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Protein

G-protein coupled receptor 78

Gene

GPR78

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 78
Gene namesi
Name:GPR78
ORF Names:UNQ5925/PRO19818
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000155269.11
HGNCiHGNC:4528 GPR78
MIMi606921 gene
neXtProtiNX_Q96P69

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 47CytoplasmicSequence analysisAdd BLAST19
Transmembranei48 – 68Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini69 – 80ExtracellularSequence analysisAdd BLAST12
Transmembranei81 – 101Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini102 – 122CytoplasmicSequence analysisAdd BLAST21
Transmembranei123 – 143Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini144 – 168ExtracellularSequence analysisAdd BLAST25
Transmembranei169 – 189Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini190 – 242CytoplasmicSequence analysisAdd BLAST53
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 277ExtracellularSequence analysisAdd BLAST14
Transmembranei278 – 297Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini298 – 363CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi236R → E: No effect on constitutive activity. 1 Publication1

Organism-specific databases

DisGeNETi27201
OpenTargetsiENSG00000155269
PharmGKBiPA28921

Polymorphism and mutation databases

BioMutaiGPR78

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695851 – 363G-protein coupled receptor 78Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 156PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96P69
PeptideAtlasiQ96P69
PRIDEiQ96P69
ProteomicsDBi77643

PTM databases

iPTMnetiQ96P69
PhosphoSitePlusiQ96P69

Expressioni

Tissue specificityi

High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.1 Publication

Gene expression databases

BgeeiENSG00000155269
CleanExiHS_GPR78
ExpressionAtlasiQ96P69 baseline and differential
GenevisibleiQ96P69 HS

Organism-specific databases

HPAiHPA013209

Interactioni

Protein-protein interaction databases

BioGridi118076, 1 interactor
STRINGi9606.ENSP00000371927

Structurei

3D structure databases

ProteinModelPortaliQ96P69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00390000005107
HOGENOMiHOG000059564
HOVERGENiHBG051804
InParanoidiQ96P69
KOiK08418
OMAiALSADQW
OrthoDBiEOG091G0BFV
PhylomeDBiQ96P69
TreeFamiTF332434

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96P69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGEALLAG LLVMVLAVAL LSNALVLLCC AYSAELRTRA SGVLLVNLSL
60 70 80 90 100
GHLLLAALDM PFTLLGVMRG RTPSAPGACQ VIGFLDTFLA SNAALSVAAL
110 120 130 140 150
SADQWLAVGF PLRYAGRLRP RYAGLLLGCA WGQSLAFSGA ALGCSWLGYS
160 170 180 190 200
SAFASCSLRL PPEPERPRFA AFTATLHAVG FVLPLAVLCL TSLQVHRVAR
210 220 230 240 250
RHCQRMDTVT MKALALLADL HPSVRQRCLI QQKRRRHRAT RKIGIAIATF
260 270 280 290 300
LICFAPYVMT RLAELVPFVT VNAQWGILSK CLTYSKAVAD PFTYSLLRRP
310 320 330 340 350
FRQVLAGMVH RLLKRTPRPA STHDSSLDVA GMVHQLLKRT PRPASTHNGS
360
VDTENDSCLQ QTH
Length:363
Mass (Da):39,332
Last modified:April 13, 2004 - v2
Checksum:i2C0052A0A1A22A93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216L → V in AAL26479 (PubMed:11574155).Curated1
Sequence conflicti226 – 227QR → HG in AAL26479 (PubMed:11574155).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024258201R → S. Corresponds to variant dbSNP:rs17844778Ensembl.1
Natural variantiVAR_033474330A → T. Corresponds to variant dbSNP:rs11941659Ensembl.1
Natural variantiVAR_033475342R → H. Corresponds to variant dbSNP:rs9685931Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411107 mRNA Translation: AAL26479.1
AB065673 Genomic DNA Translation: BAC05898.1
AY359107 mRNA Translation: AAQ89465.1
BC057778 mRNA Translation: AAH57778.1
BC069343 mRNA Translation: AAH69343.1
BC069813 mRNA Translation: AAH69813.1
CCDSiCCDS3403.1
RefSeqiNP_543009.2, NM_080819.4
UniGeneiHs.740355

Genome annotation databases

EnsembliENST00000382487; ENSP00000371927; ENSG00000155269
GeneIDi27201
KEGGihsa:27201
UCSCiuc003glk.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGPR78_HUMAN
AccessioniPrimary (citable) accession number: Q96P69
Secondary accession number(s): Q8NGV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: April 13, 2004
Last modified: June 20, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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