FCRL3

Functionⁱ

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).4 Publications

GO - Molecular functionⁱ

kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19843936
phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19843936
protein phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12051764
protein tyrosine kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12051764

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of B cell receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 19843936
negative regulation of immunoglobulin production
Source: UniProtKB
Inferred from direct assayⁱ
- 23857366
positive regulation of B cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 23857366
positive regulation of MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 23857366
positive regulation of protein serine/threonine phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12051764
regulation of B cell activation
Source: UniProtKB
Inferred from direct assayⁱ
- 23857366
regulation of B cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 23857366
regulation of calcium ion import
Source: UniProtKB
Inferred from direct assayⁱ
- 19843936
regulation of toll-like receptor 9 signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 23857366

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fc receptor-like protein 3Curated Short name: FcR-like protein 3Curated Short name: FcRL3Curated Alternative name(s): Fc receptor homolog 3Curated Short name: FcRH3Curated IFGP family protein 3 Short name: hIFGP3 Immune receptor translocation-associated protein 3 SH2 domain-containing phosphatase anchor protein 2 CD_antigen: CD307c
Gene namesⁱ	Name:FCRL3Imported Synonyms:FCRH3Imported, IFGP3Imported, IRTA3Imported, SPAP2Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160856.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18506 FCRL3
MIMⁱ	606510 gene
neXtProtⁱ	NX_Q96P31

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 573	ExtracellularSequence analysisAdd BLAST	556
Transmembraneⁱ	574 – 594	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	595 – 734	CytoplasmicSequence analysisAdd BLAST	140

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Rheumatoid arthritis (RA)9 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	650	Y → F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-662; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-662. Decreases calcium influx inhibition; when associated with F-662 and F-722. Decreases calcium influx inhibition; when associated with F-692 and F-722. 2 Publications	1
Mutagenesisⁱ	662	Y → F: Reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN6. No effect on interaction with PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-650. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-722. 2 Publications	1
Mutagenesisⁱ	692	Y → F: Partially reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN11. No effect on interaction with PTPN6. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-722. Alters binding with PTPN6 and PTPN11; when associated with F-772. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-722. 2 Publications	1
Mutagenesisⁱ	722	Y → F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-692. Alters binding with PTPN6 and PTPN11; when associated with F-692. Decreases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-650 and F-692. Decreases calcium influx inhibition; when associated with F-692. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	115352
MIMⁱ	180300 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000160856
PharmGKBⁱ	PA142671767

Polymorphism and mutation databases

BioMutaⁱ	FCRL3
DMDMⁱ	74761021

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000331640	18 – 734	Fc receptor-like protein 3Add BLAST		717

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	44 ↔ 82	PROSITE-ProRule annotation
Disulfide bondⁱ	120 ↔ 163	PROSITE-ProRule annotation
Disulfide bondⁱ	211 ↔ 260	PROSITE-ProRule annotation
Disulfide bondⁱ	309 ↔ 358	PROSITE-ProRule annotation
Disulfide bondⁱ	404 ↔ 451	PROSITE-ProRule annotation
Disulfide bondⁱ	497 ↔ 544	PROSITE-ProRule annotation
Glycosylationⁱ	561	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	650	Phosphotyrosine1 Publication	1
Modified residueⁱ	662	Phosphotyrosine1 Publication	1
Modified residueⁱ	692	Phosphotyrosine1 Publication	1
Modified residueⁱ	722	Phosphotyrosine1 Publication	1

Post-translational modificationⁱ

Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q96P31
PeptideAtlas More...PeptideAtlasⁱ	Q96P31
PRIDEⁱ	Q96P31
ProteomicsDBⁱ	77608 77609 [Q96P31-2] 77610 [Q96P31-3] 77611 [Q96P31-4] 77612 [Q96P31-5] 77613 [Q96P31-6] 77614 [Q96P31-7]

PTM databases

iPTMnetⁱ	Q96P31
PhosphoSitePlusⁱ	Q96P31

Expressionⁱ

Tissue specificityⁱ

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B-cells with innate-like features (at protein level) (PubMed:23857366). Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level). Expressed in a population of thymically derived natrurally ocurring regulatory T-cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142). Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus.7 Publications

