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Entry version 182 (07 Apr 2021)
Sequence version 2 (16 May 2006)
Previous versions | rss
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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Gene

AGAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.Curated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

GTPase activity is stimulated by oxidative stress.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi98 – 105GTPSequence analysis8
Nucleotide bindingi142 – 146GTPSequence analysis5
Nucleotide bindingi198 – 201GTPSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri641 – 664C4-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96P47

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Short name:
AGAP-3
Alternative name(s):
CRAM-associated GTPase
Short name:
CRAG
Centaurin-gamma-3
Short name:
Cnt-g3
MR1-interacting protein
Short name:
MRIP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGAP3
Synonyms:CENTG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16923, AGAP3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96P47

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000133612.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116988

Open Targets

More...
OpenTargetsi
ENSG00000133612

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26413

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96P47, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AGAP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97535922

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000742201 – 875Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei324PhosphothreonineCombined sources1
Modified residuei326PhosphothreonineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96P47

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96P47

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96P47

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96P47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96P47

PeptideAtlas

More...
PeptideAtlasi
Q96P47

PRoteomics IDEntifications database

More...
PRIDEi
Q96P47

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19042
3514
77618 [Q96P47-1]
77619 [Q96P47-2]
77620 [Q96P47-3]
77621 [Q96P47-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96P47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96P47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133612, Expressed in right frontal lobe and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96P47, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96P47, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000133612, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PML.

Interacts with expanded polyglutamine proteins.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125551, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q96P47, 19 interactors

Molecular INTeraction database

More...
MINTi
Q96P47

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380413

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96P47, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1875
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96P47

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96P47

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini367 – 605PHPROSITE-ProRule annotationAdd BLAST239
Domaini626 – 746Arf-GAPPROSITE-ProRule annotationAdd BLAST121
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati748 – 777ANK 1Add BLAST30
Repeati785 – 814ANK 2Add BLAST30
Repeati818 – 847ANK 3Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 375Small GTPase-likeAdd BLAST292

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri641 – 664C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0705, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007326_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96P47

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMSEVPK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96P47

TreeFam database of animal gene trees

More...
TreeFami
TF317762

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.30.29.30, 2 hits
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001806, Small_GTPase
IPR020849, Small_GTPase_Ras-type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF01412, ArfGap, 1 hit
PF00071, Ras, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405, REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105, ArfGap, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
SSF57863, SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50115, ARFGAP, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51421, RAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96P47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNFQAGGGQS PQQQQQLAGG PPQQFALSNS AAIRAEIQRF ESVHPNIYAI
60 70 80 90 100
YDLIERIEDL ALQNQIREHV ISIEDSFVNS QEWTLSRSVP ELKVGIVGNL
110 120 130 140 150
SSGKSALVHR YLTGTYVQEE SPEGGRFKKE IVVDGQSYLL LIRDEGGPPE
160 170 180 190 200
LQFAAWVDAV VFVFSLEDEI SFQTVYNYFL RLCSFRNASE VPMVLVGTQD
210 220 230 240 250
AISAANPRVI DDSRARKLST DLKRCTYYET CATYGLNVER VFQDVAQKVV
260 270 280 290 300
ALRKKQQLAI GPCKSLPNSP SHSAVSAASI PAVHINQATN GGGSAFSDYS
310 320 330 340 350
SSVPSTPSIS QRELRIETIA ASSTPTPIRK QSKRRSNIFT SRKGADLDRE
360 370 380 390 400
KKAAECKVDS IGSGRAIPIK QGILLKRSGK SLNKEWKKKY VTLCDNGLLT
410 420 430 440 450
YHPSLHDYMQ NIHGKEIDLL RTTVKVPGKR LPRATPATAP GTSPRANGLS
460 470 480 490 500
VERSNTQLGG GTGAPHSASS ASLHSERPLS SSAWAGPRPE GLHQRSCSVS
510 520 530 540 550
SADQWSEATT SLPPGMQHPA SGPAEVLSSS PKLDPPPSPH SNRKKHRRKK
560 570 580 590 600
STGTPRPDGP SSATEEAEES FEFVVVSLTG QTWHFEASTA EERELWVQSV
610 620 630 640 650
QAQILASLQG CRSAKDKTRL GNQNAALAVQ AVRTVRGNSF CIDCDAPNPD
660 670 680 690 700
WASLNLGALM CIECSGIHRH LGAHLSRVRS LDLDDWPPEL LAVMTAMGNA
710 720 730 740 750
LANSVWEGAL GGYSKPGPDA CREEKERWIR AKYEQKLFLA PLPSSDVPLG
760 770 780 790 800
QQLLRAVVED DLRLLVMLLA HGSKEEVNET YGDGDGRTAL HLSSAMANVV
810 820 830 840 850
FTQLLIWYGV DVRSRDARGL TPLAYARRAG SQECADILIQ HGCPGEGCGL
860 870
APTPNREPAN GTNPSAELHR SPSLL
Length:875
Mass (Da):95,044
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F0D04EE00F42E1E
GO
Isoform 2 (identifier: Q96P47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MNFQ → MFGGAGPG
     9-15: QSPQQQQ → GPSQ

