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Protein

Interleukin-17F

Gene

IL17F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).By similarity5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-448424 Interleukin-17 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17F
Short name:
IL-17F
Alternative name(s):
Cytokine ML-1
Gene namesi
Name:IL17F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112116.9
HGNCiHGNC:16404 IL17F
MIMi606496 gene
neXtProtiNX_Q96PD4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Candidiasis, familial, 6 (CANDF6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
See also OMIM:613956
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06581395S → L in CANDF6. 1 PublicationCorresponds to variant dbSNP:rs748486078EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi112744
MalaCardsiIL17F
MIMi613956 phenotype
OpenTargetsiENSG00000112116
Orphaneti1334 Chronic mucocutaneous candidiasis
PharmGKBiPA29800

Polymorphism and mutation databases

BioMutaiIL17F
DMDMi239938888

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000001543231 – 163Interleukin-17FAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47Interchain (with C-137)1 Publication
Glycosylationi83N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi102 ↔ 1521 Publication
Disulfide bondi107 ↔ 1541 Publication
Disulfide bondi137Interchain (with C-47)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96PD4
PeptideAtlasiQ96PD4
PRIDEiQ96PD4
ProteomicsDBi77668

PTM databases

iPTMnetiQ96PD4
PhosphoSitePlusiQ96PD4

Expressioni

Tissue specificityi

Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Gene expression databases

BgeeiENSG00000112116 Expressed in 13 organ(s), highest expression level in right testis
CleanExiHS_IL17F
HS_IL24
GenevisibleiQ96PD4 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked (PubMed:19838198). Heterodimer with IL17A (PubMed:17355969).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE73EBI-10292310,EBI-10172181

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125201, 31 interactors
IntActiQ96PD4, 1 interactor
STRINGi9606.ENSP00000337432

Structurei

Secondary structure

1163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96PD4
SMRiQ96PD4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96PD4

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYVF Eukaryota
ENOG410YVBI LUCA
GeneTreeiENSGT00930000150940
HOGENOMiHOG000064520
HOVERGENiHBG006143
InParanoidiQ96PD4
KOiK05494
OMAiLCPPLED
OrthoDBiEOG091G0RG1
PhylomeDBiQ96PD4
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96PD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVKTLHGPA MVKYLLLSIL GLAFLSEAAA RKIPKVGHTF FQKPESCPPV
60 70 80 90 100
PGGSMKLDIG IINENQRVSM SRNIESRSTS PWNYTVTWDP NRYPSEVVQA
110 120 130 140 150
QCRNLGCINA QGKEDISMNS VPIQQETLVV RRKHQGCSVS FQLEKVLVTV
160
GCTCVTPVIH HVQ
Length:163
Mass (Da):18,045
Last modified:June 16, 2009 - v3
Checksum:iE5287737C9E7BD46
GO

Sequence cautioni

The sequence AAL14427 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06581395S → L in CANDF6. 1 PublicationCorresponds to variant dbSNP:rs748486078EnsemblClinVar.1
Natural variantiVAR_058287126E → G. Corresponds to variant dbSNP:rs2397084EnsemblClinVar.1
Natural variantiVAR_058288155V → I. Corresponds to variant dbSNP:rs11465553EnsemblClinVar.1
Natural variantiVAR_058289161H → R1 PublicationCorresponds to variant dbSNP:rs763780EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384857 mRNA Translation: AAK83350.1
AL034343 Genomic DNA No translation available.
BC070124 mRNA Translation: AAH70124.1
AF332389 mRNA Translation: AAL14427.1 Sequence problems.
CCDSiCCDS4938.1
RefSeqiNP_443104.1, NM_052872.3
XP_011512578.1, XM_011514276.1
UniGeneiHs.272295

Genome annotation databases

EnsembliENST00000336123; ENSP00000337432; ENSG00000112116
GeneIDi112744
KEGGihsa:112744
UCSCiuc003pam.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384857 mRNA Translation: AAK83350.1
AL034343 Genomic DNA No translation available.
BC070124 mRNA Translation: AAH70124.1
AF332389 mRNA Translation: AAL14427.1 Sequence problems.
CCDSiCCDS4938.1
RefSeqiNP_443104.1, NM_052872.3
XP_011512578.1, XM_011514276.1
UniGeneiHs.272295

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JPYX-ray2.85A/B/X/Y31-163[»]
3JVFX-ray3.30A/B31-163[»]
5N92X-ray2.30F31-163[»]
5NANX-ray3.30E/F31-163[»]
ProteinModelPortaliQ96PD4
SMRiQ96PD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125201, 31 interactors
IntActiQ96PD4, 1 interactor
STRINGi9606.ENSP00000337432

PTM databases

iPTMnetiQ96PD4
PhosphoSitePlusiQ96PD4

Polymorphism and mutation databases

BioMutaiIL17F
DMDMi239938888

Proteomic databases

PaxDbiQ96PD4
PeptideAtlasiQ96PD4
PRIDEiQ96PD4
ProteomicsDBi77668

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336123; ENSP00000337432; ENSG00000112116
GeneIDi112744
KEGGihsa:112744
UCSCiuc003pam.2 human

Organism-specific databases

CTDi112744
DisGeNETi112744
EuPathDBiHostDB:ENSG00000112116.9
GeneCardsiIL17F
HGNCiHGNC:16404 IL17F
MalaCardsiIL17F
MIMi606496 gene
613956 phenotype
neXtProtiNX_Q96PD4
OpenTargetsiENSG00000112116
Orphaneti1334 Chronic mucocutaneous candidiasis
PharmGKBiPA29800
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYVF Eukaryota
ENOG410YVBI LUCA
GeneTreeiENSGT00930000150940
HOGENOMiHOG000064520
HOVERGENiHBG006143
InParanoidiQ96PD4
KOiK05494
OMAiLCPPLED
OrthoDBiEOG091G0RG1
PhylomeDBiQ96PD4
TreeFamiTF314701

Enzyme and pathway databases

ReactomeiR-HSA-448424 Interleukin-17 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

EvolutionaryTraceiQ96PD4
GenomeRNAii112744
PROiPR:Q96PD4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112116 Expressed in 13 organ(s), highest expression level in right testis
CleanExiHS_IL17F
HS_IL24
GenevisibleiQ96PD4 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL17F_HUMAN
AccessioniPrimary (citable) accession number: Q96PD4
Secondary accession number(s): Q6NSI0
, Q7Z6P4, Q96PI8, Q9NUE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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