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UniProtKB - Q96PE3 (INP4A_HUMAN)

Entry version 139 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Inositol polyphosphate-4-phosphatase type I A

Gene

INPP4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355).

Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity).

Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity).

May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).

By similarity3 Publications

Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.2 Publications
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei895Phosphocysteine intermediate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS00551-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.66, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96PE3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-1660516, Synthesis of PIPs at the early endosome membrane
R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00944

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000900

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol polyphosphate-4-phosphatase type I AImported
Alternative name(s):
Inositol polyphosphate 4-phosphatase type I1 Publication
Type I inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.663 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INPP4A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6074, INPP4A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600916, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96PE3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000040933

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi731D → N: Complete loss of lipid phosphatase activity. 1 Publication1
Mutagenesisi895C → S: Does not rescue the wortmannin-induced dilation of endosomes due to accumulation of (PtdIns(3,4)P2). 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3631

MalaCards human disease database

More...MalaCardsi		INPP4A

Open Targets

More...OpenTargetsi		ENSG00000040933

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29882

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96PE3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INPP4A

Domain mapping of disease mutations (DMDM)

More...DMDMi		73920059

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902321 – 977Inositol polyphosphate-4-phosphatase type I AAdd BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei355PhosphotyrosineCombined sources1
Modified residuei487PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96PE3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96PE3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96PE3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96PE3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96PE3

PeptideAtlas

More...PeptideAtlasi		Q96PE3

PRoteomics IDEntifications database

More...PRIDEi		Q96PE3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77678 [Q96PE3-1]
77679 [Q96PE3-2]
77680 [Q96PE3-3]
77681 [Q96PE3-4]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		INPP4A

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96PE3, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96PE3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q96PE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96PE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000040933, Expressed in dorsolateral prefrontal cortex and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96PE3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96PE3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000040933, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with INPP5F.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109843, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q96PE3, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000074304

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96PE3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96PE3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 153C2PROSITE-ProRule annotationAdd BLAST128

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4428, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157360

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007802_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96PE3

Identification of Orthologs from Complete Genome Data

More...OMAi		EMINKTQ

Database of Orthologous Groups

More...OrthoDBi		129165at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96PE3

TreeFam database of animal gene trees

More...TreeFami		TF325637

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR039034, INPP4

The PANTHER Classification System

More...PANTHERi		PTHR12187, PTHR12187, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PE3-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAREHSPRH GARARAMQRA STIDVAADML GLSLAGNIQD PDEPILEFSL 
        60         70         80         90        100
ACSELHTPSL DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS 
       110        120        130        140        150
IAFFQDSLIN QMTQVKLSVY DVKDRSQGTM YLLGSGTFIV KDLLQDRHHR 
       160        170        180        190        200
LHLTLRSAES DRVGNITVIG WQMEEKSDQR PPVTRSVDTV NGRMVLPVDE 
       210        220        230        240        250
SLTEALGIRS KYASLRKDTL LKSVFGGAIC RMYRFPTTDG NHLRILEQMA 
       260        270        280        290        300
ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT 
       310        320        330        340        350
IILTYQENLT DLHQYRGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG 
       360        370        380        390        400
SDQNYDIVTI GAPAAHCQGF KSGGLRKKLH KFEETKKHFE ECCTSSGCQS 
       410        420        430        440        450
IIYIPQDVVR AKEIIAQINT LKTQVSYYAE RLSRAAKDRS ATGLERTLAI 
       460        470        480        490        500
LADKTRQLVT VCDCKLLANS IHGLNAARPD YIASKASPTS TEEEQVMLRN 
       510        520        530        540        550
DQDTLMARWT GRNSRSSLQV DWHEEEWEKV WLNVDKSLEC IIQRVDKLLQ 
       560        570        580        590        600
KERLHGEGCE DVFPCAGSCT SKKGNPDSHA YWIRPEDPFC DVPSSPCPST 
       610        620        630        640        650
MPSTACHPHL TTHCSPPPEE SSPGEWSEAL YPLLTTLTDC VAMMSDKAKK 
       660        670        680        690        700
AMVFLLMQDS APTIATYLSL QYRRDVVFCQ TLTALICGFI IKLRNCLHDD 
       710        720        730        740        750
GFLRQLYTIG LLAQFESLLS TYGEELAMLE DMSLGIMDLR NVTFKVTQAT 
       760        770        780        790        800
SSASADMLPV ITGNRDGFNV RVPLPGPLFD ALPREIQSGM LLRVQPVLFN 
       810        820        830        840        850
VGINEQQTLA ERFGDTSLQE VINVESLVRL NSYFEQFKEV LPEDCLPRSR 
       860        870        880        890        900
SQTCLPELLR FLGQNVHARK NKNVDILWQA AEICRRLNGV RFTSCKSAKD 
       910        920        930        940        950
RTAMSVTLEQ CLILQHEHGM APQVFTQALE CMRSEGCRRE NTMKNVGSRK 
       960        970 
YAFNSLQLKA FPKHYRPPEG TYGKVET
Length:977
Mass (Da):109,956
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14087B24256B2D05
GO
Isoform 2 (identifier: Q96PE3-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1

