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UniProtKB - Q96P70 (IPO9_HUMAN)

Entry version 176 (02 Jun 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Importin-9

Gene

IPO9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430).

Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430).

Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430).

At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430).

The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430).

Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430).

Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430).

Mediates the nuclear import of actin (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96P70

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Importin-9
Short name:
Imp9
Alternative name(s):
Ran-binding protein 9
Short name:
RanBP9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IPO9
Synonyms:IMP9, KIAA1192, RANBP9
ORF Names:HSPC273
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19425, IPO9

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96P70

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198700.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55705

Open Targets

More...OpenTargetsi		ENSG00000198700

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134930111

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96P70, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IPO9

Domain mapping of disease mutations (DMDM)

More...DMDMi		41688593

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207542 – 1041Importin-9Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96P70

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96P70

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96P70

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96P70

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96P70

PeptideAtlas

More...PeptideAtlasi		Q96P70

PRoteomics IDEntifications database

More...PRIDEi		Q96P70

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77644

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96P70

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q96P70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96P70

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96P70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198700, Expressed in cerebellum and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96P70, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96P70, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198700, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds with high affinity to RPS7 and RPL18A (PubMed:11823430). The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones, RPL4 and RPL6 with low affinity (PubMed:11823430).

Interacts with PPP2R1A and PPP2R1B (PubMed:12670497).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120830, 121 interactors

Protein interaction database and analysis system

More...IntActi		Q96P70, 67 interactors

Molecular INTeraction database

More...MINTi		Q96P70

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354742

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96P70, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11041
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96P70

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 119Importin N-terminalPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni936 – 967DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi946 – 966Acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2274, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008224

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008920_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96P70

Identification of Orthologs from Complete Genome Data

More...OMAi		TMALCKL

Database of Orthologous Groups

More...OrthoDBi		546100at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96P70

TreeFam database of animal gene trees

More...TreeFami		TF323706

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR001494, Importin-beta_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03810, IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00913, IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96P70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAAGAA SGLPGPVAQG LKEALVDTLT GILSPVQEVR AAAEEQIKVL 
        60         70         80         90        100
EVTEEFGVHL AELTVDPQGA LAIRQLASVI LKQYVETHWC AQSEKFRPPE 
       110        120        130        140        150
TTERAKIVIR ELLPNGLRES ISKVRSSVAY AVSAIAHWDW PEAWPQLFNL 
       160        170        180        190        200
LMEMLVSGDL NAVHGAMRVL TEFTREVTDT QMPLVAPVIL PEMYKIFTMA 
       210        220        230        240        250
EVYGIRTRSR AVEIFTTCAH MICNMEELEK GAAKVLIFPV VQQFTEAFVQ 
       260        270        280        290        300
ALQIPDGPTS DSGFKMEVLK AVTALVKNFP KHMVSSMQQI LPIVWNTLTE 
       310        320        330        340        350
SAAFYVRTEV NYTEEVEDPV DSDGEVLGFE NLVFSIFEFV HALLENSKFK 
       360        370        380        390        400
STVKKALPEL IYYIILYMQI TEEQIKVWTA NPQQFVEDED DDTFSYTVRI 
       410        420        430        440        450
AAQDLLLAVA TDFQNESAAA LAAAATRHLQ EAEQTKNSGT EHWWKIHEAC 
       460        470        480        490        500
MLALGSVKAI ITDSVKNGRI HFDMHGFLTN VILADLNLSV SPFLLGRALW 
       510        520        530        540        550
AASRFTVAMS PELIQQFLQA TVSGLHETQP PSVRISAVRA IWGYCDQLKV 
       560        570        580        590        600
SESTHVLQPF LPSILDGLIH LAAQFSSEVL NLVMETLCIV CTVDPEFTAS 
       610        620        630        640        650
MESKICPFTI AIFLKYSNDP VVASLAQDIF KELSQIEACQ GPMQMRLIPT 
       660        670        680        690        700
LVSIMQAPAD KIPAGLCATA IDILTTVVRN TKPPLSQLLI CQAFPAVAQC 
       710        720        730        740        750
TLHTDDNATM QNGGECLRAY VSVTLEQVAQ WHDEQGHNGL WYVMQVVSQL 
       760        770        780        790        800
LDPRTSEFTA AFVGRLVSTL ISKAGRELGE NLDQILRAIL SKMQQAETLS 
       810        820        830        840        850
VMQSLIMVFA HLVHTQLEPL LEFLCSLPGP TGKPALEFVM AEWTSRQHLF 
       860        870        880        890        900
YGQYEGKVSS VALCKLLQHG INADDKRLQD IRVKGEEIYS MDEGIRTRSK 
       910        920        930        940        950
SAKNPERWTN IPLLVKILKL IINELSNVME ANAARQATPA EWSQDDSNDM 
       960        970        980        990       1000
WEDQEEEEEE EEDGLAGQLL SDILATSKYE EDYYEDDEED DPDALKDPLY 
      1010       1020       1030       1040 
QIDLQAYLTD FLCQFAQQPC YIMFSGHLND NERRVLQTIG I
Length:1,041
Mass (Da):115,963
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1842C357AEDFD90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SVH5Q5SVH5_HUMAN
Importin-9
IPO9
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28951 differs from that shown. Reason: Frameshift.Curated
The sequence BAA86506 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55181 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11173 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti632E → G in BAC11173 (PubMed:14702039).Curated1
Sequence conflicti916K → R in BAC11173 (PubMed:14702039).Curated1
Sequence conflicti935R → P in BAB55181 (PubMed:14702039).Curated1
Sequence conflicti960E → G in BAC11173 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF410465 mRNA Translation: AAL01416.1
AL645504 Genomic DNA No translation available.
AK001264 mRNA Translation: BAA91588.1 Different initiation.
AK027532 mRNA Translation: BAB55181.1 Different initiation.
AK074740 mRNA Translation: BAC11173.1 Different initiation.
AK094603 mRNA Translation: BAC04383.1 Sequence problems.
CH471067 Genomic DNA Translation: EAW91376.1
BC003604 mRNA Translation: AAH03604.2
AF161391 mRNA Translation: AAF28951.1 Frameshift.
AL834323 mRNA Translation: CAD38991.1
AB033018 mRNA Translation: BAA86506.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1415.1