Developmental stageⁱ

In B-cells, expression increases as a function of differentiation and peaks on memory B-cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000160856
ExpressionAtlasⁱ	Q96P31 baseline and differential
Genevisibleⁱ	Q96P31 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048022

HPAⁱ

HPA048022

Interactionⁱ

Subunit structureⁱ

Interacts (via phosphorylated ITIM motifs) with phosphatases INPP5D, PTPN6 and PTPN11. Interacts (via ITIM motifs) SYK and ZAP70.2 Publications

GO - Molecular functionⁱ

kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19843936
phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19843936
protein phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12051764
protein tyrosine kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12051764

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	125428, 6 interactors
IntActⁱ	Q96P31, 5 interactors
STRINGⁱ	9606.ENSP00000357167

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96P31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	21 – 98	Ig-like C2-type 1Add BLAST	78
Domainⁱ	99 – 182	Ig-like C2-type 2Add BLAST	84
Domainⁱ	192 – 270	Ig-like C2-type 3Add BLAST	79
Domainⁱ	284 – 369	Ig-like C2-type 4Add BLAST	86
Domainⁱ	383 – 470	Ig-like C2-type 5Add BLAST	88
Domainⁱ	476 – 563	Ig-like C2-type 6Add BLAST	88

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	648 – 653	ITIM motif 1	6
Motifⁱ	660 – 665	ITIM motif 2	6
Motifⁱ	690 – 695	ITIM motif 3	6
Motifⁱ	720 – 725	ITIM motif 4	6

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IH5T Eukaryota ENOG410YF57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119130
HOVERGENⁱ	HBG074073
InParanoidⁱ	Q96P31
KEGG Orthology (KO) More...KOⁱ	K06727
OMAⁱ	TVTFSWH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03OP
PhylomeDBⁱ	Q96P31
TreeFamⁱ	TF351107

Family and domain databases

Gene3Dⁱ	2.60.40.10, 6 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013151 Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047 ig, 1 hit PF13895 Ig_2, 4 hits
SMARTⁱ	View protein in SMART SM00409 IG, 6 hits SM00408 IGc2, 5 hits
SUPFAMⁱ	SSF48726 SSF48726, 6 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 6 hits

Sequences (7)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q96P31-1) [UniParc]FASTA Add to basket

Also known as: Spap2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180        190        200
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST 
       210        220        230        240        250
PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM 
       260        270        280        290        300
WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI 
       310        320        330        340        350
EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE 
       360        370        380        390        400
SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL 
       410        420        430        440        450
ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS 
       460        470        480        490        500
CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL 
       510        520        530        540        550
RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL 
       560        570        580        590        600
GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR 
       610        620        630        640        650
RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY 
       660        670        680        690        700
SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKTHP 
       710        720        730 
DDSAGEASSR GRAHEEDDEE NYENVPRVLL ASDH

Length:734

Mass (Da):80,856

Last modified:December 1, 2001 - v1

Checksum:ⁱB3411B73A35EC668

GO

Isoform 2 (identifier: Q96P31-2) [UniParc]FASTA Add to basket

Also known as: Spap2b

The sequence of this isoform differs from the canonical sequence as follows:
187-282: ELFLHPVLRA...SLRSQIRVQR → G

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        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180        190        200
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQGVPV SNVNLEIRPT 
       210        220        230        240        250
GGQLIEGENM VLICSVAQGS GTVTFSWHKE GRVRSLGRKT QRSLLAELHV 
       260        270        280        290        300
LTVKESDAGR YYCAADNVHS PILSTWIRVT VRIPVSHPVL TFRAPRAHTV 
       310        320        330        340        350
VGDLLELHCE SLRGSPPILY RFYHEDVTLG NSSAPSGGGA SFNLSLTAEH 
       360        370        380        390        400
SGNYSCDADN GLGAQHSHGV SLRVTVPVSR PVLTLRAPGA QAVVGDLLEL 
       410        420        430        440        450
HCESLRGSFP ILYWFYHEDD TLGNISAHSG GGASFNLSLT TEHSGNYSCE 
       460        470        480        490        500
ADNGLGAQHS KVVTLNVTGT SRNRTGLTAA GITGLVLSIL VLAAAAALLH 
       510        520        530        540        550
YARARRKPGG LSATGTSSHS PSECQEPSSS RPSRIDPQEP THSKPLAPME 
       560        570        580        590        600
LEPMYSNVNP GDSNPIYSQI WSIQHTKENS ANCPMMHQEH EELTVLYSEL 
       610        620        630 
KKTHPDDSAG EASSRGRAHE EDDEENYENV PRVLLASDH

