UniProtKB - Q96P70 (IPO9_HUMAN)
Protein
Importin-9
Gene
IPO9
Organism
Homo sapiens (Human)
Status
Functioni
Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430). Mediates the nuclear import of actin (By similarity).By similarity1 Publication
GO - Molecular functioni
- histone binding Source: UniProtKB
- nuclear import signal receptor activity Source: UniProtKB
- Ran GTPase binding Source: InterPro
GO - Biological processi
- protein import into nucleus Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96P70 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Importin-9Short name: Imp9 Alternative name(s): Ran-binding protein 9 Short name: RanBP9 |
Gene namesi | Name:IPO9 Synonyms:IMP9, KIAA1192, RANBP9 ORF Names:HSPC273 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198700.9 |
HGNCi | HGNC:19425, IPO9 |
neXtProti | NX_Q96P70 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nuclear envelope Source: GO_Central
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55705 |
OpenTargetsi | ENSG00000198700 |
PharmGKBi | PA134930111 |
Miscellaneous databases
Pharosi | Q96P70, Tbio |
Polymorphism and mutation databases
BioMutai | IPO9 |
DMDMi | 41688593 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000120754 | 2 – 1041 | Importin-9Add BLAST | 1040 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q96P70 |
jPOSTi | Q96P70 |
MassIVEi | Q96P70 |
MaxQBi | Q96P70 |
PaxDbi | Q96P70 |
PeptideAtlasi | Q96P70 |
PRIDEi | Q96P70 |
ProteomicsDBi | 77644 |
PTM databases
iPTMneti | Q96P70 |
MetOSitei | Q96P70 |
PhosphoSitePlusi | Q96P70 |
SwissPalmi | Q96P70 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198700, Expressed in cerebellum and 252 other tissues |
ExpressionAtlasi | Q96P70, baseline and differential |
Genevisiblei | Q96P70, HS |
Organism-specific databases
HPAi | ENSG00000198700, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- histone binding Source: UniProtKB
- Ran GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 120830, 112 interactors |
IntActi | Q96P70, 61 interactors |
MINTi | Q96P70 |
STRINGi | 9606.ENSP00000354742 |
Miscellaneous databases
RNActi | Q96P70, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96P70 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 119 | Importin N-terminalPROSITE-ProRule annotationAdd BLAST | 77 |
Sequence similaritiesi
Belongs to the importin beta family.Curated
Phylogenomic databases
eggNOGi | KOG2274, Eukaryota |
GeneTreei | ENSGT00390000008224 |
HOGENOMi | CLU_008920_0_0_1 |
InParanoidi | Q96P70 |
OMAi | TMALCKL |
OrthoDBi | 546100at2759 |
PhylomeDBi | Q96P70 |
TreeFami | TF323706 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR001494, Importin-beta_N |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96P70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAAAGAA SGLPGPVAQG LKEALVDTLT GILSPVQEVR AAAEEQIKVL
60 70 80 90 100
EVTEEFGVHL AELTVDPQGA LAIRQLASVI LKQYVETHWC AQSEKFRPPE
110 120 130 140 150
TTERAKIVIR ELLPNGLRES ISKVRSSVAY AVSAIAHWDW PEAWPQLFNL
160 170 180 190 200
LMEMLVSGDL NAVHGAMRVL TEFTREVTDT QMPLVAPVIL PEMYKIFTMA
210 220 230 240 250
EVYGIRTRSR AVEIFTTCAH MICNMEELEK GAAKVLIFPV VQQFTEAFVQ
260 270 280 290 300
ALQIPDGPTS DSGFKMEVLK AVTALVKNFP KHMVSSMQQI LPIVWNTLTE
310 320 330 340 350
SAAFYVRTEV NYTEEVEDPV DSDGEVLGFE NLVFSIFEFV HALLENSKFK
360 370 380 390 400
STVKKALPEL IYYIILYMQI TEEQIKVWTA NPQQFVEDED DDTFSYTVRI
410 420 430 440 450
AAQDLLLAVA TDFQNESAAA LAAAATRHLQ EAEQTKNSGT EHWWKIHEAC
460 470 480 490 500
MLALGSVKAI ITDSVKNGRI HFDMHGFLTN VILADLNLSV SPFLLGRALW
510 520 530 540 550
AASRFTVAMS PELIQQFLQA TVSGLHETQP PSVRISAVRA IWGYCDQLKV
560 570 580 590 600
SESTHVLQPF LPSILDGLIH LAAQFSSEVL NLVMETLCIV CTVDPEFTAS
610 620 630 640 650
MESKICPFTI AIFLKYSNDP VVASLAQDIF KELSQIEACQ GPMQMRLIPT
660 670 680 690 700
LVSIMQAPAD KIPAGLCATA IDILTTVVRN TKPPLSQLLI CQAFPAVAQC
710 720 730 740 750
TLHTDDNATM QNGGECLRAY VSVTLEQVAQ WHDEQGHNGL WYVMQVVSQL
760 770 780 790 800
LDPRTSEFTA AFVGRLVSTL ISKAGRELGE NLDQILRAIL SKMQQAETLS
810 820 830 840 850
VMQSLIMVFA HLVHTQLEPL LEFLCSLPGP TGKPALEFVM AEWTSRQHLF
860 870 880 890 900
YGQYEGKVSS VALCKLLQHG INADDKRLQD IRVKGEEIYS MDEGIRTRSK
910 920 930 940 950
SAKNPERWTN IPLLVKILKL IINELSNVME ANAARQATPA EWSQDDSNDM
960 970 980 990 1000
WEDQEEEEEE EEDGLAGQLL SDILATSKYE EDYYEDDEED DPDALKDPLY
1010 1020 1030 1040
QIDLQAYLTD FLCQFAQQPC YIMFSGHLND NERRVLQTIG I
