UniProtKB - Q96P31 (FCRL3_HUMAN)
Fc receptor-like protein 3
FCRL3
Functioni
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366).
Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936).
Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).
4 PublicationsGO - Molecular functioni
- kinase binding Source: UniProtKB
- phosphatase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- protein tyrosine kinase binding Source: UniProtKB
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- cell surface receptor signaling pathway Source: GO_Central
- negative regulation of B cell receptor signaling pathway Source: UniProtKB
- negative regulation of immunoglobulin production Source: UniProtKB
- positive regulation of B cell proliferation Source: UniProtKB
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of protein serine/threonine phosphatase activity Source: UniProtKB
- regulation of B cell activation Source: UniProtKB
- regulation of B cell differentiation Source: UniProtKB
- regulation of calcium ion import Source: UniProtKB
- regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q96P31 |
SignaLinki | Q96P31 |
Names & Taxonomyi
Protein namesi | Recommended name: Fc receptor-like protein 3CuratedShort name: FcR-like protein 3Curated Short name: FcRL3Curated Alternative name(s): Fc receptor homolog 3Curated Short name: FcRH3Curated IFGP family protein 3 Short name: hIFGP3 Immune receptor translocation-associated protein 3 SH2 domain-containing phosphatase anchor protein 2 CD_antigen: CD307c |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18506, FCRL3 |
MIMi | 606510, gene |
neXtProti | NX_Q96P31 |
VEuPathDBi | HostDB:ENSG00000160856 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell surface Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 573 | ExtracellularSequence analysisAdd BLAST | 556 | |
Transmembranei | 574 – 594 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 595 – 734 | CytoplasmicSequence analysisAdd BLAST | 140 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Rheumatoid arthritis (RA)9 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 650 | Y → F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-662; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-662. Decreases calcium influx inhibition; when associated with F-662 and F-722. Decreases calcium influx inhibition; when associated with F-692 and F-722. 2 Publications | 1 | |
Mutagenesisi | 662 | Y → F: Reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN6. No effect on interaction with PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-650. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-722. 2 Publications | 1 | |
Mutagenesisi | 692 | Y → F: Partially reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN11. No effect on interaction with PTPN6. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-722. Alters binding with PTPN6 and PTPN11; when associated with F-772. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-722. 2 Publications | 1 | |
Mutagenesisi | 722 | Y → F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-692. Alters binding with PTPN6 and PTPN11; when associated with F-692. Decreases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-650 and F-692. Decreases calcium influx inhibition; when associated with F-692. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 115352 |
MIMi | 180300, phenotype |
OpenTargetsi | ENSG00000160856 |
PharmGKBi | PA142671767 |
Miscellaneous databases
Pharosi | Q96P31, Tbio |
Genetic variation databases
BioMutai | FCRL3 |
DMDMi | 74761021 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000331640 | 18 – 734 | Fc receptor-like protein 3Add BLAST | 717 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 82 | PROSITE-ProRule annotation | ||
Disulfide bondi | 120 ↔ 163 | PROSITE-ProRule annotation | ||
Disulfide bondi | 211 ↔ 260 | PROSITE-ProRule annotation | ||
Disulfide bondi | 309 ↔ 358 | PROSITE-ProRule annotation | ||
Disulfide bondi | 404 ↔ 451 | PROSITE-ProRule annotation | ||
Disulfide bondi | 497 ↔ 544 | PROSITE-ProRule annotation | ||
Glycosylationi | 561 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 650 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 662 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 692 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 722 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q96P31 |
PaxDbi | Q96P31 |
PeptideAtlasi | Q96P31 |
PRIDEi | Q96P31 |
ProteomicsDBi | 77608 [Q96P31-1] 77609 [Q96P31-2] 77610 [Q96P31-3] 77611 [Q96P31-4] 77612 [Q96P31-5] 77613 [Q96P31-6] 77614 [Q96P31-7] |
PTM databases
GlyGeni | Q96P31, 1 site |
iPTMneti | Q96P31 |
PhosphoSitePlusi | Q96P31 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000160856, Expressed in lymph node and 121 other tissues |
ExpressionAtlasi | Q96P31, baseline and differential |
Genevisiblei | Q96P31, HS |
Organism-specific databases
HPAi | ENSG00000160856, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Interacts (via phosphorylated ITIM motifs) with phosphatases INPP5D, PTPN6 and PTPN11. Interacts (via ITIM motifs) SYK and ZAP70.
2 PublicationsBinary interactionsi
Isoform 6 [Q96P31-6]
GO - Molecular functioni
- kinase binding Source: UniProtKB
- phosphatase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- protein tyrosine kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 125428, 13 interactors |
IntActi | Q96P31, 8 interactors |
STRINGi | 9606.ENSP00000357167 |
Miscellaneous databases
RNActi | Q96P31, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 98 | Ig-like C2-type 1Add BLAST | 78 | |
Domaini | 99 – 182 | Ig-like C2-type 2Add BLAST | 84 | |
Domaini | 192 – 270 | Ig-like C2-type 3Add BLAST | 79 | |
Domaini | 284 – 369 | Ig-like C2-type 4Add BLAST | 86 | |
Domaini | 383 – 470 | Ig-like C2-type 5Add BLAST | 88 | |
Domaini | 476 – 563 | Ig-like C2-type 6Add BLAST | 88 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 603 – 655 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 695 – 734 | DisorderedSequence analysisAdd BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 648 – 653 | ITIM motif 1 | 6 | |
Motifi | 660 – 665 | ITIM motif 2 | 6 | |
Motifi | 690 – 695 | ITIM motif 3 | 6 | |
Motifi | 720 – 725 | ITIM motif 4 | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 606 – 631 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 695 – 724 | Basic and acidic residuesSequence analysisAdd BLAST | 30 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S65W, Eukaryota |
GeneTreei | ENSGT01040000240447 |
HOGENOMi | CLU_023383_6_1_1 |
InParanoidi | Q96P31 |
OMAi | PWSTTFK |
OrthoDBi | 53940at2759 |
PhylomeDBi | Q96P31 |
TreeFami | TF351107 |
Family and domain databases
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 4 hits |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS
60 70 80 90 100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD
110 120 130 140 150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT
160 170 180 190 200
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST
210 220 230 240 250
PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM
260 270 280 290 300
WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI
310 320 330 340 350
EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE
360 370 380 390 400
SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL
410 420 430 440 450
ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS
460 470 480 490 500
CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL
510 520 530 540 550
RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL
560 570 580 590 600
GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR
610 620 630 640 650
RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY
660 670 680 690 700
SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKTHP
710 720 730
DDSAGEASSR GRAHEEDDEE NYENVPRVLL ASDH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GNJ6 | R4GNJ6_HUMAN | Fc receptor-like protein 3 | FCRL3 | 256 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 244 | R → K in AK098122 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 653 | V → A in AAK91779 (PubMed:11493702).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042924 | 28 | N → D2 PublicationsCorresponds to variant dbSNP:rs7522061Ensembl. | 1 | |
Natural variantiVAR_042925 | 307 | L → F. Corresponds to variant dbSNP:rs12041673EnsemblClinVar. | 1 | |
Natural variantiVAR_042926 | 445 | H → N in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042927 | 660 | P → L. Corresponds to variant dbSNP:rs944627Ensembl. | 1 | |
Natural variantiVAR_042928 | 721 | N → S. Corresponds to variant dbSNP:rs2282284Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033300 | 187 – 282 | ELFLH…IRVQR → G in isoform 2. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_033301 | 187 – 189 | ELF → GNG in isoform 4. 1 Publication | 3 | |
Alternative sequenceiVSP_033302 | 188 – 199 | LFLHP…RASSS → ARCPAAILPLQR in isoform 5. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_033303 | 190 – 734 | Missing in isoform 4. 1 PublicationAdd BLAST | 545 | |
Alternative sequenceiVSP_033304 | 200 – 734 | Missing in isoform 5. 1 PublicationAdd BLAST | 535 | |
Alternative sequenceiVSP_033305 | 378 | I → TLLSPSV in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_033306 | 698 – 707 | THPDDSAGEA → EQSSRFSMSL in isoform 7. 1 Publication | 10 | |
