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Protein

Probable G-protein coupled receptor 82

Gene

GPR82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 82
Gene namesi
Name:GPR82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000171657.5
HGNCiHGNC:4533 GPR82
MIMi300748 gene
neXtProtiNX_Q96P67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11ExtracellularSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 55CytoplasmicSequence analysisAdd BLAST23
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 92ExtracellularSequence analysisAdd BLAST16
Transmembranei93 – 115Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini116 – 156CytoplasmicSequence analysisAdd BLAST41
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 197ExtracellularSequence analysisAdd BLAST20
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 251CytoplasmicSequence analysisAdd BLAST33
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 336ExtracellularSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171657
PharmGKBiPA28926

Polymorphism and mutation databases

BioMutaiGPR82
DMDMi27734323

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695881 – 336Probable G-protein coupled receptor 82Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96P67
PRIDEiQ96P67
ProteomicsDBi77641

PTM databases

iPTMnetiQ96P67
PhosphoSitePlusiQ96P67

Expressioni

Gene expression databases

BgeeiENSG00000171657 Expressed in 87 organ(s), highest expression level in leukocyte
CleanExiHS_GPR82
GenevisibleiQ96P67 HS

Organism-specific databases

HPAiHPA035914

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303549

Structurei

3D structure databases

ProteinModelPortaliQ96P67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IISC Eukaryota
ENOG4111JUU LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000112792
HOVERGENiHBG097852
InParanoidiQ96P67
KOiK08420
OMAiRYATLMK
OrthoDBiEOG091G0DEZ
PhylomeDBiQ96P67
TreeFamiTF337127

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96P67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNNTTCIQP SMISSMALPI IYILLCIVGV FGNTLSQWIF LTKIGKKTST
60 70 80 90 100
HIYLSHLVTA NLLVCSAMPF MSIYFLKGFQ WEYQSAQCRV VNFLGTLSMH
110 120 130 140 150
ASMFVSLLIL SWIAISRYAT LMQKDSSQET TSCYEKIFYG HLLKKFRQPN
160 170 180 190 200
FARKLCIYIW GVVLGIIIPV TVYYSVIEAT EGEESLCYNR QMELGAMISQ
210 220 230 240 250
IAGLIGTTFI GFSFLVVLTS YYSFVSHLRK IRTCTSIMEK DLTYSSVKRH
260 270 280 290 300
LLVIQILLIV CFLPYSIFKP IFYVLHQRDN CQQLNYLIET KNILTCLASA
310 320 330
RSSTDPIIFL LLDKTFKKTL YNLFTKSNSA HMQSYG
Length:336
Mass (Da):38,409
Last modified:December 1, 2001 - v1
Checksum:iB7691CA18B5824A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411111 Genomic DNA Translation: AAL26482.1
AB065935 Genomic DNA Translation: BAC06150.1
AJ319076 mRNA Translation: CAC87490.1
JQ308170 Genomic DNA Translation: AFF59480.1
AB083595 Genomic DNA Translation: BAB89308.1
AK313702 mRNA Translation: BAG36448.1
AK122626 mRNA Translation: BAG53628.1
AL627402 Genomic DNA No translation available.
CH471141 Genomic DNA Translation: EAW59395.1
BC070180 mRNA Translation: AAH70180.1
CCDSiCCDS14259.1
RefSeqiNP_543007.1, NM_080817.4
XP_016884903.1, XM_017029414.1
UniGeneiHs.567457

Genome annotation databases

EnsembliENST00000302548; ENSP00000303549; ENSG00000171657
GeneIDi27197
KEGGihsa:27197
UCSCiuc004dft.3 human

Similar proteinsi

Entry informationi

Entry nameiGPR82_HUMAN
AccessioniPrimary (citable) accession number: Q96P67
Secondary accession number(s): Q5VT13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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