Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 137 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Opalin

Gene

OPALIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Opalin
Alternative name(s):
Oligodendrocytic myelin paranodal and inner loop protein
Transmembrane protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OPALIN
Synonyms:HTMP101 Publication, TMEM101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197430.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20707 OPALIN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617200 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PE5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 141CytoplasmicSequence analysisAdd BLAST91

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000197430

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398424

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96PE5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OPALIN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20532275

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725911 – 141OpalinAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi14O-linked (GalNAc...) threonineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96PE5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96PE5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96PE5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PE5

PeptideAtlas

More...
PeptideAtlasi
Q96PE5

PRoteomics IDEntifications database

More...
PRIDEi
Q96PE5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2298
2399
77682 [Q96PE5-1]
77683 [Q96PE5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain specific; expressed in oligodendrocytes (PubMed:11814680, PubMed:30837646). Expressed in oligodendrocytes in remyelinating multiple sclerosis plaques (PubMed:30837646).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197430 Expressed in corpus callosum and 55 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96PE5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96PE5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197430 Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125020, 81 interactors

Protein interaction database and analysis system

More...
IntActi
Q96PE5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360214

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96PE5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96PE5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 93Required for plasma membrane localizationBy similarityAdd BLAST17

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXMR Eukaryota
ENOG41116AS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009395

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1824653_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PE5

Identification of Orthologs from Complete Genome Data

More...
OMAi
DCGPSVG

Database of Orthologous Groups

More...
OrthoDBi
1457772at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PE5

TreeFam database of animal gene trees

More...
TreeFami
TF337818

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026609 Opalin

The PANTHER Classification System

More...
PANTHERi
PTHR21102 PTHR21102, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFSLNFTLP ANTTSSPVTG GKETDCGPSL GLAAGIPLLV ATALLVALLF
60 70 80 90 100
TLIHRRRSSI EAMEESDRPC EISEIDDNPK ISENPRRSPT HEKNTMGAQE
110 120 130 140
AHIYVKTVAG SEEPVHDRYR PTIEMERRRG LWWLVPRLSL E
Length:141
Mass (Da):15,683
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86DE9B7AF4C89B85
GO
Isoform 2 (identifier: Q96PE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSFSLNFTLPANT → MRM

Show »
Length:131
Mass (Da):14,677
Checksum:i5044A755A5F008D1
GO
Isoform 3 (identifier: Q96PE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MSFSLNFTLPANTTSSPVTGGKET → M

Show »
Length:118
Mass (Da):13,344
Checksum:i56E067D79090F3B5
GO
Isoform 4 (identifier: Q96PE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-23: Missing.

Show »
Length:130
Mass (Da):14,638
Checksum:iDFAC8A9CC52FE58B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS47A0A0A0MS47_HUMAN
Opalin
OPALIN
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTN4A0A0A0MTN4_HUMAN
Opalin
OPALIN
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0462901 – 24MSFSL…GGKET → M in isoform 3. CuratedAdd BLAST24
Alternative sequenceiVSP_0429431 – 13MSFSL…LPANT → MRM in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05489213 – 23Missing in isoform 4. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF367761 mRNA Translation: AAK62349.1
AK296462 mRNA Translation: BAG59108.1
AK289835 mRNA Translation: BAF82524.1
AK296562 mRNA Translation: BAG59182.1
AK316090 mRNA Translation: BAH14461.1
AL834229 mRNA Translation: CAD38907.1
AL136181 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49978.1
BC033737 mRNA Translation: AAH33737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41556.1 [Q96PE5-3]
CCDS44466.1 [Q96PE5-2]
CCDS60602.1 [Q96PE5-4]
CCDS7448.1 [Q96PE5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001035191.1, NM_001040102.2 [Q96PE5-3]
NP_001035192.1, NM_001040103.2 [Q96PE5-2]
NP_001271249.1, NM_001284320.1 [Q96PE5-4]
NP_001271250.1, NM_001284321.1
NP_001271251.1, NM_001284322.1 [Q96PE5-2]
NP_001271252.1, NM_001284323.1 [Q96PE5-2]
NP_001271253.1, NM_001284324.1 [Q96PE5-2]
NP_001271255.1, NM_001284326.1
NP_001271256.1, NM_001284327.1
NP_149984.1, NM_033207.4 [Q96PE5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371172; ENSP00000360214; ENSG00000197430 [Q96PE5-1]
ENST00000393871; ENSP00000377449; ENSG00000197430 [Q96PE5-3]
ENST00000419479; ENSP00000398025; ENSG00000197430 [Q96PE5-4]
ENST00000611913; ENSP00000484599; ENSG00000197430 [Q96PE5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
93377

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93377

UCSC genome browser

More...
UCSCi
uc001kmj.5 human [Q96PE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367761 mRNA Translation: AAK62349.1
AK296462 mRNA Translation: BAG59108.1
AK289835 mRNA Translation: BAF82524.1
AK296562 mRNA Translation: BAG59182.1
AK316090 mRNA Translation: BAH14461.1
AL834229 mRNA Translation: CAD38907.1
AL136181 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49978.1
BC033737 mRNA Translation: AAH33737.1
CCDSiCCDS41556.1 [Q96PE5-3]
CCDS44466.1 [Q96PE5-2]
CCDS60602.1 [Q96PE5-4]
CCDS7448.1 [Q96PE5-1]
RefSeqiNP_001035191.1, NM_001040102.2 [Q96PE5-3]
NP_001035192.1, NM_001040103.2 [Q96PE5-2]
NP_001271249.1, NM_001284320.1 [Q96PE5-4]
NP_001271250.1, NM_001284321.1
NP_001271251.1, NM_001284322.1 [Q96PE5-2]
NP_001271252.1, NM_001284323.1 [Q96PE5-2]
NP_001271253.1, NM_001284324.1 [Q96PE5-2]
NP_001271255.1, NM_001284326.1
NP_001271256.1, NM_001284327.1
NP_149984.1, NM_033207.4 [Q96PE5-1]

3D structure databases

SMRiQ96PE5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125020, 81 interactors
IntActiQ96PE5, 1 interactor
STRINGi9606.ENSP00000360214

PTM databases

iPTMnetiQ96PE5
PhosphoSitePlusiQ96PE5

Polymorphism and mutation databases

BioMutaiOPALIN
DMDMi20532275

Proteomic databases

jPOSTiQ96PE5
MassIVEiQ96PE5
MaxQBiQ96PE5
PaxDbiQ96PE5
PeptideAtlasiQ96PE5
PRIDEiQ96PE5
ProteomicsDBi2298
2399
77682 [Q96PE5-1]
77683 [Q96PE5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2734 36 antibodies

The DNASU plasmid repository

More...
DNASUi
93377

Genome annotation databases

EnsembliENST00000371172; ENSP00000360214; ENSG00000197430 [Q96PE5-1]
ENST00000393871; ENSP00000377449; ENSG00000197430 [Q96PE5-3]
ENST00000419479; ENSP00000398025; ENSG00000197430 [Q96PE5-4]
ENST00000611913; ENSP00000484599; ENSG00000197430 [Q96PE5-2]
GeneIDi93377
KEGGihsa:93377
UCSCiuc001kmj.5 human [Q96PE5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93377
EuPathDBiHostDB:ENSG00000197430.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OPALIN
HGNCiHGNC:20707 OPALIN
HPAiENSG00000197430 Tissue enriched (brain)
MIMi617200 gene
neXtProtiNX_Q96PE5
OpenTargetsiENSG00000197430
PharmGKBiPA162398424

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXMR Eukaryota
ENOG41116AS LUCA
GeneTreeiENSGT00390000009395
HOGENOMiCLU_1824653_0_0_1
InParanoidiQ96PE5
OMAiDCGPSVG
OrthoDBi1457772at2759
PhylomeDBiQ96PE5
TreeFamiTF337818

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
93377 1 hit in 779 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TMEM10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
93377
PharosiQ96PE5 Tdark

Protein Ontology

More...
PROi
PR:Q96PE5
RNActiQ96PE5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197430 Expressed in corpus callosum and 55 other tissues
ExpressionAtlasiQ96PE5 baseline and differential
GenevisibleiQ96PE5 HS

Family and domain databases

InterProiView protein in InterPro
IPR026609 Opalin
PANTHERiPTHR21102 PTHR21102, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPALI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PE5
Secondary accession number(s): A8MX69
, A8MYG4, B4DK96, B4DKH0, Q5W102
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again