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UniProtKB - Q96PC3 (AP1S3_HUMAN)

Entry version 152 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

AP-1 complex subunit sigma-3

Gene

AP1S3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96PC3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-1 complex subunit sigma-3
Alternative name(s):
Adaptor protein complex AP-1 subunit sigma-1C
Adaptor-related protein complex 1 subunit sigma-1C
Clathrin assembly protein complex 1 sigma-1C small chain
Golgi adaptor HA1/AP1 adaptin sigma-1C subunit
Sigma 1C subunit of AP-1 clathrin
Sigma-adaptin 1C
Sigma1C-adaptin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP1S3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000152056.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:18971, AP1S3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615781, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96PC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Psoriasis 15, pustular (PSORS15)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of pustular psoriasis, a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0725454F → C in PSORS15; results in decreased protein levels. 1 PublicationCorresponds to variant dbSNP:rs116107386EnsemblClinVar.1
Natural variantiVAR_07254933R → W in PSORS15; results in decreased TLR3 targeting to the endosomes indicating impaired function. 1 PublicationCorresponds to variant dbSNP:rs138292988EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		130340

MalaCards human disease database

More...MalaCardsi		AP1S3
MIMi616106, phenotype

Open Targets

More...OpenTargetsi		ENSG00000152056

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		163931, Acrodermatitis continua of Hallopeau
247353, Generalized pustular psoriasis
163927, Pustulosis palmaris et plantaris

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96PC3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AP1S3

Domain mapping of disease mutations (DMDM)

More...DMDMi		21541959

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001938011 – 154AP-1 complex subunit sigma-3Add BLAST154

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96PC3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96PC3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96PC3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96PC3

PeptideAtlas

More...PeptideAtlasi		Q96PC3

PRoteomics IDEntifications database

More...PRIDEi		Q96PC3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77660 [Q96PC3-1]
77661 [Q96PC3-2]
77662 [Q96PC3-3]
77663 [Q96PC3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96PC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96PC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152056, Expressed in corpus epididymis and 150 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96PC3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96PC3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152056, Group enriched (ductus deferens, epididymis, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126229, 16 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96PC3

Protein interaction database and analysis system

More...IntActi		Q96PC3, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379891

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96PC3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96PC3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes small subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0934, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00970000193372

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_061221_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96PC3

Identification of Orthologs from Complete Genome Data

More...OMAi		RMSSFID

Database of Orthologous Groups

More...OrthoDBi		1307450at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96PC3

TreeFam database of animal gene trees

More...TreeFami		TF312921

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016635, AP_complex_ssu
IPR022775, AP_mu_sigma_su
IPR000804, Clathrin_sm-chain_CS
IPR011012, Longin-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11753, PTHR11753, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01217, Clat_adaptor_s, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF015588, AP_complex_sigma, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF64356, SSF64356, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00989, CLAT_ADAPTOR_S, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96PC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIHFILLFSR QGKLRLQKWY ITLPDKERKK ITREIVQIIL SRGHRTSSFV 
        60         70         80         90        100
DWKELKLVYK RYASLYFCCA IENQDNELLT LEIVHRYVEL LDKYFGNVCE 
       110        120        130        140        150
LDIIFNFEKA YFILDEFIIG GEIQETSKKI AVKAIEDSDM LQEVSTVSQT 

MGER
Length:154
Mass (Da):18,280
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i178755E8EA4E9ABE
GO
Isoform 2 (identifier: Q96PC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-154: VSTVSQTMGER → NRLSPRGRDCSEPRSCHCTLA

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:164
Mass (Da):19,445
Checksum:i4588CDFD04DA9DBC
GO
Isoform 4 (identifier: Q96PC3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-154: VSTVSQTMGER → TMEEYMNKPTF

Show »
Length:154
Mass (Da):18,477
Checksum:iB0511E775FBED447
GO
Isoform 3 (identifier: Q96PC3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-104: VCELDII → TWPFARA
     105-154: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:104
Mass (Da):12,655
Checksum:i16193FBF026884ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZZ1B8ZZZ1_HUMAN
AP complex subunit sigma
AP1S3
137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8K9F8W8K9_HUMAN
AP-1 complex subunit sigma-3
AP1S3
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZK4C9JZK4_HUMAN
AP-1 complex subunit sigma-3
AP1S3
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E966G5E966_HUMAN
AP-1 complex subunit sigma-3
AP1S3 hCG_21436
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0725454F → C in PSORS15; results in decreased protein levels. 1 PublicationCorresponds to variant dbSNP:rs116107386EnsemblClinVar.1
Natural variantiVAR_07254617Q → K1 PublicationCorresponds to variant dbSNP:rs750870128Ensembl.1
Natural variantiVAR_07254722T → A1 PublicationCorresponds to variant dbSNP:rs149183052Ensembl.1
Natural variantiVAR_07254832T → I1 PublicationCorresponds to variant dbSNP:rs78536455Ensembl.1
Natural variantiVAR_07254933R → W in PSORS15; results in decreased TLR3 targeting to the endosomes indicating impaired function. 1 PublicationCorresponds to variant dbSNP:rs138292988EnsemblClinVar.1
Natural variantiVAR_07255079L → V1 PublicationCorresponds to variant dbSNP:rs34353588Ensembl.1
Natural variantiVAR_07255183I → T1 PublicationCorresponds to variant dbSNP:rs202157374Ensembl.1
Natural variantiVAR_072552124Q → E1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01594298 – 104VCELDII → TWPFARA in isoform 3. 1 Publication7
Alternative sequenceiVSP_015943105 – 154Missing in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_015944144 – 154VSTVSQTMGER → NRLSPRGRDCSEPRSCHCTL A in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_040384144 – 154VSTVSQTMGER → TMEEYMNKPTF in isoform 4. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF393369 mRNA Translation: AAL09586.1
AK299026 mRNA Translation: BAG61103.1
AC012512 Genomic DNA No translation available.
AC093884 Genomic DNA No translation available.
BC009606 mRNA Translation: AAH09606.1
BC021898 mRNA Translation: AAH21898.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42827.1 [Q96PC3-4]

