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UniProtKB - Q96P64 (AGAP4_HUMAN)
Protein
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
Gene
AGAP4
Organism
Homo sapiens (Human)
Status
Functioni
Putative GTPase-activating protein.
CuratedMiscellaneous
Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 456 – 479 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96P64 |
SignaLinki | Q96P64 |
Names & Taxonomyi
Protein namesi | Recommended name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4ImportedShort name: AGAP-4 Alternative name(s): Centaurin-gamma-like family member 1Imported Centaurin-gamma-like family member 5Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23459, AGAP4 |
neXtProti | NX_Q96P64 |
VEuPathDBi | HostDB:ENSG00000188234 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 119016 |
OpenTargetsi | ENSG00000188234 |
PharmGKBi | PA164715122 |
Miscellaneous databases
Pharosi | Q96P64, Tdark |
Genetic variation databases
BioMutai | AGAP4 |
DMDMi | 296434392 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284673 | 1 – 663 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4Add BLAST | 663 |
Proteomic databases
jPOSTi | Q96P64 |
MassIVEi | Q96P64 |
PaxDbi | Q96P64 |
PeptideAtlasi | Q96P64 |
PRIDEi | Q96P64 |
PTM databases
iPTMneti | Q96P64 |
PhosphoSitePlusi | Q96P64 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188234, Expressed in right hemisphere of cerebellum and 118 other tissues |
ExpressionAtlasi | Q96P64, baseline and differential |
Genevisiblei | Q96P64, HS |
Organism-specific databases
HPAi | ENSG00000188234, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125632, 4 interactors |
IntActi | Q96P64, 2 interactors |
MINTi | Q96P64 |
STRINGi | 9606.ENSP00000392513 |
Miscellaneous databases
RNActi | Q96P64, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 259 – 420 | PHPROSITE-ProRule annotationAdd BLAST | 162 | |
Domaini | 441 – 561 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 121 | |
Repeati | 600 – 629 | ANK 1Add BLAST | 30 | |
Repeati | 633 – 662 | ANK 2Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 185 – 216 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 231 – 255 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 359 – 381 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 519 – 540 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 235 – 250 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the centaurin gamma-like family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 456 – 479 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
ANK repeat, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0705, Eukaryota |
GeneTreei | ENSGT00940000163475 |
HOGENOMi | CLU_007326_4_0_1 |
InParanoidi | Q96P64 |
OMAi | NIAGCHI |
OrthoDBi | 751525at2759 |
PhylomeDBi | Q96P64 |
TreeFami | TF317762 |
Family and domain databases
Gene3Di | 1.10.220.150, 1 hit 1.25.40.20, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96P64-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE
110 120 130 140 150
IRRSNCTNHV STVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH
160 170 180 190 200
HITQRDADRS LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS
210 220 230 240 250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA
260 270 280 290 300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM
310 320 330 340 350
KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISTSKSNGL SKDMDTGLGD
360 370 380 390 400
SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF
410 420 430 440 450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSK AMALQSIQNM
460 470 480 490 500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD
510 520 530 540 550
WPVELRKVMS SIGNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE
560 570 580 590 600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD
610 620 630 640 650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI
660
NVLLQYGCPD KCV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0Z1 | A0A087X0Z1_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP4 | 686 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 334 | T → S in AAL10290 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031804 | 661 | K → E1 PublicationCorresponds to variant dbSNP:rs15718Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411132 mRNA Translation: AAL10290.1 AC012044 Genomic DNA No translation available. |
CCDSi | CCDS7215.1 |
RefSeqi | NP_001263272.2, NM_001276343.2 NP_597703.2, NM_133446.3 |
Genome annotation databases
Ensembli | ENST00000448048; ENSP00000392513; ENSG00000188234 |
GeneIDi | 119016 |
KEGGi | hsa:119016 |
UCSCi | uc057szm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411132 mRNA Translation: AAL10290.1 AC012044 Genomic DNA No translation available. |
CCDSi | CCDS7215.1 |
RefSeqi | NP_001263272.2, NM_001276343.2 NP_597703.2, NM_133446.3 |
3D structure databases
SMRi | Q96P64 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125632, 4 interactors |
IntActi | Q96P64, 2 interactors |
MINTi | Q96P64 |
STRINGi | 9606.ENSP00000392513 |
PTM databases
iPTMneti | Q96P64 |
PhosphoSitePlusi | Q96P64 |
Genetic variation databases
BioMutai | AGAP4 |
DMDMi | 296434392 |
Proteomic databases
jPOSTi | Q96P64 |
MassIVEi | Q96P64 |
PaxDbi | Q96P64 |
PeptideAtlasi | Q96P64 |
PRIDEi | Q96P64 |
Protocols and materials databases
Antibodypediai | 58589, 79 antibodies from 16 providers |
DNASUi | 119016 |
Genome annotation databases
Ensembli | ENST00000448048; ENSP00000392513; ENSG00000188234 |
GeneIDi | 119016 |
KEGGi | hsa:119016 |
UCSCi | uc057szm.1, human |
Organism-specific databases
CTDi | 119016 |
DisGeNETi | 119016 |
GeneCardsi | AGAP4 |
HGNCi | HGNC:23459, AGAP4 |
HPAi | ENSG00000188234, Low tissue specificity |
neXtProti | NX_Q96P64 |
OpenTargetsi | ENSG00000188234 |
PharmGKBi | PA164715122 |
VEuPathDBi | HostDB:ENSG00000188234 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0705, Eukaryota |
GeneTreei | ENSGT00940000163475 |
HOGENOMi | CLU_007326_4_0_1 |
InParanoidi | Q96P64 |
OMAi | NIAGCHI |
OrthoDBi | 751525at2759 |
PhylomeDBi | Q96P64 |
TreeFami | TF317762 |
Enzyme and pathway databases
PathwayCommonsi | Q96P64 |
SignaLinki | Q96P64 |
Miscellaneous databases
BioGRID-ORCSi | 119016, 29 hits in 598 CRISPR screens |
ChiTaRSi | AGAP4, human |
GenomeRNAii | 119016 |
Pharosi | Q96P64, Tdark |
PROi | PR:Q96P64 |
RNActi | Q96P64, protein |
Gene expression databases
Bgeei | ENSG00000188234, Expressed in right hemisphere of cerebellum and 118 other tissues |
ExpressionAtlasi | Q96P64, baseline and differential |
Genevisiblei | Q96P64, HS |
Family and domain databases
Gene3Di | 1.10.220.150, 1 hit 1.25.40.20, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGAP4_HUMAN | |
Accessioni | Q96P64Primary (citable) accession number: Q96P64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families