DGAT2

Functionⁱ

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).By similarity

Catalytic activityⁱ

Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.1 Publication

Acyl-CoA + retinol = CoA + retinyl ester.1 Publication

Activity regulationⁱ

Inhibited by niacin.By similarity

Pathwayⁱ: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functionⁱ

2-acylglycerol O-acyltransferase activity Source: Ensembl
diacylglycerol O-acyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11481335
protein homodimerization activity Source: BHF-UCL
retinol O-fatty-acyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acylglycerol acyl-chain remodeling Source: Reactome
cellular response to oleic acid Source: BHF-UCL
cellular triglyceride homeostasis Source: BHF-UCL
cholesterol homeostasis Source: BHF-UCL
diacylglycerol metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11481335
fat pad development Source: BHF-UCL
fatty acid homeostasis Source: BHF-UCL
glycerol metabolic process Source: UniProtKB-KW
lipid storage Source: BHF-UCL
long-chain fatty-acyl-CoA metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11481335
low-density lipoprotein particle clearance Source: BHF-UCL
negative regulation of fatty acid oxidation Source: Ensembl
positive regulation of gluconeogenesis Source: Ensembl
positive regulation of triglyceride biosynthetic process Source: Ensembl
regulation of cholesterol metabolic process Source: Ensembl
regulation of lipoprotein metabolic process Source: Ensembl
regulation of plasma lipoprotein particle levels Source: BHF-UCL
triglyceride biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11481335

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAⁱ	2.3.1.20 2681
Reactomeⁱ	R-HSA-1482883 Acyl chain remodeling of DAG and TAG R-HSA-75109 Triglyceride biosynthesis
SABIO-RKⁱ	Q96PD7
UniPathwayⁱ	UPA00282

Chemistry databases

SwissLipidsⁱ	SLP:000000304

SwissLipidsⁱ

SLP:000000304

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Diacylglycerol O-acyltransferase 2 (EC:2.3.1.20) Alternative name(s): Acyl-CoA retinol O-fatty-acyltransferase (EC:2.3.1.76) Short name: ARAT Short name: Retinol O-fatty-acyltransferase Diglyceride acyltransferase 2
Gene namesⁱ	Name:DGAT2 ORF Names:HMFN1045, UNQ738/PRO1433
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000062282.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16940 DGAT2
MIMⁱ	606983 gene
neXtProtⁱ	NX_Q96PD7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 69	CytoplasmicSequence analysisAdd BLAST	69
Transmembraneⁱ	70 – 88	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	89 – 92	LumenalSequence analysis	4
Transmembraneⁱ	93 – 112	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	113 – 388	CytoplasmicSequence analysisAdd BLAST	276

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Lipid droplet, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84649
MalaCards human disease database More...MalaCardsⁱ	DGAT2
Open Targets More...OpenTargetsⁱ	ENSG00000062282
Orphanetⁱ	487814 Autosomal dominant Charcot-Marie-Tooth disease type 2 due to DGAT2 mutation
PharmGKBⁱ	PA27304

Chemistry databases

ChEMBLⁱ	CHEMBL5853

ChEMBLⁱ

CHEMBL5853

Polymorphism and mutation databases

BioMutaⁱ	DGAT2
DMDMⁱ	74732654

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000249045	1 – 388	Diacylglycerol O-acyltransferase 2Add BLAST		388

Proteomic databases

PaxDbⁱ	Q96PD7
PeptideAtlas More...PeptideAtlasⁱ	Q96PD7
PRIDEⁱ	Q96PD7
ProteomicsDBⁱ	77672 77673 [Q96PD7-2]

PTM databases

iPTMnetⁱ	Q96PD7
PhosphoSitePlusⁱ	Q96PD7

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000062282 Expressed in 160 organ(s), highest expression level in upper arm skin
CleanExⁱ	HS_DGAT2
ExpressionAtlasⁱ	Q96PD7 baseline and differential
Genevisibleⁱ	Q96PD7 HS

