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Protein

Opalin

Gene

OPALIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Opalin
Alternative name(s):
Oligodendrocytic myelin paranodal and inner loop protein
Transmembrane protein 10
Gene namesi
Name:OPALIN
Synonyms:HTMP10, TMEM10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000197430.10
HGNCiHGNC:20707 OPALIN
neXtProtiNX_Q96PE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 141CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197430
PharmGKBiPA162398424

Polymorphism and mutation databases

BioMutaiOPALIN
DMDMi20532275

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725911 – 141OpalinAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi14O-linked (GalNAc...) threonineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96PE5
PaxDbiQ96PE5
PeptideAtlasiQ96PE5
PRIDEiQ96PE5
ProteomicsDBi77682
77683 [Q96PE5-2]

PTM databases

iPTMnetiQ96PE5
PhosphoSitePlusiQ96PE5

Expressioni

Tissue specificityi

Brain specific.1 Publication

Gene expression databases

BgeeiENSG00000197430 Expressed in 56 organ(s), highest expression level in corpus callosum
CleanExiHS_OPALIN
ExpressionAtlasiQ96PE5 baseline and differential
GenevisibleiQ96PE5 HS

Organism-specific databases

HPAiHPA014372

Interactioni

Protein-protein interaction databases

BioGridi125020, 80 interactors
STRINGi9606.ENSP00000360214

Structurei

3D structure databases

ProteinModelPortaliQ96PE5
SMRiQ96PE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXMR Eukaryota
ENOG41116AS LUCA
GeneTreeiENSGT00390000009395
HOGENOMiHOG000015359
HOVERGENiHBG054559
InParanoidiQ96PE5
OMAiGLWWLMP
OrthoDBiEOG091G0V86
PhylomeDBiQ96PE5
TreeFamiTF337818

Family and domain databases

InterProiView protein in InterPro
IPR026609 Opalin
PANTHERiPTHR21102 PTHR21102, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFSLNFTLP ANTTSSPVTG GKETDCGPSL GLAAGIPLLV ATALLVALLF
60 70 80 90 100
TLIHRRRSSI EAMEESDRPC EISEIDDNPK ISENPRRSPT HEKNTMGAQE
110 120 130 140
AHIYVKTVAG SEEPVHDRYR PTIEMERRRG LWWLVPRLSL E
Length:141
Mass (Da):15,683
Last modified:December 1, 2001 - v1
Checksum:i86DE9B7AF4C89B85
GO
Isoform 2 (identifier: Q96PE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSFSLNFTLPANT → MRM

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):14,677
Checksum:i5044A755A5F008D1
GO
Isoform 3 (identifier: Q96PE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MSFSLNFTLPANTTSSPVTGGKET → M

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:118
Mass (Da):13,344
Checksum:i56E067D79090F3B5
GO
Isoform 4 (identifier: Q96PE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-23: Missing.

Note: No experimental confirmation available.
Show »
Length:130
Mass (Da):14,638
Checksum:iDFAC8A9CC52FE58B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS47A0A0A0MS47_HUMAN
Opalin
OPALIN
129Annotation score:
A0A0A0MTN4A0A0A0MTN4_HUMAN
Opalin
OPALIN
79Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462901 – 24MSFSL…GGKET → M in isoform 3. CuratedAdd BLAST24
Alternative sequenceiVSP_0429431 – 13MSFSL…LPANT → MRM in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05489213 – 23Missing in isoform 4. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367761 mRNA Translation: AAK62349.1
AK296462 mRNA Translation: BAG59108.1
AK289835 mRNA Translation: BAF82524.1
AK296562 mRNA Translation: BAG59182.1
AK316090 mRNA Translation: BAH14461.1
AL834229 mRNA Translation: CAD38907.1
AL136181 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49978.1
BC033737 mRNA Translation: AAH33737.1
CCDSiCCDS41556.1 [Q96PE5-3]
CCDS44466.1 [Q96PE5-2]
CCDS60602.1 [Q96PE5-4]
CCDS7448.1 [Q96PE5-1]
RefSeqiNP_001035191.1, NM_001040102.2 [Q96PE5-3]
NP_001035192.1, NM_001040103.2 [Q96PE5-2]
NP_001271249.1, NM_001284320.1 [Q96PE5-4]
NP_001271250.1, NM_001284321.1
NP_001271251.1, NM_001284322.1 [Q96PE5-2]
NP_001271252.1, NM_001284323.1 [Q96PE5-2]
NP_001271253.1, NM_001284324.1 [Q96PE5-2]
NP_001271255.1, NM_001284326.1
NP_001271256.1, NM_001284327.1
NP_149984.1, NM_033207.4 [Q96PE5-1]
UniGeneiHs.12449

