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Protein

Cytosolic 5'-nucleotidase 1B

Gene

NT5C1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by ADP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei467NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 5'-nucleotidase activity Source: GO_Central
  • magnesium ion binding Source: InterPro
  • nucleotide binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-74259 Purine catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q96P26

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic 5'-nucleotidase 1B (EC:3.1.3.5)
Short name:
cN1B
Alternative name(s):
Autoimmune infertility-related protein
Cytosolic 5'-nucleotidase IB
Short name:
cN-IB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NT5C1B
Synonyms:AIRP
ORF Names:FKSG85
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185013.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17818 NT5C1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610526 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96P26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
93034

Open Targets

More...
OpenTargetsi
ENSG00000185013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31800

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NT5C1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47116569

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447961 – 610Cytosolic 5'-nucleotidase 1BAdd BLAST610

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96P26

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96P26

PeptideAtlas

More...
PeptideAtlasi
Q96P26

PRoteomics IDEntifications database

More...
PRIDEi
Q96P26

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77604
77605 [Q96P26-2]
77606 [Q96P26-3]
77607 [Q96P26-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96P26-3 [Q96P26-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q96P26

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96P26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96P26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185013 Expressed in 86 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_NT5C1B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96P26 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96P26 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056683

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124995, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352904

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96P26

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96P26

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi102 – 176Ser-richAdd BLAST75
Compositional biasi157 – 201Pro-richAdd BLAST45
Compositional biasi267 – 271Poly-Gln5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-nucleotidase type 3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE01 Eukaryota
ENOG410XPRD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017767

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050426

KEGG Orthology (KO)

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KOi
K01081

Identification of Orthologs from Complete Genome Data

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OMAi
MEYQLNN

Database of Orthologous Groups

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OrthoDBi
694318at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96P26

TreeFam database of animal gene trees

More...
TreeFami
TF329831

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR010394 5-nucleotidase

The PANTHER Classification System

More...
PANTHERi
PTHR31367 PTHR31367, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06189 5-nucleotidase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96P26-1) [UniParc]FASTAAdd to basket
Also known as: CN-Ib alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQTSLKQKK NEPGMRSSKE SLEAEKRKES DKTGVRLSNQ MRRAVNPNHS
60 70 80 90 100
LRCCPFQGHS SCRRCLCAAE GTALGPCHTI RIYIHMCLLW EQGQQITMMR
110 120 130 140 150
GSQESSLRKT DSRGYLVRSQ WSRISRSPST KAPSIDEPRS RNTSAKLPSS
160 170 180 190 200
STSSRTPSTS PSLHDSSPPP LSGQPSLQPP ASPQLPRSLD SRPPTPPEPD
210 220 230 240 250
PGSRRSTKMQ ENPEAWAQGI VREIRQTRDS QPLEYSRTSP TEWKSSSQRR
260 270 280 290 300
GIYPASTQLD RNSLSEQQQQ QREDEDDYEA AYWASMRSFY EKNPSCSRPW
310 320 330 340 350
PPKPKNAITI ALSSCALFNM VDGRKIYEQE GLEKYMEYQL TNENVILTPG
360 370 380 390 400
PAFRFVKALQ YVNARLRDLY PDEQDLFDIV LMTNNHAQVG VRLINSVNHY
410 420 430 440 450
GLLIDRFCLT GGKDPIGYLK AYLTNLYIAA DSEKVQEAIQ EGIASATMFD
460 470 480 490 500
GAKDMAYCDT QLRVAFDGDA VLFSDESEHF TKEHGLDKFF QYDTLCESKP
510 520 530 540 550
LAQGPLKGFL EDLGRLQKKF YAKNERLLCP IRTYLVTARS AASSGARVLK
560 570 580 590 600
TLRRWGLEID EALFLAGAPK SPILVKIRPH IFFDDHMFHI EGAQRLGSIA
610
AYGFNKKFSS
Length:610
Mass (Da):68,804
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEC0BE9E5498B3E9
GO
Isoform 2 (identifier: Q96P26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-100: Missing.

Note: No experimental confirmation available.
Show »
Length:550
Mass (Da):61,934
Checksum:iC0C913137DFD2479
GO
Isoform 3 (identifier: Q96P26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Note: No experimental confirmation available.
Show »
Length:402
Mass (Da):45,860
Checksum:iBFF1852B61C0EA5B
GO
Isoform 4 (identifier: Q96P26-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-610: LGSIAAYGFNKKFSS → KSLGWMS

