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UniProtKB - Q96P31 (FCRL3_HUMAN)

Entry version 157 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Fc receptor-like protein 3

Gene

FCRL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96P31

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fc receptor-like protein 3Curated
Short name:
FcR-like protein 3Curated
Short name:
FcRL3Curated
Alternative name(s):
Fc receptor homolog 3Curated
Short name:
FcRH3Curated
IFGP family protein 3
Short name:
hIFGP3
Immune receptor translocation-associated protein 3
SH2 domain-containing phosphatase anchor protein 2
CD_antigen: CD307c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCRL3Imported
Synonyms:FCRH3Imported, IFGP3Imported, IRTA3Imported, SPAP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000160856.20

Human Gene Nomenclature Database

More...HGNCi		HGNC:18506, FCRL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606510, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96P31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 573ExtracellularSequence analysisAdd BLAST556
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei574 – 594HelicalSequence analysisAdd BLAST21
Topological domaini595 – 734CytoplasmicSequence analysisAdd BLAST140

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Rheumatoid arthritis (RA)9 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Related information in OMIM
Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease or multiple sclerosis. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Multiple sclerosis is an autoimmune/inflammatory neurodegenerative disease which mainly affects young adults and is characterized by destruction of myelin in the central nervous system.5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi650Y → F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-662; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-662. Decreases calcium influx inhibition; when associated with F-662 and F-722. Decreases calcium influx inhibition; when associated with F-692 and F-722. 2 Publications1
Mutagenesisi662Y → F: Reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN6. No effect on interaction with PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-650. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-722. 2 Publications1
Mutagenesisi692Y → F: Partially reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN11. No effect on interaction with PTPN6. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-722. Alters binding with PTPN6 and PTPN11; when associated with F-772. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-722. 2 Publications1
Mutagenesisi722Y → F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-692. Alters binding with PTPN6 and PTPN11; when associated with F-692. Decreases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-650 and F-692. Decreases calcium influx inhibition; when associated with F-692. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		115352
MIMi180300, phenotype

Open Targets

More...OpenTargetsi		ENSG00000160856

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671767

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96P31, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FCRL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033164018 – 734Fc receptor-like protein 3Add BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 82PROSITE-ProRule annotation
Disulfide bondi120 ↔ 163PROSITE-ProRule annotation
Disulfide bondi211 ↔ 260PROSITE-ProRule annotation
Disulfide bondi309 ↔ 358PROSITE-ProRule annotation
Disulfide bondi404 ↔ 451PROSITE-ProRule annotation
Disulfide bondi497 ↔ 544PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei650Phosphotyrosine1 Publication1
Modified residuei662Phosphotyrosine1 Publication1
Modified residuei692Phosphotyrosine1 Publication1
Modified residuei722Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96P31

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96P31

PeptideAtlas

More...PeptideAtlasi		Q96P31

PRoteomics IDEntifications database

More...PRIDEi		Q96P31

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77608 [Q96P31-1]
77609 [Q96P31-2]
77610 [Q96P31-3]
77611 [Q96P31-4]
77612 [Q96P31-5]
77613 [Q96P31-6]
77614 [Q96P31-7]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96P31, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96P31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96P31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B-cells with innate-like features (at protein level) (PubMed:23857366). Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level). Expressed in a population of thymically derived natrurally ocurring regulatory T-cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142). Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus.7 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In B-cells, expression increases as a function of differentiation and peaks on memory B-cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160856, Expressed in lymph node and 120 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96P31, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96P31, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160856, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via phosphorylated ITIM motifs) with phosphatases INPP5D, PTPN6 and PTPN11. Interacts (via ITIM motifs) SYK and ZAP70.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125428, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q96P31, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357167

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96P31, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 98Ig-like C2-type 1Add BLAST78
Domaini99 – 182Ig-like C2-type 2Add BLAST84
Domaini192 – 270Ig-like C2-type 3Add BLAST79
Domaini284 – 369Ig-like C2-type 4Add BLAST86
Domaini383 – 470Ig-like C2-type 5Add BLAST88
Domaini476 – 563Ig-like C2-type 6Add BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi648 – 653ITIM motif 16
Motifi660 – 665ITIM motif 26
Motifi690 – 695ITIM motif 36
Motifi720 – 725ITIM motif 46

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S65W, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214497

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023383_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96P31

KEGG Orthology (KO)

More...KOi		K06727

Identification of Orthologs from Complete Genome Data

More...OMAi		PWSTTFK

Database of Orthologous Groups

More...OrthoDBi		53940at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96P31

TreeFam database of animal gene trees

More...TreeFami		TF351107

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00047, ig, 1 hit
PF13895, Ig_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96P31-1) [UniParc]FASTAAdd to basket
Also known as: Spap2a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLWLLLLIL TPGREQSGVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS 
        60         70         80         90        100
LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD 
       110        120        130        140        150
WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT 
       160        170        180        190        200
VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST 
       210        220        230        240        250
PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM 
       260        270        280        290        300
WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI 
       310        320        330        340        350
EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE 
       360        370        380        390        400
SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL 
       410        420        430        440        450
ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS 
       460        470        480        490        500
CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL 
       510        520        530        540        550
RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL 
       560        570        580        590        600
GAQHSKVVTL NVTGTSRNRT GLTAAGITGL VLSILVLAAA AALLHYARAR 
       610        620        630        640        650
RKPGGLSATG TSSHSPSECQ EPSSSRPSRI DPQEPTHSKP LAPMELEPMY 
       660        670        680        690        700
SNVNPGDSNP IYSQIWSIQH TKENSANCPM MHQEHEELTV LYSELKKTHP 
       710        720        730 
DDSAGEASSR GRAHEEDDEE NYENVPRVLL ASDH
Length:734
Mass (Da):80,856
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3411B73A35EC668
GO
Isoform 2 (identifier: Q96P31-2) [UniParc]FASTAAdd to basket
Also known as: Spap2b

The sequence of this isoform differs from the canonical sequence as follows:
     187-282: ELFLHPVLRA...SLRSQIRVQR → G

Show »
Length:639
Mass (Da):69,929
Checksum:iDEAD7AD4E64CA984
GO
Isoform 3 (identifier: Q96P31-3) [UniParc]FASTAAdd to basket
Also known as: Spap2c

The sequence of this isoform differs from the canonical sequence as follows:
     378-378: I → TLLSPSV

Show »
Length:740
Mass (Da):81,441
Checksum:i038AFA83A2909E46
GO
Isoform 4 (identifier: Q96P31-4) [UniParc]FASTAAdd to basket
Also known as: Spap2d

The sequence of this isoform differs from the canonical sequence as follows:
     187-189: ELF → GNG
     190-734: Missing.

Show »
Length:189
Mass (Da):21,441
Checksum:iE4A4CC249EBC65C9
GO
Isoform 5 (identifier: Q96P31-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-199: LFLHPVLRASSS → ARCPAAILPLQR
     200-734: Missing.

Show »
Length:199
Mass (Da):22,632
Checksum:iD51D6112E9DA5603
GO
Isoform 6 (identifier: Q96P31-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-734: VPRVLLASDH → ILNPRKNKVQDFPCLCNT

Show »
Length:742
Mass (Da):81,853
Checksum:iB0650200E7CA19B8
GO
Isoform 7 (identifier: Q96P31-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-707: THPDDSAGEA → EQSSRFSMSL
     708-734: Missing.

Show »
Length:707
Mass (Da):77,921
Checksum:iAC6D131F97359E8E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNJ6R4GNJ6_HUMAN
Fc receptor-like protein 3
FCRL3
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244R → K in AK098122 (PubMed:14702039).Curated1
Sequence conflicti653V → A in AAK91779 (PubMed:11493702).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04292428N → D2 PublicationsCorresponds to variant dbSNP:rs7522061Ensembl.1
Natural variantiVAR_042925307L → F. Corresponds to variant dbSNP:rs12041673EnsemblClinVar.1
Natural variantiVAR_042926445H → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042927660P → L. Corresponds to variant dbSNP:rs944627Ensembl.1
Natural variantiVAR_042928721N → S. Corresponds to variant dbSNP:rs2282284Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033300187 – 282ELFLH…IRVQR → G in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_033301187 – 189ELF → GNG in isoform 4. 1 Publication3
Alternative sequenceiVSP_033302188 – 199LFLHP…RASSS → ARCPAAILPLQR in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033303190 – 734Missing in isoform 4. 1 PublicationAdd BLAST545
Alternative sequenceiVSP_033304200 – 734Missing in isoform 5. 1 PublicationAdd BLAST535
Alternative sequenceiVSP_033305378I → TLLSPSV in isoform 3. 1 Publication1
Alternative sequenceiVSP_033306698 – 707THPDDSAGEA → EQSSRFSMSL in isoform 7. 1 Publication10
Alternative sequenceiVSP_033307708 – 734Missing in isoform 7. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_033308725 – 734VPRVLLASDH → ILNPRKNKVQDFPCLCNT in isoform 6. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY043466 mRNA Translation: AAK91779.1
AF416901 mRNA Translation: AAL13290.1
AF416902 mRNA Translation: AAL13291.1
AF416903 mRNA Translation: AAL13292.1
AF416904 mRNA Translation: AAL13293.1
AF416905 mRNA Translation: AAL13294.1
EF064732 Genomic DNA Translation: ABK41915.1
AK098122 mRNA No translation available.
AL356276 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52872.1
CH471121 Genomic DNA Translation: EAW52876.1
CH471121 Genomic DNA Translation: EAW52877.1
BC028933 mRNA Translation: AAH28933.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1167.1 [Q96P31-1]
CCDS81385.1 [Q96P31-6]

NCBI Reference Sequences

More...RefSeqi		NP_001307262.1, NM_001320333.1 [Q96P31-6]
NP_443171.2, NM_052939.3 [Q96P31-1]
XP_006711208.1, XM_006711145.1 [Q96P31-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368184; ENSP00000357167; ENSG00000160856 [Q96P31-1]
ENST00000368186; ENSP00000357169; ENSG00000160856 [Q96P31-6]
ENST00000477837; ENSP00000433430; ENSG00000160856 [Q96P31-2]
ENST00000485028; ENSP00000434331; ENSG00000160856 [Q96P31-1]
ENST00000492769; ENSP00000435487; ENSG00000160856 [Q96P31-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		115352

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:115352

UCSC genome browser

More...UCSCi		uc001fqz.5, human [Q96P31-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043466 mRNA Translation: AAK91779.1
AF416901 mRNA Translation: AAL13290.1
AF416902 mRNA Translation: AAL13291.1
AF416903 mRNA Translation: AAL13292.1
AF416904 mRNA Translation: AAL13293.1
AF416905 mRNA Translation: AAL13294.1
EF064732 Genomic DNA Translation: ABK41915.1
AK098122 mRNA No translation available.
AL356276 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52872.1
CH471121 Genomic DNA Translation: EAW52876.1
CH471121 Genomic DNA Translation: EAW52877.1
BC028933 mRNA Translation: AAH28933.1
CCDSiCCDS1167.1 [Q96P31-1]
CCDS81385.1 [Q96P31-6]
RefSeqiNP_001307262.1, NM_001320333.1 [Q96P31-6]
NP_443171.2, NM_052939.3 [Q96P31-1]
XP_006711208.1, XM_006711145.1 [Q96P31-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125428, 13 interactors
IntActiQ96P31, 8 interactors
STRINGi9606.ENSP00000357167

PTM databases

GlyGeniQ96P31, 1 site
iPTMnetiQ96P31
PhosphoSitePlusiQ96P31

Polymorphism and mutation databases

BioMutaiFCRL3
DMDMi74761021

Proteomic databases

MassIVEiQ96P31
PaxDbiQ96P31
PeptideAtlasiQ96P31
PRIDEiQ96P31
ProteomicsDBi77608 [Q96P31-1]
77609 [Q96P31-2]
77610 [Q96P31-3]
77611 [Q96P31-4]
77612 [Q96P31-5]
77613 [Q96P31-6]
77614 [Q96P31-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2552, 157 antibodies

The DNASU plasmid repository

More...DNASUi		115352

Genome annotation databases

EnsembliENST00000368184; ENSP00000357167; ENSG00000160856 [Q96P31-1]
ENST00000368186; ENSP00000357169; ENSG00000160856 [Q96P31-6]
ENST00000477837; ENSP00000433430; ENSG00000160856 [Q96P31-2]
ENST00000485028; ENSP00000434331; ENSG00000160856 [Q96P31-1]
ENST00000492769; ENSP00000435487; ENSG00000160856 [Q96P31-3]
GeneIDi115352
KEGGihsa:115352
UCSCiuc001fqz.5, human [Q96P31-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		115352
DisGeNETi115352
EuPathDBiHostDB:ENSG00000160856.20

GeneCards: human genes, protein and diseases

More...GeneCardsi		FCRL3
HGNCiHGNC:18506, FCRL3
HPAiENSG00000160856, Tissue enhanced (blood, lymphoid tissue)
MIMi180300, phenotype
606510, gene
neXtProtiNX_Q96P31
OpenTargetsiENSG00000160856
PharmGKBiPA142671767

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S65W, Eukaryota
GeneTreeiENSGT01000000214497
HOGENOMiCLU_023383_6_1_1
InParanoidiQ96P31
KOiK06727
OMAiPWSTTFK
OrthoDBi53940at2759
PhylomeDBiQ96P31
TreeFamiTF351107

Enzyme and pathway databases

PathwayCommonsiQ96P31

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		115352, 4 hits in 863 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FCRL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		115352
PharosiQ96P31, Tbio

Protein Ontology

More...PROi		PR:Q96P31
RNActiQ96P31, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160856, Expressed in lymph node and 120 other tissues
ExpressionAtlasiQ96P31, baseline and differential
GenevisibleiQ96P31, HS

Family and domain databases

Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
PfamiView protein in Pfam
PF00047, ig, 1 hit
PF13895, Ig_2, 4 hits
SMARTiView protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 5 hits
SUPFAMiSSF48726, SSF48726, 6 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCRL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96P31
Secondary accession number(s): A0N0M4
, A8MTH7, D3DVD2, Q5VXZ8, Q8N6S2, Q96LA4, Q96P27, Q96P28, Q96P29, Q96P30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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