Genome annotation databases

EnsembliENST00000371172; ENSP00000360214; ENSG00000197430 [Q96PE5-1]
ENST00000393871; ENSP00000377449; ENSG00000197430 [Q96PE5-3]
ENST00000419479; ENSP00000398025; ENSG00000197430 [Q96PE5-4]
ENST00000611913; ENSP00000484599; ENSG00000197430 [Q96PE5-2]
GeneIDi93377
KEGGihsa:93377
UCSCiuc001kmj.5 human [Q96PE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367761 mRNA Translation: AAK62349.1
AK296462 mRNA Translation: BAG59108.1
AK289835 mRNA Translation: BAF82524.1
AK296562 mRNA Translation: BAG59182.1
AK316090 mRNA Translation: BAH14461.1
AL834229 mRNA Translation: CAD38907.1
AL136181 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49978.1
BC033737 mRNA Translation: AAH33737.1
CCDSiCCDS41556.1 [Q96PE5-3]
CCDS44466.1 [Q96PE5-2]
CCDS60602.1 [Q96PE5-4]
CCDS7448.1 [Q96PE5-1]
RefSeqiNP_001035191.1, NM_001040102.2 [Q96PE5-3]
NP_001035192.1, NM_001040103.2 [Q96PE5-2]
NP_001271249.1, NM_001284320.1 [Q96PE5-4]
NP_001271250.1, NM_001284321.1
NP_001271251.1, NM_001284322.1 [Q96PE5-2]
NP_001271252.1, NM_001284323.1 [Q96PE5-2]
NP_001271253.1, NM_001284324.1 [Q96PE5-2]
NP_001271255.1, NM_001284326.1
NP_001271256.1, NM_001284327.1
NP_149984.1, NM_033207.4 [Q96PE5-1]
UniGeneiHs.12449

3D structure databases

ProteinModelPortaliQ96PE5
SMRiQ96PE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125020, 80 interactors
STRINGi9606.ENSP00000360214

PTM databases

iPTMnetiQ96PE5
PhosphoSitePlusiQ96PE5

Polymorphism and mutation databases

BioMutaiOPALIN
DMDMi20532275

Proteomic databases

MaxQBiQ96PE5
PaxDbiQ96PE5
PeptideAtlasiQ96PE5
PRIDEiQ96PE5
ProteomicsDBi77682
77683 [Q96PE5-2]

Protocols and materials databases

DNASUi93377
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371172; ENSP00000360214; ENSG00000197430 [Q96PE5-1]
ENST00000393871; ENSP00000377449; ENSG00000197430 [Q96PE5-3]
ENST00000419479; ENSP00000398025; ENSG00000197430 [Q96PE5-4]
ENST00000611913; ENSP00000484599; ENSG00000197430 [Q96PE5-2]
GeneIDi93377
KEGGihsa:93377
UCSCiuc001kmj.5 human [Q96PE5-1]

Organism-specific databases

CTDi93377
EuPathDBiHostDB:ENSG00000197430.10
GeneCardsiOPALIN
HGNCiHGNC:20707 OPALIN
HPAiHPA014372
neXtProtiNX_Q96PE5
OpenTargetsiENSG00000197430
PharmGKBiPA162398424
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXMR Eukaryota
ENOG41116AS LUCA
GeneTreeiENSGT00390000009395
HOGENOMiHOG000015359
HOVERGENiHBG054559
InParanoidiQ96PE5
OMAiGLWWLMP
OrthoDBiEOG091G0V86
PhylomeDBiQ96PE5
TreeFamiTF337818

Miscellaneous databases

GeneWikiiTMEM10
GenomeRNAii93377
PROiPR:Q96PE5

Gene expression databases

BgeeiENSG00000197430 Expressed in 56 organ(s), highest expression level in corpus callosum
CleanExiHS_OPALIN
ExpressionAtlasiQ96PE5 baseline and differential
GenevisibleiQ96PE5 HS

Family and domain databases

InterProiView protein in InterPro
IPR026609 Opalin
PANTHERiPTHR21102 PTHR21102, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPALI_HUMAN
AccessioniPrimary (citable) accession number: Q96PE5
Secondary accession number(s): A8MX69
, A8MYG4, B4DK96, B4DKH0, Q5W102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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