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5SVH5 | Q5SVH5_HUMAN | Importin-9 | IPO9 | 155 | Annotation score: |
Sequence cautioni
The sequence AAF28951 differs from that shown. Reason: Frameshift.Curated
The sequence BAA86506 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55181 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11173 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 632 | E → G in BAC11173 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 916 | K → R in BAC11173 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 935 | R → P in BAB55181 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 960 | E → G in BAC11173 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF410465 mRNA Translation: AAL01416.1 AL645504 Genomic DNA No translation available. AK001264 mRNA Translation: BAA91588.1 Different initiation. AK027532 mRNA Translation: BAB55181.1 Different initiation. AK074740 mRNA Translation: BAC11173.1 Different initiation. AK094603 mRNA Translation: BAC04383.1 Sequence problems. CH471067 Genomic DNA Translation: EAW91376.1 BC003604 mRNA Translation: AAH03604.2 AF161391 mRNA Translation: AAF28951.1 Frameshift. AL834323 mRNA Translation: CAD38991.1 AB033018 mRNA Translation: BAA86506.1 Different initiation. |
CCDSi | CCDS1415.1 |
RefSeqi | NP_060555.2, NM_018085.4 |
Genome annotation databases
Ensembli | ENST00000361565; ENSP00000354742; ENSG00000198700 |
GeneIDi | 55705 |
KEGGi | hsa:55705 |
UCSCi | uc001gwz.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF410465 mRNA Translation: AAL01416.1 AL645504 Genomic DNA No translation available. AK001264 mRNA Translation: BAA91588.1 Different initiation. AK027532 mRNA Translation: BAB55181.1 Different initiation. AK074740 mRNA Translation: BAC11173.1 Different initiation. AK094603 mRNA Translation: BAC04383.1 Sequence problems. CH471067 Genomic DNA Translation: EAW91376.1 BC003604 mRNA Translation: AAH03604.2 AF161391 mRNA Translation: AAF28951.1 Frameshift. AL834323 mRNA Translation: CAD38991.1 AB033018 mRNA Translation: BAA86506.1 Different initiation. |
CCDSi | CCDS1415.1 |
RefSeqi | NP_060555.2, NM_018085.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6N1Z | X-ray | 2.70 | A/D | 1-1041 | [»] | |
SMRi | Q96P70 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120830, 112 interactors |
IntActi | Q96P70, 61 interactors |
MINTi | Q96P70 |
STRINGi | 9606.ENSP00000354742 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | Q96P70 |
MetOSitei | Q96P70 |
PhosphoSitePlusi | Q96P70 |
SwissPalmi | Q96P70 |
Polymorphism and mutation databases
BioMutai | IPO9 |
DMDMi | 41688593 |
Proteomic databases
EPDi | Q96P70 |
jPOSTi | Q96P70 |
MassIVEi | Q96P70 |
MaxQBi | Q96P70 |
PaxDbi | Q96P70 |
PeptideAtlasi | Q96P70 |
PRIDEi | Q96P70 |
ProteomicsDBi | 77644 |
Protocols and materials databases
Antibodypediai | 34514, 149 antibodies |
Genome annotation databases
Ensembli | ENST00000361565; ENSP00000354742; ENSG00000198700 |
GeneIDi | 55705 |
KEGGi | hsa:55705 |
UCSCi | uc001gwz.4, human |
Organism-specific databases
CTDi | 55705 |
DisGeNETi | 55705 |
EuPathDBi | HostDB:ENSG00000198700.9 |
GeneCardsi | IPO9 |
HGNCi | HGNC:19425, IPO9 |
HPAi | ENSG00000198700, Low tissue specificity |
neXtProti | NX_Q96P70 |
OpenTargetsi | ENSG00000198700 |
PharmGKBi | PA134930111 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2274, Eukaryota |
GeneTreei | ENSGT00390000008224 |
HOGENOMi | CLU_008920_0_0_1 |
InParanoidi | Q96P70 |
OMAi | TMALCKL |
OrthoDBi | 546100at2759 |
PhylomeDBi | Q96P70 |
TreeFami | TF323706 |
Enzyme and pathway databases
PathwayCommonsi | Q96P70 |
Miscellaneous databases
BioGRID-ORCSi | 55705, 450 hits in 860 CRISPR screens |
ChiTaRSi | IPO9, human |
GeneWikii | IPO9 |
GenomeRNAii | 55705 |
Pharosi | Q96P70, Tbio |
PROi | PR:Q96P70 |
RNActi | Q96P70, protein |
Gene expression databases
Bgeei | ENSG00000198700, Expressed in cerebellum and 252 other tissues |
ExpressionAtlasi | Q96P70, baseline and differential |
Genevisiblei | Q96P70, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR001494, Importin-beta_N |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IPO9_HUMAN | |
Accessioni | Q96P70Primary (citable) accession number: Q96P70 Secondary accession number(s): B1ASV5 Q9ULM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 2, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM