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Entry version 164 (13 Feb 2019)
Sequence version 2 (20 Jan 2009)
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Protein

Adhesion G protein-coupled receptor A2

Gene

ADGRA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).By similarity3 Publications

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GDB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAngiogenesis, Wnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor A2Curated
Alternative name(s):
G-protein coupled receptor 1241 Publication
Tumor endothelial marker 51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRA2Imported
Synonyms:GPR1241 Publication, KIAA15311 Publication, TEM51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000020181.17

Human Gene Nomenclature Database

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HGNCi
HGNC:17849 ADGRA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606823 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96PE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 771Extracellular3 PublicationsAdd BLAST738
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei772 – 792Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini793 – 807CytoplasmicSequence analysisAdd BLAST15
Transmembranei808 – 828Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini829 – 832ExtracellularSequence analysis4
Transmembranei833 – 853Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini854 – 886CytoplasmicSequence analysisAdd BLAST33
Transmembranei887 – 907Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini908 – 924ExtracellularSequence analysisAdd BLAST17
Transmembranei925 – 945Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini946 – 1019CytoplasmicSequence analysisAdd BLAST74
Transmembranei1020 – 1040Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1041 – 1047ExtracellularSequence analysis7
Transmembranei1048 – 1068Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1069 – 1338Cytoplasmic1 PublicationAdd BLAST270

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi369R → A: Minimal effect on thrombin cleavage. Abolishes thrombin cleavage; when associated with G-398. 1 Publication1
Mutagenesisi398R → G: Minimal effect on thrombin cleavage. Abolishes thrombin cleavage; when associated with A-369. 1 Publication1
Mutagenesisi1335 – 1338Missing : Fails to interact with DLG1. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
25960

Open Targets

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OpenTargetsi
ENSG00000020181

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134869404

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGRA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
221222450

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001289834 – 1338Adhesion G protein-coupled receptor A2Add BLAST1305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi268 ↔ 328PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi690N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1107PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication
Proteolytically cleaved into two subunits, an extracellular subunit and a seven-transmembrane subunit (PubMed:22013897, PubMed:16982628). Cleaved by thrombin (F2) and MMP1 (PubMed:22013897). Also cleaved by MMP9, with lower efficiency (PubMed:22013897, PubMed:16982628). Presence of the protein disulfide-isomerase P4HB at the cell surface is additionally required for shedding of the extracellular subunit, suggesting that the subunits are linked by disulfide bonds (PubMed:22013897). Shedding is enhanced by the growth factor FGF2 and may promote cell survival during angiogenesis (PubMed:16982628).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei369 – 370Cleavage; by thrombin1 Publication2
Sitei398 – 399Cleavage; by thrombin1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96PE1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96PE1

PeptideAtlas

More...
PeptideAtlasi
Q96PE1

PRoteomics IDEntifications database

More...
PRIDEi
Q96PE1

ProteomicsDB human proteome resource

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ProteomicsDBi
77674
77675 [Q96PE1-2]
77676 [Q96PE1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96PE1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96PE1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000020181 Expressed in 193 organ(s), highest expression level in adipose tissue of abdominal region

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96PE1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96PE1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012393

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RECK; the interaction is direct (By similarity). Interacts (via PDZ-binding motif) with DLG1 (via PDZ domains) (PubMed:15021905). The cleaved extracellular subunit interacts with the integrin heterodimer ITGAV:ITGB3 (PubMed:16982628).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117450, 2 interactors

Protein interaction database and analysis system

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IntActi
Q96PE1, 3 interactors

Molecular INTeraction database

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MINTi
Q96PE1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000406367

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96PE1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati82 – 106LRR 1Sequence analysisAdd BLAST25
Repeati107 – 130LRR 2Sequence analysisAdd BLAST24
Repeati131 – 154LRR 3Sequence analysisAdd BLAST24
Repeati156 – 178LRR 4Sequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini190 – 240LRRCTSequence analysisAdd BLAST51
Domaini247 – 344Ig-likePROSITE-ProRule annotationAdd BLAST98
Domaini707 – 758GPSPROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi362 – 364RGD1 Publication3
Motifi1335 – 1338PDZ-binding1 Publication4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-rich repeats (LRRs) are important for potentiation of Wnt7 signaling.By similarity
The RGD motif is involved in integrin ITGAV:ITGB3 binding.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158941

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051777

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96PE1

KEGG Orthology (KO)

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KOi
K08461

Identification of Orthologs from Complete Genome Data

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OMAi
CKLTNLL

Database of Orthologous Groups

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OrthoDBi
31536at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96PE1

TreeFam database of animal gene trees

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TreeFami
TF331206

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
3.80.10.10, 1 hit
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF13855 LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER
60 70 80 90 100
PKGLSGGVPG PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR
110 120 130 140 150
NGSFLGLSLL EKLDLRNNII STVQPGAFLG LGELKRLDLS NNRIGCLTSE
160 170 180 190 200
TFQGLPRLLR LNISGNIFSS LQPGVFDELP ALKVVDLGTE FLTCDCHLRW
210 220 230 240 250
LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE GALELHTHHL
260 270 280 290 300
IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE
310 320 330 340 350
SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA
360 370 380 390 400
SYCPAERVAN NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS
410 420 430 440 450
RRCDRAGRWE PGDYSHCLYT NDITRVLYTF VLMPINASNA LTLAHQLRVY
460 470 480 490 500
TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM ASNLMLVDEH
510 520 530 540 550
LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN VALEAYLIKP
560 570 580 590 600
HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR
610 620 630 640 650
PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN
660 670 680 690 700
GRLFHSHSNT SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR
710 720 730 740 750
HWAEGAEPVA AWWSQEGPGE AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA
760 770 780 790 800
VLMELSAFPR EVGGAGAGLH PVVYPCTALL LLCLFATIIT YILNHSSIRV
810 820 830 840 850
SRKGWHMLLN LCFHIAMTSA VFAGGITLTN YQMVCQAVGI TLHYSSLSTL
860 870 880 890 900
LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRFYLI AGGIPLIICG
910 920 930 940 950
ITAAVNIHNY RDHSPYCWLV WRPSLGAFYI PVALILLITW IYFLCAGLRL
960 970 980 990 1000
RGPLAQNPKA GNSRASLEAG EELRGSTRLR GSGPLLSDSG SLLATGSARV
1010 1020 1030 1040 1050
GTPGPPEDGD SLYSPGVQLG ALVTTHFLYL AMWACGALAV SQRWLPRVVC
1060 1070 1080 1090 1100
SCLYGVAASA LGLFVFTHHC ARRRDVRASW RACCPPASPA APHAPPRALP
1110 1120 1130 1140 1150
AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA LGPCKLTNLQ LAQSQVCEAG
1160 1170 1180 1190 1200
AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR RAHKSRAKGH RAGEACGKNR
1210 1220 1230 1240 1250
LKALRGGAAG ALELLSSESG SLHNSPTDSY LGSSRNSPGA GLQLEGEPML
1260 1270 1280 1290 1300
TPSEGSDTSA APLSEAGRAG QRRSASRDSL KGGGALEKES HRRSYPLNAA
1310 1320 1330
SLNGAPKGGK YDDVTLMGAE VASGGCMKTG LWKSETTV
Length:1,338
Mass (Da):142,647
Last modified:January 20, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i322838CB31E99A97
GO
Isoform 2 (identifier: Q96PE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-753: Missing.

Show »
Length:1,121
Mass (Da):119,862
Checksum:i5A118A1292E3DCEE
GO
Isoform 3 (identifier: Q96PE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-1338: Missing.

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):19,530
Checksum:i28984931C571C168
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1L1H7C1L1_HUMAN
Adhesion G protein-coupled receptor...
ADGRA2
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI46775 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL11992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO27354 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA96055 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti407G → S in BAB84925 (Ref. 9) Curated1
Sequence conflicti1221S → G in BAA96055 (PubMed:10819331).Curated1
Sequence conflicti1221S → G in AAI46775 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07207929P → L Found in a family with atypical autism and severe epilepsy; unknown pathological significance. 1 Publication1
Natural variantiVAR_072561375T → K1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036215186 – 1338Missing in isoform 3. 1 PublicationAdd BLAST1153
Alternative sequenceiVSP_010076537 – 753Missing in isoform 2. 2 PublicationsAdd BLAST217

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF378755 mRNA Translation: AAL11992.1 Different initiation.
AB040964 mRNA Translation: BAA96055.2 Different initiation.
AK027296 mRNA Translation: BAB55022.1
AC138356 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63355.1
CH471080 Genomic DNA Translation: EAW63356.1
BC146774 mRNA Translation: AAI46775.1 Different initiation.
AY181242 mRNA Translation: AAO27354.1 Different initiation.
AK074099 mRNA Translation: BAB84925.2
AL110244 mRNA Translation: CAB53694.1
AL832524 mRNA Translation: CAD38629.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6097.2 [Q96PE1-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T14774

NCBI Reference Sequences

More...
RefSeqi
NP_116166.9, NM_032777.9 [Q96PE1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.274136

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315215; ENSP00000323508; ENSG00000020181 [Q96PE1-2]
ENST00000412232; ENSP00000406367; ENSG00000020181 [Q96PE1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25960

UCSC genome browser

More...
UCSCi
uc003xkj.4 human [Q96PE1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378755 mRNA Translation: AAL11992.1 Different initiation.
AB040964 mRNA Translation: BAA96055.2 Different initiation.
AK027296 mRNA Translation: BAB55022.1
AC138356 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63355.1
CH471080 Genomic DNA Translation: EAW63356.1
BC146774 mRNA Translation: AAI46775.1 Different initiation.
AY181242 mRNA Translation: AAO27354.1 Different initiation.
AK074099 mRNA Translation: BAB84925.2
AL110244 mRNA Translation: CAB53694.1
AL832524 mRNA Translation: CAD38629.1
CCDSiCCDS6097.2 [Q96PE1-1]
PIRiT14774
RefSeqiNP_116166.9, NM_032777.9 [Q96PE1-1]
UniGeneiHs.274136

3D structure databases

ProteinModelPortaliQ96PE1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117450, 2 interactors
IntActiQ96PE1, 3 interactors
MINTiQ96PE1
STRINGi9606.ENSP00000406367

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ96PE1
PhosphoSitePlusiQ96PE1

Polymorphism and mutation databases

BioMutaiADGRA2
DMDMi221222450

Proteomic databases

jPOSTiQ96PE1
PaxDbiQ96PE1
PeptideAtlasiQ96PE1
PRIDEiQ96PE1
ProteomicsDBi77674
77675 [Q96PE1-2]
77676 [Q96PE1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315215; ENSP00000323508; ENSG00000020181 [Q96PE1-2]
ENST00000412232; ENSP00000406367; ENSG00000020181 [Q96PE1-1]
GeneIDi25960
KEGGihsa:25960
UCSCiuc003xkj.4 human [Q96PE1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25960
DisGeNETi25960
EuPathDBiHostDB:ENSG00000020181.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRA2
HGNCiHGNC:17849 ADGRA2
HPAiHPA012393
MIMi606823 gene
neXtProtiNX_Q96PE1
OpenTargetsiENSG00000020181
PharmGKBiPA134869404

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000158941
HOVERGENiHBG051777
InParanoidiQ96PE1
KOiK08461
OMAiCKLTNLL
OrthoDBi31536at2759
PhylomeDBiQ96PE1
TreeFamiTF331206

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADGRA2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPR124

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25960

Protein Ontology

More...
PROi
PR:Q96PE1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000020181 Expressed in 193 organ(s), highest expression level in adipose tissue of abdominal region
ExpressionAtlasiQ96PE1 baseline and differential
GenevisibleiQ96PE1 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PE1
Secondary accession number(s): A6H8W3
, D3DSW4, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 20, 2009
Last modified: February 13, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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