UniProtKB - Q96P66 (GP101_HUMAN)
Protein
Probable G-protein coupled receptor 101
Gene
GPR101
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q96P66 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 101 |
Gene namesi | Name:GPR101 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14963, GPR101 |
MIMi | 300393, gene |
neXtProti | NX_Q96P66 |
VEuPathDBi | HostDB:ENSG00000165370.1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 68 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 69 – 89 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 90 – 106 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 107 – 127 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 149 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 150 – 170 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 196 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 197 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 218 – 399 | CytoplasmicSequence analysisAdd BLAST | 182 | |
Transmembranei | 400 – 420 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 421 – 433 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 434 – 454 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 455 – 508 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Pituitary adenoma 2, growth hormone-secreting (PITA2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072691 | 308 | E → D in PITA2. 1 PublicationCorresponds to variant dbSNP:rs73637412EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 83550 |
GeneReviewsi | GPR101 |
MalaCardsi | GPR101 |
MIMi | 300943, phenotype |
OpenTargetsi | ENSG00000165370 |
Orphaneti | 963, Acromegaly |
PharmGKBi | PA28849 |
Miscellaneous databases
Pharosi | Q96P66, Tbio |
Genetic variation databases
BioMutai | GPR101 |
DMDMi | 48474929 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069601 | 1 – 508 | Probable G-protein coupled receptor 101Add BLAST | 508 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 104 ↔ 182 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q96P66 |
PeptideAtlasi | Q96P66 |
PRIDEi | Q96P66 |
ProteomicsDBi | 77640 |
PTM databases
GlyGeni | Q96P66, 2 sites |
iPTMneti | Q96P66 |
PhosphoSitePlusi | Q96P66 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165370, Expressed in nucleus accumbens and 11 other tissues |
Genevisiblei | Q96P66, HS |
Organism-specific databases
HPAi | ENSG00000165370, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Hide detailsQ96P66
Protein-protein interaction databases
BioGRIDi | 123682, 24 interactors |
IntActi | Q96P66, 21 interactors |
STRINGi | 9606.ENSP00000298110 |
Miscellaneous databases
RNActi | Q96P66, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000162539 |
HOGENOMi | CLU_009579_3_13_1 |
InParanoidi | Q96P66 |
OMAi | KVPQWVI |
OrthoDBi | 1099940at2759 |
PhylomeDBi | Q96P66 |
TreeFami | TF331895 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96P66-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSTCTNSTR ESNSSHTCMP LSKMPISLAH GIIRSTVLVI FLAASFVGNI
60 70 80 90 100
VLALVLQRKP QLLQVTNRFI FNLLVTDLLQ ISLVAPWVVA TSVPLFWPLN
110 120 130 140 150
SHFCTALVSL THLFAFASVN TIVVVSVDRY LSIIHPLSYP SKMTQRRGYL
160 170 180 190 200
LLYGTWIVAI LQSTPPLYGW GQAAFDERNA LCSMIWGASP SYTILSVVSF
210 220 230 240 250
IVIPLIVMIA CYSVVFCAAR RQHALLYNVK RHSLEVRVKD CVENEDEEGA
260 270 280 290 300
EKKEEFQDES EFRRQHEGEV KAKEGRMEAK DGSLKAKEGS TGTSESSVEA
310 320 330 340 350
RGSEEVRESS TVASDGSMEG KEGSTKVEEN SMKADKGRTE VNQCSIDLGE
