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Entry version 179 (11 Dec 2019)
Sequence version 3 (24 Mar 2009)
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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Gene

ARAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri550 – 576C4-typePROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Alternative name(s):
Centaurin-delta-2
Short name:
Cnt-d2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARAP1
Synonyms:CENTD2, KIAA0782
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186635.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16925 ARAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606646 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96P48

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116985

Open Targets

More...
OpenTargetsi
ENSG00000186635

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164715867

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96P48 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226694321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000742141 – 1450Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1Add BLAST1450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei229PhosphoserineCombined sources1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei431PhosphotyrosineCombined sources1
Modified residuei504PhosphotyrosineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei1428PhosphoserineCombined sources1
Modified residuei1435PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96P48

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96P48

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96P48

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96P48

PeptideAtlas

More...
PeptideAtlasi
Q96P48

PRoteomics IDEntifications database

More...
PRIDEi
Q96P48

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77622 [Q96P48-6]
77623 [Q96P48-1]
77624 [Q96P48-2]
77625 [Q96P48-3]
77626 [Q96P48-4]
77627 [Q96P48-5]
77628 [Q96P48-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96P48

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96P48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186635 Expressed in 211 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96P48 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96P48 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020703
HPA070383

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TNFRSF10A.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125548, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q96P48, 18 interactors

Molecular INTeraction database

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MINTi
Q96P48

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377233

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96P48 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96P48

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 70SAMPROSITE-ProRule annotationAdd BLAST65
Domaini327 – 419PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini440 – 529PH 2PROSITE-ProRule annotationAdd BLAST90
Domaini535 – 660Arf-GAPPROSITE-ProRule annotationAdd BLAST126
Domaini743 – 850PH 3PROSITE-ProRule annotationAdd BLAST108
Domaini954 – 1139Rho-GAPPROSITE-ProRule annotationAdd BLAST186
Domaini1172 – 1261Ras-associatingPROSITE-ProRule annotationAdd BLAST90
Domaini1274 – 1396PH 4PROSITE-ProRule annotationAdd BLAST123

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri550 – 576C4-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1117 Eukaryota
COG5347 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157424

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246988

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96P48

KEGG Orthology (KO)

More...
KOi
K18439

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISNKYRQ

Database of Orthologous Groups

More...
OrthoDBi
98944at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96P48

TreeFam database of animal gene trees

More...
TreeFami
TF105769

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04385 RhoGAP_ARAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 3 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 6 (identifier: Q96P48-6) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDTRLMDMG
60 70 80 90 100
MLLPGHRRRI LAGLLRAHTS PAPAPRPTPR PVPMKRHIFR SPPVPATPPE
110 120 130 140 150
PLPTTTEDEG LPAAPPIPPR RSCLPPTCFT TPSTAAPDPV LPPLPAKRHL
160 170 180 190 200
AELSVPPVPP RTGPPRLLVS LPTKEEESLL PSLSSPPQPQ SEEPLSTLPQ
210 220 230 240 250
GPPQPPSPPP CPPEIPPKPV RLFPEFDDSD YDEVPEEGPG APARVMTKKE
260 270 280 290 300
EPPPSRVPRA VRVASLLSEG EELSGDDQGD EEEDDHAYEG VPNGGWHTSS
310 320 330 340 350
LSLSLPSTIA APHPMDGPPG GSTPVTPVIK AGWLDKNPPQ GSYIYQKRWV
360 370 380 390 400
RLDTDHLRYF DSNKDAYSKR FISVACISHV AAIGDQKFEV ITNNRTFAFR
410 420 430 440 450
AESDVERKEW MQALQQAMAE QRARARLSSA YLLGVPGSEQ PDRAGSLELR
460 470 480 490 500
GFKNKLYVAV VGDKVQLYKN LEEYHLGIGI TFIDMSVGNV KEVDRRSFDL
510 520 530 540 550
TTPYRIFSFS ADSELEKEQW LEAMQGAIAE ALSTSEVAER IWAAAPNRFC
560 570 580 590 600
ADCGAPQPDW ASINLCVVIC KRCAGEHRGL GAGVSKVRSL KMDRKVWTET
610 620 630 640 650
LIELFLQLGN GAGNRFWAAN VPPSEALQPS SSPSTRRCHL EAKYREGKYR
660 670 680 690 700
RYHPLFGNQE ELDKALCAAV TTTDLAETQA LLGCGAGINC FSGDPEAPTP
710 720 730 740 750
LALAEQAGQT LQMEFLRNNR TTEVPRLDSM KPLEKHYSVV LPTVSHSGFL
760 770 780 790 800
YKTASAGKLL QDRRAREEFS RRWCVLGDGV LSYFENERAV TPNGEIRASE
810 820 830 840 850
IVCLAVPPPD THGFEHTFEV YTEGERLYLF GLESAEQAHE WVKCIAKAFV
860 870 880 890 900
PPLAEDLLAR DFERLGRLPY KAGLSLQRAQ EGWFSLSGSE LRAVFPEGPC
910 920 930 940 950
EEPLQLRKLQ ELSIQGDSEN QVLVLVERRR TLYIQGERRL DFMGWLGAIQ
960 970 980 990 1000
KAAASMGDTL SEQQLGDSDI PVIVYRCVDY ITQCGLTSEG IYRKCGQTSK
1010 1020 1030 1040 1050
TQRLLESLRQ DARSVHLKEG EQHVDDVSSA LKRFLRDLPD GLFTRAQRLT
1060 1070 1080 1090 1100
WLEASEIEDE EEKVSRYREL LVRLPPVNRA TVKALISHLY CVQCFSDTNQ
1110 1120 1130 1140 1150
MNVHNLAIVF GPTLFQTDGQ DYKAGRVVED LINHYVVVFS VDEEELRKQR
1160 1170 1180 1190 1200
EEITAIVKMR VAGTASGTQH AGDFICTVYL EEKKAETEQH IKVPASMTAE
1210 1220 1230 1240 1250
ELTLEILDRR NVGIREKDYW TCFEVNEREE AERPLHFAEK VLPILHGLGT
1260 1270 1280 1290 1300
DSHLVVKKHQ AMEAMLLYLA SRVGDTKHGM MKFREDRSLL GLGLPSGGFH
1310 1320 1330 1340 1350
DRYFILNSSC LRLYKEVRSQ RPWSGAPETS HRPEKEWPIK SLKVYLGVKK
1360 1370 1380 1390 1400
KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV
1410 1420 1430 1440 1450
WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV
Length:1,450
Mass (Da):162,192
Last modified:March 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4B6CCC28EC4CD0D
GO
Isoform 1 (identifier: Q96P48-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ

