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Protein

Putative membrane-spanning 4-domains subfamily A member 4E

Gene

MS4A4E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Putative membrane-spanning 4-domains subfamily A member 4E
Gene namesi
Name:MS4A4E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000214787.8
HGNCiHGNC:14284 MS4A4E
MIMi608401 gene
neXtProtiNX_Q96PG1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi643680
OpenTargetsiENSG00000214787

Polymorphism and mutation databases

DMDMi189047113

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586361 – 132Putative membrane-spanning 4-domains subfamily A member 4EAdd BLAST132

Proteomic databases

PRIDEiQ96PG1
ProteomicsDBi77688
77689 [Q96PG1-2]
77690 [Q96PG1-3]

Expressioni

Gene expression databases

BgeeiENSG00000214787
CleanExiHS_MS4A4E
ExpressionAtlasiQ96PG1 baseline and differential

Organism-specific databases

HPAiHPA040075

Structurei

3D structure databases

ProteinModelPortaliQ96PG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000110654
HOGENOMiHOG000113441
InParanoidiQ96PG1
PhylomeDBiQ96PG1

Family and domain databases

InterProiView protein in InterPro
IPR030417 MS4A
IPR030425 MS4A_4A/4E
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF59 PTHR23320:SF59, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96PG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTMQGMEQT TPGAGPDVPQ LGNIDVIHSY LCKGLQEKFF KRKPKVLGVV
60 70 80 90 100
RILIALMSLS MGIIMMCVAF SSYEEHPIFV YVAYTIWGSV MYPYQLQQEL
110 120 130
EQQKVWNYLK NLSWRIMGSY LCFGERSELK PL
Note: No experimental confirmation available.
Length:132
Mass (Da):15,209
Last modified:May 20, 2008 - v2
Checksum:iEA0A274F8F576A31
GO
Isoform 2 (identifier: Q96PG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-91: Missing.

Show »
Length:89
Mass (Da):10,354
Checksum:i4A43F1751CBA07F7
GO
Isoform 3 (identifier: Q96PG1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-132: VRILIALMSL...FGERSELKPL → LCGHKFSTHS...IRRQVRRLLK

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):12,445
Checksum:iFB21F761598896FD
GO

Sequence cautioni

The sequence AAL07363 differs from that shown. Intron retention. The entire sequence corresponds to part of an intron.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 11TT → AM in BAE46883 (Ref. 3) Curated2
Sequence conflicti17D → G in BAE46883 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03385849 – 91Missing in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_03385950 – 132VRILI…ELKPL → LCGHKFSTHSVSLSVAAGIR TTKGLELSEEFKLENNGIIF VFWREIRVETTIRRQVRRLL K in isoform 3. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DC379793 mRNA No translation available.
AF354936 Genomic DNA Translation: AAL07363.1 Sequence problems.
AB231725 mRNA Translation: BAE46883.1
AB231726 mRNA Translation: BAE46884.1
AB231727 mRNA Translation: BAE46885.1
AB231728 mRNA Translation: BAE46886.1
UniGeneiHs.559934

Genome annotation databases

EnsembliENST00000398984; ENSP00000381954; ENSG00000214787 [Q96PG1-1]
ENST00000425663; ENSP00000389556; ENSG00000214787 [Q96PG1-2]
ENST00000526086; ENSP00000435601; ENSG00000214787 [Q96PG1-3]
ENST00000528394; ENSP00000436446; ENSG00000214787 [Q96PG1-1]
UCSCiuc001nox.3 human [Q96PG1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiM4A4E_HUMAN
AccessioniPrimary (citable) accession number: Q96PG1
Secondary accession number(s): Q3C1W1, Q3C1W3, Q3C1W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 20, 2008
Last modified: June 20, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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