UniProtKB - Q96P64 (AGAP4_HUMAN)

BLAST

>sp|Q96P64|AGAP4_HUMAN Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=AGAP4 PE=2 SV=2
MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS
LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK
KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS
TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK
ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD
GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
KCV

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History
Entry version 129 (07 Nov 2018)
Sequence version 2 (18 May 2010)
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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

Gene

AGAP4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Putative GTPase-activating protein.Curated

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	456 – 479	C4-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

GTPase activator activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4Imported Short name: AGAP-4 Alternative name(s): Centaurin-gamma-like family member 1Imported Centaurin-gamma-like family member 5Imported
Gene namesⁱ	Name:AGAP4Imported Synonyms:AGAP8Imported, CTGLF1Imported, CTGLF5Imported, MRIP2Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188234.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23459 AGAP4
neXtProtⁱ	NX_Q96P64

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	119016
Open Targets More...OpenTargetsⁱ	ENSG00000188234
PharmGKBⁱ	PA164715122

Polymorphism and mutation databases

BioMutaⁱ	AGAP4
DMDMⁱ	296434392

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000284673	1 – 663	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4Add BLAST		663

Proteomic databases

PaxDbⁱ	Q96P64
PeptideAtlas More...PeptideAtlasⁱ	Q96P64
PRIDEⁱ	Q96P64
ProteomicsDBⁱ	77638

PTM databases

iPTMnetⁱ	Q96P64
PhosphoSitePlusⁱ	Q96P64

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188234 Expressed in 94 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	Q96P64 baseline and differential
Genevisibleⁱ	Q96P64 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042490

HPAⁱ

HPA042490

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	125632, 2 interactors
IntActⁱ	Q96P64, 1 interactor
STRINGⁱ	9606.ENSP00000392513

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96P64
SMRⁱ	Q96P64
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	259 – 420	PHPROSITE-ProRule annotationAdd BLAST	162
Domainⁱ	441 – 561	Arf-GAPPROSITE-ProRule annotationAdd BLAST	121
Repeatⁱ	600 – 629	ANK 1Add BLAST	30
Repeatⁱ	633 – 662	ANK 2Add BLAST	30

Sequence similaritiesⁱ

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	456 – 479	C4-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0705 Eukaryota COG5347 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118874
HOGENOMⁱ	HOG000007233
HOVERGENⁱ	HBG054045
InParanoidⁱ	Q96P64
PhylomeDBⁱ	Q96P64
TreeFamⁱ	TF317762

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q96P64-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ 
        60         70         80         90        100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE 
       110        120        130        140        150
IRRSNCTNHV STVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH 
       160        170        180        190        200
HITQRDADRS LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS 
       210        220        230        240        250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA 
       260        270        280        290        300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM 
       310        320        330        340        350
KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISTSKSNGL SKDMDTGLGD 
       360        370        380        390        400
SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF 
       410        420        430        440        450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSK AMALQSIQNM 
       460        470        480        490        500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD 
       510        520        530        540        550
WPVELRKVMS SIGNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE 
       560        570        580        590        600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD 
       610        620        630        640        650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI 
       660 
NVLLQYGCPD KCV

Length:663

Mass (Da):73,070

Last modified:May 18, 2010 - v2

Checksum:ⁱ49F11692C58577E2

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X0Z1	A0A087X0Z1_HUMAN	Arf-GAP with GTPase, ANK repeat and... Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	AGAP4	686	Annotation score:
A0A087WSV4	A0A087WSV4_HUMAN	Arf-GAP with GTPase, ANK repeat and... Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	AGAP4	663	Annotation score:
A0A087WTP8	A0A087WTP8_HUMAN	Arf-GAP with GTPase, ANK repeat and... Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	AGAP4	658	Annotation score:
K7ER91	K7ER91_HUMAN	Arf-GAP with GTPase, ANK repeat and... Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	AGAP4	137	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	334	T → S in AAL10290 (Ref. 1) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031804	661	K → E1 PublicationCorresponds to variant dbSNP:rs15718Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF411132 mRNA Translation: AAL10290.1 AC012044 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7215.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001263272.2, NM_001276343.2 NP_597703.2, NM_133446.3
UniGeneⁱ	Hs.314437 Hs.536192 Hs.656384

Genome annotation databases

Ensemblⁱ	ENST00000448048; ENSP00000392513; ENSG00000188234
GeneIDⁱ	119016
KEGGⁱ	hsa:119016
UCSC genome browser More...UCSCⁱ	uc057szm.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6		HUMAN		663	UniRef90_Q96P64
AGAP5 isoform 2		PANTR		663
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7		HUMAN		663
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4		HUMAN		663
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5		HUMAN		663
+7

Protein	Similar proteins		Species	Score	Length	Source
Q96P64	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7		HUMAN		663	UniRef50_Q96P64
AGAP5 isoform 2		PANTR		663
Uncharacterized protein		MACFA		620
Uncharacterized protein		NOMLE		649
Uncharacterized protein		PONAB		662
+102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF411132 mRNA Translation: AAL10290.1 AC012044 Genomic DNA No translation available.
CCDSⁱ	CCDS7215.1
RefSeqⁱ	NP_001263272.2, NM_001276343.2 NP_597703.2, NM_133446.3
UniGeneⁱ	Hs.314437 Hs.536192 Hs.656384

3D structure databases

ProteinModelPortalⁱ	Q96P64
SMRⁱ	Q96P64
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125632, 2 interactors
IntActⁱ	Q96P64, 1 interactor
STRINGⁱ	9606.ENSP00000392513

PTM databases

iPTMnetⁱ	Q96P64
PhosphoSitePlusⁱ	Q96P64

Polymorphism and mutation databases

BioMutaⁱ	AGAP4
DMDMⁱ	296434392

Proteomic databases

PaxDbⁱ	Q96P64
PeptideAtlasⁱ	Q96P64
PRIDEⁱ	Q96P64
ProteomicsDBⁱ	77638

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000448048; ENSP00000392513; ENSG00000188234
GeneIDⁱ	119016
KEGGⁱ	hsa:119016
UCSCⁱ	uc057szm.1 human

Organism-specific databases

CTDⁱ	119016
DisGeNETⁱ	119016
EuPathDBⁱ	HostDB:ENSG00000188234.13
GeneCardsⁱ	AGAP4
HGNCⁱ	HGNC:23459 AGAP4
HPAⁱ	HPA042490
neXtProtⁱ	NX_Q96P64
OpenTargetsⁱ	ENSG00000188234
PharmGKBⁱ	PA164715122
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0705 Eukaryota COG5347 LUCA
GeneTreeⁱ	ENSGT00760000118874
HOGENOMⁱ	HOG000007233
HOVERGENⁱ	HBG054045
InParanoidⁱ	Q96P64
PhylomeDBⁱ	Q96P64
TreeFamⁱ	TF317762

Miscellaneous databases

GenomeRNAiⁱ	119016
Protein Ontology More...PROⁱ	PR:Q96P64

Gene expression databases

Bgeeⁱ	ENSG00000188234 Expressed in 94 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	Q96P64 baseline and differential
Genevisibleⁱ	Q96P64 HS

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR001849 PH_domain
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGAP4_HUMAN
Accessionⁱ	Q96P64Primary (citable) accession number: Q96P64
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q96P64 (AGAP4_HUMAN)

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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

AGAP4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