Interactionⁱ

Subunit structureⁱ

Forms multimeric complexes consisting of several DGAT2 subunits.By similarity

GO - Molecular functionⁱ

protein homodimerization activity Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	124172, 2 interactors
CORUMⁱ	Q96PD7
IntActⁱ	Q96PD7, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q96PD7
STRINGⁱ	9606.ENSP00000228027

Chemistry databases

BindingDBⁱ

Q96PD7

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96PD7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the diacylglycerol acyltransferase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0831 Eukaryota ENOG410XTG3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00750000117391
HOVERGENⁱ	HBG065791
InParanoidⁱ	Q96PD7
KEGG Orthology (KO) More...KOⁱ	K11160
OMAⁱ	LYHAMYM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BGQ
PhylomeDBⁱ	Q96PD7
TreeFamⁱ	TF314707

Family and domain databases

InterProⁱ	View protein in InterPro IPR007130 DAGAT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03982 DAGAT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96PD7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTLIAAYSG VLRGERQAEA DRSQRSHGGP ALSREGSGRW GTGSSILSAL 
        60         70         80         90        100
QDLFSVTWLN RSKVEKQLQV ISVLQWVLSF LVLGVACSAI LMYIFCTDCW 
       110        120        130        140        150
LIAVLYFTWL VFDWNTPKKG GRRSQWVRNW AVWRYFRDYF PIQLVKTHNL 
       160        170        180        190        200
LTTRNYIFGY HPHGIMGLGA FCNFSTEATE VSKKFPGIRP YLATLAGNFR 
       210        220        230        240        250
MPVLREYLMS GGICPVSRDT IDYLLSKNGS GNAIIIVVGG AAESLSSMPG 
       260        270        280        290        300
KNAVTLRNRK GFVKLALRHG ADLVPIYSFG ENEVYKQVIF EEGSWGRWVQ 
       310        320        330        340        350
KKFQKYIGFA PCIFHGRGLF SSDTWGLVPY SKPITTVVGE PITIPKLEHP 
       360        370        380 
TQQDIDLYHT MYMEALVKLF DKHKTKFGLP ETEVLEVN

Length:388

Mass (Da):43,831

Last modified:March 1, 2002 - v2

Checksum:ⁱ39EE7783A3F06593

GO

Isoform 2 (identifier: Q96PD7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
41-83: Missing.

« Hide

        10         20         30         40         50
MKTLIAAYSG VLRGERQAEA DRSQRSHGGP ALSREGSGRW GVACSAILMY 
        60         70         80         90        100
IFCTDCWLIA VLYFTWLVFD WNTPKKGGRR SQWVRNWAVW RYFRDYFPIQ 
       110        120        130        140        150
LVKTHNLLTT RNYIFGYHPH GIMGLGAFCN FSTEATEVSK KFPGIRPYLA 
       160        170        180        190        200
TLAGNFRMPV LREYLMSGGI CPVSRDTIDY LLSKNGSGNA IIIVVGGAAE 
       210        220        230        240        250
SLSSMPGKNA VTLRNRKGFV KLALRHGADL VPIYSFGENE VYKQVIFEEG 
       260        270        280        290        300
SWGRWVQKKF QKYIGFAPCI FHGRGLFSSD TWGLVPYSKP ITTVVGEPIT 
       310        320        330        340 
IPKLEHPTQQ DIDLYHTMYM EALVKLFDKH KTKFGLPETE VLEVN

Show »

Length:345

Mass (Da):39,044

Checksum:ⁱCDDCB976A9D4E539

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

S4R3S3	S4R3S3_HUMAN	Diacylglycerol O-acyltransferase 2 Diacylglycerol O-acyltransferase 2	DGAT2	295	Annotation score:
S4R383	S4R383_HUMAN	Diacylglycerol O-acyltransferase 2 Diacylglycerol O-acyltransferase 2	DGAT2	160	Annotation score:
S4R449	S4R449_HUMAN	Diacylglycerol O-acyltransferase 2 Diacylglycerol O-acyltransferase 2	DGAT2	113	Annotation score:
S4R3Z3	S4R3Z3_HUMAN	Diacylglycerol O-acyltransferase 2 Diacylglycerol O-acyltransferase 2	DGAT2	112	Annotation score:

Sequence cautionⁱ

The sequence BAD38635 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAD38961 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	295	W → C in AAV35727 (Ref. 7) Curated		1
Sequence conflictⁱ	304	Q → H in AAV35727 (Ref. 7) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_077236	223	Y → H Found in patients with Charcot-Marie-Tooth disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869025595EnsemblClinVar.	1
Natural variantⁱVAR_033864	317	R → G. Corresponds to variant dbSNP:rs34421064Ensembl.	1
Natural variantⁱVAR_033865	361	M → I. Corresponds to variant dbSNP:rs34113941Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_020356	41 – 83	Missing in isoform 2. 1 PublicationAdd BLAST		43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF384161 mRNA Translation: AAK84176.2 AB048286 mRNA Translation: BAB40641.2 AY358532 mRNA Translation: AAQ88896.1 AL834287 mRNA Translation: CAD38961.1 Different initiation. CR749377 mRNA Translation: CAH18230.1 AP001922 Genomic DNA No translation available. BC015234 mRNA Translation: AAH15234.1 AY780647 mRNA Translation: AAV35727.1 AB073384 mRNA Translation: BAD38635.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31642.1 [Q96PD7-1] CCDS58162.1 [Q96PD7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001240820.1, NM_001253891.1 [Q96PD7-2] NP_115953.2, NM_032564.4 [Q96PD7-1]
UniGeneⁱ	Hs.129798

Genome annotation databases

Ensemblⁱ	ENST00000228027; ENSP00000228027; ENSG00000062282 [Q96PD7-1] ENST00000376262; ENSP00000365438; ENSG00000062282 [Q96PD7-2]
GeneIDⁱ	84649
KEGGⁱ	hsa:84649
UCSC genome browser More...UCSCⁱ	uc001oxa.4 human [Q96PD7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96PD7	DGAT2 isoform 3		PANTR		388	UniRef100_Q96PD7
Uncharacterized protein		PANPA		388
Diacylglycerol O-acyltransferase 2		GORGO		388
Diacylglycerol O-acyltransferase 2 (Fragment)		HUMAN		160
DGAT2 isoform 6 (Fragment)		PONAB		160
+7
Q96PD7-2	DGAT2 isoform 4		PANTR		345	UniRef100_A0A2I3RQ20
Uncharacterized protein		PANPA		345
Diacylglycerol O-acyltransferase 2		GORGO		345
Diacylglycerol O-acyltransferase 2 (Fragment)		HUMAN		295
DGAT2 isoform 5 (Fragment)		PONAB		295
+1

Protein	Similar proteins		Species	Score	Length	Source
Q96PD7	Diacylglycerol O-acyltransferase 2		MOUSE		388	UniRef90_Q9DCV3
Diacylglycerol O-acyltransferase 2		RAT		388
Diacylglycerol O-acyltransferase 2		BOVIN		361
Diacylglycerol O-acyltransferase 2		PONAB		445
Diacylglycerol O-acyltransferase 2		CASCN		388
+122
Q96PD7-2	Uncharacterized protein		MACMU		345	UniRef90_F7A7D0
Uncharacterized protein		COLAP		345
Uncharacterized protein		CERAT		345
Uncharacterized protein		RHIRO		345
Uncharacterized protein		PAPAN		345
+21

Protein	Similar proteins		Species	Score	Length	Source
Q96PD7	Diacylglycerol O-acyltransferase 2		MOUSE		388	UniRef50_Q9DCV3
Diacylglycerol O-acyltransferase 2		RAT		388
Diacylglycerol O-acyltransferase 2		BOVIN		361
Diacylglycerol O-acyltransferase 2		PONAB		445
Uncharacterized protein		CAVPO		388
+372
Q96PD7-2	2-acylglycerol O-acyltransferase 3		HUMAN		341	UniRef50_Q86VF5
Diacylglycerol O-acyltransferase 2		XENLA		361
Diacylglycerol O-acyltransferase 2		XENTR		361
Diacylglycerol O-acyltransferase 2		DANRE		361
Uncharacterized protein		CHLSB		341
+202