Show »

Length:639

Mass (Da):69,929

Checksum:ⁱDEAD7AD4E64CA984

GO

Isoform 3 (identifier: Q96P31-3) [UniParc]FASTA Add to basket

Also known as: Spap2c

The sequence of this isoform differs from the canonical sequence as follows:
378-378: I → TLLSPSV

« Hide

        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180        190        200
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST 
       210        220        230        240        250
PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM 
       260        270        280        290        300
WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI 
       310        320        330        340        350
EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE 
       360        370        380        390        400
SDAGRYYCAA DNVHSPILST WIRVTVRTLL SPSVPVSHPV LTFRAPRAHT 
       410        420        430        440        450
VVGDLLELHC ESLRGSPPIL YRFYHEDVTL GNSSAPSGGG ASFNLSLTAE 
       460        470        480        490        500
HSGNYSCDAD NGLGAQHSHG VSLRVTVPVS RPVLTLRAPG AQAVVGDLLE 
       510        520        530        540        550
LHCESLRGSF PILYWFYHED DTLGNISAHS GGGASFNLSL TTEHSGNYSC 
       560        570        580        590        600
EADNGLGAQH SKVVTLNVTG TSRNRTGLTA AGITGLVLSI LVLAAAAALL 
       610        620        630        640        650
HYARARRKPG GLSATGTSSH SPSECQEPSS SRPSRIDPQE PTHSKPLAPM 
       660        670        680        690        700
ELEPMYSNVN PGDSNPIYSQ IWSIQHTKEN SANCPMMHQE HEELTVLYSE 
       710        720        730        740
LKKTHPDDSA GEASSRGRAH EEDDEENYEN VPRVLLASDH

Show »

Length:740

Mass (Da):81,441

Checksum:ⁱ038AFA83A2909E46

GO

Isoform 4 (identifier: Q96P31-4) [UniParc]FASTA Add to basket

Also known as: Spap2d

The sequence of this isoform differs from the canonical sequence as follows:
187-189: ELF → GNG
190-734: Missing.

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        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180 
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQGNG

Show »

Length:189

Mass (Da):21,441

Checksum:ⁱE4A4CC249EBC65C9

GO

Isoform 5 (identifier: Q96P31-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
188-199: LFLHPVLRASSS → ARCPAAILPLQR
200-734: Missing.

« Hide

        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180        190 
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQEARC PAAILPLQR

Show »

Length:199

Mass (Da):22,632

Checksum:ⁱD51D6112E9DA5603

GO

Isoform 6 (identifier: Q96P31-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
725-734: VPRVLLASDH → ILNPRKNKVQDFPCLCNT

« Hide

        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180        190        200
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST 
       210        220        230        240        250
PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM 
       260        270        280        290        300
WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI 
       310        320        330        340        350
EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE 
       360        370        380        390        400
SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL 
       410        420        430        440        450
ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS 
       460        470        480        490        500
CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL 
       510        520        530        540        550
RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL 
       560        570        580        590        600
GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR 
       610        620        630        640        650
RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY 
       660        670        680        690        700
SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKTHP 
       710        720        730        740 
DDSAGEASSR GRAHEEDDEE NYENILNPRK NKVQDFPCLC NT

Note: No experimental confirmation available.

Show »

Length:742

Mass (Da):81,853

Checksum:ⁱB0650200E7CA19B8

GO

Isoform 7 (identifier: Q96P31-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
698-707: THPDDSAGEA → EQSSRFSMSL
708-734: Missing.

« Hide

        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180        190        200
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST 
       210        220        230        240        250
PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM 
       260        270        280        290        300
WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI 
       310        320        330        340        350
EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE 
       360        370        380        390        400
SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL 
       410        420        430        440        450
ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS 
       460        470        480        490        500
CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL 
       510        520        530        540        550
RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL 
       560        570        580        590        600
GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR 
       610        620        630        640        650
RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY 
       660        670        680        690        700
SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKEQS 

SRFSMSL

Show »

Length:707

Mass (Da):77,921

Checksum:ⁱAC6D131F97359E8E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	244	R → K in AK098122 (PubMed:14702039).Curated		1
Sequence conflictⁱ	653	V → A in AAK91779 (PubMed:11493702).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_042924	28	N → D2 PublicationsCorresponds to variant dbSNP:rs7522061Ensembl.	1
Natural variantⁱVAR_042925	307	L → F. Corresponds to variant dbSNP:rs12041673Ensembl.	1
Natural variantⁱVAR_042926	445	H → N in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_042927	660	P → L. Corresponds to variant dbSNP:rs944627Ensembl.	1
Natural variantⁱVAR_042928	721	N → S. Corresponds to variant dbSNP:rs2282284Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_033300	187 – 282	ELFLH…IRVQR → G in isoform 2. 1 PublicationAdd BLAST	96
Alternative sequenceⁱVSP_033301	187 – 189	ELF → GNG in isoform 4. 1 Publication	3
Alternative sequenceⁱVSP_033302	188 – 199	LFLHP…RASSS → ARCPAAILPLQR in isoform 5. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_033303	190 – 734	Missing in isoform 4. 1 PublicationAdd BLAST	545
Alternative sequenceⁱVSP_033304	200 – 734	Missing in isoform 5. 1 PublicationAdd BLAST	535
Alternative sequenceⁱVSP_033305	378	I → TLLSPSV in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_033306	698 – 707	THPDDSAGEA → EQSSRFSMSL in isoform 7. 1 Publication	10
Alternative sequenceⁱVSP_033307	708 – 734	Missing in isoform 7. 1 PublicationAdd BLAST	27
Alternative sequenceⁱVSP_033308	725 – 734	VPRVLLASDH → ILNPRKNKVQDFPCLCNT in isoform 6. 1 Publication	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY043466 mRNA Translation: AAK91779.1 AF416901 mRNA Translation: AAL13290.1 AF416902 mRNA Translation: AAL13291.1 AF416903 mRNA Translation: AAL13292.1 AF416904 mRNA Translation: AAL13293.1 AF416905 mRNA Translation: AAL13294.1 EF064732 Genomic DNA Translation: ABK41915.1 AK098122 mRNA No translation available. AL356276 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52872.1 CH471121 Genomic DNA Translation: EAW52876.1 CH471121 Genomic DNA Translation: EAW52877.1 BC028933 mRNA Translation: AAH28933.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1167.1 [Q96P31-1] CCDS81385.1 [Q96P31-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001307262.1, NM_001320333.1 [Q96P31-6] NP_443171.2, NM_052939.3 [Q96P31-1] XP_006711208.1, XM_006711145.1 [Q96P31-1]
UniGeneⁱ	Hs.292449

Genome annotation databases

Ensemblⁱ	ENST00000368184; ENSP00000357167; ENSG00000160856 [Q96P31-1] ENST00000368186; ENSP00000357169; ENSG00000160856 [Q96P31-6] ENST00000477837; ENSP00000433430; ENSG00000160856 [Q96P31-2] ENST00000485028; ENSP00000434331; ENSG00000160856 [Q96P31-1] ENST00000492769; ENSP00000435487; ENSG00000160856 [Q96P31-3]
GeneIDⁱ	115352
KEGGⁱ	hsa:115352
UCSC genome browser More...UCSCⁱ	uc001fqz.5 human [Q96P31-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q96P31	Fc receptor like 3		PANPA		742
FCRL3 isoform 4		PANTR		742
Fc receptor-like protein 3 (Fragment)		HUMAN		256
FCRL3 isoform 4		PONAB		742
Fc receptor like 3		NOMLE		742
+16
Q96P31-2	FCRL3 isoform 6 (Fragment)		PONAB		640
Fc receptor-like 3, isoform CRA_b		HUMAN		639
FCRL3 isoform 6		PANTR		639

Protein	Similar proteins		Species	Score	Length
Q96P31	Fc receptor like 3		PANPA		742
FCRL3 isoform 4		PANTR		742
Fc receptor-like protein 3 (Fragment)		HUMAN		256
Fc receptor like 3		NOMLE		742
FCRL3 isoform 4		PONAB		742
+59
Q96P31-2	FCRL3 isoform 6 (Fragment)		PONAB		640
FCRL3 isoform 6		PANTR		639
Fc receptor-like 3, isoform CRA_b		HUMAN		639
UPI0006B3CF84		CANLF		657
UPI000D53BFCC		BOVIN		675
+74

