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Entry version 144 (13 Nov 2019)
Sequence version 4 (07 Sep 2016)
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Protein

Melanoma inhibitory activity protein 2

Gene

MIA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cargo receptor activity Source: UniProtKB
  • enzyme activator activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5694530 Cargo concentration in the ER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma inhibitory activity protein 2Curated
Alternative name(s):
CTAGE family member 5 ER export factorImported
Meningioma-expressed antigen 6/111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIA2Imported
Synonyms:CTAGE5Imported, MEA11, MEA6, MGEA11, MGEA6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18432 MIA2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608001 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96PC5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 605LumenalCuratedAdd BLAST586
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei606 – 626Sequence analysisAdd BLAST21
Topological domaini627 – 646LumenalCuratedAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei647 – 667HelicalSequence analysisAdd BLAST21
Topological domaini668 – 1412CytoplasmicCuratedAdd BLAST745

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoantibodies against MIA2 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi679Y → A: No effect on interaction with PERB. 1 Publication1
Mutagenesisi697K → A: Loss of interaction with PERB. Unable to recruit PERB to the endoplasmic reticulum exit sites. Loss of function in collagen VII transport. No effect on interaction with MIA3. 1 Publication1
Mutagenesisi705S → A: Decreased interaction with PERB. No effect on interaction with MIA3. 1 Publication1
Mutagenesisi720L → A: No effect on interaction with PERB. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4253

Open Targets

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OpenTargetsi
ENSG00000150527

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134870998

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96PC5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HGNC:18432

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153584

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001903120 – 1412Melanoma inhibitory activity protein 2Add BLAST1393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96PC5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96PC5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96PC5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96PC5

PeptideAtlas

More...
PeptideAtlasi
Q96PC5

PRoteomics IDEntifications database

More...
PRIDEi
Q96PC5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33711
48581
48582
48583
48584
48585
48586
48587
48588
77665 [Q96PC5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96PC5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96PC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver and weakly in testis. Expression was higher in patients with severe fibrosis or inflammation and chronic hepatitis (PubMed:12586826). Isoform 1 is specifically expressed in lung, testis, small intestine, colon, pancreas, kidney, liver and prostate (PubMed:27138255). Isoform 8 is expressed only in testis (at the protein level). Isoform 8 (at protein level) and isoform 9 are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 9, but not isoform 5A, is expressed in head and neck squamous cell carcinoma (PubMed:12839582).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000150526 Expressed in 68 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96PC5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96PC5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000387
HPA000922
HPA054066
HPA055459

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MIA3 (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179).

Interacts with the COPII coat subunits SEC23A, SEC23B and maybe SEC24C (PubMed:21525241, PubMed:27551091).

Interacts with PREB; recruits PREB to endoplasmic reticulum exit sites (PubMed:25202031, PubMed:27170179).

Interacts with APOB (PubMed:27138255).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110409, 67 interactors
125559, 3 interactors

Protein interaction database and analysis system

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IntActi
Q96PC5, 54 interactors

Molecular INTeraction database

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MINTi
Q96PC5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000379462

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96PC5

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 101SH3PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni669 – 1258Mediates interaction with MIA31 PublicationAdd BLAST590
Regioni1259 – 1412Proline-rich domain (PRD); mediates interaction with the COPII coat subunits SEC23A and SEC23B2 PublicationsAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili725 – 850Sequence analysisAdd BLAST126
Coiled coili948 – 1102Sequence analysisAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1297 – 1408Pro-richPROSITE-ProRule annotationAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The proline-rich domain (PRD) contains repeated PPP motifs. A single PPP motif is necessary and sufficient to mediate interaction with the COPII coat subunits SEC23A and SEC23B (PubMed:21525241, PubMed:27551091). The coiled coil domains mediate interaction with MIA3 (PubMed:21525241). The first coiled coil domain mediates interaction with PREB (PubMed:25202031).3 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated

Keywords - Domaini

Coiled coil, SH3 domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIF2 Eukaryota
ENOG410IJV2 Eukaryota
ENOG410ZUJU LUCA
ENOG41118PB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182767

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000220907

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96PC5

KEGG Orthology (KO)

