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Entry version 105 (08 May 2019)
Sequence version 3 (18 May 2010)
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Protein

Membrane-spanning 4-domains subfamily A member 10

Gene

MS4A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.37.2.1 the cd20 ca(2+) channel (cd20) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 10
Alternative name(s):
CD20 antigen-like 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MS4A10
Synonyms:CD20L7, MS4A9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13368 MS4A10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608403 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PG2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 91ExtracellularSequence analysis9
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 121CytoplasmicSequence analysis9
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 171ExtracellularSequence analysisAdd BLAST29
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 267CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000172689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31110

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MS4A10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439309

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001586461 – 267Membrane-spanning 4-domains subfamily A member 10Add BLAST267

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PG2

PeptideAtlas

More...
PeptideAtlasi
Q96PG2

PRoteomics IDEntifications database

More...
PRIDEi
Q96PG2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77691

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96PG2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PG2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172689 Expressed in 5 organ(s), highest expression level in small intestine Peyer's patch

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014778

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
131117, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311862

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWNC Eukaryota
ENOG41117F3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010921

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060092

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PG2

KEGG Orthology (KO)

More...
KOi
K22189

Identification of Orthologs from Complete Genome Data

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OMAi
KSWYPFW

Database of Orthologous Groups

More...
OrthoDBi
1363106at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PG2

TreeFam database of animal gene trees

More...
TreeFami
TF339722

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A

The PANTHER Classification System

More...
PANTHERi
PTHR23320 PTHR23320, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04103 CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96PG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS
60 70 80 90 100
QKKSSLLKEL GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA
110 120 130 140 150
SFLISGILAI TMKTFSKTYL KMLCLMTNLI SLFCVLSGLF VISKDLFLES
160 170 180 190 200
PFESPIWRMY PNSTVHIQRL ELALLCFTVL ELFLPVPTAV TAWRGDCPSA
210 220 230 240 250
KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ RLREVKQVAP
260
DTWIVTDGAA IWTQTAN
Length:267
Mass (Da):29,747
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39FC0395825B2E78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48E → D in BAC85498 (PubMed:14702039).Curated1
Sequence conflicti263T → A in BAC85498 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057652219P → L. Corresponds to variant dbSNP:rs12419635Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122633 mRNA Translation: BAC85498.1
AP004243 Genomic DNA No translation available.
BC137259 mRNA Translation: AAI37260.1
BC137263 mRNA Translation: AAI37264.1
AF354934 Genomic DNA Translation: AAL07361.1
AF354935 Genomic DNA Translation: AAL07362.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7992.1

NCBI Reference Sequences

More...
RefSeqi
NP_996776.2, NM_206893.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308287; ENSP00000311862; ENSG00000172689

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
341116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:341116

UCSC genome browser

More...
UCSCi
uc001npz.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122633 mRNA Translation: BAC85498.1
AP004243 Genomic DNA No translation available.
BC137259 mRNA Translation: AAI37260.1
BC137263 mRNA Translation: AAI37264.1
AF354934 Genomic DNA Translation: AAL07361.1
AF354935 Genomic DNA Translation: AAL07362.1
CCDSiCCDS7992.1
RefSeqiNP_996776.2, NM_206893.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi131117, 7 interactors
STRINGi9606.ENSP00000311862

Protein family/group databases

TCDBi1.A.37.2.1 the cd20 ca(2+) channel (cd20) family

PTM databases

iPTMnetiQ96PG2
PhosphoSitePlusiQ96PG2

Polymorphism and mutation databases

BioMutaiMS4A10
DMDMi296439309

Proteomic databases

PaxDbiQ96PG2
PeptideAtlasiQ96PG2
PRIDEiQ96PG2
ProteomicsDBi77691
TopDownProteomicsiQ96PG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308287; ENSP00000311862; ENSG00000172689
GeneIDi341116
KEGGihsa:341116
UCSCiuc001npz.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
341116

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MS4A10

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0026191
HGNCiHGNC:13368 MS4A10
HPAiHPA014778
MIMi608403 gene
neXtProtiNX_Q96PG2
OpenTargetsiENSG00000172689
PharmGKBiPA31110

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWNC Eukaryota
ENOG41117F3 LUCA
GeneTreeiENSGT00390000010921
HOGENOMiHOG000060092
InParanoidiQ96PG2
KOiK22189
OMAiKSWYPFW
OrthoDBi1363106at2759
PhylomeDBiQ96PG2
TreeFamiTF339722

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
341116

Protein Ontology

More...
PROi
PR:Q96PG2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172689 Expressed in 5 organ(s), highest expression level in small intestine Peyer's patch

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
PANTHERiPTHR23320 PTHR23320, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM4A10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PG2
Secondary accession number(s): B2RP45, Q96PG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 105 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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