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF384161 mRNA Translation: AAK84176.2 AB048286 mRNA Translation: BAB40641.2 AY358532 mRNA Translation: AAQ88896.1 AL834287 mRNA Translation: CAD38961.1 Different initiation. CR749377 mRNA Translation: CAH18230.1 AP001922 Genomic DNA No translation available. BC015234 mRNA Translation: AAH15234.1 AY780647 mRNA Translation: AAV35727.1 AB073384 mRNA Translation: BAD38635.1 Different initiation.
CCDSⁱ	CCDS31642.1 [Q96PD7-1] CCDS58162.1 [Q96PD7-2]
RefSeqⁱ	NP_001240820.1, NM_001253891.1 [Q96PD7-2] NP_115953.2, NM_032564.4 [Q96PD7-1]
UniGeneⁱ	Hs.129798

3D structure databases

ProteinModelPortalⁱ	Q96PD7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124172, 2 interactors
CORUMⁱ	Q96PD7
IntActⁱ	Q96PD7, 2 interactors
MINTⁱ	Q96PD7
STRINGⁱ	9606.ENSP00000228027

Chemistry databases

BindingDBⁱ	Q96PD7
ChEMBLⁱ	CHEMBL5853
SwissLipidsⁱ	SLP:000000304

PTM databases

iPTMnetⁱ	Q96PD7
PhosphoSitePlusⁱ	Q96PD7

Polymorphism and mutation databases

BioMutaⁱ	DGAT2
DMDMⁱ	74732654

Proteomic databases

PaxDbⁱ	Q96PD7
PeptideAtlasⁱ	Q96PD7
PRIDEⁱ	Q96PD7
ProteomicsDBⁱ	77672 77673 [Q96PD7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84649
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000228027; ENSP00000228027; ENSG00000062282 [Q96PD7-1] ENST00000376262; ENSP00000365438; ENSG00000062282 [Q96PD7-2]
GeneIDⁱ	84649
KEGGⁱ	hsa:84649
UCSCⁱ	uc001oxa.4 human [Q96PD7-1]

Organism-specific databases

CTDⁱ	84649
DisGeNETⁱ	84649
EuPathDBⁱ	HostDB:ENSG00000062282.14
GeneCardsⁱ	DGAT2
HGNCⁱ	HGNC:16940 DGAT2
MalaCardsⁱ	DGAT2
MIMⁱ	606983 gene
neXtProtⁱ	NX_Q96PD7
OpenTargetsⁱ	ENSG00000062282
Orphanetⁱ	487814 Autosomal dominant Charcot-Marie-Tooth disease type 2 due to DGAT2 mutation
PharmGKBⁱ	PA27304
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0831 Eukaryota ENOG410XTG3 LUCA
GeneTreeⁱ	ENSGT00750000117391
HOVERGENⁱ	HBG065791
InParanoidⁱ	Q96PD7
KOⁱ	K11160
OMAⁱ	LYHAMYM
OrthoDBⁱ	EOG091G0BGQ
PhylomeDBⁱ	Q96PD7
TreeFamⁱ	TF314707

Enzyme and pathway databases

UniPathwayⁱ	UPA00282
BRENDAⁱ	2.3.1.20 2681
Reactomeⁱ	R-HSA-1482883 Acyl chain remodeling of DAG and TAG R-HSA-75109 Triglyceride biosynthesis
SABIO-RKⁱ	Q96PD7

Miscellaneous databases

ChiTaRSⁱ	DGAT2 human
GenomeRNAiⁱ	84649
Protein Ontology More...PROⁱ	PR:Q96PD7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000062282 Expressed in 160 organ(s), highest expression level in upper arm skin
CleanExⁱ	HS_DGAT2
ExpressionAtlasⁱ	Q96PD7 baseline and differential
Genevisibleⁱ	Q96PD7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007130 DAGAT
Pfamⁱ	View protein in Pfam PF03982 DAGAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DGAT2_HUMAN
Accessionⁱ	Q96PD7Primary (citable) accession number: Q96PD7 Secondary accession number(s): A6ND76 Q9BYE5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
	Last sequence update:	March 1, 2002
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96PD7 (DGAT2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Diacylglycerol O-acyltransferase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: triacylglycerol biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: triacylglycerol biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