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KOi
K23703

Identification of Orthologs from Complete Genome Data

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OMAi
DHTGPDC

Database of Orthologous Groups

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OrthoDBi
135910at2759

TreeFam database of animal gene trees

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TreeFami
TF332724

Family and domain databases

Conserved Domains Database

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CDDi
cd11892 SH3_MIA2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035555 MIA2_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF07653 SH3_2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PC5-3) [UniParc]FASTAAdd to basket
Also known as: TALI1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKFGVHRIL LLAISLTKCL ESTKLLADLK KCGDLECEAL INRVSAMRDY
60 70 80 90 100
RGPDCRYLNF TKGEEISVYV KLAGEREDLW AGSKGKEFGY FPRDAVQIEE
110 120 130 140 150
VFISEEIQMS TKESDFLCLL GVSYTFDNED SELNGDYGEN IYPYEEDKDE
160 170 180 190 200
KSSIYESDFQ IEPGFYATYE STLFEDQVPA LEAPEDIGST SESKDWEEVV
210 220 230 240 250
VESMEQDRIP EVHVPPSSAV SGVKEWFGLG GEQAEEKAFE SVIEPVQESS
260 270 280 290 300
FRSRKIAVED ENDLEELNNG EPQTEHQQES ESEIDSVPKT QSELASESEH
310 320 330 340 350
IPKPQSTGWF GGGFTSYLGF GDEDTGLELI AEESNPPLQD FPNSISSDKE
360 370 380 390 400
ATVPCTEILT EKKDTITNDS LSLKPSWFDF GFAILGFAYA KEDKIMLDDR
410 420 430 440 450
KNEEDGGADE HEHPLTSELD PEKEQEIETI KIIETEDQID KKPVSEKTDE
460 470 480 490 500
SDTIPYLKKF LYNFDNPWNF QNIPKETELP FPKQILDQNN VIENEETGEF
510 520 530 540 550
SIDNYPTDNT KVMIFKSSYS LSDMVSNIEL PTRIHEEVYF EPSSSKDSDE
560 570 580 590 600
NSKPSVDTEG PALVEIDRSV ENTLLNSQMV STDNSLSSQN YISQKEDASE
610 620 630 640 650
FQILKYLFQI DVYDFMNSAF SPIVILTERV VAALPEGMRP DSNLYGFPWE
660 670 680 690 700
LVICAAVVGF FAVLFFLWRS FRSVRSRLYV GREKKLALML SGLIEEKSKL
710 720 730 740 750
LEKFSLVQKE YEGYEVESSL KDASFEKEAT EAQSLEATCE KLNRSNSELE
760 770 780 790 800
DEILCLEKEL KEEKSKHSEQ DELMADISKR IQSLEDESKS LKSQVAEAKM
810 820 830 840 850
TFKIFQMNEE RLKIAIKDAL NENSQLQESQ KQLLQEAEVW KEQVSELNKQ
860 870 880 890 900
KVTFEDSKVH AEQVLNDKES HIKTLTERLL KMKDWAAMLG EDITDDDNLE
910 920 930 940 950
LEMNSESENG AYLDNPPKGA LKKLIHAAKL NASLKTLEGE RNQIYIQLSE
960 970 980 990 1000
VDKTKEELTE HIKNLQTEQA SLQSENTHFE NENQKLQQKL KVMTELYQEN
1010 1020 1030 1040 1050
EMKLHRKLTV EENYRLEKEE KLSKVDEKIS HATEELETYR KRAKDLEEEL
1060 1070 1080 1090 1100
ERTIHSYQGQ IISHEKKAHD NWLAARNAER NLNDLRKENA HNRQKLTETE
1110 1120 1130 1140 1150
LKFELLEKDP YALDVPNTAF GREHSPYGPS PLGWPSSETR AFLSPPTLLE
1160 1170 1180 1190 1200
GPLRLSPLLP GGGGRGSRGP GNPLDHQITN ERGESSCDRL TDPHRAPSDT
1210 1220 1230 1240 1250
GSLSPPWDQD RRMMFPPPGQ SYPDSALPPQ RQDRFCSNSG RLSGPAELRS
1260 1270 1280 1290 1300
FNMPSLDKMD GSMPSEMESS RNDTKDDLGN LNVPDSSLPA ENEATGPGFV
1310 1320 1330 1340 1350
PPPLAPIRGP LFPVDARGPF LRRGPPFPPP PPGAMFGASR DYFPPGDFPG
1360 1370 1380 1390 1400
PPPAPFAMRN VYPPRGFPPY LPPRPGFFPP PPHSEGRSEF PSGLIPPSNE
1410
PATEHPEPQQ ET
Note: Readthrough transcript producing a functional fusion protein MIA2-CTAGE5 with similarity to MIA3.2 Publications
Length:1,412
Mass (Da):159,836
Last modified:September 7, 2016 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE870056BF9D5A0B2
GO
Isoform 2 (identifier: Q96PC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     631-654: VAALPEGMRPDSNLYGFPWELVIC → SLPFKPFAIILPILLNIRVATKYV
     655-1412: Missing.

