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Protein

Bcl-2-binding component 3

Gene

BBC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 3: Does not affect cell growth.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96PG8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-binding component 3
Alternative name(s):
JFY-1
p53 up-regulated modulator of apoptosis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BBC3
Synonyms:PUMA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105327.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17868 BBC3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605854 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PG8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27113

Open Targets

More...
OpenTargetsi
ENSG00000105327

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38471

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USPL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
391738062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004175721 – 261Bcl-2-binding component 3Add BLAST261

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PG8

PeptideAtlas

More...
PeptideAtlasi
Q96PG8

PRoteomics IDEntifications database

More...
PRIDEi
Q96PG8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77692
77693 [Q96PG8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PG8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by TP53.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105327 Expressed in 218 organ(s), highest expression level in dorsal plus ventral thalamus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96PG8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96PG8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB007752

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 3: Does not interact with BCL2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118009, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q96PG8, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000404503

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96PG8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96PG8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contrary to isoforms 1 and 2, isoforms 3 and 4 do not contain any BH3 motif.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IW36 Eukaryota
ENOG41119TR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00710000107236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000151283

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PG8

KEGG Orthology (KO)

More...
KOi
K10132

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHQPNPG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G12PL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PG8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031661 Bbc3

The PANTHER Classification System

More...
PANTHERi
PTHR28639 PTHR28639, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 4 (identifier: Q96PG8-2) [UniParc]FASTAAdd to basket
Also known as: PUMA gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKFGMGSAQA CPCQVPRAAS TTWVPCQICG PRERHGPRTP GGQLPGARRG
60 70 80 90 100
PGPRRPAPLP ARPPGALGSV LRPLRARPGC RPRRPHPAAR CLPLRPHRPT
110 120 130 140 150
RRHRRPGGFP LAWGSPQPAP RPAPGRSSAL ALAGGAAPGV ARAQRPGGSG
160 170 180 190 200
GRSHPGGPGS PRGGGTVGPG DRGPAAADGG RPQRTVRAAE TRGAAAAPPL
210 220 230 240 250
TLEGPVQSHH GTPALTQGPQ SPRDGAQLGA CTRPVDVRDS GGRPLPPPDT
260
LASAGDFLCT M
Length:261
Mass (Da):26,498
Last modified:June 13, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47BE86F942BD0452
GO
Isoform 3 (identifier: Q96PG8-1) [UniParc]FASTAAdd to basket
Also known as: PUMA delta

The sequence of this isoform differs from the canonical sequence as follows:
     30-189: Missing.

Show »
Length:101
Mass (Da):10,326
Checksum:i87EE064B28C97F14
GO
Isoform 1 (identifier: Q9BXH1-1) [UniParc]FASTAAdd to basket
Also known as: PUMA alpha
The sequence of this isoform can be found in the external entry Q9BXH1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:193
Mass (Da):20,532
GO
Isoform 2 (identifier: Q9BXH1-2) [UniParc]FASTAAdd to basket
Also known as: PUMA beta
The sequence of this isoform can be found in the external entry Q9BXH1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:131
Mass (Da):14,459
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04378130 – 189Missing in isoform 3. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF354656 mRNA Translation: AAK39544.1
AC008532 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57467.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46128.1 [Q96PG8-1]
CCDS46129.1 [Q96PG8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001120712.1, NM_001127240.2 [Q96PG8-2]
NP_001120714.1, NM_001127242.2 [Q96PG8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.467020

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300880; ENSP00000300880; ENSG00000105327 [Q96PG8-1]
ENST00000449228; ENSP00000404503; ENSG00000105327 [Q96PG8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27113

UCSC genome browser

More...
UCSCi
uc010ekz.4 human [Q96PG8-2]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354656 mRNA Translation: AAK39544.1
AC008532 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57467.1
CCDSiCCDS46128.1 [Q96PG8-1]
CCDS46129.1 [Q96PG8-2]
RefSeqiNP_001120712.1, NM_001127240.2 [Q96PG8-2]
NP_001120714.1, NM_001127242.2 [Q96PG8-1]
UniGeneiHs.467020

3D structure databases

ProteinModelPortaliQ96PG8
SMRiQ96PG8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118009, 7 interactors
IntActiQ96PG8, 8 interactors
STRINGi9606.ENSP00000404503

PTM databases

iPTMnetiQ96PG8
PhosphoSitePlusiQ96PG8

Polymorphism and mutation databases

BioMutaiUSPL1
DMDMi391738062

Proteomic databases

PaxDbiQ96PG8
PeptideAtlasiQ96PG8
PRIDEiQ96PG8
ProteomicsDBi77692
77693 [Q96PG8-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300880; ENSP00000300880; ENSG00000105327 [Q96PG8-1]
ENST00000449228; ENSP00000404503; ENSG00000105327 [Q96PG8-2]
GeneIDi27113
KEGGihsa:27113
UCSCiuc010ekz.4 human [Q96PG8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27113
DisGeNETi27113
EuPathDBiHostDB:ENSG00000105327.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BBC3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0174298
HGNCiHGNC:17868 BBC3
HPAiCAB007752
MIMi605854 gene
neXtProtiNX_Q96PG8
OpenTargetsiENSG00000105327
PharmGKBiPA38471

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IW36 Eukaryota
ENOG41119TR LUCA
GeneTreeiENSGT00710000107236
HOGENOMiHOG000151283
InParanoidiQ96PG8
KOiK10132
OMAiCHQPNPG
OrthoDBiEOG091G12PL
PhylomeDBiQ96PG8

Enzyme and pathway databases

SIGNORiQ96PG8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BBC3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
P53_upregulated_modulator_of_apoptosis

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27113

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105327 Expressed in 218 organ(s), highest expression level in dorsal plus ventral thalamus
ExpressionAtlasiQ96PG8 baseline and differential
GenevisibleiQ96PG8 HS

Family and domain databases

InterProiView protein in InterPro
IPR031661 Bbc3
PANTHERiPTHR28639 PTHR28639, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBBC3B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 7, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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