Note: No experimental confirmation available.
Show »
Length:602
Mass (Da):68,022
Checksum:i1D2A9C840FE9ED0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C4AM88C4AM88_HUMAN
Cytosolic 5'-nucleotidase 1B
NT5C1B
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZQ4H7BZQ4_HUMAN
Cytosolic 5'-nucleotidase 1B
NT5C1B
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW75C9JW75_HUMAN
Cytosolic 5'-nucleotidase 1B
NT5C1B
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK39108 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK83285 differs from that shown. Reason: Frameshift at position 320.Curated
The sequence BAC04103 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC44363 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173G → R in AAL11910 (Ref. 2) Curated1
Sequence conflicti287R → K in AAK39108 (Ref. 1) Curated1
Sequence conflicti297S → W in AAK39108 (Ref. 1) Curated1
Sequence conflicti351P → Q in AAL11910 (Ref. 2) Curated1
Sequence conflicti362V → I in BAC04174 (PubMed:14702039).Curated1
Sequence conflicti528L → P in CAC44363 (PubMed:11690631).Curated1
Sequence conflicti552L → F in AAK39108 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0102021 – 208Missing in isoform 3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_01020141 – 100Missing in isoform 2. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_010203596 – 610LGSIA…KKFSS → KSLGWMS in isoform 4. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF356185 mRNA Translation: AAK39108.1 Different initiation.
AF417165 mRNA Translation: AAL11910.1
AK093234 mRNA Translation: BAC04103.1 Different initiation.
AK093464 mRNA Translation: BAC04174.1
AK057444 mRNA Translation: BAB71489.1
AC079148 Genomic DNA Translation: AAX93260.1
CH471053 Genomic DNA Translation: EAX00853.1
BC136387 mRNA Translation: AAI36388.1
BC171761 mRNA Translation: AAI71761.1
AF352326 mRNA Translation: AAK83285.1 Frameshift.
AJ295254 mRNA Translation: CAC44363.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33149.1 [Q96P26-2]
CCDS33150.1 [Q96P26-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001002006.1, NM_001002006.2 [Q96P26-1]
NP_001186015.1, NM_001199086.1
NP_001186016.1, NM_001199087.1
NP_001186017.1, NM_001199088.1
NP_001186033.1, NM_001199104.1 [Q96P26-4]
NP_150278.2, NM_033253.3 [Q96P26-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.744358

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304081; ENSP00000305979; ENSG00000185013 [Q96P26-2]
ENST00000359846; ENSP00000352904; ENSG00000185013 [Q96P26-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100526794
93034

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100526794
hsa:93034

UCSC genome browser

More...
UCSCi
uc002rcz.4 human [Q96P26-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356185 mRNA Translation: AAK39108.1 Different initiation.
AF417165 mRNA Translation: AAL11910.1
AK093234 mRNA Translation: BAC04103.1 Different initiation.
AK093464 mRNA Translation: BAC04174.1
AK057444 mRNA Translation: BAB71489.1
AC079148 Genomic DNA Translation: AAX93260.1
CH471053 Genomic DNA Translation: EAX00853.1
BC136387 mRNA Translation: AAI36388.1
BC171761 mRNA Translation: AAI71761.1
AF352326 mRNA Translation: AAK83285.1 Frameshift.
AJ295254 mRNA Translation: CAC44363.1 Different initiation.
CCDSiCCDS33149.1 [Q96P26-2]
CCDS33150.1 [Q96P26-1]
RefSeqiNP_001002006.1, NM_001002006.2 [Q96P26-1]
NP_001186015.1, NM_001199086.1
NP_001186016.1, NM_001199087.1
NP_001186017.1, NM_001199088.1
NP_001186033.1, NM_001199104.1 [Q96P26-4]
NP_150278.2, NM_033253.3 [Q96P26-2]
UniGeneiHs.744358

3D structure databases

ProteinModelPortaliQ96P26
SMRiQ96P26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124995, 2 interactors
STRINGi9606.ENSP00000352904

PTM databases

DEPODiQ96P26
iPTMnetiQ96P26
PhosphoSitePlusiQ96P26

Polymorphism and mutation databases

BioMutaiNT5C1B
DMDMi47116569

Proteomic databases

jPOSTiQ96P26
PaxDbiQ96P26
PeptideAtlasiQ96P26
PRIDEiQ96P26
ProteomicsDBi77604
77605 [Q96P26-2]
77606 [Q96P26-3]
77607 [Q96P26-4]
TopDownProteomicsiQ96P26-3 [Q96P26-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304081; ENSP00000305979; ENSG00000185013 [Q96P26-2]
ENST00000359846; ENSP00000352904; ENSG00000185013 [Q96P26-1]
GeneIDi100526794
93034
KEGGihsa:100526794
hsa:93034
UCSCiuc002rcz.4 human [Q96P26-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
100526794
93034
DisGeNETi93034
EuPathDBiHostDB:ENSG00000185013.16

GeneCards: human genes, protein and diseases

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GeneCardsi
NT5C1B
HGNCiHGNC:17818 NT5C1B
HPAiHPA056683
MIMi610526 gene
neXtProtiNX_Q96P26
OpenTargetsiENSG00000185013
PharmGKBiPA31800

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE01 Eukaryota
ENOG410XPRD LUCA
GeneTreeiENSGT00390000017767
HOVERGENiHBG050426
KOiK01081
OMAiMEYQLNN
OrthoDBi694318at2759
PhylomeDBiQ96P26
TreeFamiTF329831

Enzyme and pathway databases

ReactomeiR-HSA-74259 Purine catabolism
SABIO-RKiQ96P26

Miscellaneous databases

Protein Ontology

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PROi
PR:Q96P26

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000185013 Expressed in 86 organ(s), highest expression level in sperm
CleanExiHS_NT5C1B
ExpressionAtlasiQ96P26 baseline and differential
GenevisibleiQ96P26 HS

Family and domain databases

InterProiView protein in InterPro
IPR010394 5-nucleotidase
PANTHERiPTHR31367 PTHR31367, 1 hit
PfamiView protein in Pfam
PF06189 5-nucleotidase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5NT1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96P26
Secondary accession number(s): B5MCR0
, B7ZVX7, Q53RX2, Q8N9W3, Q8NA26, Q96DU5, Q96KE6, Q96M25, Q96SA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: January 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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