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Entry version 147 (26 Feb 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Rho guanine nucleotide exchange factor 17

Gene

ARHGEF17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 17
Alternative name(s):
164 kDa Rho-specific guanine-nucleotide exchange factor
Short name:
p164-RhoGEF
Short name:
p164RhoGEF
Tumor endothelial marker 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF17
Synonyms:KIAA0337, TEM4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21726 ARHGEF17

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PE2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9828

Open Targets

More...
OpenTargetsi
ENSG00000110237

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134884537

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96PE2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74724250

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002865891 – 2063Rho guanine nucleotide exchange factor 17Add BLAST2063

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphoserineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei387PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei619PhosphoserineBy similarity1
Modified residuei696PhosphoserineBy similarity1
Modified residuei699PhosphothreonineBy similarity1
Modified residuei702PhosphothreonineBy similarity1
Modified residuei735PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei961PhosphoserineBy similarity1
Modified residuei1002PhosphoserineBy similarity1
Modified residuei1331PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96PE2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96PE2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96PE2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96PE2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96PE2

PeptideAtlas

More...
PeptideAtlasi
Q96PE2

PRoteomics IDEntifications database

More...
PRIDEi
Q96PE2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77677

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PE2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110237 Expressed in left lobe of thyroid gland and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96PE2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96PE2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007991

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115166, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q96PE2, 22 interactors

Molecular INTeraction database

More...
MINTi
Q96PE2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263674

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96PE2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1066 – 1254DHPROSITE-ProRule annotationAdd BLAST189

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi201 – 204Poly-Gln4
Compositional biasi230 – 235Poly-Ser6
Compositional biasi252 – 256Poly-Glu5
Compositional biasi566 – 569Poly-Ser4
Compositional biasi672 – 675Poly-Ser4
Compositional biasi707 – 710Poly-Arg4
Compositional biasi963 – 1054Pro-richAdd BLAST92
Compositional biasi1990 – 1996Poly-Pro7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IRSX Eukaryota
ENOG410XSIJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153798

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_237760_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96PE2

KEGG Orthology (KO)

More...
KOi
K20689

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPDSGCE

Database of Orthologous Groups

More...
OrthoDBi
652460at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96PE2