Show »
Length:876
Mass (Da):94,743
Checksum:iA068C38000F6F33E
GO
Isoform 3 (identifier: Q96P47-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-360: SRKGADLDREKKAAECKVDS → ICATVSNFSSTKRPFQLLPN
     361-875: Missing.

Show »
Length:360
Mass (Da):39,610
Checksum:iD9D68897C6E2C0DD
GO
Isoform 4 (identifier: Q96P47-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: Q → QSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQ

Show »
Length:911
Mass (Da):97,951
Checksum:i9D5B0058D20EB3DC
GO
Isoform 5 (identifier: Q96P47-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.
     463-565: Missing.

Show »
Length:580
Mass (Da):62,846
Checksum:i26A2BBC97484F5C6
GO
Isoform 6 (identifier: Q96P47-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: Q → QSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQ
     341-360: SRKGADLDREKKAAECKVDS → ICATVSNFSSTKRPFQLLPN
     361-875: Missing.

Show »
Length:396
Mass (Da):42,517
Checksum:i2AB030A89989B7C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y873H0Y873_HUMAN
Arf-GAP with GTPase, ANK repeat and...
AGAP3
404Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESL9E7ESL9_HUMAN
Arf-GAP with GTPase, ANK repeat and...
AGAP3
576Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J975C9J975_HUMAN
Arf-GAP with GTPase, ANK repeat and...
AGAP3
343Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5G0H7C5G0_HUMAN
Arf-GAP with GTPase, ANK repeat and...
AGAP3
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4F1H7C4F1_HUMAN
Arf-GAP with GTPase, ANK repeat and...
AGAP3
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4U6H7C4U6_HUMAN
Arf-GAP with GTPase, ANK repeat and...
AGAP3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548901 – 192Missing in isoform 5. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_0185341 – 4MNFQ → MFGGAGPG in isoform 2. 1 Publication4
Alternative sequenceiVSP_0185359 – 15QSPQQQQ → GPSQ in isoform 2. 1 Publication7
Alternative sequenceiVSP_04037315Q → QSLAAPGGGGAAAQQLVCGG QFGGAGPGAGGGGGPSQ in isoform 4 and isoform 6. Curated1
Alternative sequenceiVSP_018536341 – 360SRKGA…CKVDS → ICATVSNFSSTKRPFQLLPN in isoform 3 and isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_018537361 – 875Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST515
Alternative sequenceiVSP_054891463 – 565Missing in isoform 5. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF359283 mRNA Translation: AAK48932.2
AF413079 mRNA Translation: AAL04173.1
AK055393 mRNA Translation: BAG51510.1
AC010973 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54026.1
CH471173 Genomic DNA Translation: EAW54028.1
AB209781 mRNA Translation: BAD93018.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43681.1 [Q96P47-4]
CCDS55185.1 [Q96P47-6]
CCDS64802.1 [Q96P47-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001036000.1, NM_001042535.3 [Q96P47-6]
NP_001268229.1, NM_001281300.1 [Q96P47-5]
NP_114152.3, NM_031946.6 [Q96P47-4]
XP_016867223.1, XM_017011734.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397238; ENSP00000380413; ENSG00000133612 [Q96P47-4]
ENST00000463381; ENSP00000418016; ENSG00000133612 [Q96P47-5]
ENST00000473312; ENSP00000418921; ENSG00000133612 [Q96P47-6]
ENST00000622464; ENSP00000480655; ENSG00000133612 [Q96P47-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116988

