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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

Gene

AGAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4Imported
Short name:
AGAP-4
Alternative name(s):
Centaurin-gamma-like family member 1Imported
Centaurin-gamma-like family member 5Imported
Gene namesi
Name:AGAP4Imported
Synonyms:AGAP8Imported, CTGLF1Imported, CTGLF5Imported, MRIP2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000188234.13
HGNCiHGNC:23459 AGAP4
neXtProtiNX_Q96P64

Pathology & Biotechi

Organism-specific databases

DisGeNETi119016
OpenTargetsiENSG00000188234
PharmGKBiPA164715122

Polymorphism and mutation databases

BioMutaiAGAP4
DMDMi296434392

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846731 – 663Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4Add BLAST663

Proteomic databases

PaxDbiQ96P64
PeptideAtlasiQ96P64
PRIDEiQ96P64
ProteomicsDBi77638

PTM databases

iPTMnetiQ96P64
PhosphoSitePlusiQ96P64

Expressioni

Gene expression databases

BgeeiENSG00000188234
ExpressionAtlasiQ96P64 baseline and differential
GenevisibleiQ96P64 HS

Organism-specific databases

HPAiHPA042490

Interactioni

Protein-protein interaction databases

BioGridi125632, 2 interactors
IntActiQ96P64, 1 interactor
STRINGi9606.ENSP00000392513

Structurei

3D structure databases

ProteinModelPortaliQ96P64
SMRiQ96P64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 420PHPROSITE-ProRule annotationAdd BLAST162
Domaini441 – 561Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati600 – 629ANK 1Add BLAST30
Repeati633 – 662ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0705 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
HOGENOMiHOG000007233
HOVERGENiHBG054045
InParanoidiQ96P64
PhylomeDBiQ96P64
TreeFamiTF317762

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q96P64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE
110 120 130 140 150
IRRSNCTNHV STVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH
160 170 180 190 200
HITQRDADRS LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS
210 220 230 240 250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA
260 270 280 290 300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM
310 320 330 340 350
KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISTSKSNGL SKDMDTGLGD
360 370 380 390 400
SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF
410 420 430 440 450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSK AMALQSIQNM
460 470 480 490 500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD
510 520 530 540 550
WPVELRKVMS SIGNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE
560 570 580 590 600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD
610 620 630 640 650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI
660
NVLLQYGCPD KCV
Length:663
Mass (Da):73,070
Last modified:May 18, 2010 - v2
Checksum:i49F11692C58577E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334T → S in AAL10290 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031804661K → E1 PublicationCorresponds to variant dbSNP:rs15718Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411132 mRNA Translation: AAL10290.1
AC012044 Genomic DNA No translation available.
CCDSiCCDS7215.1
RefSeqiNP_001263272.2, NM_001276343.2
NP_597703.2, NM_133446.3
UniGeneiHs.314437
Hs.536192
Hs.656384

Genome annotation databases

EnsembliENST00000448048; ENSP00000392513; ENSG00000188234
GeneIDi119016
KEGGihsa:119016
UCSCiuc057szm.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAGAP4_HUMAN
AccessioniPrimary (citable) accession number: Q96P64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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