360 370 380 390 400
DDMEFGEDDI NFSEDDVEAV NIPESLPPSR RNSNSNPPLP RCYQCKAAKV
410 420 430 440 450
IFIIIFSYVL SLGPYCFLAV LAVWVDVETQ VPQWVITIII WLFFLQCCIH
460 470 480 490 500
PYVYGYMHKT IKKEIQDMLK KFFCKEKPPK EDSHPDLPGT EGGTEGKIVP
SYDSATFP
Sequence cautioni
The sequence BAC06152 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049398 | 124 | V → L. Corresponds to variant dbSNP:rs1190736Ensembl. | 1 | |
Natural variantiVAR_072691 | 308 | E → D in PITA2. 1 PublicationCorresponds to variant dbSNP:rs73637412EnsemblClinVar. | 1 | |
Natural variantiVAR_049399 | 376 | L → P. Corresponds to variant dbSNP:rs5931046Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411115 Genomic DNA Translation: AAL26486.1 AB083588 Genomic DNA Translation: BAB89301.1 AB065937 Genomic DNA Translation: BAC06152.1 Different initiation. AL390879 Genomic DNA No translation available. CH471150 Genomic DNA Translation: EAW88450.1 BC069439 mRNA Translation: AAH69439.1 |
CCDSi | CCDS14662.1 |
RefSeqi | NP_473362.1, NM_054021.1 |
Genome annotation databases
Ensembli | ENST00000651716; ENSP00000498972; ENSG00000165370 |
GeneIDi | 83550 |
KEGGi | hsa:83550 |
UCSCi | uc011mwh.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411115 Genomic DNA Translation: AAL26486.1 AB083588 Genomic DNA Translation: BAB89301.1 AB065937 Genomic DNA Translation: BAC06152.1 Different initiation. AL390879 Genomic DNA No translation available. CH471150 Genomic DNA Translation: EAW88450.1 BC069439 mRNA Translation: AAH69439.1 |
CCDSi | CCDS14662.1 |
RefSeqi | NP_473362.1, NM_054021.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123682, 24 interactors |
IntActi | Q96P66, 21 interactors |
STRINGi | 9606.ENSP00000298110 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q96P66, 2 sites |
iPTMneti | Q96P66 |
PhosphoSitePlusi | Q96P66 |
Genetic variation databases
BioMutai | GPR101 |
DMDMi | 48474929 |
Proteomic databases
PaxDbi | Q96P66 |
PeptideAtlasi | Q96P66 |
PRIDEi | Q96P66 |
ProteomicsDBi | 77640 |
Protocols and materials databases
Antibodypediai | 392, 234 antibodies |
DNASUi | 83550 |
Genome annotation databases
Ensembli | ENST00000651716; ENSP00000498972; ENSG00000165370 |
GeneIDi | 83550 |
KEGGi | hsa:83550 |
UCSCi | uc011mwh.2, human |
Organism-specific databases
CTDi | 83550 |
DisGeNETi | 83550 |
GeneCardsi | GPR101 |
GeneReviewsi | GPR101 |
HGNCi | HGNC:14963, GPR101 |
HPAi | ENSG00000165370, Tissue enriched (brain) |
MalaCardsi | GPR101 |
MIMi | 300393, gene 300943, phenotype |
neXtProti | NX_Q96P66 |
OpenTargetsi | ENSG00000165370 |
Orphaneti | 963, Acromegaly |
PharmGKBi | PA28849 |
VEuPathDBi | HostDB:ENSG00000165370.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000162539 |
HOGENOMi | CLU_009579_3_13_1 |
InParanoidi | Q96P66 |
OMAi | KVPQWVI |
OrthoDBi | 1099940at2759 |
PhylomeDBi | Q96P66 |
TreeFami | TF331895 |
Enzyme and pathway databases
PathwayCommonsi | Q96P66 |
Miscellaneous databases
BioGRID-ORCSi | 83550, 3 hits in 494 CRISPR screens |
GeneWikii | GPR101 |
GenomeRNAii | 83550 |
Pharosi | Q96P66, Tbio |
PROi | PR:Q96P66 |
RNActi | Q96P66, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165370, Expressed in nucleus accumbens and 11 other tissues |
Genevisiblei | Q96P66, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP101_HUMAN | |
Accessioni | Q96P66Primary (citable) accession number: Q96P66 Secondary accession number(s): Q5JSM8, Q8NG93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants