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Protein

WD repeat and FYVE domain-containing protein 2

Gene

WDFY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 352FYVE-typePROSITE-ProRule annotationAdd BLAST72

GO - Molecular functioni

GO - Biological processi

  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96P53

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and FYVE domain-containing protein 2
Alternative name(s):
Propeller-FYVE protein1 Publication
Short name:
Prof
WD40- and FYVE domain-containing protein 2
Zinc finger FYVE domain-containing protein 22
Gene namesi
Name:WDFY2
Synonyms:WDF2, ZFYVE22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139668.8
HGNCiHGNC:20482 WDFY2
MIMi610418 gene
neXtProtiNX_Q96P53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi115825
OpenTargetsiENSG00000139668
PharmGKBiPA134870231

Polymorphism and mutation databases

BioMutaiWDFY2
DMDMi51316902

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513361 – 400WD repeat and FYVE domain-containing protein 2Add BLAST400

Proteomic databases

EPDiQ96P53
MaxQBiQ96P53
PaxDbiQ96P53
PeptideAtlasiQ96P53
PRIDEiQ96P53
ProteomicsDBi77632

PTM databases

iPTMnetiQ96P53
PhosphoSitePlusiQ96P53

Expressioni

Gene expression databases

BgeeiENSG00000139668 Expressed in 204 organ(s), highest expression level in vagina
CleanExiHS_WDFY2
ExpressionAtlasiQ96P53 baseline and differential
GenevisibleiQ96P53 HS

Interactioni

Subunit structurei

Homodimer (PubMed:16792529). Interacts (via WD repeats 1-3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1 (By similarity). Forms a complex with AKT1 and FOXO1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi125458, 27 interactors
IntActiQ96P53, 5 interactors
STRINGi9606.ENSP00000298125

Structurei

3D structure databases

ProteinModelPortaliQ96P53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Add BLAST40
Repeati66 – 105WD 2Add BLAST40
Repeati112 – 150WD 3Add BLAST39
Repeati153 – 192WD 4Add BLAST40
Repeati197 – 236WD 5Add BLAST40
Repeati240 – 279WD 6Add BLAST40
Repeati364 – 399WD 7Add BLAST36

Domaini

The FYVE-type zinc finger is essential for its vesicular localization.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 352FYVE-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1409 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00670000098022
HOGENOMiHOG000007835
HOVERGENiHBG054128
InParanoidiQ96P53
OMAiTWHCSES
OrthoDBiEOG091G0ANN
PhylomeDBiQ96P53
TreeFamiTF314470

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits
PS50178 ZF_FYVE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96P53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV
60 70 80 90 100
WLKRDSGQYW PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED
110 120 130 140 150
YNKMTPVKNY QAHQSRVTMI LFVLELEWVL STGQDKQFAW HCSESGQRLG
160 170 180 190 200
GYRTSAVASG LQFDVETRHV FIGDHSGQVT ILKLEQENCT LVTTFRGHTG
210 220 230 240 250
GVTALCWDPV QRVLFSGSSD HSVIMWDIGG RKGTAIELQG HNDRVQALSY
260 270 280 290 300
AQHTRQLISC GGDGGIVVWN MDVERQETPE WLDSDSCQKC DQPFFWNFKQ
310 320 330 340 350
MWDSKKIGLR QHHCRKCGKA VCGKCSSKRS SIPLMGFEFE VRVCDSCHEA
360 370 380 390 400
ITDEERAPTA TFHDSKHNIV HVHFDATRGW LLTSGTDKVI KLWDMTPVVS
Length:400
Mass (Da):45,154
Last modified:August 16, 2004 - v2
Checksum:i57868799A6C3C7C7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZX3A0A087WZX3_HUMAN
WD repeat and FYVE domain-containin...
WDFY2
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110Y → C in AAL04162 (Ref. 1) Curated1
Sequence conflicti197G → E in AAL04162 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411978 mRNA Translation: AAL04162.1
AL136525 Genomic DNA No translation available.
AL139183 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08883.1
BC014004 mRNA Translation: AAH14004.1
CCDSiCCDS9429.1
RefSeqiNP_443182.1, NM_052950.3
UniGeneiHs.208550
Hs.46506

Genome annotation databases

EnsembliENST00000298125; ENSP00000298125; ENSG00000139668
GeneIDi115825
KEGGihsa:115825
UCSCiuc001vfp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411978 mRNA Translation: AAL04162.1
AL136525 Genomic DNA No translation available.
AL139183 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08883.1
BC014004 mRNA Translation: AAH14004.1
CCDSiCCDS9429.1
RefSeqiNP_443182.1, NM_052950.3
UniGeneiHs.208550
Hs.46506

3D structure databases

ProteinModelPortaliQ96P53
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125458, 27 interactors
IntActiQ96P53, 5 interactors
STRINGi9606.ENSP00000298125

PTM databases

iPTMnetiQ96P53
PhosphoSitePlusiQ96P53

Polymorphism and mutation databases

BioMutaiWDFY2
DMDMi51316902

Proteomic databases

EPDiQ96P53
MaxQBiQ96P53
PaxDbiQ96P53
PeptideAtlasiQ96P53
PRIDEiQ96P53
ProteomicsDBi77632

Protocols and materials databases

DNASUi115825
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298125; ENSP00000298125; ENSG00000139668
GeneIDi115825
KEGGihsa:115825
UCSCiuc001vfp.4 human

Organism-specific databases

CTDi115825
DisGeNETi115825
EuPathDBiHostDB:ENSG00000139668.8
GeneCardsiWDFY2
HGNCiHGNC:20482 WDFY2
MIMi610418 gene
neXtProtiNX_Q96P53
OpenTargetsiENSG00000139668
PharmGKBiPA134870231
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1409 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00670000098022
HOGENOMiHOG000007835
HOVERGENiHBG054128
InParanoidiQ96P53
OMAiTWHCSES
OrthoDBiEOG091G0ANN
PhylomeDBiQ96P53
TreeFamiTF314470

Enzyme and pathway databases

SignaLinkiQ96P53

Miscellaneous databases

ChiTaRSiWDFY2 human
GenomeRNAii115825
PROiPR:Q96P53
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139668 Expressed in 204 organ(s), highest expression level in vagina
CleanExiHS_WDFY2
ExpressionAtlasiQ96P53 baseline and differential
GenevisibleiQ96P53 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDFY2_HUMAN
AccessioniPrimary (citable) accession number: Q96P53
Secondary accession number(s): B1AL86, Q96CS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 12, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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