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UniProtKB - Q96P70 (IPO9_HUMAN)

Protein

Importin-9

Gene

IPO9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430). Mediates the nuclear import of actin (By similarity).By similarity1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • protein transporter activity Source: UniProtKB
  • Ran GTPase binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-9
Short name:
Imp9
Alternative name(s):
Ran-binding protein 9
Short name:
RanBP9
Gene namesi
Name:IPO9
Synonyms:IMP9, KIAA1192, RANBP9
ORF Names:HSPC273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198700.9
HGNCiHGNC:19425 IPO9
neXtProtiNX_Q96P70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55705
OpenTargetsiENSG00000198700
PharmGKBiPA134930111

Polymorphism and mutation databases

BioMutaiIPO9
DMDMi41688593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001207542 – 1041Importin-9Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96P70
MaxQBiQ96P70
PaxDbiQ96P70
PeptideAtlasiQ96P70
PRIDEiQ96P70
ProteomicsDBi77644

PTM databases

iPTMnetiQ96P70
PhosphoSitePlusiQ96P70
SwissPalmiQ96P70

Expressioni

Gene expression databases

BgeeiENSG00000198700 Expressed in 240 organ(s), highest expression level in cerebellum
CleanExiHS_IPO9
HS_RANBP9
ExpressionAtlasiQ96P70 baseline and differential
GenevisibleiQ96P70 HS

Organism-specific databases

HPAiHPA059540

Interactioni

Subunit structurei

Binds with high affinity to RPS7 and RPL18A (PubMed:11823430). The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones, RPL4 and RPL6 with low affinity (PubMed:11823430). Interacts with PPP2R1A and PPP2R1B (PubMed:12670497).2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi120830, 92 interactors
IntActiQ96P70, 26 interactors
MINTiQ96P70
STRINGi9606.ENSP00000354742

Structurei

3D structure databases

ProteinModelPortaliQ96P70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 119Importin N-terminalPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

eggNOGiKOG2274 Eukaryota
COG5657 LUCA
GeneTreeiENSGT00390000008224
HOVERGENiHBG049054
InParanoidiQ96P70
KOiK20224
OMAiTMALCKL
OrthoDBiEOG091G01DL
PhylomeDBiQ96P70
TreeFamiTF323706

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96P70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAAGAA SGLPGPVAQG LKEALVDTLT GILSPVQEVR AAAEEQIKVL 
        60         70         80         90        100
EVTEEFGVHL AELTVDPQGA LAIRQLASVI LKQYVETHWC AQSEKFRPPE 
       110        120        130        140        150
TTERAKIVIR ELLPNGLRES ISKVRSSVAY AVSAIAHWDW PEAWPQLFNL 
       160        170        180        190        200
LMEMLVSGDL NAVHGAMRVL TEFTREVTDT QMPLVAPVIL PEMYKIFTMA 
       210        220        230        240        250
EVYGIRTRSR AVEIFTTCAH MICNMEELEK GAAKVLIFPV VQQFTEAFVQ 
       260        270        280        290        300
ALQIPDGPTS DSGFKMEVLK AVTALVKNFP KHMVSSMQQI LPIVWNTLTE 
       310        320        330        340        350
SAAFYVRTEV NYTEEVEDPV DSDGEVLGFE NLVFSIFEFV HALLENSKFK 
       360        370        380        390        400
STVKKALPEL IYYIILYMQI TEEQIKVWTA NPQQFVEDED DDTFSYTVRI 
       410        420        430        440        450
AAQDLLLAVA TDFQNESAAA LAAAATRHLQ EAEQTKNSGT EHWWKIHEAC 
       460        470        480        490        500
MLALGSVKAI ITDSVKNGRI HFDMHGFLTN VILADLNLSV SPFLLGRALW 
       510        520        530        540        550
AASRFTVAMS PELIQQFLQA TVSGLHETQP PSVRISAVRA IWGYCDQLKV 
       560        570        580        590        600
SESTHVLQPF LPSILDGLIH LAAQFSSEVL NLVMETLCIV CTVDPEFTAS 
       610        620        630        640        650
MESKICPFTI AIFLKYSNDP VVASLAQDIF KELSQIEACQ GPMQMRLIPT 
       660        670        680        690        700
LVSIMQAPAD KIPAGLCATA IDILTTVVRN TKPPLSQLLI CQAFPAVAQC 
       710        720        730        740        750
TLHTDDNATM QNGGECLRAY VSVTLEQVAQ WHDEQGHNGL WYVMQVVSQL 
       760        770        780        790        800
LDPRTSEFTA AFVGRLVSTL ISKAGRELGE NLDQILRAIL SKMQQAETLS 
       810        820        830        840        850
VMQSLIMVFA HLVHTQLEPL LEFLCSLPGP TGKPALEFVM AEWTSRQHLF 
       860        870        880        890        900
YGQYEGKVSS VALCKLLQHG INADDKRLQD IRVKGEEIYS MDEGIRTRSK 
       910        920        930        940        950
SAKNPERWTN IPLLVKILKL IINELSNVME ANAARQATPA EWSQDDSNDM 
       960        970        980        990       1000
WEDQEEEEEE EEDGLAGQLL SDILATSKYE EDYYEDDEED DPDALKDPLY 
      1010       1020       1030       1040 
QIDLQAYLTD FLCQFAQQPC YIMFSGHLND NERRVLQTIG I
Length:1,041
Mass (Da):115,963
Last modified:January 23, 2007 - v3
Checksum:iA1842C357AEDFD90
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SVH5Q5SVH5_HUMAN
Importin-9
IPO9
155Annotation score:

