG8-2]
GeneIDi27113
KEGGihsa:27113
UCSCiuc010ekz.4 human [Q96PG8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354656 mRNA Translation: AAK39544.1
AC008532 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57467.1
CCDSiCCDS46128.1 [Q96PG8-1]
CCDS46129.1 [Q96PG8-2]
RefSeqiNP_001120712.1, NM_001127240.2 [Q96PG8-2]
NP_001120714.1, NM_001127242.2 [Q96PG8-1]
UniGeneiHs.467020

3D structure databases

ProteinModelPortaliQ96PG8
SMRiQ96PG8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118009, 7 interactors
IntActiQ96PG8, 8 interactors
STRINGi9606.ENSP00000404503

PTM databases

iPTMnetiQ96PG8
PhosphoSitePlusiQ96PG8

Polymorphism and mutation databases

BioMutaiUSPL1
DMDMi391738062

Proteomic databases

PaxDbiQ96PG8
PeptideAtlasiQ96PG8
PRIDEiQ96PG8
ProteomicsDBi77692
77693 [Q96PG8-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300880; ENSP00000300880; ENSG00000105327 [Q96PG8-1]
ENST00000449228; ENSP00000404503; ENSG00000105327 [Q96PG8-2]
GeneIDi27113
KEGGihsa:27113
UCSCiuc010ekz.4 human [Q96PG8-2]

Organism-specific databases

CTDi27113
DisGeNETi27113
EuPathDBiHostDB:ENSG00000105327.15
GeneCardsiBBC3
H-InvDBiHIX0174298
HGNCiHGNC:17868 BBC3
HPAiCAB007752
MIMi605854 gene
neXtProtiNX_Q96PG8
OpenTargetsiENSG00000105327
PharmGKBiPA38471
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW36 Eukaryota
ENOG41119TR LUCA
GeneTreeiENSGT00710000107236
HOGENOMiHOG000151283
InParanoidiQ96PG8
KOiK10132
OMAiCHQPNPG
OrthoDBiEOG091G12PL
PhylomeDBiQ96PG8

Enzyme and pathway databases

SIGNORiQ96PG8

Miscellaneous databases

ChiTaRSiBBC3 human
GeneWikiiP53_upregulated_modulator_of_apoptosis
GenomeRNAii27113
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105327 Expressed in 218 organ(s), highest expression level in dorsal plus ventral thalamus
ExpressionAtlasiQ96PG8 baseline and differential
GenevisibleiQ96PG8 HS

Family and domain databases

InterProiView protein in InterPro
IPR031661 Bbc3
PANTHERiPTHR28639 PTHR28639, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBBC3B_HUMAN
AccessioniPrimary (citable) accession number: Q96PG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 7, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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