TreeFam database of animal gene trees

More...
TreeFami
TF324157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR039917 ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12877 PTHR12877, 1 hit
PTHR12877:SF15 PTHR12877:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96PE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGAPRPQL YRSVSFKLLE RWSGGPGLRE EDTDTPGLRR RASCRPTTAA
60 70 80 90 100
RGQPSRRVSK LASGPLAAPA QPRPLRSLSP SVRQLSRRFD APRLDDGSAG
110 120 130 140 150
TRDGGVLPAA AEEAAEGPAR GAWPSVTEMR KLFGGPGSRR PSADSESPGT
160 170 180 190 200
PSPDGAAWEP PARESRQPPT PPPRTCFPLA GLRSARPLTG PETEGRLRRP
210 220 230 240 250
QQQQERAQRP ADGLHSWHIF SQPQAGARAS CSSSSIAASY PVSRSRAASS
260 270 280 290 300
SEEEEEGPPQ LPGAQSPAYH GGHSSGSDDD RDGEGGHRWG GRPGLRPGSS
310 320 330 340 350
LLDQDCRPDS DGLNLSSMNS AGVSGSPEPP TSPRAPREEG LREWGSGSPP
360 370 380 390 400
CVPGPQEGLR PMSDSVGGAF RVAKVSFPSY LASPAGSRGS SRYSSTETLK
410 420 430 440 450
DDDLWSSRGS GGWGVYRSPS FGAGEGLLRS QARTRAKGPG GTSRALRDGG
460 470 480 490 500
FEPEKSRQRK SLSNPDIASE TLTLLSFLRS DLSELRVRKP GGSSGDRGSN
510 520 530 540 550
PLDGRDSPSA GGPVGQLEPI PIPAPASPGT RPTLKDLTAT LRRAKSFTCS
560 570 580 590 600
EKPMARRLPR TSALKSSSSE LLLTGPGAEE DPLPLIVQDQ YVQEARQVFE
610 620 630 640 650
KIQRMGAQQD DGSDAPPGSP DWAGDVTRGQ RSQEELSGPE SSLTDEGIGA
660 670 680 690 700
DPEPPVAAFC GLGTTGMWRP LSSSSAQTNH HGPGTEDSLG GWALVSPETP
710 720 730 740 750
PTPGALRRRR KVPPSGSGGS ELSNGEAGEA YRSLSDPIPQ RHRAATSEEP
760 770 780 790 800
TGFSVDSNLL GSLSPKTGLP ATSAMDEGLT SGHSDWSVGS EESKGYQEVI
810 820 830 840 850
QSIVQGPGTL GRVVDDRIAG KAPKKKSLSD PSRRGELAGP GFEGPGGEPI
860 870 880 890 900
REVEPMLPPS SSEPILVEQR AEPEEPGATR SRAQSERALP EALPPPATAH
910 920 930 940 950
RNFHLDPKLA DILSPRLIRR GSKKRPARSS HQELRRDEGS QDQTGSLSRA
960 970 980 990 1000
RPSSRHVRHA SVPATFMPIV VPEPPTSVGP PVAVPEPIGF PTRAHPTLQA
1010 1020 1030 1040 1050
PSLEDVTKQY MLNLHSGEVP APVPVDMPCL PLAAPPSAEA KPPEAARPAD
1060 1070 1080 1090 1100
EPTPASKCCS KPQVDMRKHV AMTLLDTEQS YVESLRTLMQ GYMQPLKQPE
1110 1120 1130 1140 1150
NSVLCDPSLV DEIFDQIPEL LEHHEQFLEQ VRHCMQTWHA QQKVGALLVQ
1160 1170 1180 1190 1200
SFSKDVLVNI YSAYIDNFLN AKDAVRVAKE ARPAFLKFLE QSMRENKEKQ
1210 1220 1230 1240 1250
ALSDLMIKPV QRIPRYELLV KDLLKHTPED HPDHPLLLEA QRNIKQVAER
1260 1270 1280 1290 1300
INKGVRSAEE AERHARVLQE IEAHIEGMED LQAPLRRFLR QEMVIEVKAI
1310 1320 1330 1340 1350
GGKKDRSLFL FTDLIVCTTL KRKSGSLRRS SMSLYTAASV IDTASKYKML
1360 1370 1380 1390 1400
WKLPLEDADI IKGASQATNR ENIQKAISRL DEDLTTLGQM SKLSESLGFP
1410 1420 1430 1440 1450
HQSLDDALRD LSAAMHRDLS EKQALCYALS FPPTKLELCA TRPEGTDSYI
1460 1470 1480 1490 1500
FEFPHPDARL GFEQAFDEAK RKLASSKSCL DPEFLKAIPI MKTRSGMQFS
1510 1520 1530 1540 1550
CAAPTLNSCP EPSPEVWVCN SDGYVGQVCL LSLRAEPDVE ACIAVCSARI
1560 1570 1580 1590 1600
LCIGAVPGLQ PRCHREPPPS LRSPPETAPE PAGPELDVEA AADEEAATLA
1610 1620 1630 1640 1650
EPGPQPCLHI SIAGSGLEMT PGLGEGDPRP ELVPFDSDSD DESSPSPSGT
1660 1670 1680 1690 1700
LQSQASRSTI SSSFGNEETP SSKEATAETT SSEEEQEPGF LPLSGSFGPG
1710 1720 1730 1740 1750
GPCGTSPMDG RALRRSSHGS FTRGSLEDLL SVDPEAYQSS VWLGTEDGCV
1760 1770 1780 1790 1800
HVYQSSDSIR DRRNSMKLQH AASVTCILYL NNQVFVSLAN GELVVYQREA
1810 1820 1830 1840 1850
GHFWDPQNFK SVTLGTQGSP ITKMVSVGGR LWCGCQNRVL VLSPDTLQLE
1860 1870 1880 1890 1900
HMFYVGQDSS RCVACMVDSS LGVWVTLKGS AHVCLYHPDT FEQLAEVDVT
1910 1920 1930 1940 1950
PPVHRMLAGS DAIIRQHKAA CLRITALLVC EELLWVGTSA GVVLTMPTSP
1960 1970 1980 1990 2000
GTVSCPRAPL SPTGLGQGHT GHVRFLAAVQ LPDGFNLLCP TPPPPPDTGP
2010 2020 2030 2040 2050
EKLPSLEHRD SPWHRGPAPA RPKMLVISGG DGYEDFRLSS GGGSSSETVG
2060
RDDSTNHLLL WRV
Length:2,063
Mass (Da):221,673
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76A53FF6CBF5F5C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YFZ8H0YFZ8_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF17
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4D7A0A2R8Y4D7_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF17
1,044Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti722L → F in BAA20795 (PubMed:9205841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032132450G → E. Corresponds to variant dbSNP:rs3741150Ensembl.1
Natural variantiVAR_0321331465A → D. Corresponds to variant dbSNP:rs2298808Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF378754 mRNA Translation: AAL11991.1
CH471076 Genomic DNA Translation: EAW74891.1
BC050031 mRNA Translation: AAH50031.1
BC137228 mRNA Translation: AAI37229.1
AK074500 mRNA No translation available.
AB002335 mRNA Translation: BAA20795.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8221.1