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:116988

UCSC genome browser

More...
UCSCi
uc003wje.3, human [Q96P47-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359283 mRNA Translation: AAK48932.2
AF413079 mRNA Translation: AAL04173.1
AK055393 mRNA Translation: BAG51510.1
AC010973 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54026.1
CH471173 Genomic DNA Translation: EAW54028.1
AB209781 mRNA Translation: BAD93018.1
CCDSiCCDS43681.1 [Q96P47-4]
CCDS55185.1 [Q96P47-6]
CCDS64802.1 [Q96P47-5]
RefSeqiNP_001036000.1, NM_001042535.3 [Q96P47-6]
NP_001268229.1, NM_001281300.1 [Q96P47-5]
NP_114152.3, NM_031946.6 [Q96P47-4]
XP_016867223.1, XM_017011734.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IHWX-ray1.92A90-255[»]
SMRiQ96P47
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125551, 27 interactors
IntActiQ96P47, 19 interactors
MINTiQ96P47
STRINGi9606.ENSP00000380413

PTM databases

iPTMnetiQ96P47
PhosphoSitePlusiQ96P47

Genetic variation databases

BioMutaiAGAP3
DMDMi97535922

Proteomic databases

EPDiQ96P47
jPOSTiQ96P47
MassIVEiQ96P47
MaxQBiQ96P47
PaxDbiQ96P47
PeptideAtlasiQ96P47
PRIDEiQ96P47
ProteomicsDBi19042
3514
77618 [Q96P47-1]
77619 [Q96P47-2]
77620 [Q96P47-3]
77621 [Q96P47-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1445, 151 antibodies

The DNASU plasmid repository

More...
DNASUi
116988

Genome annotation databases

EnsembliENST00000397238; ENSP00000380413; ENSG00000133612 [Q96P47-4]
ENST00000463381; ENSP00000418016; ENSG00000133612 [Q96P47-5]
ENST00000473312; ENSP00000418921; ENSG00000133612 [Q96P47-6]
ENST00000622464; ENSP00000480655; ENSG00000133612 [Q96P47-1]
GeneIDi116988
KEGGihsa:116988
UCSCiuc003wje.3, human [Q96P47-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116988
DisGeNETi116988

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AGAP3
HGNCiHGNC:16923, AGAP3
HPAiENSG00000133612, Tissue enhanced (brain)
neXtProtiNX_Q96P47
OpenTargetsiENSG00000133612
PharmGKBiPA26413
VEuPathDBiHostDB:ENSG00000133612.18

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0705, Eukaryota
GeneTreeiENSGT00940000159586
HOGENOMiCLU_007326_4_0_1
InParanoidiQ96P47
OMAiNMSEVPK
PhylomeDBiQ96P47
TreeFamiTF317762

Enzyme and pathway databases

PathwayCommonsiQ96P47

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
116988, 7 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AGAP3, human
EvolutionaryTraceiQ96P47

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CENTG3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
116988
PharosiQ96P47, Tdark

Protein Ontology

More...
PROi
PR:Q96P47
RNActiQ96P47, protein

Gene expression databases

BgeeiENSG00000133612, Expressed in right frontal lobe and 212 other tissues
ExpressionAtlasiQ96P47, baseline and differential
GenevisibleiQ96P47, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.30.29.30, 2 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001806, Small_GTPase
IPR020849, Small_GTPase_Ras-type
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF01412, ArfGap, 1 hit
PF00071, Ras, 1 hit
PRINTSiPR00405, REVINTRACTNG
SMARTiView protein in SMART
SM00105, ArfGap, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
SSF57863, SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50115, ARFGAP, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51421, RAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGAP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96P47
Secondary accession number(s): B3KNZ8
, E9PAL8, Q59EN0, Q96RK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 16, 2006
Last modified: April 7, 2021
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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