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Protein

Pyroglutamylated RFamide peptide receptor

Gene

QRFPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Pyroglutamylated RFamide peptide receptor
Alternative name(s):
AQ27
G-protein coupled receptor 103
Orexigenic neuropeptide QRFP receptor
SP9155
Gene namesi
Name:QRFPR
Synonyms:GPR103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000186867.10
HGNCiHGNC:15565 QRFPR
MIMi606925 gene
neXtProtiNX_Q96P65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 81CytoplasmicSequence analysisAdd BLAST14
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 120ExtracellularSequence analysisAdd BLAST18
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 162CytoplasmicSequence analysisAdd BLAST21
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 212ExtracellularSequence analysisAdd BLAST29
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 271CytoplasmicSequence analysisAdd BLAST38
Transmembranei272 – 292Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini293 – 311ExtracellularSequence analysisAdd BLAST19
Transmembranei312 – 332Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini333 – 431CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84109
OpenTargetsiENSG00000186867
PharmGKBiPA164725243

Chemistry databases

ChEMBLiCHEMBL5852
GuidetoPHARMACOLOGYi333

Polymorphism and mutation databases

BioMutaiQRFPR
DMDMi47117904

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700971 – 431Pyroglutamylated RFamide peptide receptorAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96P65
PaxDbiQ96P65
PeptideAtlasiQ96P65
PRIDEiQ96P65
ProteomicsDBi77639

PTM databases

iPTMnetiQ96P65
PhosphoSitePlusiQ96P65

Expressioni

Tissue specificityi

Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.2 Publications

Gene expression databases

BgeeiENSG00000186867
CleanExiHS_QRFPR
ExpressionAtlasiQ96P65 baseline and differential
GenevisibleiQ96P65 HS

Organism-specific databases

HPAiHPA014300

Interactioni

Protein-protein interaction databases

BioGridi123897, 1 interactor
IntActiQ96P65, 2 interactors
STRINGi9606.ENSP00000377948

Chemistry databases

BindingDBiQ96P65

Structurei

3D structure databases

ProteinModelPortaliQ96P65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148959
HOGENOMiHOG000136537
HOVERGENiHBG067831
InParanoidiQ96P65
KOiK08378
OMAiGNALVFY
OrthoDBiEOG091G0976
PhylomeDBiQ96P65
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96P65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL
60 70 80 90 100
TGVLIFALAL FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP
110 120 130 140 150
VTMLQNISDN WLGGAFICKM VPFVQSTAVV TEILTMTCIA VERHQGLVHP
160 170 180 190 200
FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM WHVQQLEIKY DFLYEKEHIC
210 220 230 240 250
CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE LWIKKRVGDG
260 270 280 290 300
SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN
310 320 330 340 350
FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC
360 370 380 390 400
IVNKTFSPAQ RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL
410 420 430
CEQTEEKKKL KRHLALFRSE LAENSPLDSG H
Length:431
Mass (Da):49,488
Last modified:May 10, 2004 - v2
Checksum:i778D9AE70528024D
GO

Sequence cautioni

The sequence AAL26488 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29LY → VH in BAC98938 (PubMed:12960173).Curated2
Sequence conflicti220 – 266VILFL…SKIAR → SSSSSCLLW in AAL26488 (PubMed:11574155).CuratedAdd BLAST47

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04943761F → V. Corresponds to variant dbSNP:rs17438900Ensembl.1
Natural variantiVAR_049438149H → Q. Corresponds to variant dbSNP:rs11947418Ensembl.1
Natural variantiVAR_049439344L → S. Corresponds to variant dbSNP:rs2302310Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411117 mRNA Translation: AAL26488.1 Different initiation.
AB109629 mRNA Translation: BAC98938.1
CCDSiCCDS3719.1
RefSeqiNP_937822.2, NM_198179.2
UniGeneiHs.368977

Genome annotation databases

EnsembliENST00000394427; ENSP00000377948; ENSG00000186867
GeneIDi84109
KEGGihsa:84109
UCSCiuc010inj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiQRFPR_HUMAN
AccessioniPrimary (citable) accession number: Q96P65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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