The sequence of this isoform differs from the canonical sequence as follows:
     574-613: GNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTH → D

Show »
Length:938
Mass (Da):105,699
Checksum:i02E47A7528C9C4F7
GO
Isoform 3 (identifier: Q96PE3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-393: Missing.

Show »
Length:972
Mass (Da):109,344
Checksum:i63238BA562D67D76
GO
Isoform 4 (identifier: Q96PE3-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     574-613: GNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTH → D
     935-977: EGCRRENTMK...PEGTYGKVET → IGTREVVTQK...AYLVTKLRCK

Note: Inactive.Curated
Show »
Length:954
Mass (Da):107,297
Checksum:iA0899227C8C4BA85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZB2B8ZZB2_HUMAN
Inositol polyphosphate-4-phosphatas...
INPP4A
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti767G → E in AAH28361 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059359604T → A. Corresponds to variant dbSNP:rs2278206Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015240389 – 393Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_015241574 – 613GNPDS…HLTTH → D in isoform 2 and isoform 4. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_015242935 – 977EGCRR…GKVET → IGTREVVTQKNLSGLVPIRD LRLDPSLLCSIPLLALSPNL LIVWLFLSIAYLVTKLRCK in isoform 4. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U26398 mRNA Translation: AAB01068.1
U96919 mRNA Translation: AAB72150.1
AF368319 mRNA Translation: AAK58870.1
AC010134 Genomic DNA Translation: AAX93230.1
BC028361 mRNA Translation: AAH28361.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46369.1 [Q96PE3-1]
CCDS46370.1 [Q96PE3-2]
CCDS46371.1 [Q96PE3-3]
CCDS46372.1 [Q96PE3-4]

Protein sequence database of the Protein Information Resource

More...PIRi		B57487

NCBI Reference Sequences

More...RefSeqi		NP_001127696.1, NM_001134224.1 [Q96PE3-1]
NP_001127697.1, NM_001134225.1 [Q96PE3-3]
NP_001557.1, NM_001566.2 [Q96PE3-4]
NP_004018.1, NM_004027.2 [Q96PE3-2]
XP_016859487.1, XM_017003998.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000074304; ENSP00000074304; ENSG00000040933 [Q96PE3-1]
ENST00000409016; ENSP00000386704; ENSG00000040933 [Q96PE3-2]
ENST00000409540; ENSP00000387294; ENSG00000040933 [Q96PE3-4]
ENST00000409851; ENSP00000386777; ENSG00000040933 [Q96PE3-3]
ENST00000523221; ENSP00000427722; ENSG00000040933 [Q96PE3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3631

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3631

UCSC genome browser

More...UCSCi		uc002syx.4, human [Q96PE3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26398 mRNA Translation: AAB01068.1
U96919 mRNA Translation: AAB72150.1
AF368319 mRNA Translation: AAK58870.1
AC010134 Genomic DNA Translation: AAX93230.1
BC028361 mRNA Translation: AAH28361.1
CCDSiCCDS46369.1 [Q96PE3-1]
CCDS46370.1 [Q96PE3-2]
CCDS46371.1 [Q96PE3-3]
CCDS46372.1 [Q96PE3-4]
PIRiB57487
RefSeqiNP_001127696.1, NM_001134224.1 [Q96PE3-1]
NP_001127697.1, NM_001134225.1 [Q96PE3-3]
NP_001557.1, NM_001566.2 [Q96PE3-4]
NP_004018.1, NM_004027.2 [Q96PE3-2]
XP_016859487.1, XM_017003998.1

3D structure databases

SMRiQ96PE3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109843, 13 interactors
IntActiQ96PE3, 4 interactors
STRINGi9606.ENSP00000074304

Chemistry databases

SwissLipidsiSLP:000000900

PTM databases

DEPODiINPP4A
GlyGeniQ96PE3, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96PE3
MetOSiteiQ96PE3
PhosphoSitePlusiQ96PE3

Genetic variation databases

BioMutaiINPP4A
DMDMi73920059

Proteomic databases

EPDiQ96PE3
jPOSTiQ96PE3
MassIVEiQ96PE3
MaxQBiQ96PE3
PaxDbiQ96PE3
PeptideAtlasiQ96PE3
PRIDEiQ96PE3
ProteomicsDBi77678 [Q96PE3-1]
77679 [Q96PE3-2]
77680 [Q96PE3-3]
77681 [Q96PE3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		41266, 107 antibodies

The DNASU plasmid repository

More...DNASUi		3631

Genome annotation databases

EnsembliENST00000074304; ENSP00000074304; ENSG00000040933 [Q96PE3-1]
ENST00000409016; ENSP00000386704; ENSG00000040933 [Q96PE3-2]
ENST00000409540; ENSP00000387294; ENSG00000040933 [Q96PE3-4]
ENST00000409851; ENSP00000386777; ENSG00000040933 [Q96PE3-3]
ENST00000523221; ENSP00000427722; ENSG00000040933 [Q96PE3-1]
GeneIDi3631
KEGGihsa:3631
UCSCiuc002syx.4, human [Q96PE3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3631
DisGeNETi3631

GeneCards: human genes, protein and diseases

More...GeneCardsi		INPP4A
HGNCiHGNC:6074, INPP4A
HPAiENSG00000040933, Low tissue specificity
MalaCardsiINPP4A
MIMi600916, gene
neXtProtiNX_Q96PE3
OpenTargetsiENSG00000040933
PharmGKBiPA29882
VEuPathDBiHostDB:ENSG00000040933

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4428, Eukaryota
GeneTreeiENSGT00940000157360
HOGENOMiCLU_007802_0_0_1
InParanoidiQ96PE3
OMAiEMINKTQ
OrthoDBi129165at2759
PhylomeDBiQ96PE3
TreeFamiTF325637

Enzyme and pathway databases

UniPathwayiUPA00944
BioCyciMetaCyc:HS00551-MONOMER
BRENDAi3.1.3.66, 2681
PathwayCommonsiQ96PE3
ReactomeiR-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-1660516, Synthesis of PIPs at the early endosome membrane
R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3631, 11 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		INPP4A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		INPP4A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3631
PharosiQ96PE3, Tbio

Protein Ontology

More...PROi		PR:Q96PE3
RNActiQ96PE3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000040933, Expressed in dorsolateral prefrontal cortex and 233 other tissues
ExpressionAtlasiQ96PE3, baseline and differential
GenevisibleiQ96PE3, HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR039034, INPP4
PANTHERiPTHR12187, PTHR12187, 1 hit
SUPFAMiSSF49562, SSF49562, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINP4A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PE3
Secondary accession number(s): O15326
, Q13187, Q53TD8, Q8TC02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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