Sequence cautioni

The sequence AAF28951 differs from that shown. Reason: Frameshift at position 982.Curated
The sequence BAA86506 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55181 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11173 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti632E → G in BAC11173 (PubMed:14702039).Curated1
Sequence conflicti916K → R in BAC11173 (PubMed:14702039).Curated1
Sequence conflicti935R → P in BAB55181 (PubMed:14702039).Curated1
Sequence conflicti960E → G in BAC11173 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410465 mRNA Translation: AAL01416.1
AL645504 Genomic DNA No translation available.
AK001264 mRNA Translation: BAA91588.1 Different initiation.
AK027532 mRNA Translation: BAB55181.1 Different initiation.
AK074740 mRNA Translation: BAC11173.1 Different initiation.
AK094603 mRNA Translation: BAC04383.1 Sequence problems.
CH471067 Genomic DNA Translation: EAW91376.1
BC003604 mRNA Translation: AAH03604.2
AF161391 mRNA Translation: AAF28951.1 Frameshift.
AL834323 mRNA Translation: CAD38991.1
AB033018 mRNA Translation: BAA86506.1 Different initiation.
CCDSiCCDS1415.1
RefSeqiNP_060555.2, NM_018085.4
UniGeneiHs.596014

Genome annotation databases

EnsembliENST00000361565; ENSP00000354742; ENSG00000198700
GeneIDi55705
KEGGihsa:55705
UCSCiuc001gwz.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410465 mRNA Translation: AAL01416.1
AL645504 Genomic DNA No translation available.
AK001264 mRNA Translation: BAA91588.1 Different initiation.
AK027532 mRNA Translation: BAB55181.1 Different initiation.
AK074740 mRNA Translation: BAC11173.1 Different initiation.
AK094603 mRNA Translation: BAC04383.1 Sequence problems.
CH471067 Genomic DNA Translation: EAW91376.1
BC003604 mRNA Translation: AAH03604.2
AF161391 mRNA Translation: AAF28951.1 Frameshift.
AL834323 mRNA Translation: CAD38991.1
AB033018 mRNA Translation: BAA86506.1 Different initiation.
CCDSiCCDS1415.1
RefSeqiNP_060555.2, NM_018085.4
UniGeneiHs.596014

3D structure databases

ProteinModelPortaliQ96P70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120830, 92 interactors
IntActiQ96P70, 26 interactors
MINTiQ96P70
STRINGi9606.ENSP00000354742

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ96P70
PhosphoSitePlusiQ96P70
SwissPalmiQ96P70

Polymorphism and mutation databases

BioMutaiIPO9
DMDMi41688593

Proteomic databases

EPDiQ96P70
MaxQBiQ96P70
PaxDbiQ96P70
PeptideAtlasiQ96P70
PRIDEiQ96P70
ProteomicsDBi77644

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361565; ENSP00000354742; ENSG00000198700
GeneIDi55705
KEGGihsa:55705
UCSCiuc001gwz.4 human

Organism-specific databases

CTDi55705
DisGeNETi55705
EuPathDBiHostDB:ENSG00000198700.9
GeneCardsiIPO9
HGNCiHGNC:19425 IPO9
HPAiHPA059540
neXtProtiNX_Q96P70
OpenTargetsiENSG00000198700
PharmGKBiPA134930111
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2274 Eukaryota
COG5657 LUCA
GeneTreeiENSGT00390000008224
HOVERGENiHBG049054
InParanoidiQ96P70
KOiK20224
OMAiTMALCKL
OrthoDBiEOG091G01DL
PhylomeDBiQ96P70
TreeFamiTF323706

Miscellaneous databases

ChiTaRSiIPO9 human
GeneWikiiIPO9
GenomeRNAii55705
PROiPR:Q96P70

Gene expression databases

BgeeiENSG00000198700 Expressed in 240 organ(s), highest expression level in cerebellum
CleanExiHS_IPO9
HS_RANBP9
ExpressionAtlasiQ96P70 baseline and differential
GenevisibleiQ96P70 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPO9_HUMAN
AccessioniPrimary (citable) accession number: Q96P70
Secondary accession number(s): B1ASV5
, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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