Alternative sequenceiVSP_033307 | 708 – 734 | Missing in isoform 7. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_033308 | 725 – 734 | VPRVLLASDH → ILNPRKNKVQDFPCLCNT in isoform 6. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY043466 mRNA Translation: AAK91779.1 AF416901 mRNA Translation: AAL13290.1 AF416902 mRNA Translation: AAL13291.1 AF416903 mRNA Translation: AAL13292.1 AF416904 mRNA Translation: AAL13293.1 AF416905 mRNA Translation: AAL13294.1 EF064732 Genomic DNA Translation: ABK41915.1 AK098122 mRNA No translation available. AL356276 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52872.1 CH471121 Genomic DNA Translation: EAW52876.1 CH471121 Genomic DNA Translation: EAW52877.1 BC028933 mRNA Translation: AAH28933.1 |
CCDSi | CCDS1167.1 [Q96P31-1] CCDS81385.1 [Q96P31-6] |
RefSeqi | NP_001307262.1, NM_001320333.1 [Q96P31-6] NP_443171.2, NM_052939.3 [Q96P31-1] XP_006711208.1, XM_006711145.1 [Q96P31-1] |
Genome annotation databases
Ensembli | ENST00000368184; ENSP00000357167; ENSG00000160856 ENST00000368186; ENSP00000357169; ENSG00000160856 [Q96P31-6] ENST00000477837; ENSP00000433430; ENSG00000160856 [Q96P31-2] ENST00000485028; ENSP00000434331; ENSG00000160856 ENST00000492769; ENSP00000435487; ENSG00000160856 [Q96P31-3] |
GeneIDi | 115352 |
KEGGi | hsa:115352 |
MANE-Selecti | ENST00000368184.8; ENSP00000357167.3; NM_052939.4; NP_443171.2 |
UCSCi | uc001fqz.5, human [Q96P31-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY043466 mRNA Translation: AAK91779.1 AF416901 mRNA Translation: AAL13290.1 AF416902 mRNA Translation: AAL13291.1 AF416903 mRNA Translation: AAL13292.1 AF416904 mRNA Translation: AAL13293.1 AF416905 mRNA Translation: AAL13294.1 EF064732 Genomic DNA Translation: ABK41915.1 AK098122 mRNA No translation available. AL356276 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52872.1 CH471121 Genomic DNA Translation: EAW52876.1 CH471121 Genomic DNA Translation: EAW52877.1 BC028933 mRNA Translation: AAH28933.1 |
CCDSi | CCDS1167.1 [Q96P31-1] CCDS81385.1 [Q96P31-6] |
RefSeqi | NP_001307262.1, NM_001320333.1 [Q96P31-6] NP_443171.2, NM_052939.3 [Q96P31-1] XP_006711208.1, XM_006711145.1 [Q96P31-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125428, 13 interactors |
IntActi | Q96P31, 8 interactors |
STRINGi | 9606.ENSP00000357167 |
PTM databases
GlyGeni | Q96P31, 1 site |
iPTMneti | Q96P31 |
PhosphoSitePlusi | Q96P31 |
Genetic variation databases
BioMutai | FCRL3 |
DMDMi | 74761021 |
Proteomic databases
MassIVEi | Q96P31 |
PaxDbi | Q96P31 |
PeptideAtlasi | Q96P31 |
PRIDEi | Q96P31 |
ProteomicsDBi | 77608 [Q96P31-1] 77609 [Q96P31-2] 77610 [Q96P31-3] 77611 [Q96P31-4] 77612 [Q96P31-5] 77613 [Q96P31-6] 77614 [Q96P31-7] |
Protocols and materials databases
Antibodypediai | 2552, 174 antibodies from 23 providers |
DNASUi | 115352 |
Genome annotation databases
Ensembli | ENST00000368184; ENSP00000357167; ENSG00000160856 ENST00000368186; ENSP00000357169; ENSG00000160856 [Q96P31-6] ENST00000477837; ENSP00000433430; ENSG00000160856 [Q96P31-2] ENST00000485028; ENSP00000434331; ENSG00000160856 ENST00000492769; ENSP00000435487; ENSG00000160856 [Q96P31-3] |
GeneIDi | 115352 |
KEGGi | hsa:115352 |
MANE-Selecti | ENST00000368184.8; ENSP00000357167.3; NM_052939.4; NP_443171.2 |
UCSCi | uc001fqz.5, human [Q96P31-1] |
Organism-specific databases
CTDi | 115352 |
DisGeNETi | 115352 |
GeneCardsi | FCRL3 |
HGNCi | HGNC:18506, FCRL3 |
HPAi | ENSG00000160856, Tissue enriched (lymphoid) |
MIMi | 180300, phenotype 606510, gene |
neXtProti | NX_Q96P31 |
OpenTargetsi | ENSG00000160856 |
PharmGKBi | PA142671767 |
VEuPathDBi | HostDB:ENSG00000160856 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S65W, Eukaryota |
GeneTreei | ENSGT01040000240447 |
HOGENOMi | CLU_023383_6_1_1 |
InParanoidi | Q96P31 |
OMAi | PWSTTFK |
OrthoDBi | 53940at2759 |
PhylomeDBi | Q96P31 |
TreeFami | TF351107 |
Enzyme and pathway databases
PathwayCommonsi | Q96P31 |
SignaLinki | Q96P31 |
Miscellaneous databases
BioGRID-ORCSi | 115352, 4 hits in 1029 CRISPR screens |
GeneWikii | FCRL3 |
GenomeRNAii | 115352 |
Pharosi | Q96P31, Tbio |
PROi | PR:Q96P31 |
RNActi | Q96P31, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160856, Expressed in lymph node and 121 other tissues |
ExpressionAtlasi | Q96P31, baseline and differential |
Genevisiblei | Q96P31, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 4 hits |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FCRL3_HUMAN | |
Accessioni | Q96P31Primary (citable) accession number: Q96P31 Secondary accession number(s): A0N0M4 Q96P30 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot