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UniProtKB - Q96PD6 (MOGT1_HUMAN)
Protein
2-acylglycerol O-acyltransferase 1
Gene
MOGAT1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine.
By similarityCatalytic activityi
- EC:2.3.1.22By similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
: triacylglycerol biosynthesis Pathwayi
This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.
GO - Molecular functioni
- 2-acylglycerol O-acyltransferase activity Source: Reactome
- diacylglycerol O-acyltransferase activity Source: Ensembl
GO - Biological processi
- diacylglycerol biosynthetic process Source: GO_Central
- glycerol metabolic process Source: UniProtKB-KW
- lipid metabolic process Source: GO_Central
- triglyceride biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Glycerol metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.22, 2681 |
PathwayCommonsi | Q96PD6 |
Reactomei | R-HSA-75109, Triglyceride biosynthesis |
SignaLinki | Q96PD6 |
UniPathwayi | UPA00282 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-acylglycerol O-acyltransferase 1Curated (EC:2.3.1.22By similarity)Alternative name(s): Acyl-CoA:monoacylglycerol acyltransferase 1 Short name: MGAT1 Diacylglycerol O-acyltransferase candidate 2 Short name: hDC2 Diacylglycerol acyltransferase 2-like protein 1 Monoacylglycerol O-acyltransferase 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18210, MOGAT1 |
MIMi | 610268, gene |
neXtProti | NX_Q96PD6 |
VEuPathDBi | HostDB:ENSG00000124003 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 40 – 60 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 132 – 152 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 116255 |
OpenTargetsi | ENSG00000124003 |
PharmGKBi | PA27305 |
Miscellaneous databases
Pharosi | Q96PD6, Tbio |
Genetic variation databases
BioMutai | MOGAT1 |
DMDMi | 292495019 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249058 | 1 – 335 | 2-acylglycerol O-acyltransferase 1Add BLAST | 335 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q96PD6 |
PaxDbi | Q96PD6 |
PeptideAtlasi | Q96PD6 |
PRIDEi | Q96PD6 |
PTM databases
GlyGeni | Q96PD6, 3 sites |
iPTMneti | Q96PD6 |
PhosphoSitePlusi | Q96PD6 |
Expressioni
Tissue specificityi
Expressed in stomach and liver.1 Publication
Gene expression databases
Bgeei | ENSG00000124003, Expressed in gall bladder and 83 other tissues |
Genevisiblei | Q96PD6, HS |
Organism-specific databases
HPAi | ENSG00000124003, Tissue enriched (gallbladder) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125495, 1 interactor |
STRINGi | 9606.ENSP00000406674 |
Miscellaneous databases
RNActi | Q96PD6, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the diacylglycerol acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01030000234582 |
HOGENOMi | CLU_023995_0_1_1 |
InParanoidi | Q96PD6 |
OMAi | PVFREYM |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q96PD6 |
TreeFami | TF314707 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96PD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVEFAPLNI QLARRLQTVA VLQWVLKYLL LGPMSIGITV MLIIHNYLFL
60 70 80 90 100
YIPYLMWLYF DWHTPERGGR RSSWIKNWTL WKHFKDYFPI HLIKTQDLDP
110 120 130 140 150
SHNYIFGFHP HGIMAVGAFG NFSVNYSDFK DLFPGFTSYL HVLPLWFWCP
160 170 180 190 200
VFREYVMSVG LVSVSKKSVS YMVSKEGGGN ISVIVLGGAK ESLDAHPGKF
210 220 230 240 250
TLFIRQRKGF VKIALTHGAS LVPVVSFGEN ELFKQTDNPE GSWIRTVQNK
260 270 280 290 300
LQKIMGFALP LFHARGVFQY NFGLMTYRKA IHTVVGRPIP VRQTLNPTQE
310 320 330
QIEELHQTYM EELRKLFEEH KGKYGIPEHE TLVLK
Sequence cautioni
The sequence AAX81987 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 – 31 | KYLLL → SFLT in AAK84178 (PubMed:11481335).Curated | 5 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055695 | 13 | A → T. Corresponds to variant dbSNP:rs35959734Ensembl. | 1 | |
Natural variantiVAR_027389 | 163 | S → P. Corresponds to variant dbSNP:rs1868024Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF384163 mRNA Translation: AAK84178.1 AC104772 Genomic DNA Translation: AAX81987.1 Sequence problems. BN000154 mRNA Translation: CAD89265.1 |
CCDSi | CCDS46524.1 |
RefSeqi | NP_477513.2, NM_058165.2 |
Genome annotation databases
Ensembli | ENST00000446656; ENSP00000406674; ENSG00000124003 |
GeneIDi | 116255 |
KEGGi | hsa:116255 |
MANE-Selecti | ENST00000446656.4; ENSP00000406674.3; NM_058165.3; NP_477513.2 |
UCSCi | uc010fws.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF384163 mRNA Translation: AAK84178.1 AC104772 Genomic DNA Translation: AAX81987.1 Sequence problems. BN000154 mRNA Translation: CAD89265.1 |
CCDSi | CCDS46524.1 |
RefSeqi | NP_477513.2, NM_058165.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125495, 1 interactor |
STRINGi | 9606.ENSP00000406674 |
PTM databases
GlyGeni | Q96PD6, 3 sites |
iPTMneti | Q96PD6 |
PhosphoSitePlusi | Q96PD6 |
Genetic variation databases
BioMutai | MOGAT1 |
DMDMi | 292495019 |
Proteomic databases
jPOSTi | Q96PD6 |
PaxDbi | Q96PD6 |
PeptideAtlasi | Q96PD6 |
PRIDEi | Q96PD6 |
Protocols and materials databases
Antibodypediai | 34362, 111 antibodies from 21 providers |
DNASUi | 116255 |
Genome annotation databases
Ensembli | ENST00000446656; ENSP00000406674; ENSG00000124003 |
GeneIDi | 116255 |
KEGGi | hsa:116255 |
MANE-Selecti | ENST00000446656.4; ENSP00000406674.3; NM_058165.3; NP_477513.2 |
UCSCi | uc010fws.2, human |
Organism-specific databases
CTDi | 116255 |
DisGeNETi | 116255 |
GeneCardsi | MOGAT1 |
HGNCi | HGNC:18210, MOGAT1 |
HPAi | ENSG00000124003, Tissue enriched (gallbladder) |
MIMi | 610268, gene |
neXtProti | NX_Q96PD6 |
OpenTargetsi | ENSG00000124003 |
PharmGKBi | PA27305 |
VEuPathDBi | HostDB:ENSG00000124003 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01030000234582 |
HOGENOMi | CLU_023995_0_1_1 |
InParanoidi | Q96PD6 |
OMAi | PVFREYM |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q96PD6 |
TreeFami | TF314707 |
Enzyme and pathway databases
UniPathwayi | UPA00282 |
BRENDAi | 2.3.1.22, 2681 |
PathwayCommonsi | Q96PD6 |
Reactomei | R-HSA-75109, Triglyceride biosynthesis |
SignaLinki | Q96PD6 |
Miscellaneous databases
BioGRID-ORCSi | 116255, 6 hits in 1039 CRISPR screens |
ChiTaRSi | MOGAT1, human |
GenomeRNAii | 116255 |
Pharosi | Q96PD6, Tbio |
PROi | PR:Q96PD6 |
RNActi | Q96PD6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124003, Expressed in gall bladder and 83 other tissues |
Genevisiblei | Q96PD6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MOGT1_HUMAN | |
Accessioni | Q96PD6Primary (citable) accession number: Q96PD6 Secondary accession number(s): Q6IEE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | March 23, 2010 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families