NCBI Reference Sequences

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RefSeqi
NP_055601.2, NM_014786.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263674; ENSP00000263674; ENSG00000110237

Database of genes from NCBI RefSeq genomes

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GeneIDi
9828

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9828

UCSC genome browser

More...
UCSCi
uc001otu.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Undiagnosed Disease Network

ARHGEF17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378754 mRNA Translation: AAL11991.1
CH471076 Genomic DNA Translation: EAW74891.1
BC050031 mRNA Translation: AAH50031.1
BC137228 mRNA Translation: AAI37229.1
AK074500 mRNA No translation available.
AB002335 mRNA Translation: BAA20795.2
CCDSiCCDS8221.1
RefSeqiNP_055601.2, NM_014786.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGridi115166, 21 interactors
IntActiQ96PE2, 22 interactors
MINTiQ96PE2
STRINGi9606.ENSP00000263674

PTM databases

iPTMnetiQ96PE2
PhosphoSitePlusiQ96PE2

Polymorphism and mutation databases

BioMutaiARHGEF17
DMDMi74724250

Proteomic databases

EPDiQ96PE2
jPOSTiQ96PE2
MassIVEiQ96PE2
MaxQBiQ96PE2
PaxDbiQ96PE2
PeptideAtlasiQ96PE2
PRIDEiQ96PE2
ProteomicsDBi77677

Genome annotation databases

EnsembliENST00000263674; ENSP00000263674; ENSG00000110237
GeneIDi9828
KEGGihsa:9828
UCSCiuc001otu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9828
DisGeNETi9828

GeneCards: human genes, protein and diseases

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GeneCardsi
ARHGEF17
HGNCiHGNC:21726 ARHGEF17
HPAiHPA007991
neXtProtiNX_Q96PE2
OpenTargetsiENSG00000110237
PharmGKBiPA134884537

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IRSX Eukaryota
ENOG410XSIJ LUCA
GeneTreeiENSGT00940000153798
HOGENOMiCLU_237760_0_0_1
InParanoidiQ96PE2
KOiK20689
OMAiCPDSGCE
OrthoDBi652460at2759
PhylomeDBiQ96PE2
TreeFamiTF324157

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARHGEF17 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9828
PharosiQ96PE2 Tbio

Protein Ontology

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PROi
PR:Q96PE2
RNActiQ96PE2 protein

Gene expression databases

BgeeiENSG00000110237 Expressed in left lobe of thyroid gland and 216 other tissues
ExpressionAtlasiQ96PE2 baseline and differential
GenevisibleiQ96PE2 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR039917 ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877 PTHR12877, 1 hit
PTHR12877:SF15 PTHR12877:SF15, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHGH_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PE2
Secondary accession number(s): B2RP20
, Q86XU2, Q8N2S0, Q9Y4G3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: February 26, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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