Note: No experimental confirmation available.
Show »
Length:654
Mass (Da):74,089
Checksum:iD2C7C8DD246107CC
GO
Isoform 4 (identifier: Q96PC5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-637: Missing.
     1123-1165: Missing.

Show »
Length:732
Mass (Da):83,373
Checksum:i3A7C4AC2B3D65396
GO
Isoform 5 (identifier: Q96PC5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-620: Missing.
     621-629: SPIVILTER → MELKSPEEE
     711-736: Missing.
     1255-1325: Missing.
     1333-1355: Missing.

Show »
Length:672
Mass (Da):76,880
Checksum:iCA742CB43201E4FE
GO
Isoform 6 (identifier: Q96PC5-7) [UniParc]FASTAAdd to basket
Also known as: MEA6

The sequence of this isoform differs from the canonical sequence as follows:
     1-608: Missing.
     609-628: QIDVYDFMNSAFSPIVILTE → MEEPGVTPQPYLGLLLEELR

Show »
Length:804
Mass (Da):90,996
Checksum:iEB2CAC59C4ED7867
GO
Isoform 7 (identifier: Q96PC5-8) [UniParc]FASTAAdd to basket
Also known as: MEA11

The sequence of this isoform differs from the canonical sequence as follows:
     1-608: Missing.
     609-628: QIDVYDFMNSAFSPIVILTE → MEEPGVTPQPYLGLLLEELR
     1123-1165: Missing.

Show »
Length:761
Mass (Da):86,532
Checksum:iB101FD49659A2F30
GO
Isoform 8 (identifier: Q96PC5-9) [UniParc]FASTAAdd to basket
Also known as: 5A

The sequence of this isoform differs from the canonical sequence as follows:
     1-637: Missing.

Show »
Length:775
Mass (Da):87,837
Checksum:i46C11CD859A408FF
GO
Isoform 9 (identifier: Q96PC5-10) [UniParc]FASTAAdd to basket
Also known as: 5B

The sequence of this isoform differs from the canonical sequence as follows:
     1-608: Missing.
     609-628: QIDVYDFMNSAFSPIVILTE → MEEPGVTPQPYLGLLLEELR
     1358-1379: MRNVYPPRGFPPYLPPRPGFFP → SARSPPGAGAPASGRGLGGPQK
     1380-1412: Missing.

Show »
Length:771
Mass (Da):86,811
Checksum:i2E5D4546606E6EC3
GO
Isoform 10 (identifier: Q96PC5-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.

Show »
Length:724
Mass (Da):81,841
Checksum:iAFE56681C351F234
GO
Isoform 11 (identifier: Q96PC5-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-608: Missing.
     609-628: QIDVYDFMNSAFSPIVILTE → MEEPGVTPQPYLGLLLEELR
     736-736: E → EVENQM

Show »
Length:809
Mass (Da):91,598
Checksum:i93E6E1B2E908306B
GO
Isoform 12 (identifier: Q96PC5-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
     736-736: E → EVENQM

Show »
Length:729
Mass (Da):82,443
Checksum:i31620F247C9CF9A1
GO
Isoform 13 (identifier: Q96PC5-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-620: Missing.
     621-629: SPIVILTER → MELKSPEEE