Show »
Length:1,210
Mass (Da):136,264
Checksum:i31486141B6648495
GO
Isoform 2 (identifier: Q96P48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-249: APARVMTKK → MTLSGSRGQ
     1320-1330: Missing.

Show »
Length:1,199
Mass (Da):135,066
Checksum:i95873FE63A8C3320
GO
Isoform 3 (identifier: Q96P48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1320-1330: Missing.

Show »
Length:1,439
Mass (Da):160,994
Checksum:iA46A522E287CC2C3
GO
Isoform 4 (identifier: Q96P48-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Show »
Length:1,205
Mass (Da):135,834
Checksum:iA679C6A273660197
GO
Isoform 5 (identifier: Q96P48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-760: Missing.
     761-767: QDRRARE → MDASGKG
     1320-1330: Missing.

Show »
Length:679
Mass (Da):77,550
Checksum:i2F50EB6053978B37
GO
Isoform 7 (identifier: Q96P48-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
     604-664: Missing.
     1320-1330: Missing.

Show »
Length:1,133
Mass (Da):127,665
Checksum:i69A2D13CDDA77185
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EU13E7EU13_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP1
1,194Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSJ2A0A0A0MSJ2_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP1
679Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGD1H0YGD1_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP1
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBT0F8WBT0_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP1
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWQ2F5GWQ2_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP1
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWN4F5GWN4_HUMAN
Arf-GAP with Rho-GAP domain, ANK re...
ARAP1
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34502 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92710 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1408V → M in AAH56401 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055529358R → Q. Corresponds to variant dbSNP:rs34976830Ensembl.1
Natural variantiVAR_0610231047Q → E1 PublicationCorresponds to variant dbSNP:rs56200889Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0149981 – 760Missing in isoform 5. 1 PublicationAdd BLAST760
Alternative sequenceiVSP_0150001 – 245Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST245
Alternative sequenceiVSP_0366071 – 240Missing in isoform 1 and isoform 2. 3 PublicationsAdd BLAST240
Alternative sequenceiVSP_036608241 – 249APARVMTKK → MTLSGSRGQ in isoform 1 and isoform 2. 3 Publications9
Alternative sequenceiVSP_043530604 – 664Missing in isoform 7. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_015001761 – 767QDRRARE → MDASGKG in isoform 5. 1 Publication7
Alternative sequenceiVSP_0003111320 – 1330Missing in isoform 2, isoform 3, isoform 5 and isoform 7. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY049732 mRNA Translation: AAL12169.1
AJ621557 mRNA Translation: CAF21317.1
AB018325 mRNA Translation: BAA34502.2 Different initiation.
AY553630 mRNA Translation: AAT36325.1
AB209473 mRNA Translation: BAD92710.1 Different initiation.
AP002381 Genomic DNA No translation available.
AP003065 Genomic DNA No translation available.
BC008315 mRNA Translation: AAH08315.1
BC021244 mRNA No translation available.
BC056401 mRNA Translation: AAH56401.1
BC140792 mRNA Translation: AAI40793.1
AF411983 mRNA Translation: AAL04167.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41687.1 [Q96P48-6]
CCDS44671.1 [Q96P48-7]
CCDS8217.2 [Q96P48-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
C59431