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY043466 mRNA Translation: AAK91779.1 AF416901 mRNA Translation: AAL13290.1 AF416902 mRNA Translation: AAL13291.1 AF416903 mRNA Translation: AAL13292.1 AF416904 mRNA Translation: AAL13293.1 AF416905 mRNA Translation: AAL13294.1 EF064732 Genomic DNA Translation: ABK41915.1 AK098122 mRNA No translation available. AL356276 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52872.1 CH471121 Genomic DNA Translation: EAW52876.1 CH471121 Genomic DNA Translation: EAW52877.1 BC028933 mRNA Translation: AAH28933.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1167.1 [Q96P31-1] CCDS81385.1 [Q96P31-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001307262.1, NM_001320333.1 [Q96P31-6] NP_443171.2, NM_052939.3 [Q96P31-1] XP_006711208.1, XM_006711145.1 [Q96P31-1]
UniGeneⁱ	Hs.292449

3D structure databases

ProteinModelPortalⁱ	Q96P31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125428, 6 interactors
IntActⁱ	Q96P31, 5 interactors
STRINGⁱ	9606.ENSP00000357167

PTM databases

iPTMnetⁱ	Q96P31
PhosphoSitePlusⁱ	Q96P31

Polymorphism and mutation databases

BioMutaⁱ	FCRL3
DMDMⁱ	74761021

Proteomic databases

PaxDbⁱ	Q96P31
PeptideAtlas More...PeptideAtlasⁱ	Q96P31
PRIDEⁱ	Q96P31
ProteomicsDBⁱ	77608 77609 [Q96P31-2] 77610 [Q96P31-3] 77611 [Q96P31-4] 77612 [Q96P31-5] 77613 [Q96P31-6] 77614 [Q96P31-7]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	115352
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368184; ENSP00000357167; ENSG00000160856 [Q96P31-1] ENST00000368186; ENSP00000357169; ENSG00000160856 [Q96P31-6] ENST00000477837; ENSP00000433430; ENSG00000160856 [Q96P31-2] ENST00000485028; ENSP00000434331; ENSG00000160856 [Q96P31-1] ENST00000492769; ENSP00000435487; ENSG00000160856 [Q96P31-3]
GeneIDⁱ	115352
KEGGⁱ	hsa:115352
UCSC genome browser More...UCSCⁱ	uc001fqz.5 human [Q96P31-1]

Organism-specific databases

CTDⁱ	115352
DisGeNET More...DisGeNETⁱ	115352
EuPathDBⁱ	HostDB:ENSG00000160856.20
GeneCardsⁱ	FCRL3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18506 FCRL3
Human Protein Atlas More...HPAⁱ	HPA048022
MIMⁱ	180300 phenotype 606510 gene
neXtProtⁱ	NX_Q96P31
Open Targets More...OpenTargetsⁱ	ENSG00000160856
PharmGKBⁱ	PA142671767
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH5T Eukaryota ENOG410YF57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119130
HOVERGENⁱ	HBG074073
InParanoidⁱ	Q96P31
KEGG Orthology (KO) More...KOⁱ	K06727
OMAⁱ	TVTFSWH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03OP
PhylomeDBⁱ	Q96P31
TreeFamⁱ	TF351107

Miscellaneous databases

GeneWikiⁱ	FCRL3
GenomeRNAiⁱ	115352
Protein Ontology More...PROⁱ	PR:Q96P31
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160856
ExpressionAtlasⁱ	Q96P31 baseline and differential
Genevisibleⁱ	Q96P31 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 6 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013151 Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047 ig, 1 hit PF13895 Ig_2, 4 hits
SMARTⁱ	View protein in SMART SM00409 IG, 6 hits SM00408 IGc2, 5 hits
SUPFAMⁱ	SSF48726 SSF48726, 6 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FCRL3_HUMAN
Accessionⁱ	Q96P31Primary (citable) accession number: Q96P31 Secondary accession number(s): A0N0M4 Q96P30
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
	Last sequence update:	December 1, 2001
	Last modified:	July 18, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q96P31 (FCRL3_HUMAN)

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Fc receptor-like protein 3

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