NCBI Reference Sequences

More...RefSeqi		NP_001034658.1, NM_001039569.1 [Q96PC3-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396654; ENSP00000379891; ENSG00000152056 [Q96PC3-4]
ENST00000415298; ENSP00000401705; ENSG00000152056 [Q96PC3-3]
ENST00000443700; ENSP00000397155; ENSG00000152056 [Q96PC3-2]
ENST00000446015; ENSP00000388738; ENSG00000152056 [Q96PC3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		130340

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:130340

UCSC genome browser

More...UCSCi		uc002vnn.4, human [Q96PC3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393369 mRNA Translation: AAL09586.1
AK299026 mRNA Translation: BAG61103.1
AC012512 Genomic DNA No translation available.
AC093884 Genomic DNA No translation available.
BC009606 mRNA Translation: AAH09606.1
BC021898 mRNA Translation: AAH21898.1
CCDSiCCDS42827.1 [Q96PC3-4]
RefSeqiNP_001034658.1, NM_001039569.1 [Q96PC3-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HMYX-ray7.00S1-154[»]
6CM9electron microscopy3.73S1-154[»]
6CRIelectron microscopy6.80S/a/b1-142[»]
6D83electron microscopy4.27S1-154[»]
6D84electron microscopy6.72Q/S1-154[»]
6DFFelectron microscopy3.90S1-154[»]
SMRiQ96PC3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126229, 16 interactors
ComplexPortaliCPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant
CORUMiQ96PC3
IntActiQ96PC3, 7 interactors
STRINGi9606.ENSP00000379891

PTM databases

iPTMnetiQ96PC3
PhosphoSitePlusiQ96PC3

Polymorphism and mutation databases

BioMutaiAP1S3
DMDMi21541959

Proteomic databases

jPOSTiQ96PC3
MassIVEiQ96PC3
MaxQBiQ96PC3
PaxDbiQ96PC3
PeptideAtlasiQ96PC3
PRIDEiQ96PC3
ProteomicsDBi77660 [Q96PC3-1]
77661 [Q96PC3-2]
77662 [Q96PC3-3]
77663 [Q96PC3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54195, 97 antibodies

Genome annotation databases

EnsembliENST00000396654; ENSP00000379891; ENSG00000152056 [Q96PC3-4]
ENST00000415298; ENSP00000401705; ENSG00000152056 [Q96PC3-3]
ENST00000443700; ENSP00000397155; ENSG00000152056 [Q96PC3-2]
ENST00000446015; ENSP00000388738; ENSG00000152056 [Q96PC3-1]
GeneIDi130340
KEGGihsa:130340
UCSCiuc002vnn.4, human [Q96PC3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		130340
DisGeNETi130340
EuPathDBiHostDB:ENSG00000152056.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		AP1S3
HGNCiHGNC:18971, AP1S3
HPAiENSG00000152056, Group enriched (ductus deferens, epididymis, seminal vesicle)
MalaCardsiAP1S3
MIMi615781, gene
616106, phenotype
neXtProtiNX_Q96PC3
OpenTargetsiENSG00000152056
Orphaneti163931, Acrodermatitis continua of Hallopeau
247353, Generalized pustular psoriasis
163927, Pustulosis palmaris et plantaris

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0934, Eukaryota
GeneTreeiENSGT00970000193372
HOGENOMiCLU_061221_4_1_1
InParanoidiQ96PC3
OMAiRMSSFID
OrthoDBi1307450at2759
PhylomeDBiQ96PC3
TreeFamiTF312921

Enzyme and pathway databases

PathwayCommonsiQ96PC3
ReactomeiR-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		130340, 7 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AP1S3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		130340
PharosiQ96PC3, Tbio

Protein Ontology

More...PROi		PR:Q96PC3
RNActiQ96PC3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152056, Expressed in corpus epididymis and 150 other tissues
ExpressionAtlasiQ96PC3, baseline and differential
GenevisibleiQ96PC3, HS

Family and domain databases

InterProiView protein in InterPro
IPR016635, AP_complex_ssu
IPR022775, AP_mu_sigma_su
IPR000804, Clathrin_sm-chain_CS
IPR011012, Longin-like_dom_sf
PANTHERiPTHR11753, PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217, Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588, AP_complex_sigma, 1 hit
SUPFAMiSSF64356, SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989, CLAT_ADAPTOR_S, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP1S3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96PC3
Secondary accession number(s): B4DQZ1, Q8WTY1, Q96DD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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