Note: Gene prediction based on EST data.Curated
Show »
Length:792
Mass (Da):89,647
Checksum:i0C9C6951D420A590
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V599G3V599_HUMAN
Melanoma inhibitory activity protei...
MIA2
1,339Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5K6G3V5K6_HUMAN
Melanoma inhibitory activity protei...
MIA2
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3C4G3V3C4_HUMAN
Melanoma inhibitory activity protei...
MIA2
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4M1G3V4M1_HUMAN
Melanoma inhibitory activity protei...
MIA2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB86589 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAL26990 differs from that shown. Probable cloning artifact.Curated
The sequence BAB15339 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83Missing in AAL26990 (PubMed:12586826).Curated1
Sequence conflicti698S → N in CAE45997 (PubMed:17974005).Curated1
Sequence conflicti753I → M in CAE45997 (PubMed:17974005).Curated1
Sequence conflicti803K → Q in AAB86589 (PubMed:9356211).Curated1
Sequence conflicti803K → Q in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti806Q → P in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti1154R → T in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti1197P → L in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti1202S → F in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti1212R → M in AAN77610 (PubMed:12839582).Curated1
Sequence conflicti1384S → F in AAN77610 (PubMed:12839582).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036460437D → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047891813K → N1 PublicationCorresponds to variant dbSNP:rs17855896Ensembl.1
Natural variantiVAR_047892858K → E. Corresponds to variant dbSNP:rs10162564Ensembl.1
Natural variantiVAR_047893968E → Q4 PublicationsCorresponds to variant dbSNP:rs1950952Ensembl.1
Natural variantiVAR_047894983N → S. Corresponds to variant dbSNP:rs17109109Ensembl.1
Natural variantiVAR_0478951307I → V3 PublicationsCorresponds to variant dbSNP:rs1140952Ensembl.1
Natural variantiVAR_0478961346G → R3 PublicationsCorresponds to variant dbSNP:rs1060878Ensembl.1
Isoform 6 (identifier: Q96PC5-7)
Natural varianti6V → A ) (Ref.1. 1 PublicationCorresponds to variant dbSNP:rs7140561Ensembl.1
Isoform 7 (identifier: Q96PC5-8)
Natural varianti6V → A1 PublicationCorresponds to variant dbSNP:rs7140561Ensembl.1
Isoform 9 (identifier: Q96PC5-10)
Natural varianti6V → A1 PublicationCorresponds to variant dbSNP:rs7140561Ensembl.1
Isoform 11 (identifier: Q96PC5-12)
Natural varianti6V → A1 PublicationCorresponds to variant dbSNP:rs7140561Ensembl.1
Natural varianti11Y → D in dbSNP:1141138. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0600031 – 688Missing in isoform 10 and isoform 12. Add BLAST688
Alternative sequenceiVSP_0600041 – 637Missing in isoform 4 and isoform 8. Add BLAST637
Alternative sequenceiVSP_0600051 – 620Missing in isoform 5 and isoform 13. Add BLAST620
Alternative sequenceiVSP_0600061 – 608Missing in isoform 6, isoform 7, isoform 9 and isoform 11. Add BLAST608
Alternative sequenceiVSP_060007609 – 628QIDVY…VILTE → MEEPGVTPQPYLGLLLEELR in isoform 6, isoform 7, isoform 9 and isoform 11. Add BLAST20
Alternative sequenceiVSP_060008621 – 629SPIVILTER → MELKSPEEE in isoform 5 and isoform 13. 9
Alternative sequenceiVSP_058472631 – 654VAALP…ELVIC → SLPFKPFAIILPILLNIRVA TKYV in isoform 2. Add BLAST24
Alternative sequenceiVSP_058473655 – 1412Missing in isoform 2. Add BLAST758
Alternative sequenceiVSP_060009711 – 736Missing in isoform 5. Add BLAST26
Alternative sequenceiVSP_060010736E → EVENQM in isoform 11 and isoform 12. 1
Alternative sequenceiVSP_0600111123 – 1165Missing in isoform 4 and isoform 7. Add BLAST43
Alternative sequenceiVSP_0600121255 – 1325Missing in isoform 5. Add BLAST71
Alternative sequenceiVSP_0600131333 – 1355Missing in isoform 5. Add BLAST23
Alternative sequenceiVSP_0600141358 – 1379MRNVY…PGFFP → SARSPPGAGAPASGRGLGGP QK in isoform 9. Add BLAST22
Alternative sequenceiVSP_0600151380 – 1412Missing in isoform 9. Add BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73682 mRNA Translation: AAB86589.1 Different initiation.
U94780 mRNA Translation: AAB86593.1
AF338233 mRNA Translation: AAN77610.1
AF338234 mRNA Translation: AAN77611.1
KX388743 mRNA Translation: ANN89694.1
AK026057 mRNA Translation: BAB15339.1 Different initiation.
AK091252 mRNA Translation: BAG52318.1
AK298935 mRNA Translation: BAG61038.1
BX640994 mRNA Translation: CAE45997.1
AL132639 Genomic DNA No translation available.
AL157791 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65808.1
CH471078 Genomic DNA Translation: EAW65812.1
CH471078 Genomic DNA Translation: EAW65813.1
CH471078 Genomic DNA Translation: EAW65814.1
CH471078 Genomic DNA Translation: EAW65818.1
BC051363 mRNA Translation: AAH51363.2
BC064355 mRNA Translation: AAH64355.1
BC130537 mRNA Translation: AAI30538.1
BC130563 mRNA Translation: AAI30564.1
AF390175 mRNA Translation: AAL26990.2 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58316.1 [Q96PC5-12]
CCDS58317.1 [Q96PC5-13]
CCDS86384.1 [Q96PC5-3]
CCDS86385.1 [Q96PC5-10]
CCDS86386.1 [Q96PC5-11]
CCDS9672.1 [Q96PC5-2]
CCDS9673.1 [Q96PC5-14]
CCDS9674.1 [Q96PC5-7]
CCDS9675.1 [Q96PC5-8]
CCDS9676.1 [Q96PC5-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001234917.1, NM_001247988.1 [Q96PC5-5]
NP_001234918.1, NM_001247989.1 [Q96PC5-12]
NP_001234919.1, NM_001247990.1 [Q96PC5-13]
NP_001316143.1, NM_001329214.1 [Q96PC5-3]
NP_005921.2, NM_005930.3 [Q96PC5-7]
NP_473365.3, NM_054024.3 [Q96PC5-2]
NP_976229.1, NM_203354.2 [Q96PC5-14]
NP_976231.1, NM_203356.2 [Q96PC5-9]
XP_006720211.1, XM_006720148.2
XP_011535086.1, XM_011536784.2
XP_011535087.1, XM_011536785.2 [Q96PC5-11]
XP_016876809.1, XM_017021320.1
XP_016876814.1, XM_017021325.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280082; ENSP00000280082; ENSG00000150527 [Q96PC5-2]
ENST00000280083; ENSP00000280083; ENSG00000150527 [Q96PC5-7]
ENST00000341502; ENSP00000339286; ENSG00000150527 [Q96PC5-10]
ENST00000341749; ENSP00000343897; ENSG00000150527 [Q96PC5-14]
ENST00000348007; ENSP00000343912; ENSG00000150527 [Q96PC5-8]
ENST00000396158; ENSP00000379462; ENSG00000150527 [Q96PC5-12]
ENST00000396165; ENSP00000379468; ENSG00000150527 [Q96PC5-9]
ENST00000553352; ENSP00000450449; ENSG00000150527 [Q96PC5-9]
ENST00000556148; ENSP00000452562; ENSG00000150527 [Q96PC5-13]
ENST00000557038; ENSP00000450869; ENSG00000150527 [Q96PC5-11]
ENST00000640607; ENSP00000491014; ENSG00000150527 [Q96PC5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4253

UCSC genome browser

More...
UCSCi
uc001wux.4 human [Q96PC5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73682 mRNA Translation: AAB86589.1 Different initiation.
U94780 mRNA Translation: AAB86593.1
AF338233 mRNA Translation: AAN77610.1
AF338234 mRNA Translation: AAN77611.1
KX388743 mRNA Translation: ANN89694.1
AK026057 mRNA Translation: BAB15339.1 Different initiation.
AK091252 mRNA Translation: BAG52318.1
AK298935 mRNA Translation: BAG61038.1
BX640994 mRNA Translation: CAE45997.1
AL132639 Genomic DNA No translation available.
AL157791 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65808.1
CH471078 Genomic DNA Translation: EAW65812.1
CH471078 Genomic DNA Translation: EAW65813.1
CH471078 Genomic DNA Translation: EAW65814.1
CH471078 Genomic DNA Translation: EAW65818.1
BC051363 mRNA Translation: AAH51363.2
BC064355 mRNA Translation: AAH64355.1
BC130537 mRNA Translation: AAI30538.1
BC130563 mRNA Translation: AAI30564.1
AF390175 mRNA Translation: AAL26990.2 Sequence problems.
CCDSiCCDS58316.1 [Q96PC5-12]
CCDS58317.1 [Q96PC5-13]
CCDS86384.1 [Q96PC5-3]
CCDS86385.1 [Q96PC5-10]
CCDS86386.1 [Q96PC5-11]
CCDS9672.1 [Q96PC5-2]
CCDS9673.1 [Q96PC5-14]
CCDS9674.1 [Q96PC5-7]
CCDS9675.1 [Q96PC5-8]
CCDS9676.1 [Q96PC5-9]
RefSeqiNP_001234917.1, NM_001247988.1 [Q96PC5-5]
NP_001234918.1, NM_001247989.1 [Q96PC5-12]
NP_001234919.1, NM_001247990.1 [Q96PC5-13]
NP_001316143.1, NM_001329214.1 [Q96PC5-3]
NP_005921.2, NM_005930.3 [Q96PC5-7]
NP_473365.3, NM_054024.3 [Q96PC5-2]
NP_976229.1, NM_203354.2 [Q96PC5-14]
NP_976231.1, NM_203356.2 [Q96PC5-9]
XP_006720211.1, XM_006720148.2
XP_011535086.1, XM_011536784.2
XP_011535087.1, XM_011536785.2 [Q96PC5-11]
XP_016876809.1, XM_017021320.1
XP_016876814.1, XM_017021325.1

3D structure databases

SMRiQ96PC5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110409, 67 interactors
125559, 3 interactors
IntActiQ96PC5, 54 interactors
MINTiQ96PC5
STRINGi9606.ENSP00000379462

PTM databases

iPTMnetiQ96PC5
PhosphoSitePlusiQ96PC5

Polymorphism and mutation databases

BioMutaiHGNC:18432
DMDMi308153584

Proteomic databases

EPDiQ96PC5
jPOSTiQ96PC5
MassIVEiQ96PC5
PaxDbiQ96PC5
PeptideAtlasiQ96PC5
PRIDEiQ96PC5
ProteomicsDBi33711
48581
48582
48583
48584
48585
48586
48587
48588
77665 [Q96PC5-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
117153

Genome annotation databases

EnsembliENST00000280082; ENSP00000280082; ENSG00000150527 [Q96PC5-2]
ENST00000280083; ENSP00000280083; ENSG00000150527 [Q96PC5-7]
ENST00000341502; ENSP00000339286; ENSG00000150527 [Q96PC5-10]
ENST00000341749; ENSP00000343897; ENSG00000150527 [Q96PC5-14]
ENST00000348007; ENSP00000343912; ENSG00000150527 [Q96PC5-8]
ENST00000396158; ENSP00000379462; ENSG00000150527 [Q96PC5-12]
ENST00000396165; ENSP00000379468; ENSG00000150527 [Q96PC5-9]
ENST00000553352; ENSP00000450449; ENSG00000150527 [Q96PC5-9]
ENST00000556148; ENSP00000452562; ENSG00000150527 [Q96PC5-13]
ENST00000557038; ENSP00000450869; ENSG00000150527 [Q96PC5-11]
ENST00000640607; ENSP00000491014; ENSG00000150527 [Q96PC5-3]
GeneIDi4253
KEGGihsa:4253
UCSCiuc001wux.4 human [Q96PC5-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4253
DisGeNETi4253

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MIA2
HGNCiHGNC:18432 MIA2
HPAiHPA000387
HPA000922
HPA054066
HPA055459
MIMi608001 gene
neXtProtiNX_Q96PC5
OpenTargetsiENSG00000150527
PharmGKBiPA134870998

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIF2 Eukaryota
ENOG410IJV2 Eukaryota
ENOG410ZUJU LUCA
ENOG41118PB LUCA
GeneTreeiENSGT00950000182767
HOGENOMiHOG000220907
InParanoidiQ96PC5
KOiK23703
OMAiDHTGPDC
OrthoDBi135910at2759
TreeFamiTF332724

Enzyme and pathway databases

ReactomeiR-HSA-5694530 Cargo concentration in the ER

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MIA2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MIA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4253
PharosiQ96PC5

Protein Ontology

More...
PROi
PR:Q96PC5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150526 Expressed in 68 organ(s), highest expression level in intestine
ExpressionAtlasiQ96PC5 baseline and differential
GenevisibleiQ96PC5 HS

Family and domain databases

CDDicd11892 SH3_MIA2, 1 hit
InterProiView protein in InterPro
IPR035555 MIA2_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PC5
Secondary accession number(s): A0A193H6U5
, A1L4H0, B3KRA6, B4DQS6, D3DSA6, G3XAC5, O00169, O15320, Q6MZN2, Q6P2R8, Q86TF6, Q8IX92, Q8IX93, Q9H6C1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: September 7, 2016
Last modified: November 13, 2019
This is version 144 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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