NCBI Reference Sequences

More...RefSeqi		NP_060555.2, NM_018085.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361565; ENSP00000354742; ENSG00000198700

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55705

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55705

UCSC genome browser

More...UCSCi		uc001gwz.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410465 mRNA Translation: AAL01416.1
AL645504 Genomic DNA No translation available.
AK001264 mRNA Translation: BAA91588.1 Different initiation.
AK027532 mRNA Translation: BAB55181.1 Different initiation.
AK074740 mRNA Translation: BAC11173.1 Different initiation.
AK094603 mRNA Translation: BAC04383.1 Sequence problems.
CH471067 Genomic DNA Translation: EAW91376.1
BC003604 mRNA Translation: AAH03604.2
AF161391 mRNA Translation: AAF28951.1 Frameshift.
AL834323 mRNA Translation: CAD38991.1
AB033018 mRNA Translation: BAA86506.1 Different initiation.
CCDSiCCDS1415.1
RefSeqiNP_060555.2, NM_018085.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6N1ZX-ray2.70A/D1-1041[»]
SMRiQ96P70
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120830, 121 interactors
IntActiQ96P70, 67 interactors
MINTiQ96P70
STRINGi9606.ENSP00000354742

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

iPTMnetiQ96P70
MetOSiteiQ96P70
PhosphoSitePlusiQ96P70
SwissPalmiQ96P70

Genetic variation databases

BioMutaiIPO9
DMDMi41688593

Proteomic databases

EPDiQ96P70
jPOSTiQ96P70
MassIVEiQ96P70
MaxQBiQ96P70
PaxDbiQ96P70
PeptideAtlasiQ96P70
PRIDEiQ96P70
ProteomicsDBi77644

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34514, 159 antibodies

The DNASU plasmid repository

More...DNASUi		55705

Genome annotation databases

EnsembliENST00000361565; ENSP00000354742; ENSG00000198700
GeneIDi55705
KEGGihsa:55705
UCSCiuc001gwz.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55705
DisGeNETi55705

GeneCards: human genes, protein and diseases

More...GeneCardsi		IPO9
HGNCiHGNC:19425, IPO9
HPAiENSG00000198700, Low tissue specificity
neXtProtiNX_Q96P70
OpenTargetsiENSG00000198700
PharmGKBiPA134930111
VEuPathDBiHostDB:ENSG00000198700.9

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2274, Eukaryota
GeneTreeiENSGT00390000008224
HOGENOMiCLU_008920_0_0_1
InParanoidiQ96P70
OMAiTMALCKL
OrthoDBi546100at2759
PhylomeDBiQ96P70
TreeFamiTF323706

Enzyme and pathway databases

PathwayCommonsiQ96P70

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55705, 464 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IPO9, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IPO9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55705
PharosiQ96P70, Tbio

Protein Ontology

More...PROi		PR:Q96P70
RNActiQ96P70, protein

Gene expression databases

BgeeiENSG00000198700, Expressed in cerebellum and 253 other tissues
ExpressionAtlasiQ96P70, baseline and differential
GenevisibleiQ96P70, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR001494, Importin-beta_N
PfamiView protein in Pfam
PF03810, IBN_N, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPO9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96P70
Secondary accession number(s): B1ASV5
, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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