NCBI Reference Sequences

More...
RefSeqi
NP_001035207.1, NM_001040118.2 [Q96P48-6]
NP_001128662.1, NM_001135190.1 [Q96P48-7]
NP_056057.2, NM_015242.4 [Q96P48-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334211; ENSP00000335506; ENSG00000186635 [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635 [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635 [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635 [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635 [Q96P48-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
116985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:116985

UCSC genome browser

More...
UCSCi
uc001osr.4 human [Q96P48-6]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049732 mRNA Translation: AAL12169.1
AJ621557 mRNA Translation: CAF21317.1
AB018325 mRNA Translation: BAA34502.2 Different initiation.
AY553630 mRNA Translation: AAT36325.1
AB209473 mRNA Translation: BAD92710.1 Different initiation.
AP002381 Genomic DNA No translation available.
AP003065 Genomic DNA No translation available.
BC008315 mRNA Translation: AAH08315.1
BC021244 mRNA No translation available.
BC056401 mRNA Translation: AAH56401.1
BC140792 mRNA Translation: AAI40793.1
AF411983 mRNA Translation: AAL04167.1
CCDSiCCDS41687.1 [Q96P48-6]
CCDS44671.1 [Q96P48-7]
CCDS8217.2 [Q96P48-4]
PIRiC59431
RefSeqiNP_001035207.1, NM_001040118.2 [Q96P48-6]
NP_001128662.1, NM_001135190.1 [Q96P48-7]
NP_056057.2, NM_015242.4 [Q96P48-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X1VX-ray1.58B76-91[»]
SMRiQ96P48
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi125548, 28 interactors
IntActiQ96P48, 18 interactors
MINTiQ96P48
STRINGi9606.ENSP00000377233

PTM databases

iPTMnetiQ96P48
PhosphoSitePlusiQ96P48

Polymorphism and mutation databases

BioMutaiARAP1
DMDMi226694321

Proteomic databases

EPDiQ96P48
jPOSTiQ96P48
MassIVEiQ96P48
PaxDbiQ96P48
PeptideAtlasiQ96P48
PRIDEiQ96P48
ProteomicsDBi77622 [Q96P48-6]
77623 [Q96P48-1]
77624 [Q96P48-2]
77625 [Q96P48-3]
77626 [Q96P48-4]
77627 [Q96P48-5]
77628 [Q96P48-7]

Genome annotation databases

EnsembliENST00000334211; ENSP00000335506; ENSG00000186635 [Q96P48-4]
ENST00000359373; ENSP00000352332; ENSG00000186635 [Q96P48-3]
ENST00000393605; ENSP00000377230; ENSG00000186635 [Q96P48-1]
ENST00000393609; ENSP00000377233; ENSG00000186635 [Q96P48-6]
ENST00000429686; ENSP00000403127; ENSG00000186635 [Q96P48-7]
GeneIDi116985
KEGGihsa:116985
UCSCiuc001osr.4 human [Q96P48-6]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116985
DisGeNETi116985
EuPathDBiHostDB:ENSG00000186635.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARAP1
HGNCiHGNC:16925 ARAP1
HPAiCAB020703
HPA070383
MIMi606646 gene
neXtProtiNX_Q96P48
OpenTargetsiENSG00000186635
PharmGKBiPA164715867

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00940000157424
HOGENOMiHOG000246988
InParanoidiQ96P48
KOiK18439
OMAiISNKYRQ
OrthoDBi98944at2759
PhylomeDBiQ96P48
TreeFamiTF105769

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARAP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CENTD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
116985
PharosiQ96P48 Tbio

Protein Ontology

More...
PROi
PR:Q96P48
RNActiQ96P48 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186635 Expressed in 211 organ(s), highest expression level in blood
ExpressionAtlasiQ96P48 baseline and differential
GenevisibleiQ96P48 HS

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 3 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96P48
Secondary accession number(s): A3KLL7
, B2RTS2, O94879, Q4LDD5, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 24, 2009
Last modified: December 11, 2019
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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